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Autoimmunity Volume 35, 2002 - Issue 2
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Research Article

Autoantibodies in Neuropsychiatric Lupus

Deanne L.V. Greenwood Department of Pathology and Immunology, Monash University Medical School, Prahran, Vic. 3181, Australia
,
Veronika M. Gitlits Department of Pathology and Immunology, Monash University Medical School, Prahran, Vic. 3181, Australia
,
Frank Alderuccio Department of Pathology and Immunology, Monash University Medical School, Prahran, Vic. 3181, Australia
,
John W. Sentry Department of Pathology and Immunology, Monash University Medical School, Prahran, Vic. 3181, Australia
&
Ban-Hock Toh Department of Pathology and Immunology, Monash University Medical School, Prahran, Vic. 3181, Australia
Pages 79-86 | Published online: 07 Jul 2009

  • ACR ad hoc committee on neuropsychiatric lupus nomenclature (1999) "The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes", Arthritis Rheum. 42, 599 - 608
  • Hanly, J.G. (1998) "Evaluation of patients with CNS involvement in SLE", Baillieres Clin. Rheumatol. 12, 415431
  • Hay, E.M. and Isenberg, D.A. (1993) "Autoantibodies in central nervous system lupus", Br. J. Rheum. 32, 329 - 332
  • Nakamura, R.M. (1997) "Role of antibody tests in the diagnostic evaluation of neuropsychiatric systemic lupus erythematosus", Clin. Lab. Med. 17, 379 - 393
  • Bluestein, H.G. (1978) "Neurocytotoxic antibodies in the serum of patients with systemic lupus erythematosus", Proc. Natl Acad. Sci. USA 75, 3965 - 3970
  • Toh, B.H. and Mackay, I.R. (1981) "Autoantibody to a novel antigen in systemic lupus erythematosus and in normal human sera", Clin. Exp. Immunol. 44, 555 - 559
  • Klein, R., Richter, C. and Berg, P.A. (1991) "Antibodies against central nervous system tissue (anti-CNS) detected by ELISA and western blotting: marker antibodies for neuropsychiatric manifestations in connective tissue disease", Autoimmunity 10, 133 - 144
  • Hanson, V.G., Horowitx, M., Rosenbluth, D., Spiera, H. and Puszkin, S. (1992) "Systemic lupus erythematosus with central nervous system involvement show autoantibodies to a 50 kDa neuronal membrane protein", J. Exp. Med. 176, 565 - 573
  • Hanly, J.G. and Hong, C. (1993) "Antibodies to brain integral membrane proteins in systemic lupus erythematosus", J. Immunol. Meth. 161, 107 - 118
  • Weiner, S.M., Klein, R. and Berg, P.A. (2000) "A longitudinal study of autoantibodies against central nervous system tissue and gangliosides in connective tissue diseases", Rheumatol. Int. 19, 83 - 88
  • Robbins, M.L., Kornguth, S.E., Bell, C.L., Kalinke, T., England, D., Turski, P. and Graziano, F.M. (1988) "Antineurofilament antibody evaluation in neuropsychiatric systemic lupus erythematosus", Arthritis Rheum. 31, 623 - 631
  • Gitlits, V.M., Sentry, J.W., Matthew, L.S., Smith, A.I. and Toh, B.H. (2001) "Identification of synapsin 1 as a novel autoantigen", J. Invest. Med. 49, 276 - 283
  • Wilson, H.A., Winfield, J.B., Lahita, R.G. and Koffler, D. (1979) "Association of IgG anti-brain antibodies with central nervous system dysfunction in systemic lupus erythematosus", Arthritis Rheum. 22, 458 - 462
  • Bluestein, H.G., Williams, G.W. and Steinberg, A.D. (1981) "Cerebrospinal fluid antibodies to neuronal cells; association with neuropsychiatric manifestations of systemic lupus erythematosus", Am. J. Med. 70, 240 - 246
  • West, S.G., Wener, M.H. and Kotzin, B.L. (1995) "Neuropsychiatric lupus erythematosus: a 10 yr prospective study on the value of diagnostic tests", Am. J. Med. 99, 153 - 163
  • Isshi, K. and Hirohata, S. (1998) "Differential roles of the anti-ribosomal P antibody and anti-neuronal antibody in the pathogenesis of central nervous system involvement in systemic-lupus erythematosus", Arthritis Rheum. 41, 1819 - 1827
  • Mittal, K.K., Rossen, R.D., Butler, W.T., Johnson, A.H., Leachman, R.D., Nora, J.J., Rochelle, D.G. and Brooks, D.K. (1970) "Lymphocytotoxic antibody response to cardiac allotransplantation in man. I. Correlation with post-transplantation clinical course", J. Immunol. 105, 1427 - 1431
  • Shaw, J.F. (1971) "Lymphocytotoxins in lupus erythematosus", Ala J. Med. Sci. 8, 210 - 214
  • Stastny, P. and Ziff, M. (1971) "Antibodies against cell membrane constituents in systemic lupus erythematosus and related diseases. I. Cytotoxic effect of serum from patients with systemic lupus erythematosus (SLE) for allogeneic and for autologous lymphocytes", Clin. Exp. Immunol. 8, 543 - 550
  • Bluestein, H.G. and Zvaifler, N.J. (1976) "Brain-reactive lymphocytotoxic antibodies in the serum of patients with systemic lupus erythematosus", J. Clin. Invest. 57, 509 - 516
  • Bresnihan, B., Oliver, M., Williams, B. and Hughes, G.R. (1979) "An antineuronal antibody cross-reacting with erythrocytes and lymphocytes in systemic lupus erythematosus", Arthritis Rheum. 22, 313 - 320
  • Bluestein, H.G. (1978) "Neurocytotoxic antibodies in serum of patients with systemic lupus erythematosus", Proc. Natl Acad. Sci. USA 75, 3965 - 3969
  • Ochola, J., Hussain, M., Khamashta, M., Hughes, G.R. and Vergani, D. (1995) "Detection of brain-reactive autoantibodies in the sera of patients with systemic lupus erythematosus and cerebral involvement", J. Immunol. Meth. 185, 259 - 261
  • Terasaki, P.I., Mottironi, V.D. and Barnett, E.V. (1970) "Cytotoxins in disease. Autocytotoxins in lupus", N. Engl. J. Med. 283, 724 - 728
  • Winfield, J.B., Winchester, R.J. and Kunkel, H.J. (1975) "Proceedings: various types of antilymphocyte antibodies in patients with systemic lupus erythematosus (SLE) and their relationship with lymphopenia", Arthritis Rheum. 18, 284 - 285
  • Denburg, S.D., Behmann, S.A., Carbotte, R.M. and Denburg, J.A. (1994) "Lymphocyte antigens in neuropsychiatric systemic lupus erythematosus. Relationship of lymphocyte antibody specificities to clinical disease", Arthritis Rheum. 37, 369 - 375
  • Denburg, J.A. and Behmann, S.A. (1994) "Lymphocyte and neuronal antigens in neuropsychiatric lupus: presence of an elutable, immunoprecipitable lymphocyte/neuronal 52 kd reactivity", Ann. Rheum. Dis. 53, 304 - 308
  • Arnett, F.C., Reveille, J.D., Moutsopoulos, H.M., Georgescu, L. and Elkon, K.B. (1996) "Ribosomal P autoantibodies in systemic lupus erythematosus. Frequencies in different ethnic groups and clinical and immunogenetic associations", Arthritis Rheum. 39, 1833 - 1839
  • Teh, L.S., Doherty, D.G. and Williams, B.D. (1994) "HLA-DRB genes and antiribosomal P antibodies in systemic lupus erythematosus", Br. J. Rheumatol. 33, 1125 - 1126
  • Chiradello, A., Doria, A., Zampieri, S., Gerli, E., Rapizzi, E. and Gambari, P.F. (2000) "Anti-ribosomal P protein antibodies detected by immunoblotting in patients with connective tissue diseases; their specificity for SLE an association with IgG anticardiolipin antibodies", Ann. Rheum. Dis. 59, 975 - 981
  • Koren, E., Reichlin, M.W., Koscec, M., Fugate, R.D. and Reichlin, M. (1992) "Autoantibodies to the ribosomal P proteins react with a plasma membrane target on human cells", J. Clin. Invest. 89, 1236 - 1241
  • Yoshio, T., Masuyama, J. and Kano, S. (1996) "Antiribosomal P0 protein antibodies react with the surface of human umbilical vein endothelial cells", J. Rheumatol. 23, 1311 - 1312
  • Fabien, N., Moreira, A., Lavergne, J.P., Desbos, A., Surgey, P., Alves de Olivera, C., et al., (1999) "Autoantibodies directed against the ribosomal P proteins are not only directed against a common epitope of the P0, P1 and P2 proteins", J. Autoimmun. 13, 103 - 110
  • Takeda, K., Rayno, K., Wolfson-Reichlin, M. and Reichlin, M. (1999) "Heterogeneity of anti-dsDNA antibodies in their cross-reaction with ribosomal P protein", J. Autoimmun. 13, 423 - 428
  • Sun, K.H., Hong, C.C., Tang, S.J., Sun, G.H., Liu, W.T., Han, S.H. and Yu, C.L. (1999) "Anti-dsDNA autoantibody cross-reacts with the C-terminal hydrophobic cluster region containing phenylalanines in the acidic ribosomal phosphoprotein P1 to exert a cytostatic effect on the cells", Biochem. Biophys. Res. Commun. 263, 334 - 339
  • Pan, Z.J., Anderson, C.J. and Stafford, H.A. (1998) "Anti-idiotypic antibodies prevent the serologic detection of antiribosomal P autoantibodies in healthy adults", J. Clin. Invest. 102, 215 - 222
  • Schneebaum, A.B., Singleton, J.D., West, S.G., Blodgett, J.K., Allen, L.G., Cheronis, J.C. and Kotzin, B.L. (1991) "Association of psychiatric manifestations with antibodies to ribosomal P protein in systemic lupus erythematosus", Am. J. Med. 90, 54 - 62
  • Mathy, J.P., Baum, R. and Toh, B.H. (1980) "Autoantibody to ribosomes and systemic lupus erythematosus", Clin. Exp. Immunol. 41, 73 - 80
  • Bonfa, E., Golombek, S.J., Kaufman, L.D., Skelly, S., Weissbach, H., Brot, N. and Elkon, K.B. (1987) "Association between lupus psychosis and anti-ribosomal P protein antibodies", N. Engl. J. Med. 317, 265 - 271
  • Rayno, K. and Reichlin, M. (2000) "Evaluation of assays for the detection of autoantibodies to ribosomal P protein", Clin. Immunol. 95, 99 - 103
  • Tzioufas, A.G., Tzortzakis, N.G., Panou-Pomonis, E., Boki, K.A., Sakarellos-Daitsiotis, M., Sakarellos, C. and Moutsopoulos, H.M. (2000) "The clinical relevance of antibodies to ribosomal-P common epitope in two targeted systemic lupus erythematosus populations: a large cohort of consecutive patients with active central nervous system involvement", Ann. Rheum. Dis. 59, 99 - 104
  • Caponi, L., Pegoraro, S., Di Bartolo, V., Rovero, P., Revoltella, R. and Bombardieri, S. (1995) "Autoantobodies directed against ribosomal P proteins: use of a multiple antigen peptide as the coating agent in ELISA", J. Immunol. Meth. 179, 193 - 202
  • Teh, L.S. and Isenberg, D.A. (1994) "Antiribosomal P protein antibodies in systemic lupus erythematosus. A reappraisal", Arthritis Rheum. 37, 307 - 315
  • Iverson, G.L. (1996) "Are antibodies to ribosomal P proteins a clinically useful predictor of neuropsychiatric manifestations in patients with systemic lupus erythematosus", Lupus 5, 634 - 635
  • Galli, M., Comfurius, P., Maassen, C., Hemker, H.C., de Baets, M.H., van Breda-Vriesman, P.J., Barbui, T., Zwaal, R.F. and Bevers, E.M. (1990) "Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor", Lancet 335, 1544 - 1547
  • Matsuura, E., Igarashi, Y., Fujimoto, M., Ichikawa, K. and Koike, T. (1990) "Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease", Lancet 336, 177 - 178
  • McNeil, H.P., Simpson, R.J., Chesterman, C.N. and Krilis, S.A. (1990) "Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H)", Proc. Natl Acad. Sci. USA 87, 4120 - 4124
  • Amigo, M.C. and Khamashta, M.A. (2000) "Antiphospholipid (Hughes) syndrome in systemic lupus erythematosus", Rheum. Dis. Clin. North Am. 26, 331 - 348
  • Wilson, W.A., Gharavi, A.E., Koike, T., Lockshin, M.D., Branch, D.W., Piette, J.C., Brey, R., Derksen, R., Harris, E.N., Hughes, G.R., Triplett, D.A. and Khamashta, M.A. (1999) "International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop", Arthritis Rheum. 42, 1309 - 1311
  • Grommica-Ihle, E. and Schossler, W. (2000) "Antiphospholipid syndrome", Inter. Arch. Allergy Immunol. 123, 67 - 76
  • Mouritsen, S., Hoier-Madsen, M., Wiik, A., Orum, O. and Strandberg Pedersen, N. (1989) "The specificity of anti-cardiolipin antibodies from syphilis patients and from patients with systemic lupus erythematosus", Exp. Immunol. 76, 178 - 183
  • Harris, E.N., Asherson, R.A. and Hughes, G.R. (1988) "Antiphospholipid antibodies-autoantibodies with a difference", Annu. Rev. Med. 39, 261 - 271
  • Ordi-Ros, J., Selva-O'Callaghan, A., Monegal-Ferran, F., Monasterio-Aspiri, Y., Juste-Sanchez, C., Vilardell-Tarres, M., et al., (1994) "Prevalence, significance, and specificity of antibodies to phospholipids in Q fever", Clin. Infect. Dis. 18 (1994), 213 - 218
  • Canoso, R.T., Zon, L.I. and Groopman, J.E. (1987) "Anticardiolipin antibodies associated with HTLV-III infection", Br. J. Haematol. 65, 495 - 498
  • Canoso, R.T. and Sise, H.S. (1982) "Chlorpromazine-induced lupus anticoagulant and associated immunologic abnormalities", Am. J. Hematol. 13, 121 - 129
  • Reddel, S.W. and Krilis, S.A. (1999) "Testing for and clinical significance of anti-cardiolipin antibodies", Clin. Diagn. Lab. Immunol. 6, 775 - 782
  • Love, P.E. and Santoro, S.A. (1990) "Antiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders. Prevalence and clinical significance", Ann. Int. Med. 112, 682 - 698
  • Cuadrado, M.J., Tinahones, F., Camps, M.T., de Ramon, E., Gomez-Zumaquero, J.M., Mujic, F., Khamashta, M.A. and Hughes, G.R. (1998) "Antiphospholipid, anti-beta2-glycoprotein-1 and anti-oxidized low density lipoprotein antibodies in antiphospholipid syndrome", QJM 91, 619 - 626
  • Gomez-Pacheco, L., Villa, A.R., Drenkard, C., Cabiedes, J., Cabral, A.R. and Alarcon-Segovia, D. (1999) "Serum anti-beta2-glycoprotein-1 and anticardiolopin antibodies during thrombosis in systemic lupus erythematosus patients", Am. J. Med. 106, 417 - 423
  • Bruce, I.N., Clark-Soloninka, C.A., Spitzer, K.A., et al., (2000) "Prevalence of antibodies to beta2-glycoprotein I in systemic lupus erythematosus and their association with antiphospholipid antibody syndrome criteria: a single center study and literature review", J. Rheum. 27, 2833 - 2837
  • Senecal, J.L., Rauch, J., Grodzicky, T., Raynauld, J.P., Uthman, I., Nava, A., Guimond, M. and Raymond, Y. (1999) "Strong association of autoantibodies to nuclear lamin B1 with lupus anticoagulant antibodies in systemic lupus erythematosus", Arthritis Rheum. 42, 1347 - 1353
  • Harris, E.N. and Peirangeli, S. (1997) "Antiphospholipid antibodies and cerebral lupus", Ann. NY Acad. Sci. 823, 270 - 278
  • Alarcon-Segovia, D., Estanol, B., Garcia-Ramos, G. and Villa, A.R. (1997) "Antiphospholipid antibodies and the antiphospholipid syndrome. Clinical relevance in neuropsychiatric systemic lupus erythematosus", Ann. NY Acad. Sci. 823, 279 - 288
  • Karassa, F.B., Ioannidis, J.P., Touloumi, G., Boki, K.A. and Moiutsopoulos, H.M. (2000) "Risk factors for central nervous system involvement in systemic lupus erythematosus", QJM 93, 169 - 194
  • Herranz, M.T., Rivier, G., Khamashta, M.A., Blaser, K.U. and Hughes, G.R. (1994) "Association between antiphospholipid antibodies and epilepsy in patients with systemic lupus erythematosus", Arthritis Rheum. 37, 568 - 571
  • Hanly, J.G., Hong, C., Smith, S. and Fisk, J.D. (1999) "A prospective study of cognitive function and anticardiolipin antibodies in systemic lupus erythematosus", Arthritis Rheum. 42, 728 - 734
  • Menon, S., Jameson-Shortall, E., Newman, S.P., Hall-Craggs, M.R., Chinn, R. and Isenberg, D.A. (1999) "A longitudinal study of anticardiolipin antibody levels and cognitive functioning in systemic lupus erythematosus", Arthritis Rheum. 42, 735 - 741
  • Hirano, T., Hashimoto, H., Shiokawa, Y., Iwamori, M., Nagai, Y., Kasai, M., Ochiai, Y. and Okumura, K. (1980) "Antiglycolipid autoantibody detected in the sera of patients with systemic lupus erythematosus", J. Clin. Invest. 66, 1437 - 1440
  • Costallat, L.T.L., de Oliveira, R.M., Santiago, M.B., Cossermelli, W. and Samara, A.M. (1990) "Neuropsychiatric manifestations of systemic lupus erythematosus: the value of anticardiolipin, antiganglisides and antigalactocerebroside antibodies", Clin. Rheumatol. 9, 489 - 497
  • Martinez, X., Tintore, M., Montalban, J., Ordi, J., Villardell, M. and Codina, A. (1992) "Antibodies against gangliosides in patients with SLE and neurological manifestations", Lupus 1, 299 - 302
  • Galeazzi, M., Annunziata, P., Sebastiani, G.D., Bellisai, F., Campanella, V., Ferrara, G.B., et al., (2000) "Anti-ganglioside antibodies in a large cohort of European patients with systemic lupus erythematosus: clinical, serological, and HLA class II gene associations. European concerted action on the immunogenetics of SLE", J. Rheumatol. 27, 135141
  • Moore, P.M. and Lisak, R.P. (1995) "Systemic lupus erythematosus: immunopathogeneis of neurologic dysfunction", Springer Semin. Immunopathol. 17, 43 - 60
  • Hess, D.C. (1997) "Cerebral lupus vasculopathy. Mechanisms and clinical relevance", Ann. NY Acad. Sci. 823, 154 - 168
  • McCune, W.J. and Globus, J. (1988) "Neuropsychiatric lupus", Rheum. Dis. Clin. North Am. 14, 149 - 167
  • Dickstein, J.B., Moldofsky, H., Lue, F.A. and Hay, J.B. (1999) "Intracerebroventricular injection of TNF-alpha promotes sleep and is recovered in cervical lymph", Am. J. Physiol. 276, R1018 - R1022
  • Weller, R.O., Massey, A., Kuo, Y.M. and Roher, A.E. (2000) "Cerebral amyloid angiopathy: accumulation of A beta in interstitial fluid drainage pathways in Alzheimer's disease", Ann. NY Acad. Sci. 903, 110 - 117
  • Gaburo, Jr., N., Timo-laria, C. and Bueno, C. (1995) "In vivo effects of antiribosomal P protein antibodies injections into lateral ventricle of the rat brain", Arthritis Rheum. 38, S297
  • Sun, I.S.H., Liu, W.T., Tsai, C.Y., Liao, T.S., Lin, W.M. and Yu, C.L. (1992) "Inhibition of astrocyte proliferation and binding to brain tissue of anticardiolipin antibodies purified from lupus serum", Ann. Rheum. Dis. 51, 707 - 712
  • Fischer, H.G. and Bielinsky, A.K. (1999) "Antigen presentation function of brain-derived dendriform cells depends on astrocyte help", Int. Immunol. 11, 1265 - 1274
  • Aloisi, F., Ria, F. and Adorini, L. (2000) "Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes", Immunol. Today 21, 141 - 147
  • Fischer, H.G., Bonifas, U. and Reichmann, G. (2000) "Phenotype and functions of brain dendritic cells emerging during chronic infection of mice with Toxoplasma gondii", J. Immunol. 164, 4826 - 4834
  • Hanly, J.G., Hong, C. and White, T.D. (1993) "Brain synaptosomal antibodies in systemic lupus erythematosus", Lupus 2, 35 - 45
  • Hanly, J.G., Fisk, J.D. and Eastwood, B. (1994) "Brain reactive autoantibodies and cognitive impairment in systemic lupus erythematosus", Lupus 3, 193 - 199
  • Arnett, F.C., Reveille, J.D., Moutsopoulos, H.M., Georgescu, L. and Elkon, K.B. (1996) "Ribosomal P antibodies in systemic lupus erythematosus", Arthritis Rheum. 39, 1833 - 1839
  • Georgescu, L., Mevorach, D., Arnett, F.C., Reveille, J.D. and Elkon, K.B. (1997) "Anti-P antibodies and neuropsychiatric lupus erythematosus", Ann. NY Acad. Sci. 823, 263 - 269
  • Roubey, R.A. (1996) "Immunology of the antiphospholipid syndrome", Arthritis Rheum. 39, 1444 - 1454

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