Advanced search
Publication Cover
Autoimmunity Volume 35, 2002 - Issue 6
Submit an article Journal homepage
24
Views
22
CrossRef citations to date
0
Altmetric
Research Article

TNF-α and -β Gene Polymorphisms in Multiple Sclerosis: A Highly Significant Role for Determinants in the First Intron of the TNF-β Gene

Jose Americo M. Fernandes Filho Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
,
Christian A. Vedeler Department of Neurology, Haukeland Hospital, University of Bergen, Norway
,
Kjell-Morten Myhr Department of Neurology, Haukeland Hospital, University of Bergen, Norway
,
Harald Nyland Department of Neurology, Haukeland Hospital, University of Bergen, Norway
&
Janardan P. Pandey Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
Pages 377-380 | Published online: 07 Jul 2009

  • Reboul, J., Mertens, C., Levillayer, F., Eichenbaum-Voline, S., Vilkoren, T., Cournu, I., et al. (2000) "Cytokines in genetic susceptibility to multiple sclerosis: a candidate gene approach", J. Neuroimmunol. 102, 107 - 112
  • Oksenberg, J.R., Baranzini, S.E., Barcellos, L.F. and Hauser, S.L. (2001) "Multiple sclerosis: genomic rewards", J. Neuroimmunol. 113, 171 - 184
  • Kantarci, O.H., de Andrade, M. and Weinshenker, B.G. (2002) "Identifying disease modifying genes in multiple sclerosis", J. Neuroimmunol. 123, 144 - 159
  • Mycko, M.P., Kwinkowski, M., Tronczynska, E., Szymanska, B. and Selmaj, K.W. (1998) "Multiple sclerosis: the frequency of allelic forms of tumor necrosis factor and lymphotoxin-alpha", J. Neuroimmunol. 84, 198 - 206
  • Suen, W.E., Bergman, C.M., Hjelmstrom, P. and Ruddle, N.H. (1997) "A critical role for lymphotoxin in experimental allergic encephalomyelitis", J. Exp. Med. 186, 1233 - 1240
  • Hauser, S.L., Doolittle, T.H., Lincoln, R., Brown, R.H. and Dinarello, C.A. (1990) "Cytokine accumulations in CSF of multiple sclerosis patients: frequent detection of interleukin-1 and tumor necrosis factor but not interleukin-6", Neurology 40, 1735 - 1739
  • Rieckmann, P., Albrecht, M., Kitze, B., Weber, T., Tumani, H., Broocks, A., et al. (1994) "Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis", Neurology 44, 1523 - 1526
  • Selmaj, K., Raine, C.S., Cannella, B. and Brosnan, C.F. (1991) "Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions", J. Clin. Investig. 87, 949 - 954
  • Selmaj, K., Raine, C.S., Farooq, M., Norton, W.T. and Brosnan, C.F. (1991) "Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin", J. Immunol. 147, 1522 - 1529
  • Abraham, L.J. and Kroeger, K.M. (1999) "Impact of the −308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: relevance to disease", J. Leukoc. Biol. 66, 562 - 566
  • Whichelow, C.E., Hitman, G.A., Raafat, I., Bottazzo, G.F. and Sachs, J.A. (1996) "The effect of TNF*B gene polymorphism on TNF-alpha and -beta secretion levels in patients with insulin-dependent diabetes mellitus and healthy controls", Eur. J. Immunogenet. 23, 425 - 435
  • Poser, C.M., Paty, D.W., Scheinberg, L., McDonald, W.I., Davis, F.A., Ebers, G.C., et al. (1983) "New diagnostic criteria for multiple sclerosis: guidelines for research protocols", Ann. Neurol. 13, 227 - 231
  • Lublin, F.D. and Reingold, S.C. (1996) "Defining the clinical course of multiple sclerosis: results of an international survey", Neurology 46, 907 - 911
  • Galbraith, G.M.P., Steed, R.B., Sanders, J.J. and Pandey, J.P. (1998) "Tumor necrosis factor alpha production by oral leukocytes: influence of tumor necrosis factor genotype", J. Periodontol. 69, 428 - 433
  • Messer, G., Spengler, U., Jung, M.C., Honold, G., Blomer, K., Pape, G.R., et al. (1991) "Polymorphic structure of the tumor necrosis factor (TNF) locus: An NcoI polymorphism in the first intron of the human TNF- β gene correlates with a variant amino acid in position 26 and a reduced level of TNF- β production", J. Exp. Med. 173, 209 - 219
  • Pociot, F., Briant, L., Jongeneel, C.V., Molvig, J., Worsaae, H., Abbal, M., et al. (1993) "Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-α and TNF-β by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus", Eur. J. Immunol. 23, 224 - 231
  • Stuber, F., Petersen, M., Bokelmann, F. and Schade, U. (1996) "A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-α concentrations and outcome of patients with severe sepsis", Crit. Care Med. 24, 381 - 384
  • Jongeneel, C.V., Briant, L., Udalova, I.A., Sevin, A., Nedospasov, S.A. and Cambon-Thomsen, A. (1991) "Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes", Proc. Natl Acad. Sci. USA. 88, 9717 - 9721
  • Gabriel, S.B., Schaffner, S.F., Nguyen, H., Moore, J.M., Roy, J., Blumenstiel, B., et al. (2002) "The structure of haplotype blocks in the human genome", Science 296, 2225 - 2229
  • He, B., Navikas, V., Lundahl, J., Soderstrom, M. and Hillert, J. (1995) "Tumor necrosis factor α−308 alleles in multiple sclerosis and optic neuritis", J. Neuroimmunol. 63, 143 - 147
  • Huizinga, T.W., Westendorp, R.G., Bollen, E.L., Keijsers, V., Brinkman, B.M., Langermans, J.A., et al. (1997) "TNF-α promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients", J. Neuroimmunol. 72, 149 - 153
  • Wingerchuk, D., Liu, Q., Sobell, J., Sommer, S. and Weinshenker, B.G. (1997) "A population-based case-control study of the tumor necrosis factor alpha −308 polymorphism in multiple sclerosis", Neurology 49, 626 - 628
  • Vandevyver, C., Raus, P., Stinissen, P., Philippaerts, L., Cassiman, J.J. and Raus, J. (1994) "Polymorphism of the tumour necrosis factor beta gene in multiple sclerosis and rheumatoid arthritis", Eur. J. Immunogenet. 21, 377 - 382
  • Risch, N. and Merikangas, K. (1996) "The future of genetic studies of complex human diseases", Science 273, 1516 - 1517
  • Dahlman, I., Eaves, I.A., Kosoy, R., Morrison, V.A., Heward, J., Gough, S.C., et al. (2002) "Parameters for reliable results in genetic association studies in common disease", Nat. Genet. 30, 149 - 150

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.