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Original Article

The IL-12 Role in Donor Cell Engraftment in a Murine Model of Semiallogenic GVH Disease with Signs of Autoimmune Disease

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Pages 155-170 | Received 28 Jul 2003, Accepted 24 Nov 2003, Published online: 07 Jul 2009

References

  • Gelpi, C., Rodriguez-Sanchez, J.L., Martinez, MA., Craft, J. and Hardin, J.A. (1988) "Murine graft versus host disease: a model for study of mechanisms that generate autoantibodies to ribonucleo-proteins", J. Immunol. 140, 4160–4166.
  • Gelpi, C., Martinez, MA., Vidal, S., Algueró, A., Juarez, C., Hardin, J. and Rodriguez-Sanchez, J.L. (1990) "Different strains of donor parental lymphoid cells induced different models of chronic graft-versus-host disease in murine (Balb/c x A/J)F1 hybrid hosts", ClM. Immunol. Immunopathol. 56, 298–310.
  • Vidal, S., Labrador, M., Rodriguez-Sanchez, J.L. and Gelpi, C. (1996) "The role of Balb/c donor CD8+ lymphocytes in graft-versus host disease in (Balb/c x A/J)F1 (CAF1) Mice", J. Immunol. 156, 997–1005.
  • Trembleau, S., Germann, T., Gately, M.K. and Adorini, L. (1995) "The role of IL-12 in the induction of organ-specific autoimmune diseases", Immunol. Today 68, 333–336.
  • Chen, E., Keystone, E.C. and Fish, EN. (1993) "Restricted cytokine expression in rheumatoid arthritis", Arthritis Rheum. 36, 901–910.
  • Morita, Y, Yamamura, M., Nishida, K., Harada, S., Okamoto, H., Inoue, M., et al. (1998) "Expression of interleukin-12 in synovial tissue from patients with rheumatoid arthritis", Arthritis Rheum. 41, 306–314.
  • Parks, E., Strieter, R.M., Lukacs, NW., Gauldie, J., Hitt, M., Graham, F.L. and Kunkel, S.L. (1998) "Transient gene transfer of IL-12 regulates and disease severity in experimental arthritis", J. Immunol. 160, 4615–4619.
  • Joosten, LAB., Lubberts, E., Helsen, MA. and van Den Berg, W.B. (1997) "Dual role of IL-12 in early and late stages of murine collagen type 11 arthritis", J. Immunol. 159, 4094–4102.
  • Kasama, T., Yamazaki, J., Hanaoka, R., Miwa, Y., Hatano, Y, Kobayashi, K., Negishi, M., Ide, H. and Adachi, M. (1999) "Biphasic regulation of the development of murine type 11 collagen-induced arthritis by interleukin-12: possible involvement of endogenous interleukin-10 and tumor necrosis factor alpha", Arthritis Rheum. 42, 100–109.
  • McIntyre, K.W., Schuster, D.J., Gilloly, KM., Warner, R.R., Connaughton, SE., Hall, LB., et al. (1996) "Reduced incidence and severity of collagen-induced arthritis in IL-12-deficient mice", Eur. J. Immunol. 26, 2933–2938.
  • Sveliga, J., Hess, H., Rude, E., Schmitt, E. and Germann, T. (1996) "1L-12 promotes cellular but not humoral type 11 collagen-specific Thl-type responses in C57BL/6 and B10.Q mice and fails to induce arthritis", Int. Immunol. 8, 1221–1227.
  • Joosten, LAB., Heuvelmans-Jacobs, M., Lubbert, E., van de Loo, F.A.J., Bakker, AC., Helsen, M.M.A., Richards, C.D. and van der Berg, W.B. (2002) "Local interleukin-12 gene transfer promotes conversion of an acute arthritis to a chronic destructive arthritis", Arthritis Rheum. 46, 1379–1389.
  • Hess, H., Gately, M.K., Rude, E., Schmitt, E., Szeliga, J. and Germann, T. (1996) "High doses of IL-12 inhibit the development of joint disease in DBA/1 mice immunized with type 11 collagen in complete Freund's adjuvant", Eur. J. Immunol. 26, 187–191.
  • Peeva, E., Fishman, AD., Goddard, G., Wadler, S. and Barland, P. (2000) "Rheumatoid arthritis exarcerbation caused by exogenous interleukin-12", Arthritis Rheum. 43, 461 —463.
  • Kim, W.U., Min, S.Y., Cho, ML., Youn, J., Min, J.K., Lee, S.H., et al. (2000) "The role of IL-12 in inflammatory activity of patients with rheumatoid arthritis (RA)", Clin. Exp. Immunol. 119, 175–181.
  • Courtenay, J.S., Dallman, M.J., Dayan, AD., Martin, A. and Mosedale, B. (1980) "Immunization against heterologous type 11 collagen-induced arthritis in mice", Nature 2843, 666–668.
  • Joosten, LAB., Lubberts, E., Durez, P., Helsen, M.M.A., Jacobs, M.J.M., Goldman, M. and van den Berg, W.B. (1997) "Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis", Arthritis Rheum. 40, 249–260.
  • Dey, BR., Yang, Y.G., Szot, G.L., Pearson, D.A. and Sykes, M. (1998) "Interleukin-12 inhibits graft-versus-host disease through a Fas-mediated mechanism associated with alterations in donor T-cell activation and expansion", Blood 91, 3315–3322.
  • Sykes, M., Pearson, D.A., Taylor, RA., Szot, G.L., Goldman, S.J. and Blazar, BR. (1999) "Dose and timing of interleukin (IL-12) and timing and type of total-body irradiation: effects on graft-vs-host disease inhibition and toxicity of exogenous IL-12 in murine bone marrow transplant recipients", Biol. Blood Marrow Transplant. 5, 277–284.
  • Via, C.H.S., Rus, V., Gately, M.K. and Finkelman, F. (1994) "IL-12 stimulates the development of acute graft-versus-host disease in mice that normally would develop chronic, autoimmune graft-versus-host disease", J. Immunol. 153, 4040.
  • Fowler, D.H., Kurasawa, K., Husebekk, A., Cohen, RA. and Gress, RE. (1994) "Cells of Th2 cytokine phenotype prevent LPS-Induced lethality during murine graft-versus-host reaction", J. Immunol. 152, 1004–1009.
  • Gelpi, C., Martinez, M., Vidal, S., Targoff, IN. and Rodriguez-Sanchez, J.L. (1994) "Anti-transfer RNA associated protein antibodies in a murine model of chronic graft versus host disease", J. Immunol. 152, 1989–1999.
  • Weber, K.T., Bibring, T. and Osborn, M.L. (1975) "Specific visualization of tubulin containing structures in tissue culture cells by immunofluorescence", Exp. Cell Res. 95, 111–114.
  • Vmcent, C., Serre, G., Lapeyre, F., Found& B., Ayrolles, C., Fournié, A., et al. (1989) "High diagnostic value in rheumatoid arthritis of antibodies to the stratum corneum of rat esophagus epithelium, so-called "antikeratin antibodies", Ann. Rheum. Dis. 48, 712–722.
  • Lerner, MR. and Steitz, J.A. (1979) "Antibodies to small nuclear RNAs complex with proteins are produced by patients with systemic lupus erythematous", Proc. Natl Acad. Sci. USA 76, 5495–5498.
  • Matsumoto, I., Maccioni, M., Lee, D.M., Maurice, M., Simmons, B., Brennr, M., Mathis, D. and Benoist, C.H. (2002) "How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease", Nat. Immunol. 3, 360–365.
  • Morris, S.C., Madden, KB., Adamovicz, J.J., Gause, W.C., Hubbard, BR., Gately, M.K. and Finkelman, F.D. (1994) "Effects of 1L-12 in in-vivo cytokine gene expression and Ig isotype selection", J. Immunol. 152, 1047–1056.
  • Svetiv, A., Finkelma, F.D., Jian, T.C., Dieffenbach, C.W., Scott, D.E., Mc Carthy, K.F., Steinberg, A.D. and Gauser, W.C. (1991) "Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody", J. Immunol. 147, 2391–2397.
  • Mariner, J.M., Lantz, V, Waldmann, T.A. and Azimi, N. (2001) "Human T cell lymphotropic virus type I tax activates IL-1512a gene expression through a NF-kB site", J. Immunol. 166, 2602–2609.
  • Shustov, A., Nguyen, P., Finkelman, ED., Elkon, KB. and Via, C.S. (1998) "Differential expression of Fos and Fas ligand in acute and chronic graft-vs-host disease: up-regulation of Fas and Fas ligand requires CD8+ T cell activation and IFN-y production", J. Immunol. 161, 2848–2855.
  • Via, CS., Sharrow, S.O. and Shearer, G.M. (1987) "Role of cytotoxic T lymphocytes in the prevention of lupus-like disease accurring in a murine model of graft-versus-host disease", J. Immunol. 139, 1840.
  • Lamouseé-Smith, E.S.N., Dougall, D.S. and McCarthy, S.A. (1999) "Cytokine requirements for production of a novel anti-CD8-resistant CTL population", J. Immunol. 163, 4160–4167.
  • Gleichmann, E., Pals, S.T., Rolink, A.G., Radaszkiewicz, T. and Gleichmann, H. (1984) "Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseases", Immunol. Today 5, 324–327.
  • Okubo, T., Hagiwara, E., Ohno, S., Tsuji, T., Ihata, A., Ueda, A., Shirai, A., Aoki, I., Okuda, K., Miyazaki, J. and Ishigatsubo, Y. (1999) "Administration of an 1L-12-encoding DNA plasmid prevents the development of chronic graft-versus-host disease (GYM)", J. Immunol. 162, 4013–4017.
  • Okamoto, I., Kohno, K., Tanimoto, T., Iwaki, K., Ishihara, T., Akamatsu, S., Ikegami, H. and Kurimoto, M. (2000) "IL-18 prevents the development of chronic graft-versus-host disease in mice", J. Immunol. 164, 6067–6074.
  • Sykes, M., Szot, G.L., Nguyen, P.L. and Pearson, D.A. (1995) "1L-12 inhibits murine graft-versus-host disease", Blood 86, 2429–2438.
  • Williamson, E., Garside, P., Bradley, LA. and Mowat, A.M. (1996) "1L-12 is a central mediator of acute graft-versus-host disease in mice", Immunol 157, 689–699.
  • Sprent, J.M., Schaefer, M. and Korngold, R. (1990) "Role of T cell subsets in lethal graft-versus-host disease directed to class I versus class 11 H-2 differences. II. Protective effects of L3T4+ cells in anti-class 11 GVHD", J. Immunol. 144, 2946–2953.
  • Gleichmann, E., Pals, ST., Rolink, A.G., Radaszldewicz, T. and Gleichmann, H. (1984) "Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseases", Immunol. Today 5, 324–328.
  • Orange, J.S., Wolf, S.F. and Birob, C.A. (1994) "Effects of 1L-12 on the response and susceptibility to experimental viral infections", J. Immunol. 152, 1253–1264.
  • Murphy, W.J., Welniak, L.A., Taub, D.D., Wiltrout, R.H., Taylor, RA., Vallera, D.A., Kopf, M., Young, H., Longo, DL. and Blazar, B.R. (1998) "Differential effects of the absence of interferon-fly and 1L-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice", J. Clin. Investig. 102, 1742–1748.
  • Yang, Y.G., Sergio, J.J., Pearson, D.A. and Sykes, M. (1998) "Donor derived interferon gamma is required for inhibition of acute graft-vs-host disease by interleukin 12", J. Clin. Investig. 102, 2126–2135.
  • Laureys, BR., Renauld, J.C. and Houssiau, F.A. (1998) "Inhibition of in vitro immunoglobulin production by IL-12 in murine chronic graft-vs-host disease: synergism with 1L-18", Eur. J. Immunol. 28, 2017–2024.
  • Fantuzzi, G., Reed, D.A. and Dinarello, ChA. (1999) "1L-12-induced 1F1\ly is dependent on caspase-1 processing of the 1L-18 precursor", J. Clin. Invest. 104, 761–767.
  • Tomura, M., Thou, X.Y., Maruo, S., Ahn, H-J., Hamaoka, T., Okamura, R, Nakanishi, K., Tanimoto, T., Kurimoto, M. and Fujiwara, H. (1998) "A critical role for 1L-18 in the proliferation and activation ok NK1.1 + CD3- cells", J. Immunol. 160, 4738–4746.
  • Feldmann, M., Brennan, F.M. and Maini, RN. (1996) "Rheumatoid Arthritis", Cell 85, 307–310.
  • Bix, B.M., Wang, Z., Thiel, B., Schork, N.J. and Locksley, R.M. (1989) "Genetic regulation of commitment to 1L-4 T cell-intrinsic mechanism", J. Exp. Med. 188, 2289–2299.

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