References
- Tokano, Y, Morimoto, S., Kaneko, H., Amano, H., Nozawa, K., Takasald, Y. and Hashimoto, H. (1999) "Levels of IL-12 in the sera of patients with systemic lupus erythematosus (SLE)—relation to ml- and Th2-derived cytokines", Clin. Exp. Immunol. 116, 169–173
- Hooks, J.J., Moutsopoulos, H.M., Geis, SA., Stahl, NI., Decker, J.L. and Notkins, Al. (1979) "Immune interferon in the circulation of patients with autoimmune disease", N. Engl. J. Med. 301, 5–8
- al-Janadi, M., al-Balla, S., al-Dalaan, A. and Raziuddin, S. (1993) "Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis, and other rheumatic diseases", J. ClM. Immunol. 13, 58–67
- Matei, I., Ghyka, G., Savi, I. and Tudor, A. (1990) "Correlation of serum interferon with some clinical and humoral signs of systemic lupus erythematosus", Med. Intern. 28, 289–294
- Csiszar, A., Nagy, G., Gergely, P., Pozsonyi, T. and Pocsik, E. (2000) "Increased interferon-gamma (IFN-gamma), IL-10 and decreased IL-4 mRNA expression in peripheral blood mono-nuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE)", Clin. Exp. Immunol. 122, 464–470
- Viallard, J.F., Pellegrin, J.L., Ranchin, V., Schaeverbeke, T., Dehais, J., Longy-Boursier, M., Ragnaud, J.M., Leng, B. and Moreau, J.F. (1999) "Thl (IL-2, interferon-gamma (IFN-gamma)) and Th2 (IL-10, IL-4) cytokine production by peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE)", Clin. Exp. Immunol. 115, 189–195
- Gerez, L., Shkolnik, T., Hirschmann, O., Lorber, M., Arad, G. and Kaempfer, R. (1997) "Hyperinducible expression of the interferon-gamma (IFN-gannna) gene and its suppression in systemic lupus erythematosus (SLE)", Clin. Exp. Immunol. 109, 296–303
- Ytterberg, SR. and Schnitzer, T.J. (1982) "Serum interferon levels in patients with systemic lupus erythematosus", Arthritis Rheum. 25, 401 —406
- Yokoyama, H., Takabatake, T., Takaeda, M., Wada, T., Naito, T., Ikeda, K., Goshima, S., Takasawa, K., Tomosugi, N., Kobayashi, K., et al., (1992) "Up-regulated MHC-class 11 expression and gamma-IFN and soluble IL-2R in lupus nephritis", Kidney Int. 42, 755–763
- Machold, K.P. and Smolen, J.S. (1990) "Interferon-gamma induced exacerbation of systemic lupus erythematosus", J. Rheumatol. 17, 831–832
- Raanani, P. and Ben-Bassat, I. (2002) "Immune-mediated complications during interferon therapy in hematological patients", Acta HaematoL 107, 133–144
- Tanaka, Y, Nakashima, H., Hisano, C., Kohsaka, T., Nemoto, Y, Niko, H., Otsuka, T., Imamura, T. and Niho, Y. (1999) "Association of the interferon-gamma receptor variant (Val 14Met) with systemic lupus erythematosus", Immunogenetics 49, 266–271
- Nakashima, H., Inoue, H., Akahoshi, M., Tanaka, Y, Yamaoka, K., Ogami, E., Nagano, S., Arinobu, Y., Niiro, H., Otsuka, T. and Niho, Y. (1999) "The combination of polymorphisms within interferon-gamma receptor 1 and receptor 2 associated with the risk of systemic lupus erythematosus", FEBS Lett. 453, 187–190
- Prud'homme, G.J., Kono, D.H. and Theofilopoulos, AN. (1995) "Quantitative polymerase chain reaction analysis reveals marked overexpression of interleukin-1 beta, interleukin-1 and interferon-gamma mRNA in the lymph nodes of lupus-prone mice", Mol. Immunol. 32, 495–503
- Shirai, A., Conover, J. and Klinman, D.M. (1995) "Increased activation and altered ratio of interferon-gamma: interleukin-4 secreting cells in MRL-lpr/lpr mice", Autoimmunity 21, 107–116
- Manolios, N., Schrieber, L., Nelson, M. and Geczy, C.L. (1989) "Enhanced interferon-gamma (IFN) production by lymph node cells from autoimmune (MRL/1, MRL/n) mice", Clin. Exp. Immunol. 76, 301–306
- Umland, SE, Go, ME, Cupp, J.E. and Howard, M. (1989) "Responses of B cells from autoimmune mice to IL-5", J. Immunol. 142, 1528–1535
- McMurray, R.W., Hoffman, R.W., Nelson, W. and Walker, S.E. (1997) "Cytokine mRNA expression in the B/W mouse model of systemic lupus erythematosus—analyses of strain, gender, and age effects", Clin. Immunol. Immunopathol. 84, 260–268
- Fan, X. and Wuthrich, RP. (1997) "Upregulation of lymphoid and renal interferon-gamma mRNA in autoimmune MRL-Fas(lpr) mice with lupus nephritis", Inflammation 21, 105–112
- Huang, FE, Feng, G.J., Lindop, G., Stott, D.I. and Liew, F.Y. (1996) "The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice", J. Exp. Med. 183, 1447–1459
- Takahashi, S., Fossati, L., Iwamoto, I., Merino, J., Motta, R., Kobayakawa, T. and Izui, S. (1996) "Imbalance towards Th 1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice", J. Clin. Investig. 97, 1597–1604
- Adam, C., Thoua, Y, Ronco, P., Verroust, P., Tovey, M. and Morel-Maroger, L. (1980) "The effect of exogenous interferon: acceleration of autoimmune and renal diseases in (NZB/W) Fl mice", Clin. Exp. Immunol. 40, 373–382
- Hasegawa, K., Hayashi, T. and Maeda, K. (2002) "Promotion of lupus in NZB x NZWF1 mice by plasmids encoding interferon (IFN)-gamma but not by those encoding interleukin (IL)-4", J. Comp. PathoL 127, 1–6
- Hayashi, T., Hasegawa, K., Ohta, A. and Maeda, K. (2001) "Reduction of serum interferon (IFN)-gamma concentration and lupus development in NZB x NZWF(1) mice by lactic dehydro-genase virus infection", J. Comp. PathoL 125, 285–291
- Schwarting, A., Tesch, G., Kinoshita, K., Maron, R., Weiner, H.L. and Kelley, V.R. (1999) "IL-12 drives 1FN-gamma-dependent autoimmune kidney disease in MRL-Fas(lpr) mice", J. Immunol. 163, 6884–6891
- Seery, J.P., Carroll, J.M., Cattell, V. and Watt, F.M. (1997) "Antinuclear autoantibodies and lupus nephritis in transgenic mice expressing interferon gamma in the epidermis", J. Exp. Med. 186, 1451–1459
- Klinman, D.M. (1990) "IgG1 and IgG2a production by autoimmune B cells treated in vitro with IL-4 and IFN-gamma", J. Immunol. 144, 2529–2534
- Ozmen, L., Roman, D., Fountoulakis, M., Schmid, G., Ryffel, B. and Garotta, G. (1995) "Experimental therapy of systemic lupus erythematosus: the treatment of NZB/W mice with mouse soluble interferon-gamma receptor inhibits the onset of glomerulone-phritis", Eur. J. Immunol. 25, 6–12
- Jacob, CO., van der Meide, PH. and McDevitt, HO. (1987) "In vivo treatment of (NZB x NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon", J. Exp. Med. 166, 798–803
- Lawson, B.R., Prud'honune, G.J., Chang, Y., Gardner, H.A., Kuan, J., Kono, D.H. and Theofilopoulos, A.N. (2000) "Treatment of murine lupus with cDNA encoding IFN-ganunaR/Fc", J. Clin. Investig. 106, 207–215
- Peng, S.L., Moslehi, J. and Craft, J. (1997) "Roles of interferon-gamma and interleukin-4 in murine lupus", J. Clin. Investig. 99, 1936–1946
- Balomenos, D., Rumold, R. and Theofilopoulos, A.N. (1998) "Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice", J. Clin. Investig. 101, 364–371
- Haas, C., Ryffel, B. and Le Hir, M. (1998) "IFN-gamma receptor deletion prevents autoantibody production and glomerulonephritis in lupus-prone (NZB x NZW)F1 mice", J. Immunol. 160, 3713–3718
- Haas, C., Ryffel, B. and Le, H.M. (1997) "IFN-ganuna is essential for the development of autoimmune glomerulonephritis in MRL/Ipr mice", J. Immunol. 158, 5484–5491
- Schwarting, A., Wada, T., Kinoshita, K., Tesch, G. and Kelley, V.R. (1998) "IFN-ganuna receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Fas(lpr) mice", J. Immunol. 161, 494–503
- Peng, S.L., Szabo, S.J. and Glimcher, L.H. (2002) "T-bet regulates IgG class switching and pathogenic autoantibody production", Proc. Natl Acad. Sci. USA 99, 5545–5550
- Kono, D.H., Balomenos, D., Pearson, DL., Park, M.S., Hildebrandt, B., Hultman, P. and Pollard, K.M. (1998) "The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-gamma and not Th 1/Th2 imbalance", J. Immunol. 161, 234–240
- Richards, H.B., Satoh, M., Jennette, J.C., Croker, B.P., Yoshida, H. and Reeves, W.H. (2001) "Interferon-gamma is required for lupus nephritis in mice treated with the hydrocarbon oil pristane", Kidney Int. 60, 2173 — 2180
- Preble, O.T., Black, R.I., Friedman, R.M., Klippel, J.H. and Vilcek, J. (1982) "Systemic lupus erythematosus: presence in human serum of an unusual acid-labile leukocyte interferon", Science 216, 429–431
- Bengtsson, A.A., Sturfelt, G., Truedsson, L., Blomberg, J., Alm, G., Vallin, H. and Ronnblom, L. (2000) "Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies", Lupus 9, 664 —671
- Ioannou, Y. and Isenberg, D.A. (2000) "Current evidence for the induction of autoimmune rheumatic manifestations by cytokine therapy", Arthritis Rheum. 43, 1431–1442
- Wilson, L.E., Widman, D., Dilunan, S.H. and Gorevic, P.D. (2002) "Autoimmune disease complicating antiviral therapy for hepatitis C virus infection", Semin. Arthritis Rheum. 32, 163–173
- Ronnblom, L. and Alm, G.V. (2001) "An etiopathogenic role for the type I IFN system in SLE", Trends Immunol. 22, 427–431
- Ronnblom, L. and Alm, G.V. (2002) "The natural interferon-alpha producing cells in systemic lupus erythematosus", Hum. Immunol. 63, 1181–1193
- Jahnsen, F.L., Farkas, L., Lund-Johansen, F. and Brandtzaeg, P. (2002) "Involvement of plasmacytoid dendritic cells in human diseases", Hum. Immunol. 63, 1201–1205
- Dzionek, A., Inagald, Y, Okawa, K., Nagafune, J., Rock, J.J., Sohma, Y, Winkels, G., Zysk, M., Yamaguchi, Y. and Schmitz, J.J. (2002) "Plasmacytoid dendritic cells: from specific surface markers to specific cellular functions(1)", Hum. Immunol. 63, 1133–1148
- Palucka, A.K., Banchereau, J., Blanco, P. and Pascual, V. (2002) "The interplay of dendritic cell subsets in systemic lupus erythematosus", Immunol. Cell Biol. 80, 484–488
- Magnusson, M., Magnusson, S., Vallin, H., Ronnblom, L. and Alm, G.V. (2001) "Importance of CpG dinucleotides in activation of natural IFN-alpha-producing cells by a lupus-related oligo-deoxynucleotide", Scand. J. Immunol. 54, 543–550
- Bave, U., Vallin, H., Alm, G.V. and Ronnblom, L. (2001) "Activation of natural interferon-alpha producing cells by apoptotic U937 cells combined with lupus IgG and its regulation by cytokines", J. Autoimmun. 17, 71–80
- Blomberg, S., Eloranta, M.L., Cederblad, B., Nordlin, K., Alm, G.V. and Ronnblom, L. (2001) "Presence of cutaneous interferon-alpha producing cells in patients with systemic lupus erythema-tosus", Lupus 10, 484–490
- Farkas, L., Beiske, K., Lund-Johansen, F., Brandtzaeg, P. and Jahnsen, FL. (2001) "Plasmacytoid dendritic cells (natural interferon-alpha/beta-producing cells) accumulate in cutaneous lupus erythematosus lesions", Am. J. Pathol. 159, 237–243
- Blanco, P., Palucka, A.K., Gill, M., Pascual, V. and Banchereau, J. (2001) "Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus", Science 294, 1540–1543
- Gill, M.A., Blanco, P., Arce, E., Pascual, V., Banchereau, J. and Palucka, A.K. (2002) "Blood dendritic cells and DC-poietins in systemic lupus erythematosus", Hum. Immunol. 63, 1172–1180
- Bennett, L., Palucka, A.K., Arce, E., Cantrell, V., Borvak, J., Banchereau, J. and Pascual, V. (2003) "Interferon and granulopoie-sis signatures in systemic lupus erythematosus blood", J. Exp. Med. 197, 711–723
- Baechler, E.C., Batliwalla, F.M., Karypis, G., Gaffney, P.M., Ortmann, WA., Espe, K.J., Shark, KB., Grande, W.J., Hughes, K.M., Kapur, V., Gregersen, P.K. and Behrens, T.W. (2003) "Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus", Proc. Natl Acad. Sci. USA 100, 2610–2615
- Carpenter, D.F., Steinberg, A.D., Schur, P.H. and Talal, N. (1970) "The pathogenesis of autoimmunity in New Zealand mice. II. Acceleration of glomerulonephritis by polyinosinic-polycytidylic acid", Lab. Investig. 23, 628–634
- Gresser, J., Morel-Maroger, L., Verroust, P., Riviere, Y. and Guillon, J.C. (1978) "Anti-interferon globulin inhibits the development of glomerulonephritis in mice infected at birth with lymphocytic choriomeningitis virus", Proc. Natl Acad. Sci. USA 75, 3413–3416
- Braun, D., Geraldes, P. and Demengeot, J. (2003) "Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice", J. Autoimmun. 20, 15–25
- Kono, D.H. and Theofilopoulos, A.N. (2000) "Genetics of systemic autoimmunity in mouse models of lupus", Int. Rev. Immunol. 19, 367–387
- Kotenko, S.V., Gallagher, G., Baum, V.V., Lewis-Antes, A., Shen, M., Shah, N.K., Langer, J.A., Sheikh, F., Dickensheets, H. and Donnelly, R.P. (2003) "IFN-lambdas mediate antiviral protection through a distinct class 11 cytokine receptor complex", Nat. Immunol. 4, 69–77
- Sheppard, P., Kindsvogel, W., Xu, W., Henderson, K., Schlutsmeyer, S., Whitmore, T.E., Kuestner, R., Garrigues, U., Birks, C., Roraback, J., Ostrander, C., Dong, D., Shin, J., Presnell, S., Fox, B., Haldeman, B., Cooper, E., Taft, D., Gilbert, T., Grant, F.J., Tackett, M., Krivan, W., McKnight, G., Clegg, C., Foster, D. and Klucher, K.M. (2003) "IL-28, IL-29 and their class 11 cytokine receptor IL-28R", Nat. Immunol. 4, 63–68
- Vilcek, J. (2003) "Novel interferons", Nat. Immunol. 4, 8–9
- Kotenko, S.V. (2002) "The family of IL-10-related cytokines and their receptors: related, but to what extent?", Cytokine Growth Factor Rev. 13, 223–240
- Santiago-Raber, M.L., Baccala, R., Haraldsson, K.M., Choubey, D., Stewart, TA., Kono, D.H. and Theofilopoulos, A.N. (2003) "Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice", J. Exp. Med. 197, 777–788
- Theofilopoulos, AN. and Dixon, F.J. (1985) "Murine models of systemic lupus erythematosus", Adv. Immunol. 37, 269–390
- Murakami, M., Tsubata, T., Okamoto, M., Shimizu, A., Kumagai, S., Imura, H. and Honjo, T. (1992) "Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice [see comments]", Nature 357, 77–80
- Murakami, M., Yoshioka, H., Shirai, T., Tsubata, T. and Honjo, T. (1995) "Prevention of autoinunune symptoms in autoimmune-prone mice by elimination of B-1 cells", Int. Immunol. 7, 877–882
- Nisitani, S., Tsubata, T., Murakami, M. and Honjo, T. (1995) "Administration of interleukin-5 or -10 activates peritoneal B-1 cells and induces autoimmune hemolytic anemia in anti-erythrocyte autoantibody-transgenic mice", Eur. J. Immunol. 25, 3047–3052
- Watanabe, N., lkuta, K., Nisitani, S., Chiba, T. and Honjo, T. (2002) "Activation and differentiation of autoreactive B-1 cells by interleukin 10 induce autoimmune hemolytic anemia in Fas-deficient antierythrocyte immunoglobulin transgenic mice", J. Exp. Med. 196, 141–146
- Velupillai, P., Sypek, J. and Ham, DA. (1996) "Interleukin-12 and -10 and gamma interferon regulate polyclonal and ligand-specific expansion of murine B-1 cells", Infect. Immun. 64, 4557–4560
- Ansel, KM., Harris, R.B. and Cyster, J.G. (2002) "CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity", Immunity 16, 67–76
- Balabanian, K., Foussat, A., Bouchet-Delbos, L., Couderc, J., Krzysiek, R., Amara, A., Baleux, F., Portier, A., Galanaud, P. and Emilie, D. (2002) "Interleukin-10 modulates the sensitivity of peritoneal B lymphocytes to chemokines with opposite effects on stromal cell-derived factor-1 and B-lymphocyte chemoattractant", Blood 99, 427–436
- Biron, CA. (2001) "Interferons alpha and beta as immune regulators—a new look", Immunity 14, 661–664
- Taniguchi, T. and Takaoka, A. (2001) "A weak signal for strong responses: interferon-alpha/beta revisited", Nat. Rev. Mol. Cell Biol. 2, 378–386
- Wiesemann, E., Sonmez, D., Heidenreich, F. and Windhagen, A. (2002) "Interferon-beta increases the stimulatory capacity of monocyte-derived dendritic cells to induce IL-13, IL-5 and IL-10 in autologous T-cells", J. Neuroimmunol. 123, 160–169
- Byrnes, A.A., McArthur, J.C. and Karp, C.L. (2002) "Interferon-beta therapy for multiple sclerosis induces reciprocal changes in interleukin-12 and interleukin-10 production", Ann. NeuroL 51, 165–174
- Le Bon, A., Schiavoni, G., D'Agostino, G., Gresser, I., Belardelli, F. and Tough, D.F. (2001) "Type I interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo", Immunity 14, 461–470
- Lin, Q., Dong, C. and Cooper, MD. (1998) "Impairment of T and B cell development by treatment with a type I interferon", J. Exp. Med. 187, 79–87
- Su, L. and David, M. (1999) "Inhibition of B cell receptor-mediated apoptosis by 1FN", J. Immunol. 162, 6317–6321
- Braun, D., Caramalho, I. and Demengeot, J. (2002) "1FN-alpha/ beta enhances BCR-dependent B cell responses", Int. Immunol. 14,411–419
- Yang, C.H., Murti, A., Pfeffer, SR., Basu, L, Kim, J.G. and Pfeffer, L.M. (2000) "1FNalpha/beta promotes cell survival by activating NF-kappa B", Proc. Nall Acad. Sci. USA 97, 13631–13636
- Chen, S.Y., Takeoka, Y, Pike-Nobile, L, Ansari, A.A., Boyd, R. and Gershwin, M.E. (1997) "Autoantibody production and cytokine profiles of MHC class I (beta2-microglobulin) gene deleted New Zealand black (NZB) mice", Clin. Immunol. Immunopathol. 84, 318–327
- Penninger, J.M., Sirard, C., Mittrucker, H.W., Chidgey, A., Kozieradzki, I., Nghiem, M., Hakem, A., Kimura, T., Timms, E., Boyd, R., Taniguchi, T., Matsuyama, T. and Mak, T.W. (1997) "The interferon regulatory transcription factor 1RF-1 controls positive and negative selection of CD8+ thymocytes", Immunity 7, 243–254
- Matsuyama, T., Kimura, T., Kitagawa, M., Pfeffer, K., Kawakami, T., Watanabe, N., Kundig, TM., Amakawa, R., Kishihara, K., Wakeham, A., et al. (1993) "Targeted disruption of IRF-1 or 1RF-2 results in abnormal type I 1FN gene induction and aberrant lymphocyte development", Cell 75, 83–97
- Tada, Y., Ho, A., Matsuyama, T. and Mak, T.W. (1997) "Reduced incidence and severity of antigen-induced autoimmune diseases in mice lacking interferon regulatory factor-1", J. Exp. Med. 185, 231–238
- Nakazawa, T., Satoh, J., Takahashi, K., Sakata, Y, Ikehata, F., Takizawa, Y, Band°, S.I., Housai, T., Li, Y, Chen, C., Masuda, T., Kure, S., Kato, I., Takasawa, S., Taniguchi, T., Okamoto, H. and Toyota, T. (2001) "Complete suppression of insulitis and diabetes in NOD mice lacking interferon regulatory factor-1", J. Autoimmun. 17, 119–125
- Hida, S., Ogasawara, K., Sato, K., Abe, M., Takayanagi, H., Yokochi, T., Sato, T., Hirose, S., Shirai, T., Tald, S. and Taniguchi, T. (2000) "CD8(+) T cell-mediated skin disease in mice lacking 1RF-2, the transcriptional attenuator of interferon-alpha/beta signaling", Immunity 13, 643–655
- Marrack, P., Kappler, J. and Mitchell, T. (1999) "Type I interferons keep activated T cells alive", J. Exp. Med. 189, 521–530
- Tough, D.F., Borrow, P. and Sprent, J. (1996) "Induction of bystander T cell proliferation by viruses and type I interferon in vivo", Science 272, 1947–1950
- Zhang, X., Sun, S., Hwang, I., Tough, D.F. and Sprent, J. (1998) "Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15", Immunity 8, 591–599
- Ogasawara, K., Hida, S., Weng, Y., Saiura, A., Sato, K., Takayanagi, H., Sakaguchi, S., Yokochi, T., Kodama, T., Naitoh, M., De Martino, J.A. and Taniguchi, T. (2002) "Requirement of the IFN-alpha/beta-induced CXCR3 chemokine signalling for CD8 + T cell activation", Genes Cells 7, 309–320
- Taniguchi, T., Ogasawara, K., Takaoka, A. and Tanaka, N. (2001) "1RF family of transcription factors as regulators of host defense", Annu. Rev. Immunol. 19, 623–655
- Vyse, T.J. and Kotzin, B.L. (1998) "Genetic susceptibility to systemic lupus erythematosus", Annu. Rev. Immunol. 16, 261–292
- Wakeland, E.K., Liu, K., Graham, R.R. and Behrens, T.W. (2001) "Delineating the genetic basis of systemic lupus erythematosus", Immunity 15, 397–408
- Rozzo, S.J., Allard, J.D., Choubey, D., Vyse, T.J., Izui, S., Peitz, G. and Kotzin, B.L. (2001) "Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus", Immunity 15, 435–443
- Choubey, D. and Kotzin, B.L. (2002) "Interferon-inducible p202 in the susceptibility to systemic lupus", Front. Biosci. 7, e252—e262
- Takaoka, A., Mitani, Y, Suemori, H., Sato, M., Yokochi, T., Noguchi, S., Tanaka, N. and Taniguchi, T. (2000) "Cross talk between interferon-gamma and -alpha/beta signaling com-ponents in caveolar membrane domains", Science 288, 2357–2360
- Nguyen, KB., Watford, W.T., Salomon, R., Hofmann, SR., Pien, G.C., Morinobu, A., Gadina, M., O'Shea, J.J. and Biron, CA. (2002) "Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection", Science 297, 2063–2066
- Montoya, M., Schiavoni, G., Mattel, F., Gresser, I., Belardelli, F., Borrow, P. and Tough, D.F. (2002) "Type I interferons produced by dendritic cells promote their phenotypic and functional acti-vation", Blood 99, 3263–3271
- Mattel, F., Schiavoni, G., Belardelli, F. and Tough, D.F. (2001) "IL-15 is expressed by dendritic cells in response to type I 1FN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation", J. Immunol. 167, 1179–1187
- Stewart, T.A. (2003) "Neutralizing interferon alpha as a therapeutic approach to autoimmune diseases", Cytokine Growth Factor Rev. 242, 1–16