Advanced search
Publication Cover
Autoimmunity Volume 35, 2002 - Issue 8
Submit an article Journal homepage
24
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Prevalence of Autoantibodies to the p53 Protein in Autoimmune Hepatitis

Johannes Herkel The I. Department of Medicine, Johannes Gutenberg University, Langenbeckstr. 1, 55101 Mainz, Germany
,
Jan-Philip Modrow The I. Department of Medicine, Johannes Gutenberg University, Langenbeckstr. 1, 55101 Mainz, Germany
,
Sonja Bamberger The I. Department of Medicine, Johannes Gutenberg University, Langenbeckstr. 1, 55101 Mainz, Germany
,
Stephan Kanzler The I. Department of Medicine, Johannes Gutenberg University, Langenbeckstr. 1, 55101 Mainz, Germany
,
Varda Rotter The Department of Molecular Cell Biology, The Weizmann Institute of Science, 76100 Rehovot, Israel
,
Irun R. Cohen The Department of Immunology, The Weizmann Institute of Science, 76100 Rehovot, Israel
&
Ansgar W. Lohse The I. Department of Medicine, Johannes Gutenberg University, Langenbeckstr. 1, 55101 Mainz, Germany
 show all
Pages 493-496 | Published online: 07 Jul 2009

  • Alvarez, F., Berg, P.A., Bianchi, F.B., Bianchi, L., Burroughs. A.K., Cancado, E.L., el al. (1999) "International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis", J. Hepatol. 31, 929-938.
  • Meyer zum Büschenfelde, K.H., Lohse, A.W., Manns, M. and Poralla, T. (1990) "Autoimmunity and liver disease". Hepatology 12, 354-363.
  • McFarlane, I.G., Vergani, D. and Eddleston, A.L.W.F. (1998) "Pathogenesis of autoimmune hepatitis". In: Krawitt, E.L., Wiesner, R.H. and Nishioka, M., eds. Autoimmune Liver Diseases (Elsevier Science, Amsterdam), p. 35.
  • Offer, H., Milyavsky, M., Erez, N., Matas, D., Zurer, L., Harris, C.C. and Rotter, V. (2001) "Structural and functional involvement of p53 in BER in vitro and in vivo". Oncoxene 20, 581-589.
  • Ko, L.J. and Prives, C. (1996) "p53: puzzle and paradigm", Genes Deu 10, 1054-1072.
  • Moll, U.M., LaQuaglia, M., Benard, J. and Riou, G. (1995) "Wildtype p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors". Proc. Natl Acad. Sci. USA 92, 4407-4411.
  • Firestein, G.S., Nguyen, K., Aupperle, K.R., Yeo, M., Boyle, D.L. and Zvaifler, N.J. (1996) "Apoptosis in rheumatoid arthritis: p53 overexpression in rheumatoid arthritis synovium". Am. J. Pathol. 149, 2143-2151.
  • Maacke, H., Kessler, A., Schmiegel, W., Roeder, C. Vogel, I., Depert, W. and Kalthoff, H. (1997) "Overexpression of p53 protein during pancreatitis", Br. J. Cancer 75, 1501 -1504.
  • Soussi, T. (2000) "p53 Antibodies in the sera of patients with various types of cancer: a review". Cancer Res. 60, 1777-1788.
  • Raedle, J., Oremek, G., Welker, M., Roth, W.K., Caspary, W.F. and Zeuem, S. (1996) "p53 Autoantibodies in patients with pancreatitis and pancreatic carcinoma", Pancreas 13, 241-246.
  • Fricke, H., Urban, S., Noehl, N. and Folwaczny, C. (1998) "Serum p53 antibodies in patients with chronic inflammatory bowel disease". Gut 42, 899.
  • Kuhn, H.M., Kromminga, A., Flammann, H.T., Frey, M., Layer, P. and Arndt. R. (1999) "p53 Autoantibodies in patients with autoimmune diseases: a quantitative approach". Autoimmunity 31, 229-235.
  • Kovacs, B., Patel, A., Hershey, J.N., Dennis, G.J., Kirschfink, M. and Tsokos, G.C. (1997) "Antibodies against p53 in sera from patients with systemic lupus erythematosus and other rheumatic diseases". Arthritis Rheum. 40, 980-982.
  • Herkel, J., Mimran, A., Erez, N., Kam, N., Lohse, A.W., MarkerHermann, E., Rotter, V. and Cohen, I.R. (2001) "Autoimmunity to the p53 protein is a feature of systemic lupus erythematosus (SLE) related to anti-DNA antibodies". J. Autoimmun. 17, 63-69.
  • Di Cesare, E., Previti, M., Lombardo, F., Di Benedetto, A., Mazzu, N., Romano, G., et al. (2001) "Serum anti-p53 autoantibodies in patients with type 1 diabetes". Ann. Clin. Lab. Sci. 31, 253-258.
  • Lubin, R., Schlichtholz, B., Bengoufa, D., Zaleman, G., Tredaniel, J., Hirsch, A., et al. (1993) "Analysis of p53 antibodies in patients with various cancers define B-cell epitopes of human p53: distribution on primary structure and exposure on protein surface". Cancer Res. 53. 5872-5876.
  • [17) Livni, N., Eid, A., Han, Y. Rivkind, A., Rosenmann, E., Blendis, L.M., Shouval, D. and Galun, E. (1995) "p53 Expression in patients with cirrhosis with and without hepatocellular carcinoma". Cancer 75, 2420-2426.
  • Akyol, G., Dursun, A., Poyraz, A., Uluoglu, O., Ataoglu, O., Edaly, N. and Memis, L. (1999) "PS3 and proliferating cell nuclear antigen (PCNA) expression in non-tumoral liver diseases". Pathol. Int. 49, 214-221.
  • Shohat-Foord, O., Bhattacharya, P., Reich, Z. and Rotter, V. (1991) "A DNA binding domain is contained in the C-terminus of wild type p53 protein". Nucl. Acids Res. 19, 5191-5198.
  • Herkel, J., Erez-Alon, N., Mimran, A., Wolkowicz, R., Harmelin, A., Ruiz, P., et al. (2000) "Systemic lupus erythematosus in mice, spontaneous and induced, is associated with autoimmunity to the C-terminal domain of p53 that recognizes damaged DNA". Eur J. Immunol. 30, 977-984.
  • Kanzler, S., Lohr, H., Gerken, G., Galle, P.R. and Lohse, A.W. (2001) "Long-term management and prognosis of autoimmune hepatitis (AIH): a single center experience". Z. Castroenterol. 39, 339-341, 344-338.
  • Park, S.Z., Nagomey, D.M. and Czaja, A.J. (2000) "Hepatocellular carcinoma in autoimmune hepatitis". Dig. Dis. Sci. 45, 1944-1948.
  • Arbuthnot, P. Capovilla, A. and Kew, M. (2000) "Putative role of hepatitis B virus X protein in hepatocarcinogenesis: effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways". J. Castroenterol. Hepatol. 15, 357-368.
  • Graham, A.M., Dollinger, M.M., Howie, S.E. and Harrison, D.J. (1998) "Bile duct cells in primary biliary cirrhosis are 'primed' for apoptosis". Eur. J. Gastiventerol. Hepatol. 10, 553-557.
  • Erez-Alon, N., Herkel, J., Wolkowicz, R., Ruix, P.J., Waisman, A., Rotter, V. and Cohen, I.R. (1998) "Immunity to p53 induced by an idiotypic network of anti-p53 antibodies: generation of sequencespecific anti-DNA antibodies and protection from tumor metastasis". Cancer Res. 58. 5447-5452.
  • Tsuchiya, K., Kiyosawa, K., lmai, H., Sodeyama, T. and Furuta, S. (1994) "Detection of anti-double and anti-single stranded DNA antibodies in chronic liver disease: significance of anti-double stranded DNA antibody in autoimmune hepatitis". J. Gastroenterol. 29, 152-158.
  • Chou, M.J., Lee, S.L., Chen, T.Y. and Tsay, G.J. (1995) "Specificity of antinuclear antibodies in primary biliary cirrhosis". Ann. Rheum. Dis. 54, 148-151.
  • Czaja, A.J., Morshed, S.A., Parveen, S. and Nishioka, M. (1997) "Antibodies to single-stranded and double-stranded DNA in antinuclear antibody-positive type 1-autoimmune hepatitis", Hepatology 26, 567-572.
  • Peakman, M., Bevis, L., Mieli-Vergani, G., Mowat, A.P and Vergani, D. (1989) "Double stranded DNA binding in autoimmune chronic active hepatitis and primary sclerosing cholangitis starting in childhood". Autoimmunity 3, 271-280.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.