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Autoimmunity Volume 35, 2002 - Issue 2
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Research Article

Sequencing of the Second Exon of the MHC Class II DQ6 Alleles in Patients with Type 1 Diabetes

M.L. Rayner Department of Medicine, Clinical Research Block, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, UK
,
M.A. Kelly Department of Medicine, Clinical Research Block, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, UK
,
C.H. Mijovic Department of Medicine, Clinical Research Block, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, UK
&
A.H. Barnett Department of Medicine, Clinical Research Block, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, UK
Pages 155-157 | Published online: 07 Jul 2009

  • Baisch, J.M., Week, T., Giles, R., Hoover, M., Stastny, P. and Capra, D. (1990) "Analysis of HLA-DQ genotypes and susceptibility in insulin dependent diabetes mellitus", N. Engl. J. Med. 322, 1836 - 1841
  • Sanjeevi, C.B., DeWeese, C., Landin-Olsson, M., Kochum, I., Dahlquist, G., Lernmark, Å., et al., (1997) "Analysis of critical residues of HLA-DQ6 molecules in insulin-dependent diabetes mellitus", Tissue Antigens 50, 61 - 65
  • Mijovic, C.H., Jenkins, D., Jacobs, K.H., Penny, M.A., Fletcher, J.A. and Barnett, A.H. (1991) "HLA-DQA1 and DQB1 alleles associated with genetic susceptibility to IDDM in a black population", Diabetes 40, 748 - 753
  • Cavan, D.A., Jacobs, K.H., Penny, M.A., Mijovic, C., Jenkins, D., Fletcher, J.A., et al., (1993) "Both DQA1 and DQB1 genes are implicated in HLA-associated protection from type 1 (insulin dependent) diabetes mellitus in a British Caucasian population", Diabetologia 36, 252 - 257
  • Hoover, M.L. and Marta, R.T. (1997) "Molecular modelling of HLA-DQ suggests a mechanism of resistance in type 1 diabetes", Scand. J. Immunol. 45, 193 - 202
  • Pugliese, A., Kawasaki, E., Zeller, M., Yu, L., Babu, S., Solimena, M., et al., (1999) "Sequence analysis of the diabetes-protective human leukocyte antigen--DQB1*0602 allele in unaffected, islet cell antibody--positive first degree relatives and in rare patients with type 1 diabetes", J. Clin. Endocrinol. Metab. 84, 1722 - 1728
  • Bunce, M., ONeill, C.M., Barnardo, M.C.N.M., Krausa, P., Browning, M.J., Morris, P.J., et al., (1995) "Phototyping comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 and DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP)", Tissue Antigens 46, 355 - 367
  • Nepom, G.T. and Kwok, W.W. (1998) "Molecular basis for HLA-DQ association in IDDM", Diabetes 47, 1177 - 1184
  • Graham, J., Kockum, I., Sanjeevi, C.B., Landlin-Olsson, M., Nystrom, L., Sundkvist, G., et al., (1999) "Negative association between type 1 diabetes and HLA DQB1*0602-DQA1*0102 is attenuated with age at onset", Eur. J. Immunogenet. 26, 117 - 127

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