107
Views
17
CrossRef citations to date
0
Altmetric
Original Article

Treatment with Soluble Tumor Necrosis Factor Receptor (sTNFR):Fc/p80 Fusion Protein Ameliorates Relapsing-remitting Experimental Autoimmune Encephalomyelitis and Decreases Chemokine Expression

, , , , &
Pages 465-471 | Received 14 Nov 2003, Accepted 30 Jun 2004, Published online: 07 Jul 2009

References

  • Hofman, F.M., Hinton, DR., Johnson, K. and Merrill, J.E. (1989) "Tumor necrosis factor identified in multiple sclerosis brain", J. Exp. Med. 170, 607–612.
  • Selmaj, K., Raine, CS., Canella, B. and Brosnan, C.F. (1991) "Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions", J. Clin. Investig. 87, 949–954.
  • Issazadeh, S., Ljungdahl, A., Hojeberg, B., Mustafa, M. and Olsson, T. (1995) "Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-12, cytolysin, tumor necrosis factor a and tumor necrosis factor b", J. Neuroimmuna 61, 205–212.
  • Sharief, M. and Hentges, R. (1991) "Association between tumor necrosis factor-a and disease progression in patients with multiple sclerosis", N. EngL J. Med. 325, 467–472.
  • Beck, J., Rondot, P., Catinot, L., Falcoff, E., Kirchner, H. and Wietzerbin, J. (1988) "Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation inmultiple sclerosis: do cytokines trigger off exacerbation?", Acta Neurol. Scand. 78, 318–323.
  • Chofflon, M., Juillard, C., Juillard, P., Gauthier, G. and Gar, G.E. (1992) "Tumor necrosis factor a production as a possible predictor of relapse in patients with multiple sclerosis", Eur. Cytokine Netw. 3, 523–531.
  • Glabinski, A., Mirecka, M. and Pokoca, L. (1995) "TNF alpha but not lymphotoxin is overproduced in multiple sclerosis", Acta Neurol. Scand. 91, 276–279.
  • Selmaj, K.W. and Raine, C.S. (1988) "Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro", Ann. Neurol. 23, 339–346.
  • Ruddle, N.H., Bergman, CM., McGrath, KM., Lingenheld, E.G. and Grunnet, M.L. (1990) "An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental autoimmune encephalomyelitis", J. Exp. Med. 174, 1193–1200.
  • Selmaj, K., Raine, C.S. and Cross, A.H. (1991) "Anti-tumor necrosis factor therapy abrogates autoimmune demyelination", Ann. Neurol. 30, 694–700.
  • Tartaglia, A. and Goeddel, D.V. (1992) "Two TNF receptors", Immunol. Today 13, 151–153.
  • Seckinger, P., Isaaz, S. and Dayer, J.M. (1988) "A human inhibitor of tumor necrosis factor a", J. Exp. Med. 167, 1511–1516.
  • Engelmann, RD., Aderka, D., Rubinstein, M., Rotman, D. and Wallach, D.A. (1989) "A tumor necrosis factor—binding protein purified to human urine protects cells from tumor necrosis factor toxicity", J. Biol. Chem. 264, 11974–11980.
  • Engelman, H., Novick, D. and Wallach, D. (1990) "Two tumor necrosis factor—binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors", J. Biol. Chem. 265, 1531–1536.
  • Seckinger, P., Zhang, J., Hauptmann, B. and Dayer, J.M. (1990) "Characterization of a tumor necrosis factor-a inhibitor: evidence of immunological cross-reactivity with the TNF receptor", Proc. Natl Acad. Sci. USA 87, 5188–5192.
  • Nophar, Y., Kemper, 0., Brakebusch, C., et al. (1990) "Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor", EMBO J. 9, 3269–3278.
  • Van Zee, K., Kohno, T., Fischer, E., Rock, C., Moldawer, L. and Lowry, S. (1992) "Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo", Proc. Natl Acad. Sci. USA 89, 4845–4849.
  • Mohler, KM., Torrance, D.S., Smith, C.A., et al. (1993) "Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simul-taneously as both TNF carriers and TNF antagonists", J. Immunol. 151, 1548–1561.
  • Selmaj, K., Papierz, W., Glabinski, A. and Kohno, T. (1995) "Prevention of chronic relapsing experimental autoimmune encephalomyelitis by soluble tumor necrosis factor receptor I", J. Neuroimmunol. 56, 135–141.
  • Peppel, K., Crawford, D. and Beutler, B. (1991) "A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity", J. Exp. Med. 174, 1483–1489.
  • Abraham, E., Coulson, W.F., Schwartz, M.D. and Allbee, J. (1994) "Effects of therapy with soluble tumour necrosis factor receptor fusion protein on pulmonary cytokine expression and lung injury following haemorrhage and resuscitation", Clin. Exp. Immunol. 98, 29–34.
  • Fisher, C.J.J., Agosti, J.M., Opal, S.M., et al. (1996) "Treatment of septic shock with the tumor necrosis factor receptor:fc fusion protein", N. Engl. J. Med. 334, 1697–1702.
  • Moreland, LW., Baumgartner, S.W., Schiff, M.H., et al. (1997) "Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein", N. EngL J. Med. 337, 141–147.
  • Karpus, W.J. (1999) "Chemokine regulation of inflammatory-mediated nervous system diseases", J. NeuroviroL 5, 1–2.
  • Glabinski, A. and Ransohoff, R. (1999) "Chemokines and chemokine receptors in CNS pathology", J. Neurovirol. 5, 3–12.
  • Bacon, KB. and Harrison, J.K. (2000) "Chemokines and their receptors in neurobiology: perspectives in physiology and homeostasis", J. Neuroimmunol. 104, 92–97.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.