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Autoimmunity Volume 35, 2002 - Issue 6
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Research Article

Experimental Model for Ophthalmopathy in BALB/c and Outbred (CD-1) Mice Genetically Immunized with G2s and the Thyrotropin Receptor

Masayo Yamada The Thyroid Research Laboratory, Sir Charles Tupper Medical Building, Dalhousie University, Halifax, NS, Canada B3H 4H7; The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan
,
Audrey Wu Li The Thyroid Research Laboratory, Sir Charles Tupper Medical Building, Dalhousie University, Halifax, NS, Canada B3H 4H7
,
Kenneth A. West Division of Nephrology, Department of Medicine, Dalhousie University, Halifax, NS, Canada
,
Cheng-Hsien Chang The Thyroid Research Laboratory, Sir Charles Tupper Medical Building, Dalhousie University, Halifax, NS, Canada B3H 4H7
&
Jack R. Wall The Thyroid Research Laboratory, Sir Charles Tupper Medical Building, Dalhousie University, Halifax, NS, Canada B3H 4H7
Pages 403-413 | Published online: 07 Jul 2009

  • Weetman, A.P. (1991) "Thyroid-associated eye disease: pathophysiology", Lancet 338, 25 - 28
  • Heufelder, A.E. (1997) "Retro-orbital autoimmunity", Bailliere's Clin. Endocrinol. Metab. 11, 499 - 520
  • Burch, H. and Wartofsky, L. (1993) "Graves' ophthalmopathy: current concepts regarding pathogenesis and management", Endocr. Rev. 14, 747 - 793
  • Salvi, M., Miller, A. and Wall, J.R. (1988) "Human orbital tissue and thyroid membranes express a 64 kDa protein which is recognized by autoantibodies in the serum of patients with thyroid-associated ophthalmopathy", FEBS Lett. 232, 135 - 139
  • Miller, A., Arthurs, B., Boucher, A., Liberman, A., Bernard, N., Salvi, M. and Wall, J.R. (1992) "Significance of antibodies reactive with a 64 kDa eye muscle membrane antigen in patients with thyroid autoimmunity", Thyroid 2, 197 - 202
  • Gunji, K., De Bellis, A.M., Li, A.W., Yamada, M., Kubota, S., Ackrell, B., Wengrowicz, S., Bellastella, A., Bizzarro, A., Sinisi, A. and Wall, J.R. (2000) "Cloning and characterization of the novel thyroid and eye muscle shared protein G2s: autoantibodies against G2s are closely associated with ophthalmopathy in patients with Graves' hyperthyroidism", J. Clin. Endocrinol. Metab. 85, 1641 - 1647
  • Gunji, K., De Bellis, A., Kubota, S., Swanson, J., Wengrowicz, S., Cochran, B., Ackrell, B.A., Salvi, M., Bellastella, A., Bizzarro, A., Sinisi, A.A. and Wall, J.R. (1999) "Serum antibodies against the flavoprotein subunit of succinate dehydrogenase are sensitive markers of eye muscle autoimmunity in patients with Graves' hyperthyroidism", J. Clin. Endocrinol. Metab. 84, 1255 - 1262
  • Kubota, S., Gunji, K., Ackrell, B.A.C., Cochran, B., Stolarski, C., Wengrowicz, S., Kennerdell, J.S., Hiromatsu, Y. and Wall, J.R. (1998) "The 64-kilodalton eye muscle protein is the flavoprotein subunit of mitochondrial succinate dehydrogenase: the corresponding serum antibodies are good markers of an immune-mediated damage to the eye muscle in patients with Graves' hyperthyroidism", J. Clin. Endocrinol. Metab. 83, 443 - 447
  • Gunji, K., De Bellis, A.M., Li, A.W., Yamada, M., Kubota, S., Ackrell, B.A.C., Wengrowicz, S., Bellastella, A., Bizzarro, A., Sinisi, A. and Wall, J.R. (2000) "Cloning and characterization of G2s, a novel eye muscle and thyroid shared autoantigen associated with the development of ophthalmopathy in patients with thyroid autoimmunity", J. Clin. Endocrinol. Metab. 85, 1641 - 1647
  • Gunji, K., De Bellis, A., Kubota, S., Swanson, J., Wengrowicz, S., Ackrell, B.A.C., Thompson, C., Kennerdell, J.S., Bizzarro, A. and Wall, J.R. (1999) "Serum antibodies reactive against the flavoprotein subunit of protein subunit of succinate dehydrogenase are sensitive markers of eye muscle autoimmunity in patients with Graves' hyperthyroidism", J. Clin. Endocrinol. Metab. 84, 16 - 22
  • Wall, J.R., Archibald, C., Kasper, M., Li, A.W., Yamada, M. and De Bellis, A.M. Orbital antibodies and subclass of ophthalmopathy. Proc. Int. Symp. on Thyroid-Associated Ophthalmopathy, Kyoto, Japan, October 2000 (In press).
  • Yamada, M., Li, A.W. and Wall, J.R. (2000) "Thyroid-associated ophthalmopathy: clinical features, pathogenesis and management", Crit. Rev. Clin. Lab. Sci. 37, 523 - 549
  • Bahn, R.S., Dutton, C.M., Natt, N., Bahn, R.S., Dutton, C.M., Natt, N., Joba, W., Spitzweg, C. and Heufelder, A.E. (1998) "Thyrotropin receptor expression in Graves' orbital adipose/connective tissues: potential autoantigen in Graves' ophthalmopahty", J. Clin. Endocrinol. Metab. 83, 998 - 1002
  • Ludgate, M., Crisp, M., Lane, C., Costagliola, S., Vassart, G., Weetman, A., Daunerie, C. and Many, M.C. (1998) "The thyrotropin receptor in thyroid eye disease", Thyroid 8, 411 - 413
  • Wall, J.R., Blanchard, M.E., West, K., Li, A.W. and Yamada, M. (1999) "Autoantibodies against the plasma membrane protein type XIII collagen are new markers of congestive ophthalmopathy. 72nd Annual meeting of the American Thyroid Association, Portland, OR", Thyroid (Suppl.), 50, (abstract)
  • Miller, A., Sikorska, H., Salvi, M. and Wall, J.R. (1986) "Evaluations of an enzyme-linked immunosorbent assay for the measurement of autoantibodies against eye muscle membrane antigens in Graves' ophthalmopathy", Acta Endocrinol. 113, 514 - 522
  • Kapusta, M., Salvi, M., Triller, H., Gardini, E., Bernard, N. and Wall, J.R. (1990) "Eye muscle membrane reactive antibodies are not detected in the serum of immunoglobulin fraction of patients with thyroid-associated ophthalmopathy using an ELISA and crude memebranes", Autoimmunity 7, 33 - 40
  • De Carli, M., D'Elios, M.M., Mariotti, S., Marcocci, C., Pinchera, A., Ricci, M., Romagnani, S. and del Prete, G. (1993) "Cytolytic T cells with Th1-like cytokine profile predominate in retro orbital lymphocytic infiltrates of Graves' ophthalmopathy", J. Clin. Endocrinol. Metab. 77, 1120 - 1124
  • Hiromatsu, Y., Yang, D., Bednarczuk, T., Miyake, I., Nonaka, K. and Inoue, Y. (2000) "Cytokine profiles in eye muscle tissue and orbital fat tissue from patients with thyroid-associated ophthalmopathy", J. Clin. Endocrinol. Metab. 85, 1194 - 1199
  • Aniszewski, J.P., Valyasevi, R.W. and Bahn, R.S. (2000) "Relationship between disease duration and predominant orbital T cell subset in Graves' ophthalmopathy", J. Clin. Endocrinol. Metab. 85, 776 - 780
  • Costagliola, S., Many, M.C., Stalmans-Falys, M., Vassart, G. and Ludgate, M. (1996) "Transfer of thyroiditis, with syngeneic spleen cells sensitized with the human thyrotropin receptor, to naive BALB/c and NOD mice", Endocrinology 137, 4637 - 4643
  • Yamamoto, T., Kaneko, S., Hide, M., Mochizuki, M., Morimoto, K., Yoshimura, M. and Yamamoto, S. (2002) "Increase in serum IgE levels following injection of syngeneic keratinocyte extracts in BALB/c mice", Arch. Dermatol. Res. 294, 117 - 123
  • Bahn, R.S. (2000) "Understanding the immunology of Graves' ophthalmopathy. Is it an autoimmune disease?", Endocrinol. Metab. Clin. N. Am. 29, 287 - 296
  • Noh, J.Y., Hamada, N., Inoue, Y., Ito, K. and Ito, K. (2001) "Thyroid-stimulating antibody is related to Graves' ophthalmopathy, but Thyrotropin-binding inhibitor immunoglobulin is related to hyperthyroidism in patients with Graves' disease", Thyroid 10, 809 - 813
  • Moudgil, K.D., Chang, T.T., Eradat, H., Chen, A.M., Gupta, R.S., Brahn, E. and Sercarz, E.E. (1997) "Diversification of T cell responses to carboxy-terminal determinants within the 65-kD heat-shock protein is involved in regulation of autoimmune arthritis", J. Exp. Med. 185, 1307 - 1316
  • Ludgate, M. (2000) "Animal models of Graves' disease", Eur. J. Endocrinol. 142, 1 - 8
  • Many, M.C., Costagliola, S., Detrait, M., Denef, F., Vassart, G. and Ludgate, M.C. (1999) "Development of an animal model of autoimmune thyroid eye disease", J. Immunol. 162, 4966 - 4974
  • Raikow, R.B., Tyutyunikov, A., Kennerdell, J.S., Kazim, M., Dalbow, M.H. and Scalise, D. (1992) "Correlation of serum immunoglobulin E elevations with clinical stages of dysthyroid orbitopathy", Ophthalmology 99, 361 - 365
  • Raikow, R.B., Dalbow, M.H., Kennerdell, J.S., Compher, K., Machen, L., Hiller, W. and Blendermann, D. (1990) "Immunohistochemical evidence for IgE involvement in Graves' orbitopathy", Ophthalmology 97, 629 - 635
  • Smith, T.J. and Parikh, S.J. (1999) "HMC-1 mast cells activate human orbital fibroblasts in coculture: evidence for up-regulation of prostaglandin E2 and hyaluronan synthesis", Endocrinology 140, 3518 - 3525
  • Sciaky, D., Brazer, W., Center, D.M., Cruikshank, W.W. and Smith, T.J. (2000) "Cultured human fibroblasts express constitutive IL-16 mRNA: cytokine induction of active IL-16 protein synthesis through a caspase-3-dependent mechanism", J. Immunol. 1, 3806 - 3814

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