Is Mortalin a Candidate Gene for T1DM ?

References

• Nerup, J., Mandrup-Poulsen, T., Helqvist, S., Andersen, FLU., Pociot, F., Reimers, J.I., et al. (1994) "On the pathogenesis of 1DDM", Diabetologia 37\(suppl. 2), S82—S89.
   Google Scholar
• Andersen, RU., Larsen, P.M., Fey, S.J., Karlsen, A.E., Mandrup-Poulsen, T. and Nerup, J. (1995) "Two-dimentionel gel electro-phoresis of rat islets proteins: interleukin-1 beta induced changes in protein expression are reduced by L-argenine depletion and nicotinamide", Diabetes 44, 400–407.
   PubMed Web of Science ®Google Scholar
• Andersen, H.U., Fey, S.J., Larsen, P.M., Nawrocki, A., Hejnxs, Mandrup-Poulsen, T., et al. (1997) "Interleukin-1 beta induced changes in the protein expression of rat islets: a computerized database", Electrophoresis 18, 2091–2103.
   Google Scholar
• John, N., Andersen, H., Fey, S., Larsen, P., Roepstroff, P., Larsen, M., et al. (2000) "Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans", Diabetes 49, 1819 —1829.
   Web of Science ®Google Scholar
• Mose-Larsen, P., Fey, S., Larsen, M., Nawrocki, A., Andersen, H., Kähler, H., et al. (2001) "Proteome analysis of IL-1 beta induced changes in protein expression in rat islets of Langerhans", Diabetes 50, 1056–1063.
   PubMed Web of Science ®Google Scholar
• Sparre, T., Christensen, U.B., Larsen, P.M., Fey, S.J., Wrzesinski, K., Roepstorff, P., et al. (2002) "IL-113 induced protein changes in diabetes prone BB rat islets of langerhans identified by proteome analysis", Diabetologia 45, 1550–1561.Ill]
   Google Scholar
• Karlsen, A.E., Sparre, T., Nielsen, K., Nerup, J. and Pociot, F. (2001) "Proteome analysis—A novel approach to understand the patho-genesis of Type 1 diabetes mellitus", Dis. Markers 17, 205–216.
   PubMed Web of Science ®Google Scholar
• Pociot, F. and Karlsen, A.E. (2002) "Combined genome and proteome approach to identify new susceptibility genes", Am. J. Med. Genet. 115, 55–60.
   PubMed Web of Science ®Google Scholar
• Pociot, F., Molvig, J., Wogensen, L., Worsaae, H. and Nerup, J. (1992) "A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro", Eur. J. Clin. Investig. 22, 396–402.
   PubMed Web of Science ®Google Scholar
• Pociot, F., Briant, L., Jongeneel, C.V., Molvig, J., Worsaae, H., Abbal, M., et al. (1993) "Association of tumor necrosis factor (TNF) and class 11 major histocompatibility complex alleles with the secretion of TNF-alpha and TNF-beta by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus", Eur. J. Immunol. 23, 224–231.
   PubMed Web of Science ®Google Scholar
• Ueda, H., Howson, J.M.M., Esposito, L., Heward, J., Snook, H., Chamberlain, G., et al. (2003) "Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease", Nature (London) 423, 506–511.
   PubMed Web of Science ®Google Scholar
• Johannesen, J., Pociot, F., Karlsen, A.E., Mandrup-Poulsen, T. and Nerup, J. (2001) "Strain-dependent difference in inducible nitric oxide synthesis (NOS) expression in rat pancreatic islets correlates with interferon regulating factor 1 (1RF-1) and heat shock protein 70 (HSP70) expression", Eur. Cytokine Netw. 12, 501–509.
   PubMed Web of Science ®Google Scholar
• Wadhwa, R., Kaul, S., lkawa, Y. and Sugimoto, Y. (1993a) "Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype", J. Biol. Chem. 268, 6615–6621.
   PubMed Web of Science ®Google Scholar
• Wadhwa, R., Kaul, S., lkawa, Y. and Sugimoto, Y. (1991) "Protein markers for cellular mortality and immortality", Mutat. Res. 256, 243–254.
   PubMed Web of Science ®Google Scholar
• Wadhwa, R., Taira, K. and Kaul, S.C. (2002a) "An Hsp70 family chaperone, mortalin/mthsp7O/PBP74/Grp75: what, when, and where?", Cell Stress Chaperones 7, 309–316.
   PubMed Web of Science ®Google Scholar
• Domanico, S., DeNagel, D., Dahlseid, J., Green, J. and Pierce, S. (1993) "Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family", Mol. Cell. Biol. 13, 3598–3610.
   PubMed Web of Science ®Google Scholar
• Martin, J. and Hartl, F. (1997) "Chaperone-assisted protein folding", Curr. Opin. Struct. Biol. 7, 41–52.
   PubMed Web of Science ®Google Scholar
• Mizukoshi, E., Suzuki, M., Loupatov, A., Uruno, T., Hayashi, H., Misono, T., et al. (1999) "Fibroblast growth factor-1 interacts with the glucose-regulated protein GRP75/mortalin", Biochem. J. 343, 461–466.
   PubMed Web of Science ®Google Scholar
• Sacht, G., Brigelius-Flohe, R., Kiess, M., Sztajer, H. and Flohe, L. (1999) "ATP-sensitive association of mortalin with the IL-1 receptor type I", Biofactors 9, 49–60.
   PubMed Web of Science ®Google Scholar
• Massa, S., Longo, F., Zuo, J., Wang, S., Chen, J. and Sharp, F. (1995) "Cloning of rat grp75, an hsp70-family member, and its expression in normal and ischemic brain", J. Neurosci. Res. 40, 807–819.
   PubMed Web of Science ®Google Scholar
• Bhattacharyya, T., Karnezis, A., Murphy, S., Hoang, T., Freeman, B., Phillips, B., et al. (1995) "Cloning and subcellular localization of human mitochondrial hsp70", J. Biol. Chem. 270, 1705–1710.
   PubMed Web of Science ®Google Scholar
• Wadhwa, R., Kaul, S., Sugimoto, Y. and Mitsui, Y. (1993) "Induction of cellular senescence by transfection of cytosolic mortalin cDNA in NIH 3T3 cells", J. Biol. Chem. 268, 22239–22242.
   PubMed Web of Science ®Google Scholar
• Kaul, S., Wadhwa, R., Matsuda, Y, Hensler, P., Pereira-Smith, 0., Komatsu, Y., et al. (1995) "Mouse and human chromosomal assignments of mortalin, a novel member of the murine hsp70 family of proteins", FEBS Lett. 361, 269–272.
   PubMed Web of Science ®Google Scholar
• Oksenberg, J.R. and Hauser, S.L. (1997) "New insights into the immunogenetics of multiple sclerosis", Curr. Opin. Neurol. 10, 181–185.
   PubMed Web of Science ®Google Scholar
• Rioux, J., Silverberg, M., Daly, M., Steinhart, A., McLeod, R., Griffiths, A., et al. (2000) "Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci", Am. J. Hum. Genet. 66, 1863–1870.
   PubMed Web of Science ®Google Scholar
• Los, H., Koppelman, G. and Postma, D. (1999) "The importance of genetic influences in asthma", Eur. Respir. J. 14, 1210–1227.
   PubMed Web of Science ®Google Scholar
• Davies, J.L., Kawaguchi, Y, Bennett, ST., Copeman, J.B., Cordell, H.J., Pritchard, L.E., et al. (1994) "A genome-wide search for human type 1 diabetes susceptibility genes", Nature 371, 130–136.
   PubMed Web of Science ®Google Scholar
• Concannon, P., Gogolinewens, K., Hinds, D., Wapelhorst, B., Morrison, V., Stirling, B., et al. (1998) "A second-generation screen
   Google Scholar