Toll-like Receptors and their Role in the Development of Autoimmune Diseases

References

• Hoffmann, J.A., Kafatos, F.C., Janeway, C.A., Jr. and Ezekowitz, R.A.B. (1999) "Phylogenetic perspectives in innate immunity", Science 284, 1313–1318.
   PubMed Web of Science ®Google Scholar
• Akira, S. and Sato, S. (2003) "Toll-like receptors and their signaling mechanisms", Scand. J. Infect. Dis. 35, 555–562.
   PubMed Web of Science ®Google Scholar
• Janeway, C.A. and Medzhitov, R. (2002) "Innate immune recognition", Annu. Rev. Immunol. 20, 197–216.
   PubMed Web of Science ®Google Scholar
• Pasare, C. and Medzhitov, R. (2003) "Toll-like receptors: balancing host resistance with immune tolerance", Curr. Opin. Immunol. 15, 677–682.
   PubMed Web of Science ®Google Scholar
• Takeda, K., Kaisho, T. and Akira, S. (2003) "Toll-like receptors", Annu. Rev. Iminunol. 21, 335–376.
   PubMed Web of Science ®Google Scholar
• Coutinho, A. and Poltorack, A. (2003) "Innate immunity: from lymphocyte mitogens to Toll-like receptors and back", Curr. Opin. Immunol. 15, 614–619.
   PubMedGoogle Scholar
• Schnare, M., Barton, G.M., Holt, AC., Takeda, K., Akira, S. and Medzhitov, R. (2001) "Toll-like receptors control activation of adaptive immune responses", Nat. Immunol. 2, 947–950.
   PubMed Web of Science ®Google Scholar
• Hashimoto, C., Hudson, K.L. and Anderson, KY. (1988) "The Toll gene of Drosophila, required for dorsal—ventral embryonic polarity, appears to encode a transmembrane protein", Cell 52, 269–279.
   PubMed Web of Science ®Google Scholar
• Bowie, A. and O'Neill, L.A. (2000) "The interleukin-1 receptor/ Toll-like receptor superfamily; signal generators for pro-inflam-matory interleukins and microbial products", J. Leukoc. Biol. 67, 508–514.
   PubMedGoogle Scholar
• Medzhitov, R., Preston-Hurlburt, P. and Janeway, C.A., Jr. (1997) "A human homologue of the Drosophila Toll protein signals activation of adaptive immunity", Nature 388, 394–397.
   PubMed Web of Science ®Google Scholar
• Rock, EL., Hardiman, G., Timans, J.C., Kastelein, R.A. and Bann, J.F. (1998) "A family of human receptors structurally related to Drosophila Toll", Proc. Natl Acad Sci USA 95, 588–593.
   PubMed Web of Science ®Google Scholar
• Chuang, T-H. and Ulevitch, R.J. (2001) "Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells", Biochim. Biophys. Acta 1518, 157–161.
   PubMed Web of Science ®Google Scholar
• Takeuchi, 0., Kawai, T., Muhlradt, P.F., Morr, M., Radolf, J.D., Zychlinsky, A., et al. (2001) "Discrimination of bacterial lipoproteins by Toll-like receptor-6", Int. Immunol. 13, 933–940.
   PubMedGoogle Scholar
• Nagai, Y, Akashi, S., Nagafuku, M., Ogata, M., Iwakura, Y. and Akira, S. (2002) "Essential role of MD-2 in LPS responsiveness and TLR4 distribution", Nat. Immunol. 3, 667–672.
   PubMed Web of Science ®Google Scholar
• Means, T.K., Wang, S., Lien, E., Yoshimura, A., Golenbock, D.T. and Fenton, M.J. (1999) "Human Toll-like receptors mediate cellular activation by Mycobacterium tuberculosis", J. Immunol. 163, 3920–3927.
   PubMed Web of Science ®Google Scholar
• Chu, W-M., Ostertag, D., Li, Z-W., Chang, L., Chen, Y., Hu, Y., et al. (1999) INK2 and tick are required for activating the innate response to viral infection", Immunity 11, 721–731.
   PubMed Web of Science ®Google Scholar
• Hayashi, F., Smith, K.D., Ozinsky, A., Hawn, T.R., Yi, E.C., Goodlett, DR., et al. (2001) "The innate immune response to flagellin is mediated by Toll-like receptors-5", Nature 410, 1099–1103.
   PubMed Web of Science ®Google Scholar
• Wagner, H. (2001) "Toll meets bacterial CpG-DNA", Immunity 14, 499–502.
   PubMed Web of Science ®Google Scholar
• Bulut, Y., Fayure, E., Thomas, L., Karahashi, H., Michelsen, KS., Equils, 0., et al. (2002) "Chlamydial heat shock protein 60 activates macrophages and endothelial cells through TLR4 and MD2 in a MyD88-independent pathway", J. Iminunol. 168, 1435–1440.
   Google Scholar
• Smiley, ST., King, LA. and Hancock, W.W. (2001) "Fibrinogen stimulates macrophage chemokine secretion through Toll-Like receptor 4", J. Immunol. 167, 2887–2894.
   PubMed Web of Science ®Google Scholar
• Mellman, I. and Steinman, R.M. (2001) "Dendritic cells: specialized and regulated antigen processing machines", Cell 106, 255–258.
   PubMed Web of Science ®Google Scholar
• Supajatura, V., Ushio, H., Nakao, A., Okumura, K., Ra, C. and Ogawa, H. (2001) "Protective roles of mast cells against enterobacterial infection, are mediated by Toll-like receptor 4", J. Immunol. 167, 2250–2256.
   PubMed Web of Science ®Google Scholar
• Hacker, H., Vabulas, R.M., Takeuchi, 0., Hoshino, K., Akira, S. and Wagner, H. (2000) "Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF) 6", J. Exp. Med. 192, 595–600.
   PubMedGoogle Scholar
• Suzuki, N., Suzuki, S., Duncan, G.S., Millar, D.G., Wada, T., Mirtsos, C., et al. (2002) "Severe impairment of Interleukin-1 and Toll-like receptor signaling in mice lacking 1RAK-4", Nature 416, 750–756.
   PubMed Web of Science ®Google Scholar
• Horng, T., Barton, G.M. and Medzhitov, R. (2001) "T1RAP: an adaptor molecule in the Toll signaling pathway", Nat. Immunol. 2, 835 —841.
   Google Scholar
• Li, M., Carpi°, D.F., Zheng, Y, Bruzzo, P., Singh, V, Quaaz, F., et al. (2001) "An essential role of the NFkB/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cell", J. Immunol. 166, 7128–7135.
   PubMedGoogle Scholar
• Qaaz, F., Arron, J., Zheng, Y, Choi, Y. and Beg, A.A. (2000) "Dendritic cell development and survival require distinct NFkB subunits", Immunity 16, 257–270.
   Google Scholar
• Taniguchi, T. and Takaoka, A. (2002) "The interferon-aB system in antiviral responses: a multimodal machinery of gene regulation by the 1RF family of transcription factors", Curr. Opin. Immunol. 14, 111–116.
   PubMed Web of Science ®Google Scholar
• Kaisho, T., Hoshino, K., Iwabe, T., Takeuchi, 0., Yasni, T. and Akira, S. (2002) "Endotoxin can induce MyD88-deficient dendritic cells to support Th2 cell differentiation", Int. Immunol. 14, 695–700.
   PubMedGoogle Scholar
• Vinuesa, C.G. and Goodnow, C.C. (2002) "Immunology: DNA drives autoimmunity", Nature 416, 595–598.
   PubMedGoogle Scholar
• Hannum, L.G., Ni, D., Haberman, A.M., Weigert, M.G. and Shlomchick, M.J. (1996) "A disease-related rheumatoid factor antibody, is not tolerized in a normal mouse: implications for the origins of autoantibodies in autoimmune diseases", J. Exp. Med. 184, 1269–1278.
   PubMed Web of Science ®Google Scholar
• Leadbetter, E., Rifkin, I.R., Hohlbaum, A.M., Beaudette, B.C., Shlomchik, M.J. and Rothstein-Marshak, A. (2002) "Chromatin—IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors", Nature 416, 603–607.
   PubMed Web of Science ®Google Scholar
• Anders, H.J., Veilhauer, V, Eis, V, Linde, Y., Kretzler, M., Perez De Lema, G, et al. (2004) "Activation of toll-like receptor-9 induces progression of renal disease in MLR-Fos (1pr) mice", FASEB J. 18, 155–157.
   PubMedGoogle Scholar
• Schnare, M., Barton, G.M., Holt, AC., Takeda, K., Akira, S. and Medzhitov, R. (2001) "Toll-like receptors control activation of adaptive immune responses", Nat. Immunol. 2, 947–950.
   PubMed Web of Science ®Google Scholar
• Viglianti, GA., Lau, CM., Hanley, TM., Miko, BA., Shlomchik, M.J. and Marshak-Rothstein, A. (2003) "Activation of autoreactive B cells by CpG ds DNA", Immunity 19, 837–847.
   PubMed Web of Science ®Google Scholar
• Eriksson, U., Ricci, R., Hunziker, L., Kurrer, M.O., Oudit, G.Y., Watts, T.H., et al. (2003) "Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immu-nity", Nat. Immunol. 9, 1484–1490.
   Google Scholar
• Radstake, T.R., Franke, B., Hanssen, S., Netea, M.G., Welsing, P., Barrera, P., et al. (2004) "The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome", Arthritis Rheum. 50, 999–1007.
   PubMed Web of Science ®Google Scholar
• Pasare, C. and Medzhitov, R. (2003) "Toll-pathway dependent blockade of CD4+ CD25+ T cells-mediated suppression by dendritic cells" 299, 1033–1036.
   Google Scholar
• Krieg, A.M. (2002) "A role for Toll in autoimmunity", Nat. Immunol. 3, 423–424.
   PubMed Web of Science ®Google Scholar