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Research Article

Transmembrane TNF and IFNγ Induce Caspase-independent Death of Primary Mouse Pancreatic Beta Cells

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Pages 369-375 | Published online: 07 Jul 2009

  • Thomas, H.E. and Kay, T.W. (2001) "How beta cells die in type 1 diabetes", Curr. Dir. Autoimmun. 4, 144 - 170
  • Stephens, L.A., Thomas, H.E., Ming, L., Grell, M., Darwiche, R., Volodin, L., et al., (1999) "Tumor necrosis factor-alpha-activated cell death pathways in NIT-1 insulinoma cells and primary pancreatic beta cells", Endocrinology 140, 3219 - 3227
  • Kagi, D., Ho, A., Odermatt, B., Zakarian, A., Ohashi, P.S. and Mak, T.W. (1999) "TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes", J. Immunol. 162, 4598 - 4605
  • Pakala, S.V., Chivetta, M., Kelly, C.B. and Katz, J.D. (1999) "In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha", J. Exp. Med. 189, 1053 - 1062
  • Green, E.A., Eynon, E.E. and Flavell, R.A. (1998) "Local expression of TNFalpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens", Immunity 9, 733 - 743
  • Green, E.A. and Flavell, R.A. (2000) "The temporal importance of TNFalpha expression in the development of diabetes", Immunity 12, 459 - 469
  • Christen, U., Wolfe, T., Mohrle, U., Hughes, A.C., Rodrigo, E., Green, E.A., et al., (2001) "A dual role for TNF-alpha in type 1 diabetes: islet-specific expression abrogates the ongoing autoimmune process when induced late but not early during pathogenesis", J. Immunol. 166, 7023 - 7032
  • Locksley, R.M., Killeen, N. and Lenardo, M.J. (2001) "The TNF and TNF receptor superfamilies: integrating mammalian biology", Cell 104, 487 - 501
  • Corbett, J.A. and McDaniel, M.L. (1995) "Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase", J. Exp. Med. 181, 559 - 568
  • Arnush, M., Heitmeier, M.R., Scarim, A.L., Marino, M.H., Manning, P.T. and Corbett, J.A. (1998) "IL-1 produced and released endogenously within human islets inhibits beta cell function", J. Clin. Investig. 102, 516 - 526
  • Suk, K., Kim, S., Kim, Y.H., Kim, K.A., Chang, I., Yagita, H., et al., (2001) "IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death", J. Immunol. 166, 4481 - 4489
  • Kriegler, M., Perez, C., DeFay, K., Albert, I. and Lu, S.D. (1988) "A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF", Cell 53, 45 - 53
  • Ruuls, S.R., Hoek, R.M., Ngo, V.N., McNeil, T., Lucian, L.A., Janatpour, M.J., et al., (2001) "Membrane-bound tnf supports secondary lymphoid organ structure but is subservient to secreted tnf in driving autoimmune inflammation", Immunity 15, 533 - 543
  • Huang, D.C., Hahne, M., Schroeter, M., Frei, K., Fontana, A., Villunger, A., et al., (1999) "Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L)", Proc. Natl Acad. Sci. USA 96, 14871 - 14876
  • Hamaguchi, K., Gaskins, H.R. and Leiter, E.H. (1991) "NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse", Diabetes 40, 842 - 849
  • Thomas, H.E., Darwiche, R., Corbett, J.A. and Kay, T.W. (1999) "Evidence that beta cell death in the nonobese diabetic mouse is Fas independent", J. Immunol. 163, 1562 - 1569
  • Liu, M. and Shapiro, M.E. (1995) "A new method for isolation of murine islets with markedly improved yields", Transplant. Proc. 27, 3208 - 3210
  • Nicoletti, I., Migliorati, G., Pagliacci, M.C., Grignani, F. and Riccardi, C. (1991) "A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry", J. Immunol. Methods 139, 271 - 279
  • Green, L.C., Wagner, D.A., Glogowski, J., Skipper, P.L., Wishnok, J.S. and Tannenbaum, S.R. (1982) "Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids", Anal. Biochem. 126, 131 - 138
  • Stephens, L.A., Thomas, H.E. and Kay, T.W. (1997) "Protection of NIT-1 pancreatic beta-cells from immune attack by inhibition of NF-kappaB", J. Autoimmun. 10, 293 - 298
  • Alexopoulou, L., Pasparakis, M. and Kollias, G. (1997) "A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling", Eur. J. Immunol. 27, 2588 - 2592
  • Gerspach, J., Gotz, A., Zimmermann, G., Kolle, C., Bottinger, H. and Grell, M. (2000) "Detection of membrane-bound tumor necrosis factor (TNF): an analysis of TNF-specific reagents", Microsc. Res. Tech. 50, 243 - 250
  • Lakey, J.R., Suarez-Pinzon, W.L., Strynadka, K., Korbutt, G.S., Rajotte, R.V., Mabley, J.G., et al., (2001) "Peroxynitrite is a mediator of cytokine-induced destruction of human pancreatic islet beta cells", Lab. Investig. 81, 1683 - 1692
  • Darville, M.I. and Eizirik, D.L. (1998) "Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells", Diabetologia 41, 1101 - 1108
  • Grey, S.T., Arvelo, M.B., Hasenkamp, W., Bach, F.H. and Ferran, C. (1999) "A20 inhibits cytokine-induced apoptosis and nuclear factor kB-dependent gene activation in islets", J. Exp. Med. 190, 1135 - 1145
  • Chu, Z.L., McKinsey, T.A., Liu, L., Gentry, J.J., Malim, M.H. and Ballard, D.W. (1997) "Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control", Proc. Natl Acad. Sci. USA 94, 10057 - 10062
  • De Smaele, E., Zazzeroni, F., Papa, S., Nguyen, D.U., Jin, R., Jones, J., et al., (2001) "Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling", Nature 414, 308 - 313
  • Tang, G., Minemoto, Y., Dibling, B., Purcell, N.H., Li, Z., Karin, M., et al., (2001) "Inhibition of JNK activation through NF-kappaB target genes", Nature 414, 313 - 317
  • Beg, A.A. and Baltimore, D. (1996) "An essential role for NF-kappaB in preventing TNF-alpha-induced cell death", Science 274, 782 - 784
  • Wang, C.Y., Mayo, M.W. and Baldwin, Jr., A.S. (1996) "TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB", Science 274, 784 - 787
  • Van Antwerp, D.J., Martin, S.J., Kafri, T., Green, D.R. and Verma, I.M. (1996) "Suppression of TNF-alpha-induced apoptosis by NF-kappaB", Science 274, 787 - 789
  • Sekine, N., Ishikawa, T., Okazaki, T., Hayashi, M., Wollheim, C.B. and Fujita, T. (2000) "Synergistic activation of NF-kappab and inducible isoform of nitric oxide synthase induction by interferon-gamma and tumor necrosis factor-alpha in INS-1 cells", J. Cell. Physiol. 184, 46 - 57
  • Cardozo, A.K., Heimberg, H., Heremans, Y., Leeman, R., Kutlu, B., Kruhoffer, M., et al., (2001) "A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells", J. Biol. Chem. 276, 48879 - 48886
  • Avantaggiati, M.L., Carbone, M., Graessmann, A., Nakatani, Y., Howard, B. and Levine, A.S. (1996) "The SV40 large T antigen and adenovirus E1a oncoproteins interact with distinct isoforms of the transcriptional co-activator, p300", EMBO J. 15, 2236 - 2248
  • Campbell, I.L., Cutri, A., Wilkinson, D., Boyd, A.W. and Harrison, L.C. (1989) "Intercellular adhesion molecule 1 is induced on isolated endocrine islet cells by cytokines but not by reovirus infection", Proc. Natl Acad. Sci. USA 86, 4282 - 4286
  • Savinov, A.Y., Wong, F.S. and Chervonsky, A.V. (2001) "IFN-gamma affects homing of diabetogenic T cells", J. Immunol. 167, 6637 - 6643
  • Green, E.A. and Flavell, R.A. (1999) "Tumor necrosis factor alpha and the progression of diabetes in non-obese diabetic mice", Immunol. Rev. 169, 11 - 22
  • Campbell, I.L., Oxbrow, L., West, J. and Harrison, L.C. (1988) "Regulation of MHC protein expression in pancreatic beta-cells by interferon-gamma and tumor necrosis factor-alpha", Mol. Endocrinol. 2, 101 - 107

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