Advanced search
Publication Cover
Autoimmunity Volume 37, 2004 - Issue 8
Submit an article Journal homepage
77
Views
5
CrossRef citations to date
0
Altmetric
Original Article

Non-depleting Anti-CD4 Antibody not only Prevents Onset but Resolves Sialadenitis in NOD Mice

Clare Thompson Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
,
Helle Jacobsen Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
,
Daniel Pomeranz Krummel MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
,
Kyoshi Nagai MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
&
Anne Cooke Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UKCorrespondence[email protected]
Pages 549-554 | Received 23 Jul 2004, Accepted 28 Oct 2004, Published online: 07 Jul 2009

References

  • van Blokland, S.C., van Helden-Meeuwsen, C.G., Wierenga-Wolf, A.F., Drexhage, HA., Hooijkaas, H., van de Merwe, J.P., et al. (2000) "Two different types of sialoadenitis in the NOD- and MRL/lpr mouse models for Sjogren's syndrome: A differential role for dendritic cells in the initiation of sialoadenitis?", Lab. Investig. 80, 575–585.
  • Robinson, CP., Brayer, J., Yamachika, S., Esch, T.R., Peck, A.B., Stewart, C.A. et al. (1998) "Transfer of human serum IgG to nonobese diabetic Igmu null mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sjogren's syndrome", Proc. Natl. Acad. Sci. USA 95, 7538–7543.
  • Faveeuw, C., Gagnerault, M.C. and Lepault, F. (1994) "Expression of homing and adhesion molecules in infiltrated islets ofLangerhans and salivary glands of nonobese diabetic mice", J. Immunol. 152, 5969–5978.
  • Yamano, S., Atkinson, J.C., Baum, B.J. and Fox, P.C. (1999) "Salivary gland cytokine expression in NOD and normal BALB/c mice", ClM. Immunol. 92, 265–275.
  • Routsias, J.G., Tzioufas, A.G. and Moutsopoulos, H.M. (2004) "The clinical value of intracellular autoantigens B-cell epitopes in systemic rheumatic diseases", ClM. Chim. Acta. 340, 1–25.
  • Humphreys-Beher, M.G., Brinkley, L., Purushotham, KR., Wang, EL., Nakagawa, Y., Dusek, D., et al. (1993) "Characterization of antinuclear autoantibodies present in the serum from nonobese diabetic (NOD) mice", ClM Immunol Immunopathol 68, 350–356.
  • Baxter, A.G., Horsfall, AC., Healey, D., Ozegbe, P., Day, S., Williams, D.G., et al. (1994) "Mycobacteria precipitate an SLE-like syndrome in diabetes-prone NOD mice", Immunology 83, 227–231.
  • Skarstein, K., Wahren, M., Zaura, E., Hattori, M. and Jonsson, R. (1995) "Characterization of T cell receptor repertoire and anti-Ro/SSA autoantibodies in relation to sialadenitis of NOD mice", Autoimmunity 22, 9–16.
  • Binder, A., Maddison, P.J., Skinner, P., Kurtz, A. and Isenberg, D.A. (1989) "Sjogren's syndrome: association with type-1 diabetes mellitus", Br J. Rheumatol. 28, 518–520.
  • Parish, N.M., Hutchings, PR., O'Reilly, L., Quartey-Papafio, R., Healey, D., Ozegbe, P., et al. (1995) "Tolerance induction as a therapeutic strategy for the control of autoinunune endocrine disease in mouse models", Immunol. Rev. 144, 269–300.
  • Chatenoud, L., Thervet, E., Primo, J. and Bach, J.F. (1994) "Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice", Proc. Natl. Acad. Sci. USA 91, 123–127.
  • Mauri, C., Chu, C.Q., Woodrow, D., Mori, L. and Londei, M. (1997) "Treatment of a newly established transgenic model of chronic arthritis with nondepleting anti-CD4 monoclonal antibody", J. Immunol. 159, 5032–5041.
  • Waldmann, H., Cobbold, SE, Qin, S., Benjamin, R.J. and Wise, M. (1989) "Tolerance induction in the adult using monoclonal antibodies to CD4, CD8, and CD1 la (LFA-1)", Cold Spring Harb. Symp. Quant. Biol. 54(Pt 2), 885–892.
  • Qin, S.X., Wise, M., Cobbold, SE, Leong, L., Kong, IC., Parnes, J.R., et al. (1990) "Induction of tolerance in peripheral T cells with monoclonal antibodies", Eur. J. Immunol. 20, 2737–2745.
  • Hutchings, P., O'Reilly, L., Parish, N.M., Waldmann, H. and Cooke, A. (1992) "The use of a non-depleting anti-CD4 monoclonal antibody to re-establish tolerance to beta cells in NOD mice", Eur. J. Immunol. 22, 1913–1918.
  • Chatenoud, L., Thervet, E., Primo, J. and Bach, J.F. (1992) "Remission of established disease in diabetic NOD mice induced by anti-CD3 monoclonal antibody", C R Acad. Sci. 111315, 225–228.
  • Marshall, SE., Cobbold, SE, Davies, J.D., Martin, G.M., Phillips, J.M. and Waldmann, H. (1996) "Tolerance and suppression in a primed immune system", Transplantation 62, 1614–1621.
  • Hutchings, PR., Cooke, A., Dawe, K., Waldmann, H. and Roitt, I.M. (1993) "Active suppression induced by anti-CD4", Eur. J. Immunol. 23, 965–968.
  • Qin, S., Cobbold, SE, Pope, H., Elliott, J., Kioussis, D., Davies, J., et al. (1993) " "Infectious" transplantation tolerance", Science 259, 974–977.
  • Phillips, J.M., Harach, S.Z., Parish, N.M., Fehervari, Z., Haskins, K. and Cooke, A. (2000) "Nondepleting anti-CD4 has an immediate action on diabetogenic effector cells, halting their destruction of pancreatic beta cells", J. Immunol. 165, 1949–1955.
  • O'Reilly, L.A., Healey, D., Simpson, E., Chandler, P., Lund, T., Ritter, MA., et al. (1994) "Studies on the thymus of non-obese diabetic (NOD) mice: Effect of transgene expression", Immunology 82, 275–286.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.