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Autoimmunity Volume 35, 2002 - Issue 5
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Research Article

Detection of Cytotoxic Anti-LEDGF Autoantibodies in Atopic Dermatitis

Masahiko Ayaki Center for Ophthalmic Research, Brigham and Women's Hospital, Department of Ophthalmology, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115 USA
,
Nobuyuki Ohoguro Center for Ophthalmic Research, Brigham and Women's Hospital, Department of Ophthalmology, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115 USA
,
Noriyuki Azuma National Children's Hospital, Tokyo, Japan
,
Yoshinao Majima Department of Ophthalmology, Fujita Health University, Aichi, Japan
,
Kiyomi Yata Department of Ophthalmology, Numazu City Hospital, Shizuoka, Japan
,
Nobuhiro Ibaraki Department of Ophthalmology, Nippon Medical School, Tokyo, Japan
,
Dhirendra P. Singh Center for Ophthalmic Research, Brigham and Women's Hospital, Department of Ophthalmology, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115 USA
,
Vincent Ko Department of Pathology, Chicago Methodist Hospital, Chicago, USA
&
Toshimichi Shinohara Center for Ophthalmic Research, Brigham and Women's Hospital, Department of Ophthalmology, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115 USA
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Pages 319-327 | Published online: 07 Jul 2009

  • Hoare, C., Li Wan Po, A. and Williams, H. (2000) "Systematic review of treatments for atopic eczema", Health Technol. Assess. 4, 1 - 191
  • Wuthrich, B. (1999) "Clinical aspects, epidemiology, and prognosis of atopic dermatitis", Ann. Allergy Asthma Immunol. 83, 464 - 470
  • Wood, R.A. and Doran, T.F. (1995) "Atopic disease, rhinitis and conjunctivitis, and upper respiratory infections", Curr. Opin. Pediatr. 7, 617 - 627
  • Cooper, K. (1994) "Atopic dermatitis: Recent trends in the pathogenesis and therapy", J. Investig. Dermatol. 102, 128 - 137
  • Cookson, W.O.C., Young, R.P., Sandford, A.J., Moffatt, M.F., Shirakawa, T., Sharp, P.A., Faux, J.A., Julier, C., Le Souff, P.N., Nakamura, Y., Lathrop, G.M. and Hopkin, J.M. (1992) "Maternal inheritance of atopic IgE responsiveness on chromosome 11q", Lancet 340, 381 - 384
  • Leung, D.Y.M. (1993) "The immunologic basis of atopic dermatitis", Clin. Rev. Allergy 11, 447 - 469
  • Lewis-Jones, S. (2001) "Atopic dermatitis in childhood", Hosp. Med. 62, 136 - 143
  • Blaylock, W.K. (1986) "Atopic dermatitis", In: Thiers, B.H. and Dobson, R.L., eds, Pathogenesis of Skin Disease (Churchill Livingstone, New York), pp 315 - 322
  • Leung, D.Y.M., Parkman, R., Feller, J., Wood, M. and Geha, R.S. (1982) "Cell-mediated cytotoxicity against fibroblasts in atopic dermatitis", J. Immunol. 128, 1736 - 1741
  • Cowan, A. and Klauder, J.V. (1950) "Frequency of occurrence of cataract in atopic dermatitis", Arch. Ophthalmol. 43, 759 - 768
  • Brunsting, L.A., Reed, W.B. and Bair, H.L. (1955) "Occurrence of cataract in atopic dermatitis", Arch. Dermatol. 72, 237 - 241
  • Nakano, E., Iwasaki, T., Osanai, T., Yamamoto, K. and Miyauchi, M. (1997) "Ocular complications of atopic dermatitis", J. Jpn Ophthalmol. Soc. 101, 64 - 68
  • Fagerholm, P., Palmquist, B.M. and Philipson, B. (1984) "Atopic cataract: Changes in the lens epithelium and subcapsular cortex", Graefe's Arch. Clin. Exp. Ophthalmol. 221, 149 - 152
  • Sasaki, K. and Kojima, M. (1996) "Atopic cataract; its initial lens changes", Ganka 38, 1511 - 1519
  • Mihara, E., Miyata, H., Nagata, M. and Ohama, E. (2000) "Lens epithelial cell damage and apoptosis in atopic cataract. Histopathological and immunohistochemical studies", Jpn J. Ophthalmol. 44, 695 - 696
  • Singh, D.P., Ohguro, N., Chylack, Jr, L.T. and Shinohara, T. (1999) "Lens epithelium-derived growth factor (LEDGF); Resistance to thermal and oxidative stresses", Investig. Ophthalmol. Vis. Sci. 40, 1444 - 1451
  • Singh, D.P., Ohoguro, N., Kikuchi, T., Sueno, T., Reddy, V.N., Yuge, K., Chylack, Jr, L.T. and Shinohara, T. (2000) "Lens epithelium-derived growth factor (LEDGF): Effects on growth and survival of lens epithelial cells, keratinocytes and fibroblasts", Biochem. Biophys. Res. Commun. 267, 373 - 381
  • Nakamura, M., Singh, D.P., Chylack, Jr, L.T. and Shinohara, T. (2000) "Lens epithelium-derived growth factor (LEDGF): survival of embryonic chick neuroretinal cells", Investig. Ophthalmol. Vis. Sci. 41, 1168 - 1175
  • Machida, S., Chaudhry, P., Shinohara, T., Singh, D.P., Reddy, V.K., Chylack, Jr, L.T., Sieving, P.A. and Bush, R.A. (2000) "Lens epithelium-derived growth factor (LEDGF) promotes photoreceptor survival in light-damaged and Royal College of Surgeons (RCS) rats", Investig. Ophthalmol. Vis. Sci. 42, 1087 - 1095
  • Singh, D.P., Fatma, N., Kimura, A., Chylack, Jr, L.T. and Shinohara, T. (2001) "LEDGF binds to Heat Shock (HSE) and Stress-related elements (STRE) to activate the expression of stress-related genes", Biochem. Biophy. Res. Commun. 283, 943 - 955
  • Beere, H.M., Wolf, B.B., Cain, K., Mosser, D.D., Mahboubi, A., Kuwana, T., Railor, P., Morimoto, R.I., Cohen, G.M. and Green, D.R. (2000) "Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome", Nat. Cell Biol. 2, 469 - 475
  • Bruey, J.M., Ducasse, C., Bonniaud, P., Ravagnan, L., Susin, S.A., Siaz-Latoud, C., Gurbuxani, S., Arrigo, A.P., Kroemer, G., Solary, E. and Garrido, C. (2000) "Hsp-27 negatively regulates cell death by interacting with cytochrome c", Nat. Cell Biol. 2, 645 - 652
  • Kamradt, M.C., Chen, F. and Cryns, V.L. (2001) "The small heat shock protein alpha B-crystallin negatively regulates cytochrome c-and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation", J. Biol. Chem. 276, 16059 - 16063
  • Li, C.Y., Lee, J.S., Ko, Y.G., Kim, J.I. and Seo, J.S. (2000) "Heat-shock protein 70 inhibits apoptosis downstream of cytochrome C release upstream of caspase-3 activation", J. Biol. Chem. 275, 25665 - 25671
  • Saleh, A., Srinivasula, S.M., Balkir, L., Robbins, P.D. and Alnemri, E.S. (2000) "Negative regulation of Apaf-1 apoptosome by Hsp70", Nat. Cell Biol. 2, 476 - 483
  • Fatma, N., Singh, D.P., Shinohara, T. and Chylack, Jr, L.T. (2000) "Heparin's roles in stabilizing, potentiating, and transporting LEDGF into the nucleus", Investig. Ophthalmol. Vis. Sci. 41, 2648 - 2657
  • Eigenmann, P.A. (2001) "Clinical features and diagnostic criteria of atopic dermatitis in relation to age", Pediatr. Allergy Immunol. 12, 69 - 74
  • Arita, T., Lin, L.-R., Susan, S.R. and Reddy, V.N. (1990) "Enhancement of differentiation of human lens epithelium in tissue culture by changes in cell-substrate adhesion", Investig. Ophthalmol. Vis. Sci. 31, 2395 - 2404
  • Singh, D.P., Guru, S.C., Kikuchi, T. and Shinohara, T. (1995) "Autoantibodies against beta-crystallins induse lens epithelial cell damage and cataract formation in mice", J. Immunol. 155, 993 - 999
  • Harlow, E. and Lane, D. (1988) Antibodies: A Laboratory Manual (Cold Spring Harbor Laboratory Press, New York), pp 471 - 511
  • Bradford, M.M. (1976) "A rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding", Anal. Biochem. 72, 248 - 254
  • Sasaki, K., Kojima, M., Nakaizumi, H., Kitagawa, K., Yamada, Y. and Ishizaki, H. (1998) "Early lens changes seen in patients with atopic dermatitis applying image analysis processing of Scheimpflug and specular microscopic images", Ophthalmologica 212, 88 - 94
  • Majima, K., Majima, Y. and Kousaka, M. (1998) "Cell-biological analysis of atopic cataractous lenses", Ophthalmologica 212, 310 - 317
  • Cunha-Vaz, J. (1979) "The blood-ocular barriers", Surv. Ophthalmol. 23, 279 - 296
  • Streilein, J.W. and Niederkorn, J.Y. (1981) "Induction of anterior chamber-associated immune deviation requires an intact, functional spleen", J. Exp. Med. 153, 1058 - 1067
  • Ring, J. (1983) "Plasma histamine concentrations in atopic eczema", Clin. Allergy 13, 545 - 552
  • Waitzman, M.B. and King, C.D. (1967) "Prostaglandin influences on intraocular pressure and pupil size", Am. J. Physiol. 212, 329 - 334
  • Beitch, B.R. and Eakins, K.E. (1969) "The effects of prostaglandins on the intraocular pressure of the rabbit", Br. J. Pharmacol. 37, 158 - 167
  • Cole, D.F. and Unger, W.G. (1974) "Proceedings: The role of prostaglandins in the ocular response to trauma", J. Physiol. 236, 18 - 19
  • Cole, D.F. (1974) "The site of breakdown of the blood-aqueous barrier under the influence of vaso-dilator drugs", Exp. Eye Res. 19, 591 - 607
  • Worm, A.M. and Rossing, N. (1980) "Microvascular protein leakage in extensive skin disease: Aspects of the transport mechanisms", J. Investig. Dermatol. 75, 302 - 305
  • Cole, D.F. (1974) "The site of breakdown of the blood-aqueous barrier under the influence of vaso-dilator drugs", Exp. Eye Res. 19, 591 - 607
  • Elliott, P.J., Mackic, J.B., Graney, W.F., Bartus, R.T. and Zlokovic, B.V. (1995) "RMP-7, a bradykinin agonist increases permeability of blood-ocular barriers in the guinea pig", Investig. Ophthalmol. Vis. Sci. 36, 2542 - 2547
  • Nakano, E., Iwasaki, T., Osanai, T., Yamamoto, K. and Miyauchi, M. (1977) "Ocular complication of atopic dermatitis", Nichigan Kaishi 101, 64 - 68
  • Ashton, N. and Cunha-Vas, J.G. (1965) "Effect of histamine on the permeability of the ocular vessels", Arch. Ophthalmol. 73, 211 - 223
  • Suzuki, J., Katsushima, H., Maruyama, I., Konari, K., Sekine, N. and Nakagawa, T. (1997) "Comparison of retinal breaks between patients with atopic dermatitis and mentally retarded patients with self-inflicted ocular injury", Nichigan Kaishi 101, 446 - 449
  • Leonhardt, A., Krauss, M., Gieler, U., Schweer, H., Happle, R. and Seyberth, H.W. (1997) "In vivo formation of prostaglandid E 1 and prostaglandin E 2 in atopic dermatitis", Br. J. Dermatol. 136, 337 - 340
  • Hamberg, M. and Samuelsson, B. (1971) "On the metabolism of prostaglandins E1 and E2 in man", J. Biol. Chem. 246, 6713 - 6721
  • Haman, K.J., Barker, R.L., Ten, R.M. and Gleich, G.J. (1991) "The molecular biology of eosinophil granule proteins", Int. Arch. Allergy Appl. Immunol. 94, 202 - 209
  • Young, J.D., Peterson, P., Venge, P. and Cohn, Z.A. (1986) "Mechanisms of membrane damage mediated by human eosinophil cationic protein", Nature 321, 613 - 616
  • Yokoi, N., Hirano, S., Okamoto, S., Matsumoto, Y., Yokoi, K., Ikeda, T., et al. (1996) "Association of eosinophil granule major basic protein with atopic cataract", Am. J. Ophthalmol. 122, 825 - 829
  • Mondino, B.J. and Summer, H. (1984) "Complement inhibitors in normal cornea and aqueous humor", Investig. Ophthalmol. Vis. Sci. 25, 483 - 486
  • Niederkorn, J.Y. and Streilein, J.W. (1982) "Induction of anterior chamber-associated immune deviation (ACAID) by allogeneic intraocular tumors does not require splenic metastases", J. Immunol. 128, 2470 - 2477

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