Advanced search
Publication Cover
Autoimmunity Volume 36, 2003 - Issue 2
Submit an article Journal homepage
83
Views
25
CrossRef citations to date
0
Altmetric
Research Article

Effect of Pro-inflammatory/Anti-inflammatory Agents on Cytokine Secretion by Peripheral Blood Mononuclear Cells in Rheumatoid Arthritis and Systemic Lupus Erythematosus

F. Scuderi Institute of General Pathology, Catholic University, Largo Francesco Vito, 1, 00168 Rome, Italy
,
R. Convertino Institute of Internal Medicine (Rheumatology Unit), Catholic University, Rome, Italy
,
N. Molino Institute of Hygiene, Catholic University, Rome, Italy
,
C. Provenzano Institute of General Pathology, Catholic University, Largo Francesco Vito, 1, 00168 Rome, Italy
,
M. Marino Institute of General Pathology, Catholic University, Largo Francesco Vito, 1, 00168 Rome, Italy
,
A. Zoli Institute of Internal Medicine (Rheumatology Unit), Catholic University, Rome, Italy
&
E. Bartoccioni Institute of General Pathology, Catholic University, Largo Francesco Vito, 1, 00168 Rome, Italy
 show all
Pages 71-77 | Published online: 07 Jul 2009

  • al-Janadi, M., al-Balla, S., al-Dalaan, A. and Raziuddin, S. (1993) "Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis, and other rheumatic diseases", J. Clin. Immunol. 13, 58-67.
  • Feldmann, M, Brennan, EN. and Maini, R.N. (1996) "The role of cytokines in rheumatoid arthritis", Annu. Rev. Immunol. 14, 397-440.
  • Feldmann, M. and Maini, R.N. (1999) "The role of cytokines in the pathogenesis of rheumatoid arthritis", Rheumatology 38(Suppl. 2), 3-7.
  • Alcocer-Varela, J., Llorente, L. and Alarcon-Segovia, D. (1996) "Immunoregulatory circuits and potential treatment of connective tissue diseases", Int. Arch. Allergy Immunol 111, 348-354.
  • Podolsky, O.K. (1997) "Lessons from genetic models of inflammatory bowel disease", Acta Gastroenterol. BeIg. 60, 163-165.
  • Horai, R., Asano, M., Sudo, K., Kanuka, H., Suzuki, M., Nishihara, M., et al. (2000) "Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin-1 antagonist-deficient mice", J. Exp. Med. 191, 313-320.
  • Schulze-Kbops, H., Lipsky, P.E., Kavanaugh, A.F. and Davis, L.S. (1995) "Elevated Th1- or Th0-like cytokines mRNA in peripheral circulation of patients with rheumatoid arthritis", J. Immunol. 155, 5029-5037.
  • Swaak, A.J.G., van den Brink, H.G. and Aarden, L.A. (1996) "Cytokine production (IL-6 and TNFa) in whole blood cell cultures of patients with systemic lupus erythematosus", Scand. J. RheumatoL 25, 233-238.
  • Richaud-Patin, Y., Alcocer-Varela, J. and Llorente, L. (1995) "High levels of Th2 cytokine gene expression in systemic lupus erythematosus", Reu Invest. Clin. 47, 267-272.
  • Miossec, P. and van den Berg, W. (1997) "Th1/Th2 cytokine balance in arthritis", Arthritis Rheum. 40, 2105-2115.
  • Mosmann, T.R. and Sad, S. (1996) "The expanding universe of T-cell subsets: Th1, Th2 and more", Immunol. Today 17, 138-146.
  • Jones, B.M., Liu, T. and Wong, R.W. (1999) "Reduced in vitro production of interferon-gamma, interleukin-4 and interleukin-12 and increased production of interleukin-6, interleukin-10 and tumour necrosis factor-alpha in systemic lupus erythematosus. Weak correlations of cytokine production with disease activity", Auioimmunity 31, 117-124.
  • Jouvenne, P., Vannier, E., Dinarello, C.A. and Miossec, P. (1998) "Elevated levels of soluble interleukin-1 receptor type II and interleukin-1 receptor antagonist in patients with chronic arthritis: correlations with markers of inflammation and joint destruction", Arthritis Rheum. 41, 1083-1089.
  • Ruschen, S., Stellberg, W. and Warnatz, H. (1992) "Kinetics of cytokine secretion by mononuclear cells of the blood from rheumatoid arthritis patients are different from those of healthy controls", Clin. Exp. Immunol. 89, 32-37.
  • Andersen, L.S., Petersen, J., Svenson, M. and Bendtzen, K. (1999) "Production of IL-lbeta, IL-1 receptor antagonist and IL-10 by mononuclear cells from patients with SLE", Autoimmunity 30, 235-242.
  • Lee, S.W., Tsou, A.P., Chan, H., Thomas, J., Petrie, K., Eugui, E.M. and Allison, A.C. (1988) "Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA", Proc. Nail Acad. Sci. USA 85, 1204-1208.
  • St Clair, E.W. (1999) "Interleukin 10 treatment for rheumatoid arthritis", Ann. Rheum. Dis. 58(Suppl. I), 199-1102.
  • Prud'homme, G.I. and Piccirillo, C.A. (2000) "The inhibitory effects of transforming growth factor-beta-1 (TGF-ß1) in autoimmune diseases", J. Autoimmun. 14, 23-42.
  • Donnelly, R.P., Dickensheets, H. and Finbloom, D.S. (1999) "The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes", J. Interferon Cytokiae Res. 19, 563-573.
  • Schottelius, A.I., Mayo, M.W., Sartor, R.B. and Baldwin, Ir., A.S. (1999) "Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding", J. Biol. Chem. 274, 31868-31874.
  • Cassatella, M.A., Meda, L., Gasperini, S., Calzetti, F. and Bonora, S. (1994) "Interleukin 10 (IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leukocytes by delaying mRNA degradation", J. Exp. Med. 179, 1695-1699.
  • Grondai, G., Gunnarsson, I., Ronnelid, J., Rogberg, S., Klareskog, L. and Lundberg, I. (2000) "Cytokine production, serum levels and disease activity in systemic lupus erythematosus", Clin. Exp. Rheumatol. 18, 565-570.
  • Viallard, J.F., Pellegrin, J.L., Ranchin, V, Schaeverbeke, T., Dehais, J., Longy-Boorsier, M, et al, (1999)"Th1 (IL-2,interferon-gamraa (IFN-gamma) and Th2 (IL-IO, IL-4) cytokine production by peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE)", Clin. Exp. Immunol. 115, 189-195.
  • Mongan, A.E., Ramdahin, S. and Warrington, R.J. (1997) "Interleukin-10 response abnormalities in systemic lupus erythematosus", Scand. J. Immunol. 46, 406-412.
  • Linker-Israeli, M., Honda, M., Nand, R., Mandyam, R., Mengesha, E., Wallace, D.I., el al (1999) "Exogenous IL-10 and IL-4 downregulate IL-6 production by SLE-derived PBMC", Clin. Immunol. 91,6-16.
  • Eskdale, I., Wordsworth, P., Bowman, S., Field, M. and Gallagher, G. (1997) "Association between polymorphisms at the human IL-10 locus and systemic lupus erythematosus", Tissue Antigens 49, 635-639.
  • Dendorfer, U., Oettgen, P. and Libermann, T.A. (1994) "Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide", MoI. Cell. Biol 14, 4443-4454.
  • Dokter, W.H., Kbopmans, S.B. and Vellenga, E. (1996) "Effects of IL-10 and IL-4 on LPS-induced transcription factors (AP-I, NF-IL6 and NF-kappa B) which are involved in IL-6 regulation", Leukemia 10, 1308-1316.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.