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Original Article

Monoclonal Antibodies to Thyroid Specific Autoantigens

Pages 361-366 | Published online: 07 Jul 2009

References

  • Roitt, LM., Doniach, D., Campbell, RN. and Hudson, R.V. (1956) "Autoantibodies in Hashimoto's disease (lymphadenoid goitre)", Lancet 2, 820.
  • Rose, N. and Witebsky, E. (1956) "Studies on organ specificity. V. Changes in the thyroid glands of rabbit following active immunization with rabbit thyroid extracts", J. Immunol. 76, 417.
  • Marriq, C., Rolland, M. and Lissitzky, S. (1982) "Structure—function relationship in thyroglobulin: amino acid sequence of two different thyroxine-containing peptides from porcine thyro-globulin", EMBO J. 1, 397–401.
  • Malthiery, Y. and Lissitzky, S. (1987) "Primary structure of human thyroglobulin deduced from the sequence of its 8448-base complementary DNA", Eur. J. Biochem. 165, 491–498.
  • Salvatore, G., Salvatore, M., Cahnmann, H.J. and Robbins, J. (1964) "Separaion of thyrodal iodoproteins and purification of thyroglobulin by gel filtration and density gradient centrifugation", J. Biol. Chem. 239, 3267–3274.
  • Rose, N.R., Bresler, H.S., Burek, CL., Gleason, S.L. and Kuppers, R.C. (1990) "Mapping the autoepitopes of thyroglobulin", Isr. J. Med. Sci. 26, 666–672.
  • Bresler, H.S., Burek, CL., Hoffman, W.H. and Rose, N.R. (1990) "Autoantigenic determinants on human thyroglobulin. IL Determi-nants recognized by autoantibodies from patients with chronic autoimmune thyroiditis compared to autoantibodies from healthy subjects", Clin. Immunol. Immunopathol. 54, 76–86.
  • Bresler, H.S., Burek, C.L. and Rose, N.R. (1990) "Autoantigenic determinants on human thyroglobulin. I. Determinant specificities of murine monoclonal antibodies", Clin. Immunol. Immunopathol. 54, 64–75.
  • Fukuma, N., Petersen, V.B., McLachlan, S.M., Pegg, CA. and Rees Smith, B. (1991) "Human monoclonal thyroglobulin autoantibodies of high affinity. I. Production, characterisation and interaction with murine monoclonal thyroglobulin antibodies", Autoimmunity 10, 291–295.
  • Gleason, S.L., Gearhart, P., Rose, N.R. and Kuppers, R.C. (1990) "Autoantibodies to thyroglobulin are encoded by diverse V-gene segments and recognize restricted epitopes", J. Immunol. 145, 1768–1775.
  • Prentice, L., Kiso, Y, Fukuma, N., Horimoto, M., Petersen, V., Grennan, F., Pegg, C., Furmaniak, J. and Rees Smith, B. (1995) "Monoclonal thyroglobulin autoantibodies: variable region analysis and epitope recognition", J. Clin. Endocrinol. Metab. 80, 977–986.
  • Estienne, V., McIntosh, R.S., Ruf, J., Asghar, M.S., Watson, RE, Carayon, P. and Weetman, AR (1998) "Comparative mapping of cloned human and murine antithyroglobulin antibodies: recognition by human antibodies of an immunodominant region", Thyroid 8, 643–646.
  • de Micco, C., Ruf, J., Carayon, P., Chrestian, MA., Henry, J.F. and Toga, M. (1987) "Iminunohistochemical study of thyroglobulin in thyroid carcinomas with monoclonal antibodies", Cancer 59, 471–476.
  • Kohno, Y, Tarutani, O., Sakata, S. and Nakajima, H. (1985) "Monoclonal antibodies to thyroglobulin elucidate differences in protein structure of thyroglobulin in healthy individuals and those with papillary adenocarcinoma", J. Clin. Endocrinol. Metab. 61, 343–350.
  • Taurog, A.M. (2000) "Hormone synthesis: thyroid iodine metabolism", In: Braverman LE, Utiger, RD., eds, Werner and Ingbar's The Thyroid, 8th Ed. (Lippencott Williams and Wilkins, Philadelphia), pp 61–85.
  • McLachlan, S.M. and Rapoport, B. (1992) "The molecular biology of thyroid peroxidase: cloning, expression and role as autoantigen in autoimmune thyroid disease", Endocr. Rev. 13, 192–206.
  • Kimura, S., Kotani, T., McBride, O.W., Umeki, K., Hirai, K., Nakayama, T. and Ohtald, S. (1987) "Human thyroid peroxidase: complete cDNA and protein sequence, chromosome mapping, and identification of two alternately spliced mRNAs", Proc. Natl Acad. Sci. USA 84, 5555–5559.
  • Libert, F., Ruel, J., Ludgate, M., Swillens, S., Alexander, N., Vassart, G. and Dinsart, C. (1987) "Complete nucleotide sequence of the human thyroperoxidase-microsomal antigen cDNA", Nucleic Acids Res. 15, 6735.
  • Magnusson, R.P., Chazenbalk, G.D., Gestautas, J., Seto, R, Filetti, S., DeGroot, L.J. and Rapoport, B. (1987) "Molecular cloning of the complementary deoxyribonucleic acid for human thyroid peroxi-dase", Mol. Endocrinol. 1, 856–861.
  • McLachlan, S.M. and Rapoport, B. (2000) "Autoimmune response to the thyroid in humans: thyroid peroxidase—the common autoantigenic denominator", Int. Rev. Immunol. 19, 587–618.
  • Marcocci, C. and Chiovato, L. (2000) "Thyroid-directed anti-bodies", In: Braverman LE, Utiger, R.D., eds, Werner and Ingbar's The Thyroid, 8th Ed. (Lippencott Williams and Wilkins, Philadelphia), pp 414–431.
  • Bresson, D., Cerutti, M., Devauchelle, G., Pugniere, M., Roquet, F., Bes, C., Bossard, C., Chardes, T. and Peraldi-Roux, S. (2003) "Localization of the discontinuous immunodominant region recognized by human anti-thyroperoxidase autoantibodies in autoimmune thyroid diseases", J. Biol. Chem. 278, 9560–9569.
  • Guo, J., McLachlan, S.M. and Rapoport, B. (2002) "Localization of the thyroid peroxidase autoantibody immunodominant region to a junctional region containing portions of the domains homologous to complement control protein and myeloperoxidase", J. Biol. Chem. 277, 40189–40195.
  • Gardas, A., Sohi, M.K., Sutton, B.J., McGregor, A.M. and Banga, J.P. (1997) "Purification and crystallisation of the autoantigen thyroid peroxidase from human Graves' thyroid tissue", Biochem. Biophys. Res. Commun. 234, 366–370.
  • Hendry, E., Taylor, G., Ziemnicka, K., Grennan Jones, F., Furmaniak, J. and Rees Smith, B. (1999) "Recombinant human thyroid peroxidase expressed in insect cells is soluble at high concentrations and forms diffracting crystals", J. Endocrinol. 160, R13 —R15.
  • Chacko, S., Padlan, E.A., Portolano, S., McLachlan, S.M. and Rapoport, B. (1996) "Structural studies of human autoantibodies. Crystal structure of a thyroid peroxidase autoantibody", Fab. J. Biol. Chem. 271, 12191–12198.
  • Nishikawa, T., Jaume, J.C., McLachlan, S.M. and Rapoport, B. (1995) "Human monoclonal autoantibodies against the immuno-dominant region on thyroid peroxidase: lack of cross-reactivity with related peroxidases or thyroglobulin and inability to inhibit thyroid peroxidase enzymatic activity", J. Clin. Endocrinol. Metab. 80, 1461–1466.
  • Mariotti, S., Caturegli, R, Piccolo, R, Barbesino, G. and Pinchera, A. (1990) "Antithyroid peroxidase autoantibodies in thyroid diseases", J. Clin. Endocrinol. Metab. 71, 661–669.
  • Smith, B.R. (2001) "Thyroid autoantibodies", Scand. J. Clin. Lab. Investig. Suppl., 45–52.
  • De Micco, C., Vassko, V. and Henry, J.F. (1999) "The value of thyroid peroxidase immunohistochemistry for preoperative fine-needle aspiration diagnosis of the follicular variant of papillary thyroid cancer", Surgery 126, 1200–1204.
  • De Micco, C., Zoro, R, Garcia, S., Skoog, L., Tani, EM., Carayon, R and Henry, J.F. (1994) "Thyroid peroxidase immunodetection as a tool to assist diagnosis of thyroid nodules on fine-needle aspiration biopsy", Eur. J. Endocrinol. 131, 474–479.
  • Kohn, L.D., Ban, T., Okajima, F., Shimura, H., Shimura, Y, Hidaka, A., Guiliani, C., Napolitano, G., Kosugi, S., llcuyama, S., Akamizu, T., Tahara, K. and Saji, M. (1995) Cloning and Regulation of Glycoprotein Hormone Receptor Genes (Raven Press, New York).
  • Rapoport, B. (2000) "The Thyrotropin receptor", In: Braverman LE, Utiger, RD., eds, Werner and Ingbar's The Thyroid, 8th Ed. (Lippencott Williams and Wilkins, Philadelphia), pp 219–227.
  • Valente, WA., Vitti, R, Yavin, Z., Yavin, E., Rotella, CM., Grollman, E.F., Toccafondi, R.S. and Kohn, L.D. (1982) "Monoclonal antibodies to the thyrotropin receptor: stimulating and blocking antibodies derived from the lymphocytes of patients with Graves disease", Proc. Nall Acad. Sci. USA 79, 6680–6684.
  • Kohn, L.D., Valente, W.A., Laccetti, R, Cohen, J.L., Aloj, S.M. and Grollman, E.F. (1983) "Multicomponent structure of the thyrotropin receptor: relationship to Graves' disease", Life Sci. 32, 15–30.
  • Yoshida, T., Ichikawa, Y, Ito, K. and Homma, M. (1988) "Monoclonal antibodies to the thyrotropin receptor bind to a 56-1(Da subunit of the thyrotropin receptor and show heterogeneous bioactivities", J. Biol. Chem. 263, 16341–16347.
  • Shin, E.K., Akamizu, T., Matsuda, F., Sugawa, H., Fujikura, J., Mori, T. and Honjo, T. (1994) "Variable regions of Ig heavy chain genes encoding antithyrotropin receptor antibodies of patients with Graves' disease", J. Immunol. 152, 1485–1492.
  • Akamizu, T., Mori, T. and Nakao, K. (1997) "Pathogenesis of Graves' disease: molecular analysis of anti-thyrotropin receptor antibodies", Endocr J. 44, 633–646.
  • Okuda, J., Akamizu, T., Sugawa, H., Matsuda, F., Hua, L. and Mori, T. (1994) "Preparation and characterization of monoclonal antithyro-tropin receptor antibodies obtained from peripheral lymphocytes of hypothyroid patients with primary myxedema", J. Clin. Endocrinol. Metab. 79, 1600–1604.
  • Rapoport, B., Chazenbalk, G.D., Jaume, J.C. and McLachlan, S.M. (1998) "The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies", Endocr. Rev. 19, 673–716.
  • Akamizu, T., Kohn, L.D. and Mori, T. (1995) "Molecular studies on thyrotropin (TSH) receptor and anti-TSH receptor antibodies", Endocr. J. 42, 617–627.
  • Nicholson, LB., Vlase, H., Graves, R, Nilsson, M., Moine, J., Huang, G.C., Morgenthaler, N.G., Davies, T.F., McGregor, A.M. and Banga, J.P. (1996) "Monoclonal antibodies to the human TSH receptor: epitope mapping and binding to the native receptor on the basolateral plasma membrane of thyroid follicular cells", J. MoL Endocrinol. 16, 159–170.
  • Seetharamaiah, G.S., Wagle, N.M., Morris, J.C. and Prabhakar, B.S. (1995) "Generation and characterization of monoclonal antibodies to the human thyrotropin (TSH) receptor: antibodies can bind to discrete conformational or linear epitopes and block TSH binding", Endocrinology 136, 2817–2824.
  • Vlase, H., Graves, RN., Magnusson, RP. and Davies, T.F. (1995) "Human autoantibodies to the thyrotropin receptor: recognition of linear, folded, and glycosylated recombinant extracellular domain", J. Clin. Endocrinol. Metab. 80, 46–53.
  • Akamizu, T., Moriyama, K., Miura, M., Saijo, M., Matsuda, E and Nakao, K. (1999) "Characterization of recombinant monoclonal antithyrotropin receptor antibodies (TSHRAbs) derived from lymphocytes of patients with Graves' disease: epitope and binding study of two stimulatory TSHRAbs", Endocrinology 140, 1594–1601.
  • Byun, C.H., Park, J.Y., Akamizu, T. and Chae, C.B. (2001) "Identification of the peptides that inhibit the function of human monoclonal thyroid-stimulating antibodies from phage-displayed peptide library", J. Clin. Endocrinol. Metab. 86, 3311–3318.
  • Grasso, Y.Z., Kim, MR., Faiman, C., Kohn, L.D., Tahara, K. and Gupta, M.K. (1999) "Epitope heterogeneity of thyrotropin receptor-blocking antibodies in Graves' patients as detected with wild-type versus chimeric thyrotropin receptors", Thyroid 9, 531–537.
  • Akamizu, T., Kohn, L.D., Hiratani, H., Saijo, M., Tahara, K. and Nakao, K. (2000) "Hashimoto's thyroiditis with heterogeneous antithyrotropin receptor antibodies: unique epitopes may contribute to the regulation of thyroid function by the antibodies", J. Clin. Endocrinol. Metab. 85, 2116–2121.
  • Shimojo, N., Kohno, Y., Yamaguchi, K., Kikuoka, S., Hoshioka, A., Niimi, H., Hirai, A., Tamura, Y., Saito, Y., Kohn, L.D. and Tahara, K. (1996) "Induction of Graves-like disease in mice by immunization with fibroblasts transfected with the thyrotropin receptor and a class 11 molecule", Proc. Natl Acad. Sci. USA 93, 11074–11079.
  • Costagliola, S., Many, MC., Denef, J.F., Pohlenz, J., Refetoff, S. and Vassart, G. (2000) "Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease", J. Clin. Investig. 105, 803–811.
  • Sanders, J., Jeffreys, J., Depraetere, H., Richards, T., Evans, M., Kiddie, A., Brereton, K., Groenen, M., Oda, Y, Furmaniak, J. and Rees Smith, B. (2002) "Thyroid-stimulating monoclonal anti-bodies", Thyroid 12, 1043–1050.
  • Costagliola, S., Franssen, J.D., Bonomi, M., Urizar, E., Willnich, M., Bergmann, A. and Vassart, G. (2002) "Generation of a mouse monoclonal TSH receptor antibody with stimulating activity", Biochem. Biophys. Res. Commun. 299, 891–896.
  • Ando, T., Latif, R., Pritsker, A., Moran, T., Nagayama, Y. and Davies, T.F. (2002) "A monoclonal thyroid-stimulating antibody", J. Clin. Investig. 110, 1667–1674.
  • Akamizu, T., Matsuda, F., Okuda, J., Li, H., Kanda, H., Watanabe, T., Honjo, T. and Mori, T. (1996) "Molecular analysis of stimulatory anti-thyrotropin receptor antibodies (TSAbs) involved in Graves' disease. Isolation and reconstruction of antibody genes, and production of monoclonal TSAbs", J. Immunol. 157, 3148–3152.
  • Akamizu, T. (2001) "Antithyrotropin receptor antibody: an update", Thyroid 11, 1123–1134.
  • Kim-Saijo, M., Akamizu, T., lktua, K., lida, Y, Matsubara, K., Matsuda, Y, Suzuki, M., Matsuda, F. and Nakao, N. (2003) "Generation of a Transgenic Animal Model of Hyperthyroid Graves' Disease", Eur. J. Immunol. 33, 2531–2538.
  • Rees Smith, B., McLachlan, S.M. and Furmaniak, J. (1988) "Autoantibodies to the thyrotropin receptor", Endocr. Rev. 9, 106–121.
  • Costagliola, S., Morgenthaler, N.G., Hoermann, R., Badenhoop, K., Struck, J., Freitag, D., Poertl, S., Weglohner, W., Hollidt, J.M., Quadbeck, B., Dumont, J.E., Schumm-Draeger, P.M., Bergmann, A., Mann, K., Vassart, G. and Usadel, K.H. (1999) "Second generation assay for thyrotropin receptor antibodies has superior diagnostic sensitivity for Graves' disease", J. Clin. Endocrinol. Metab. 84, 90–97.
  • Bolton, J., Sanders, J., Oda, Y., Chapman, C., Konno, R., Furmaniak, J. and Rees Smith, B. (1999) "Measurement of thyroid-stimulating hormone receptor autoantibodies by ELISA", Clin. Chem. 45, 2285–2287.
  • Carrasco, N. (2000) Thyroid Iodide Transport: the Na±/I-Symporter (NIS), 8th Ed. (Lippencott Williams and Wilkins, Philadelphia).
  • Heufelder, A.E., Joba, W. and Morgenthaler, N.G. (2001) "Autoinununity involving the human sodium/iodide symporter: fact or fiction?", Exp. Clin. Endocrinol. Diabetes 109, 35–40.
  • Ajjan, R.A., Kemp, E.H., Waterman, E.A., Watson, P.F., Endo, T., Onaya, T. and Weetman, AR (2000) "Detection of binding and blocking autoantibodies to the human sodium-iodide symporter in patients with autoimmune thyroid disease", J. Clin. Endocrinol. Metab. 85, 2020–2027.
  • Seissler, J., Wagner, S., Schott, M., Lettmann, M., Feldkamp, J., Scherbaum, W.A. and Morgenthaler, N.G. (2000) "Low frequency of autoantibodies to the human Na(+)/1(- ) symporter in patients with autoimmune thyroid disease", J. Clin. Endocrinol. Metab. 85, 4630–4634.
  • Chin, H.S., Chin, D.K., Morgenthaler, N.G., Vassart, G. and Costagliola, S. (2000) "Rarity of anti-Na+ /I- symporter (NIS) antibody with iodide uptake inhibiting activity in autoimmune thyroid diseases (AITD)", J. Clin. Endocrinol. Metab. 85, 3937–3940.
  • Kemp, E.H., Waterman, E.A., Ajjan, R.A., Smith, K.A., Watson, P.F., Ludgate, M.E. and Weetman, A.P. (2001) "Identification of antigenic domains on the human sodium-iodide symporter which are recognized by autoantibodies from patients with autoimmune thyroid disease", Clin. Exp. Immunol. 124, 377–385.
  • Pohlenz, J., Duprez, L., Weiss, R.E., Vassart, G., Refetoff, S. and Costagliola, S. (2000) "Failure of membrane targeting causes the functional defect of two mutant sodium iodide symporters", J. Clin. Endocrinol. Metab. 85, 2366–2369.

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