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Autoimmunity Volume 36, 2003 - Issue 2
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Research Article

CD45 Isoform Expression in Autoimmune Myasthenia Gravis

B. Tackenberg Department of Neurology, Philipps-University, Rudolf-Bultmann Street 8, D-35033 Marburg, Germany
,
M. Nitschke Department of Neurology, Philipps-University, Rudolf-Bultmann Street 8, D-35033 Marburg, Germany
,
N. Willcox The Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Headington, Oxford OX3 9DS, UK
,
A. Ziegler Institute of Medical Biometry and Statistics, University Hospital of Lübeck, Medical University of Lübeck, Ratzeburger Allee 160, Zentralklinikum, D-23538 Lübeck, Germany
,
S. Nessler Department of Neurology, Philipps-University, Rudolf-Bultmann Street 8, D-35033 Marburg, Germany
,
F. Schumm Department of Neurology, Christophsbad, Faurndauer Street 6-28, D-73035 Göppingen, Germany
,
W.H. Oertel Department of Neurology, Philipps-University, Rudolf-Bultmann Street 8, D-35033 Marburg, Germany
,
B. Hemmer Department of Neurology, Philipps-University, Rudolf-Bultmann Street 8, D-35033 Marburg, Germany
&
N. Sommer Department of Neurology, Philipps-University, Rudolf-Bultmann Street 8, D-35033 Marburg, Germany
 show all
Pages 117-121 | Published online: 07 Jul 2009

  • Drachmen, D.B. (1994) "Myasthenia gravis", N. Engl. J. Med. 330, 1797-1810.
  • Vincent, A., Palace, J. and Hilton-Jones, D. (2001) "Myasthenia gravis", Lancet 357, 2122-2128.
  • Hoch, W., McConville, J., Helms, S., Newsom-Davis, I., Melms, A. and 'Vincent, A. (2001) "Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies", Nat. Med. 7, 365-368.
  • Compston, D.A.S., Vincent, A., Newsom-Davis, J. and Batchelor, J.R. ( 1980) "Clinical, pathological, HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis", Brain 103, 579-601.
  • Penninger, I.M., Irie-Sasaki, J., Sasaki, T. and Oliveira-dos-Santos, A.J. (2001) "CD45: new jobs for an old acquaintance", Nat. Immunol 2, 389-396.
  • Trowbridge, I.S. and Thomas, M.L. (1994) "CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development", Annu. Rev. Immunol. 12, 85-116.
  • Rung, C., Pingel, J.T., Heikinheimo, M., Klemola, T., Varkila, K., Yoo, L.I., et al. (2000) "Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease", Nat. Med. 6, 343-345.
  • Cossarizza, A., Ortolani, C., Paganelli, R., Barbieri, D., Monti, D., Sansoni, P., et al (1996) "CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians: implications for T cell memory", Mech. Ageing Den 86, 173-195.
  • Petersen, L.D., Duinkerken, G., Braining, G.I., van Lier, R.A., de Vries, R.R. and Roep, B.O. (1996) "Increased numbers of in vivo activated T cells in patients with recent onset insulin-dependent diabetes mellitus", J. Autoimmun. 9, 731-737.
  • Neidhart, M., Pataki, F., Michel, B.A. and Fehr, K. (1996) "CD45 isoform expression on CD4+ and CD8+ peripheral blood T-lymphocytes is related to autoimmune processes and hematological manifestations in systemic lupus erythematosus", Schweiz. Med Wochenschr. 126, 1922-1925.
  • Hoffacker, V, Schultz, A., Tiesinga, J.J., Gold, R., Schalke, B., Nix, W., et al. (2000) "Thymomas alter the T-cell subset composition in the blood: a potential mechanism for thymomaassociated autoimmune disease", Blood 96, 3872-3879.
  • Buckley, C., Douek, D., Newsom-Davis, I., Vincent, A. and Willcox, N. (2001) "Mature, long-lived CD4+ and CD8+ T cells are generated by the thymoma in myasthenia gravis", Ann. Neural. 50, 64-72.
  • Iacobsen, M., Schweer, D., Ziegler, A., Gaber, R., Schock, S., Schwinzer, R., et al. (2000) "A point mutation in PTPRC is associated with the development of multiple sclerosis", Nat. Genet. 26, 495-499.
  • Vorechovsky, L, Kralovicova, I., Tchilian, E., Masterman, T, Zhang, Z., Ferry, B., et al. (2001) "Does 77C-»G in PTPRC modify autoimmune disorders linked to the major histocompatibility locus?", Nat. Genet. 29, 22-23.
  • Barcellos, L.F., Caillier, S., Dragone, L., Elder, M., Vittinghoff, E., Bucher, P., et al. (2001) "PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients", Nat. Genet. 29, 23-24.
  • Schwinzer, R. and Wonigeit, K. (1990) "Genetically determined lack of CD45R-T cells in healthy individuals. Evidence for a regulatory polymorphism of CD45R antigen expression", J. Exp. Med 171, 1803-1808.
  • Tchilian, E.Z., Dawes, R., Ramaley, P.A., Whitworth, I.A., Yuldasheva, N., Wells, S.R., et al (2002) "A CD45 polymorphism associated with abnormal splicing is absent in African populations" Immunogenetics 53, 980-983.
  • Sommer, N., Willcox, N., Harcourt, G. and Newsom-Davis, J. (1990) "Myasthenic thymus and thymoma are selectively enriched in acetylcholine receptor-reactive T cells", Ann. Neural. 28, 312-319.
  • Müller-Hermelink, U.K. and Marx, A. (1999) "Pathological aspects of malignant and benign thymic disorders", Ann. Med 31(Suppl. 2), 5-14.
  • Schwinzer, R., Witte, T., Hundrieser, J., Ehlers, S., Momot, T., Hunzelmann, N., et al. (2002) "Enhanced frequency of a PTPRC (CD45) exon A mutation (77CG) in systemic sclerosis", Genes Immunity, In press.
  • Muraro, P.A., Iacobsen, M., Necker, A., Nagle, J.W., Gaber, R., Sommer, N., et al. (2000) "Rapid identification of local T cell expansion in inflammatory organ diseases by flow cytometric T cell receptor Vbeta analysis", J. Immunol. Methods 246, 131-143.
  • Utsugisawa, K., Nagane, Y. and Tohgi, H. (2000) "Marked increase in CD44-highly positive cells in hyperplastic thymuses from patients with myasthenia gravis", Muscle Nerve 23, 507-513.
  • Sempowski, G., Thomasch, J., Gooding, M., Hale, L., Edwards, L., Ciafaloni, E., et al. (2001) "Effect of thymectomy on human peripheral blood T cell pools in myasthenia gravis", J. Immunol. 166, 2808-2817.

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