Advanced search
Publication Cover
Autoimmunity Volume 36, 2003 - Issue 1
Submit an article Journal homepage
54
Views
22
CrossRef citations to date
0
Altmetric
Research Article

Pregnancy Complications of the Antiphospholipid Syndrome

A. Tincani Servizio di Reumatologia, Allergologia e Immunologia Clinica, Spedali Civili di Brescia, P.le Spedali Civili, 1 25123 Brescia, Italy
,
G. Balestrieri Servizio di Reumatologia, Allergologia e Immunologia Clinica, Spedali Civili di Brescia, P.le Spedali Civili, 1 25123 Brescia, Italy
,
E. Danieli Servizio di Reumatologia, Allergologia e Immunologia Clinica, Spedali Civili di Brescia, P.le Spedali Civili, 1 25123 Brescia, Italy
,
D. Faden Divisione di Ostetricia e Ginecologia, Spedali Civili di Brescia, Brescia, Italy
,
A. Lojacono Divisione di Ostetricia e Ginecologia, Spedali Civili di Brescia, Brescia, Italy
,
B. Acaia Divisione di Medicina Perinatale, Clinica Ostetrica e Ginecologica Mangiagalli, Milano, Italy
,
L. Trespidi Divisione di Medicina Perinatale, Clinica Ostetrica e Ginecologica Mangiagalli, Milano, Italy
,
D. Ventura Unità di Allergologia e Immunologia Clinica, Dipartimento di Medicina Interna, Università degli Studi di Milano, IRCCS Istituto Auxologico Italiano, Milano, Italy
&
P.L. Meroni Unità di Allergologia e Immunologia Clinica, Dipartimento di Medicina Interna, Università degli Studi di Milano, IRCCS Istituto Auxologico Italiano, Milano, Italy
 show all
Pages 27-32 | Published online: 07 Jul 2009

  • Soulier, J.P. and Boffa, M.C. (1980) "Avortments à repetition, thromboses et anticoagulant circulant antithromboplastin", Noun Pnsse Med. 9, 859-864.
  • Harris, E.N., Gharavi, A.E., Boey, M.L., Patel, B.M., Mackworth-Young, C.G., Loizou, S. and Hughes, G.R. (1983) "Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus", Lancet 2(8361), 1211-1214.
  • Balestrieri, G., Tincani, A., Spatola, L., Allegri, F, Prati, E., Cananeo, R., Valesini, G., Del Papa, N. and Meroni, P. (1995) "Anti-beta 2-glycoprotein I antibodies: a marker of antiphospholipid syndrome?", Lupus 4, 122-130.
  • Arvieux, J., Darnige, L., Caron, C., Reber, G., Bensa, I.C. andColomb, M.G. (1995) "Development of an ELISA for autoanti-bodies to prothrombin showing their prevalence in patients withlupus anticoagulants", Thromb. Haemostasis 74, 1120-1125.
  • Hughes, G.R.V. (1983) "Thrombosis, abortion, cerebral disease andthe lupus anticoagulant", Br. Med. J. 287, 1088-1089.
  • Geis, W. and Branch, W. (2001) "Obstetric implications of antiphospholipid antibodies: pregnancy loss and other complications", Clin. Obstet. Oynecol 44, 2-10.
  • Laurel), A.B. and Nilsson, LM. (1957) "Hypergammaglobulinemia, circulating anticoagulant and biologic false positive Wassermann reaction: a study of 2 cases", J. Lab. Clin. Med. 49, 694-707.
  • Lee, S.L. and Sanders, M. (1955) "A disorder of blood coagulation in systemic lupus erythematosus", J. Clin. Investig. 34, 1814-1822.
  • Lockshin, M.D., Druzin, M.L., Goei, S., Qamar, T., Magid, M.S., Jovanovic, L. and Ferenc, M. (1985) "Antibody to cardiolipin as a predictor of fetal distress or death in pregnant patients with systemic lupus erythematosus", N. Engl. J. Med. 313, 152-156.
  • Lockwood, C.J., Romero, R., Feinberg, R.F., Clyne, L.P., Coster, B. and Hobbins, J.C. (1989) "The prevalence and biologic significance of lupus anticoagulant and anticardiolipin antibodies in a general obstetric population", Am. J. Obstet. Gynecol. 161, 369-373.
  • Lubbe, W.F, Palmer, S.J., Butler, W.S. and Liggins, G.C. (1983) "Fetal survival after prednisone suppression of maternal lupusanticoagulant", Lancet 1(8338), 1361-1363.
  • Wilson, W.A., Gharavi, A.E., Koike, T, Lockshin, M.D., Branch, D.W., Kette, I.C., Brey, R., Derksen, R., Harris, E.N., Hughes, G.R., Triplett, D.A. and Khamashta, M.A. (1999) "International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop", Arthritis Rheum. 42, 1309-1311.
  • Rai, R., Cohen, H., Dave, M. and Regan, L. (1997) "Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies)", BMJ 314, 253-257.
  • Silver, R.M., Porter, T.F., van Leeuween, I., Jeng, G., Scott, J.R. and Branch, D.W. (1996) "Anticardiolipin antibodies: clinical consequences of "low titers"", Obstet. Gynecol 87, 494-500.
  • Lee, R.M., Emlen, W, Scott, I.R., Branch, D.W. and Silver, R.M. (1999) "Anti-beta2-glycoprotein I antibodies in women with recurrent spontaneous abortion, unexplained fetal death and antiphospholipid syndrome", Am. J. Obstet. Gynecol. 181, 642-648.
  • Faden, D., Tincani, A., Tanzi, P., Spatola, L., Lojacono, A., Tarantini, M. and Balestrieri, G. (1997) "Anti-beta 2 glycoprotein I antibodies in a general obstetric population: preliminary results on the prevalence and correlation with pregnancy outcome. Anti-beta2 glycoprotein I antibodies are associated with some obstetrical complications, mainly preeclampsia-eclampsia", Ear. J. Obstet. Gynecol. Reprod. Biol. 73, 37-42.
  • Porter, T.F., Nelson, K., Esplin, M.S., Silver, R.M., Dowling, A. and Branch, D.W. (2002) "The prevalence and clinical consequences of antibodies to beta2 GPI in the general obstetric population", Lupus 11, 565.
  • Von Landenberg, P., Matthias, T, Zaech, J., Schultz, M., Lorber, M., Blank, M. and Shoenfeld, Y. (2003) "Anti-prothrombin antibodies are associated with pregnancy loss in patients with the antiphospholipid syndrome", Am. J. Reprod. Immunol., In press.
  • Rand, J.H. and Wu, X. (2002) "The annexins: a target of antiphospholipid antibodies", In: Asherson, R.A., Cervera, R., Piette, I.C. and Shoenfeld, Y, eds, The Antiphospholipid Syndrome II. The Autoimmune Thrombosis (Elsevier, Amsterdam), pp. 71-78.
  • Tincani, A., Spatola, L., Cinquini, M., Meroni, P.L., Balestrieri, G. and Shoenfeld, Y. (1998) "Animal models of antiphospholipid syndrome", Rev. Rhum. 65, 614-618.
  • Rote, N.S., Vogt, E., DeVere, G. and Obringer, A.R. (1998) "The role of placenta! trophoblast in the pathophysiology of the antiphospholipid antibody syndrome", Am. J. Reprod. Immunol. 39, 125-136.
  • McIntyre, I.A. (1992) "Immune recognition at the meternal-fetal intercafe: overview", Am. J. Reprod. Immunol. 28, 127-131.
  • La Rosa, L., Meroni, P.L., Tincani, A., Balestrieri, G., Faden, D., Lojacono, A., Morassi, L., Brocchi, E., Del Papa, N., Gharavi, A.E., Sammaritano, L. and Lockshin, M. (1994) "Beta 2 glycoprotein I and placenta! anticoagulant protein I in placentae from patients with antiphospholipid syndrome", J. Rheumatol. 21, 1684-1693.
  • Di Simone, N., Meroni, P.L., Del Papa, N., Raschi, E., Caliandro, D., De Carolis, C.S., Khamashta, M.A., Atsumi, T., Hughes, G.R., Balestrieri, G., Tincani, A., Casali, P. and Caruso, A. (2000) "Antiphospholipid antibodies affect trophoblast gonadotropin secretion and invasiveness by binding directly and through adhered beta2-glycoprotein I", Arthritis Rheum. 43, 140-150.
  • Ikematsu, W., Luan, F.L., La Rosa, L., Feltrami, B., Nicoletti, F., Buyon, J.P., Meroni, P.L., Balestrieri, G. and Casali, P. (1998) "Human anticardiolipin monoclonal autoantibodies cause placenta! necrosis and fetal loss in BALB/c mice", Arthritis Rheum. 41, 1026-1039.
  • Blank, M., Cohen, J., Toder, V. and Shoenfeld, Y. (1991) "Induction of anti-phospholipid syndrome in naive mice with mouse lupus monoclonal and human polyclonal anti-cardiolipin antibodies", Proc. Natl Acad Sci. 88, 3069-3073.
  • Krikun, G., Lockwood, C.J., Wu, X.X., Zhou, X.D., Culler, S., Calandri, C., Guha, A., Nemerson, Y. and Rand, J.H. (1994) "The expression of the placenta! anticoagulant protein, annexin V, by villous trophoblasts: immunolocalization and in vitro regulation", Placenta 15, 601-612.
  • Andree, H.A.M. (1992) Displacement of Factor Va by Annexin Vin Phospholipid Binding and Anticoagulant Action of Annexin V (Universitaire Pers Maastricht, The Netherlands), pp. 73-85.
  • Rand, J.H. (2000) "The pathogenic role of annexin-V in the antiphospholipid syndrome", Curr. Rheumatol. Rep. 2, 246-251.
  • Branch, D.W. (1987) "Immunologie disease and fetal death", Clin. Obstet. Gynecol. 30, 295-311.
  • Branch, D.W., Dudley, D.I., Scott, J.R. and Silver, R.M. (1992) "Antiphospholipid antibodies and fetal loss", N. Engl. J. Med. 326, 952.
  • Oshiro, B.T., Silver, R.M., Scott, J.R., Yu, H. and Branch, D.W. (1996) "Antiphospholipid antibodies and fetal death", Obstet. Gynecol. 87, 489-493.
  • Yasuda, M., Takakuwa, K., Tokunaga, A. and Tanaka, K. (1995) "Prospective studies of the association between anticardiolipin antibody and outcome of pregnancy", Obstet. Gynecol. 86, 555-559.
  • Lima, F., Khamashta, M.A., Buchanan, N.M., Kerslake, S., Hunt, B.I. and Hughes, G.R. (1996) "A study of sixty pregnancies in patients with the antiphospholipid syndrome", Clin. Exp. Rheumatol 14, 131-136.
  • Pattison, N.S., Chamley, L.W., McKay, E.J., Liggins, G.C. and Butler, W.S. (1993) "Antiphospholipid antibodies in pregnancy: prevalence and clinical associations", Br. J. Obstet. Gynaecol. 100, 909-913.
  • Moodley, J., Bhoola, V, Duursma, J., Pudifin, D., Byrne, S. and Kenoyer, D.G. (1995) "The association of antiphospholipid antibodies with severe early-onset pre-eclampsia", S. Afr. Med. J. 85, 105-107.
  • Lynch, A., Marlar, R., Murphy, J., Davila, G., Santos, M., Rutledge, J. and Emlen, W. (1994) "Antiphospholipid antibodies in predicting adverse pregnancy outcome. A prospective study", Ann. Intern. Med. 120, 470-475.
  • Branch, D.W., Porter, T.F., Rittenhouse, L., Caritis, S., Sibai, B., Hogg, B., Lindheimer, M.D., Klebanoff, M., MacPherson, C., VanDorsten, J.P., Landon, M., Paul, R., Miodovnik, M., Meis, P. and Thurnau, G. (2001) "Antiphospholipid antibodies in women at risk for preeclampsia", Am. J. Obstet. Cynecol. 184, 825-832.
  • Tincani, A. and Doria, A. (2002) "Clinical predictor of obstetrical outcome in SLE pregnancy", Arthritis Rheum. 46, 811.
  • Branch, D.W., Silver, R.M., Blackwell, J.L., Reading, J.C. and Scott, J.R. (1992) "Outcome of treated pregnancies in women with antiphospholipid syndrome: an update of the Utah experience", Obstet. Gynecol. 80, 614-620.
  • Kutteh, W.H. and Ermel, L.D. (1996) "A clinical trial for the treatment of antiphospholipid antibody-associated recurrent pregnancy loss with lower dose heparin and aspirin", Am. J. Reprod. Immunol. 35, 402-407.
  • Triplett, D.A. (1998) "Many faces of Lupus anticoagulants", Lupus 7(S2), S18-S22.
  • Tincani, A., Allegri, E, Sanmarco, M, Cinquini, M., Taglietti, M., Balestrieri, G., Koike, T., Ichikawa, K., Meroni, P. and Boffa, M.C. (2001) "Anticardiolipin antibody assay: a methodological analysis for a better consensus in routine determinations: a cooperative project of the European Antiphospholipid Forum", Thromb. Haemostasis 86, 575-583.
  • Tsutsumi, A., Ichikawa, K., Matsuura, E, Sawa, K.I. and Koike, T. (2000) "Heterogeneous behavior of antiß2GPI antibodies on various commercially available enzyme immunoassay plates coated with antiß2GPr, J. Rheum. 27, 391-396.
  • Reber, G., Schousboe, I., Tincani, A., Sanmarco, M, Kveder, T, de Moerloose, P., Boffa, M.C. and Arvieux, J. (2002) "Inter-laboratory variability of anti-beta2-glycoprotein I measurement. A collaborative study in the frame of the European Forum on Antiphospholipid Antibodies Standardization Group", Thromb. Haemostasis 88, 66-73.
  • Hasegawa, I., Takakuwa, K., Goto, S., Yamada, K., Sekizuka, N., Kanazawa, K. and Tanaka, K. (1992) "Effectiveness of prednisolone/aspirin therapy for recurrent aborters with antiphospholipid antibody", Hum. Reprod. 7, 203-207.
  • Cowchock, F.S., Reece, E.A., Baldan, D., Branch, D.W. and Plouffe, L. (1992) "Repeated fetal losses associated with antiphospholipid antibodies: a collaborative randomised trial comparing prednisone with low dose heparin treatment", Am. J. Obstet. Oynecol 166, 1318-1323.
  • Petri, M., Howard, D. and Repke, J. (1992) "Risk factors for preterm birth in lupus pregnancy: a prospective study. Proceedings of the third International Conference on SLE", Lupus IS, 159.
  • Backos, M., Rai, R., Baxter, N., Chilcott, I.T., Cohen, H. and Regan, L. (1999) "Pregnancy complications in women with recurrent miscarriage associated with antiphospholipid antibodies treated with low dose aspirin and heparin", Br. J. Obstet. Gynaecol. 106, 102-107.
  • Kutteh, W.H. (1996) "Antiphospholipid antibody associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone", Am. J. Obstet. Oynecol. 174, 1584-1589.
  • Farquharson, R.G., Quenby, S. and Greaves, M. (2002) "Antiphospholipid syndrome in pregnancy: a randomised, controlled trial of treatment", Obstet. Gynecol. 100, 408-413.
  • Pattison, N.S., Chamley, L. W, Bildsall, M., Zanderigo, A.M., Liddell, H.S. and McDougall, I. (2000) "Does aspirin have a role in improving pregnancy outcome for women with antiphospholipid syndrome?", Am. J. Obstet. Gynecol 183, 1008-1012.
  • Fishman, P., Falach-Vaknin, E., Sredni, B., Meroni, P.L., Rudniki, C. and Shoenfeld, Y. (1995) "Aspirin modulates interleukin-3 production: additional explanation for the preventive effects of aspirin in antiphospholipid antibody syndrome", J. Rheumatol. 22, 1086-1090.
  • Wegmann, T.G. (1989) "The cytokine basis for cross-talk between the maternal immune and reproductive systems", Curr. Opin. Immunol. 2, 765-769.
  • Fishman, P., Falach-Vaknin, E., Sredni, B., Meroni, P.L., Tincani, A., Dicker, D. and Shoenfeld, Y. (1996) "Aspirin-interleukin-3 interrelationships in patients with anti-phospholipid syndrome", Am. J. Reprod. Immunol. 35, 80-84.
  • Fishman, P, Falach-Vaknine, E., Zigelman, R., Bakimer, R., Sredni, B., Djaldetti, M. and Shoenfeld, Y. (1993) "Prevention of fetal loss in experimental antiphospholipid syndrome by in vivo administration of recombinant interleukin-3", J. Clin. Investig. 91, 1834-1837.
  • Chamley, L.W., Kbnarkowska, B., Duncalf, A.M., Mitchell, M.D. and Johnson, PM. (2001) "Is Interleukin-3 important in antiphospholipid antibody-mediated pregnancy failure?", Fertil. Steril. 76, 700-706.
  • Branch, D.W., Peaceman, A.M., Druzin, M., Silver, R.K., El-Sayed, Y, Silver, R.M., Esplin, M.S., Spinnato, J. and Harger, I. (2000) "A multicenter, placebo-controlled pilot study of intravenous immune globulin treatment of antiphospholipid syndrome during pregnancy. The Pregnancy Loss Study Group", Am. J. Obstet. Gynecol 182(1 Pt 1), 122-127.
  • Tincani, A., Branch, D.W., Levy, R.A., Piette, J.C, Carp, H., Rai, R.S., Khamashta, M.A. and Shoenfeld, Y (2003) 'Treatment of pregnant patients with Antiphospholipid Syndrome", Lupus In press.
  • Ruiz-Irastorza, G., Khamashta, M.A., Nelson-Piercy, C. and Hughes, G.R. (2001) "Lupus pregnancy: is heparin a risk factor for osteoporosis?", Lupus 10, 597-600.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.