Myocarditis, Microbes and Autoimmunity

References

• Gravanis, M.B. and Sternby, N.H. (1991) "Incidence of myocarditis. A 10-year autopsy study from Malmo, Sweden", Arch. PathoL Lab. Med. 115, 390–392.
   PubMed Web of Science ®Google Scholar
• Ward, C. (1978) "Severe arrhythmias in Coxsackievirus B3 myopericarditis", Arch. Dis. Child. 53, 174–176.
   Google Scholar
• Bendig, J.W.A., O'Brien, P.S., Muir, P., Porter, H.J. and Caul, E.O. (2001) "Enterovirus sequences resembling coxsackievirus A2 detected in stool and spleen from a girl with fatal myocarditis", J. Med. Virol. 64, 482–486.
   Google Scholar
• O'Connell, J.B. (1987) "The role of myocarditis in end-stage dilated cardiomyopathy", Tex. Heart Inst. J. 14, 268–275.
   PubMed Web of Science ®Google Scholar
• Sole, M.J. and Liu, P. (1993) "Viral myocarditis: a paradigm for understanding the pathogenesis and treatment of dilated cardiomyopathy", J. Am. Coll. CardioL 22, 99A–105A.
   Google Scholar
• Gillum, R.F. (1986) "Idiopathic cardiomyopathy in the United States, 1970-1982", Am. Heart J. 111, 752–755.
   PubMed Web of Science ®Google Scholar
• Goodwin, J.F. (1992) "Cardiomyopathies and specific heart muscle diseases. Definitions, terminology, classifications and new and old approaches", Postgraa Med. J. 68\(Suppl. 1), S3—S6.
   Google Scholar
• Heck, C.F., Shumway, S.J. and Kaye, M.P. (1989) "The Registry of the International Society for Heart Transplantation: sixth official report-1989", J. Heart Transplant. 8, 271–276.
   PubMedGoogle Scholar
• Mariolio, T.A., Baughman, K.L., Rodeheffer, R., Pearson, TA., Bristow, J.D., Michels, V.V., et al. (1992) "Prevalence and etiology of idiopathic dilated cardiomyopathy (summary of a National Heart, Lung, and Blood Institute workshop)", Am. J. CardioL 69, 1458–1466.
   Google Scholar
• Hyypia, T., Kallajoki, M., Maaronen, M., Stanway, G., Kandolf, R., Auvinen, R, et al. (1993) "Pathogenetic differences between coxsackie A and B virus infections in newborn mice", Virus Res. 27, 71–78.
   Google Scholar
• Grist, N.R., Bell, EL and Assaad, F. (1978) "Enteroviruses in human disease", Prog. Med. Virol. 24, 114–157.
   Google Scholar
• Gelfand, H.M. (1961) "The occurrence in nature of the coxsackie and ECHO viruses", Prog. Med. ViroL 3, 193–244.
   Google Scholar
• Woodruff, J.F. (1980) "Viral myocarditis. A review", Am. J. PathoL 101, 425–484.
   PubMed Web of Science ®Google Scholar
• Sutton, G.C., Harding, H.B., Trueheart, R.P. and Clark, H.P. (1967) "Coxsackie B4 myocarditis in an adult: successful isolation of virus from ventricular myocardium", Clin. Aviat. Aerospace Med. 38, 66–69.
   Google Scholar
• Sutton, G.C., Tobin, J.R., Fox, R.T., Freeark, R.J. and Driscoll, J.F. (1963) "Study of the pericardium and ventricular myocardium: exploratory mediastinotomy and biopsy in unexplained heart disease", JAMA 185, 786–788.
   Google Scholar
• Martino, TA., Liu, P., Petric, M. and Sole, M.J. (1995) "Enteroviral myocarditis and dilated cardiomyopathy: a review of clinical and experimental studies", In: Rotbart, HA., ed., Human Enterovirus Infections (ASM Press, Washington, D.C.), pp 291–351.
   Google Scholar
• Archard, L.C., Bowles, N.E., Cunningham, L., Freeke, C.A., Olsen, E.G., Rose, ML., et al. (1991) "Molecular probes for detection of persisting enterovirus infection of human heart and their prognostic value", Eur. Heart J. 12, 56–59.
   Google Scholar
• Riecansky, I., Schreinerova, Z., Egnerova, A., Petrovicova, A. and Bzduchova, 0. (1989) "Incidence of Coxsackie virus infection in patients with dilated cardiomyopathy", Cor Vasa 31, 225–230.
   Google Scholar
• Levi, G., Scalvini, S., Volterrani, M., Marangoni, S., Arosio, G. and Quadri, A. (1988) "Coxsackie virus heart disease: 15 years after", Eur Heart J. 9, 1303–1307.
   PubMedGoogle Scholar
• Bowles, N.E., Rose, M.L., Taylor, P., Banner, N.R., Morgan-Capner, P., Cunningham, L., et al. (1989) "End-stage dilated cardiomyopathy. Persistence of enterovirus RNA in myocardium at cardiac transplantation and lack of immune response", Circulation 80, 1128–1136.
   Google Scholar
• Paque, R.E., Gauntt, C.J. and Nealon, T.J. (1981) "Assessment of cell-mediated immunity against coxsackievirus B3-induced myocarditis in a primate model (Papio papio)", Infect. Immun. 31, 470–479.
   PubMed Web of Science ®Google Scholar
• Ren, R.B., Costantini, F., Gorgacz, E.J., Lee, J.J. and Racaniello, V.R. (1990) "Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis", Cell 63, 353–362.
   PubMed Web of Science ®Google Scholar
• Koike, S., Taya, C., Kurata, T., Abe, S., Ise, I., Yonekawa, H., et al. (1991) "Transgenic mice susceptible to poliovirus", Proc. Nati Acad. Sci. USA 88, 951–955.
   PubMed Web of Science ®Google Scholar
• Rall, G.F., Manchester, M., Daniels, L.R., Callahan, EM., Belman, A.R. and Oldstone, M.B.A. (1997) "A transgenic mouse model for measles virus infection of the brain", Proc. Nati Acad. Sci. USA 94, 4659–4663.
   PubMedGoogle Scholar
• Zhang, S. and Racaniello, V.R. (1997) "Expression of the poliovirus receptor in intestinal epithelial cells is not sufficient to permit poliovirus replication in the mouse gut", J. Virol. 71, 4915–4920.
   PubMed Web of Science ®Google Scholar
• Knowlton, K.U., Jeon, ES., Berkley, N., Wessely, R. and Huber, S.A. (1996) "A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3", J. ViroL 70, 7811–7818.
   PubMed Web of Science ®Google Scholar
• Henke, A., Huber, S.A., Stelzner, A. and Whitton, J.L. (1995) "The role of CD8+ T lymphocytes in coxsackievirus B3-induced myocarditis", J. Virol. 69, 6720–6728.
   PubMed Web of Science ®Google Scholar
• Gebhard, J.R., Perry, C.M., Harkins, S., Lane, T., Mena, I., Asensio, V.C., et al. (1998) "Coxsackievirus B3-induced myocarditis: perforin exacerbates disease, but plays no detectable role in virus clearance", Am. J. PathoL 153, 417–428.
   PubMed Web of Science ®Google Scholar
• Mena, I., Fischer, C., Gebhard, J.R., Perry, CM., Harkins, S. and Whitton, J.L. (2000) "Coxsackievirus infection of the pancreas: evaluation of receptor expression, pathogenesis, and inununo-pathology", Virology 271, 276–288.
   PubMed Web of Science ®Google Scholar
• Slifka, M.K., Pagarigan, R.R., Mena, I., Feuer, R. and Whitton, J.L. (2001) "Using recombinant coxsackievirus B3 to evaluate the induction and protective efficacy of CD8+ T cells in controlling picornaviral infection", J. Virol. 75, 2377–2387.
   PubMed Web of Science ®Google Scholar
• Feuer, R., Mena, I., Pagarigan, R.R., Harkins, S., Hassett, D.E. and Whitton, J. (2003) "Coxsackievirus B3 and the neonatal CNS: the roles of stem cells, developing neurons, and apoptosis in infection, viral dissemination, and disease", Am. J. PathoL 163, 1379–1393.
   PubMed Web of Science ®Google Scholar
• Mena, I., Perry, CM., Harkins, S., Rodriguez, F., Gebhard, J.R. and Whitton, J.L. (1999) "The role of B lymphocytes in coxsackievirus B3 infection", Am. J. PathoL 155, 1205–1215.
   PubMed Web of Science ®Google Scholar
• Gauntt, C.J., Gomez, RT., Duffey, P.S., Grant, JA., Trent, D.W., Witherspoon, S.M., et al. (1984) "Characterization and myocardi-tic capabilities of coxsackievirus B3 variants in selected mouse strains", J. ViroL 52, 598–605.
   Google Scholar
• Loudon, R.P., Moraska, A.F., Huber, S.A., Schwimmbeck, P.L. and Schultheiss, P. (1991) "An attenuated variant of Coxsackievirus B3 preferentially induces immunoregulatory T cells in vivo", J. Virol. 65, 5813–5819.
   Google Scholar
• Wolfgram, L.J., Beisel, K.W., Herskowitz, A. and Rose, N.R. (1986) "Variations in the susceptibility to Coxsackievirus B3-induced myocarditis among different strains of mice", J. Immunol. 136, 1846–1852.
   PubMed Web of Science ®Google Scholar
• Chow, L.H., Gauntt, C.J. and McManus, B.M. (1991) "Differential effects of myocarditic variants of Coxsackievirus B3 in inbred mice. A pathologic characterization of heart tissue damage", Lab. Investig. 64, 55–64.
   PubMed Web of Science ®Google Scholar
• Huber, S.A., Job, L.P., Auld, KR. and Woodruff, J.F. (1981) "Sex-related differences in the rapid production of cytotoxic spleen cells active against uninfected myofibers during Coxsackievirus B-3 infection", J. Immunol. 126, 1336–1340.
   Google Scholar
• Huber, S.A. and Pfaeffle, B. (1994) "Differential Th 1 and Th2 cell responses in male and female BALB/c mice infected with coxsackievirus group B type 3", J. ViroL 68, 5126–5132.
   PubMed Web of Science ®Google Scholar
• Khatib, R., Chason, J.L., Silberberg, B.K. and Lerner, A.M. (1980) "Age-dependent pathogenicity of group B coxsackieviruses in Swiss- Webster mice: infectivity for myocardium and pancreas", J. Infect. Dis. 141, 394–403.
   PubMed Web of Science ®Google Scholar
• Woodruff, J.F. and Kilbourne, ED. (1970) "The influence of quantitated post-weaning undernutrition on coxsackievirus B3 infection of adult mice. I. Viral persistence and increased severity of lesions", J. Infect. Dis. 121, 137–163.
   PubMed Web of Science ®Google Scholar
• Von Herrath, M.G., Fujinami, R.S. and Whitton, J.L. (2003) "Microorganisms and autoimmunity—making the barren field fertile?", Nat. Rev. MicrobioL 1, 151–157.
   PubMed Web of Science ®Google Scholar
• Huber, S.A., Job, L.P. and Woodruff, J.F. (1984) "In vitro culture of coxsackievirus group B, type 3 immune spleen cells on infected endothelial cells and biological activity of the cultured cells in vivo", Infect. Immun. 43, 567–573.
   Google Scholar
• Heim, A., Canu, A., Kirschner, P., Simon, T., Mall, G., Hofschneider, PH., et al. (1992) "Synergistic interaction of interferon-I3 and interferon--y in coxsackievirus B3-infected carrier cultures of human myocardial fibroblasts", J. Infect. Dis. 166, 958–965.
   Google Scholar
• Kandolf, R., Canu, A. and Hofschneider, PH. (1985) "Coxsackie B3 virus can replicate in cultured human foetal heart cells and is inhibited by interferon", J. MoL Cell. CardioL 17, 167–181.
   Google Scholar
• Herzum, M., Ruppert, V., Kuytz, B., Jomaa, H., Nakamura, I. and Maisch, B. (1994) "Coxsackievirus B3 infection leads to cell death of cardiac myocytes", J. MoL Cell. CardioL 26, 907–913.
   Google Scholar
• Hofschneider, PH., Klingel, K. and Kandolf, R. (1990) "Toward understanding the pathogenesis of enterovirus-induced cardio-myopathy: molecular and ultrastructural approaches", J. Struct. Biol. 104, 32–37.
   Google Scholar
• Klingel, K. and Kandolf, R. (1993) "The role of enterovirus replication in the development of acute and chronic heart muscle disease in different immunocompetent mouse strains", Scand. J. Infect. Dis. SuppL 88, 79–85.
   Google Scholar
• Gomez, R.M., Lopez Costa, J.J., Pecci Saavedra, G. and Berria, M.I. (1993) "Ultrastructural study of cell injury induced by coxsackievirus B3 in pancreatic and cardiac tissues", Medicina (B. Aires) 53, 300–306.
   Google Scholar
• McManus, B.M., Chow, L.H., Wilson, J.E., Anderson, DR., Gulizia, J.M., Gauntt, C.J., et al. (1993) "Direct myocardial injury by enterovirus: a central role in the evolution of murine myocarditis", Clin. Immunol. Immunopathol. 68, 159–169.
   PubMedGoogle Scholar
• Chow, L.H., Beisel, K.W. and McManus, B.M. (1992) "Enteroviral infection of mice with severe combined immunodeficiency. Evidence for direct viral pathogenesis of myocardial injury", Lab. Investig. 66, 24–31.
   PubMedGoogle Scholar
• Wong, C.Y., Woodruff, J.J. and Woodruff, J.F. (1977) "Generation of cytotoxic T lymphocytes during coxsackievirus B-3 infection. I. Model and viral specificity", J. Immunol. 118, 1159–1164.
   Google Scholar
• Van Houten, N. and Huber, S.A. (1989) "Role of cytotoxic T cells in experimental myocarditis", Springer Semin. ImmunopathoL 11, 61–68.
   Google Scholar
• Huber, S.A. and Job, LP. (1983) "Cellular immune mechanisms in Coxsackievirus group B, type 3 induced myocarditis in Balb/C mice", Adv. Exp. Med. Biol. 161, 491–508.
   PubMedGoogle Scholar
• Godeny, E.K. and Gauntt, C.J. (1987) "In situ immune autoradiographic identification of cells in heart tissues of mice with coxsackievirus B3-induced myocarditis", Am. J. PathoL 129, 267–276.
   Google Scholar
• Seko, Y., Shinkai, Y., Kawasaki, A., Yagita, H., Okumura, K., Takaku, F., et al. (1991) "Expression of perforin in infiltrating cells in murine hearts with acute myocarditis caused by coxsackievirus B3", Circulation 84, 788–795.
   Google Scholar
• Chen, S.X., Mei, S.W., Bao, S.H., Zheng, X.J., Chang, P.L., Yao, J.S., et al. (1993) "Immunological status and pathology of coxsackie B viral myocarditis and dilated cardiomyopathy", Chin. Med. J. (EngL ) 106, 659–664.
   Google Scholar
• Seko, Y, Tsuchimochi, H., Nakamura, T., Okumura, K., Naito, S., Imataka, K., et al. (1990) "Expression of major histocompatibility complex class I antigen in murine ventricular myocytes infected with Coxsackievirus B3", Circ. Res. 67, 360–367.
   PubMedGoogle Scholar
• Woodruff, J.F. and Woodruff, J.J. (1974) "Involvement of T lymphocytes in the pathogenesis of coxsackie virus B3 heart disease", J. Immunol. 113, 1726–1734.
   PubMed Web of Science ®Google Scholar
• Guthrie, M., Lodge, P.A. and Huber, S.A. (1984) "Cardiac injury in myocarditis induced by Coxsackievirus group B, type 3 in Balb/c mice is mediated by Lyt 2 + cytolytic lymphocytes", Cell. Immunol. 88, 558–567.
   PubMed Web of Science ®Google Scholar
• Hashimoto, I., Tatsumi, M. and Nakagawa, M. (1983) "The role of T lymphocytes in the pathogenesis of Coxsackie virus B3 heart disease", Br. J. Exp. PathoL 64, 497–504.
   PubMedGoogle Scholar
• Ytterberg, SR., Mahowald, M.L. and Messner, R.P. (1988) "T cells are required for coxsackievirus B1 induced murine polymyositis", J. Rheumatol. 15, 475–478.
   PubMedGoogle Scholar
• Kishimoto, C. and Abelmann, W.H. (1990) "In vivo significance of T cells in the development of Coxsackievirus B3 myocarditis in mice. Immature but antigen-specific T cells aggravate cardiac injury", Circ. Res. 67, 589–598.
   Google Scholar
• Mason, J.W., O'Connell, J.B., Herskowitz, A., Rose, N.R., McManus, B.M., Billingham, ME., et al. (1995) "A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators", N. Engl. J. Med. 333, 269–275.
   Google Scholar
• Klingel, K., Schnorr, J.J., Sauter, M., Szalay, G. and Kandolf, R. (2003) 132-microglobulin-associated regulation of interferon-fly and virus-specific immunoglobulin G confer resistance against the development of chronic coxsackievirus myocarditis", Am. J. Pathol. 162, 1709–1720.
   Google Scholar
• Yiyun, C., Yagi, S. and Schnurr, D. (1989) "Persistent infections by coxsackie virus B3", In: Auti, F., ed., Pathogenesis and Control of Viral Infections (Raven Press, New York), pp 105–112.
   Google Scholar
• Matteucci, D., Paglianti, M., Giangregorio, A.M., Capobianchi, MR., Dianzani, F. and Bendinelli, M. (1985) "Group B coxsackieviruses readily establish persistent infections in human lymphoid cell lines", J. ViroL 56, 651–654.
   Google Scholar
• Tam, P.E., Schmidt, A.M., Ytterberg, S.R. and Messner, R.P. (1991) "Viral persistence during the developmental phase of Coxsackievirus Bl-induced murine polymyositis", J. ViroL 65, 6654–6660.
   Google Scholar
• Tam, P.E., Schmidt, A.M., Ytterberg, S.R. and Messner, R.P. (1994) "Duration of virus persistence and its relationship to inflammation in the chronic phase of coxsackievirus Bl-induced murine polymyositis", J. Lab. Clin. Med. 123, 346–356.
   PubMed Web of Science ®Google Scholar
• Tam, P.E. and Messner, R.P. (1999) "Molecular mechanisms of coxsackievirus persistence in chronic inflarmnatory myopathy: viral RNA persists through formation of a double-stranded complex without associated genomic mutations or evolution", J. ViroL 73, 10113–10121.
   PubMed Web of Science ®Google Scholar
• Klingel, K., Hohenadl, C., Canu, A., Albrecht, M., Seemann, M., Mall, G., et al. (1992) "Ongoing enterovirusinduced myocarditis is associated with persistent heart muscle infection: quantitative analysis of virus replication, tissue damage, and inflammation", Proc. Natl Acad. Sci. USA 89, 314–318.
   PubMed Web of Science ®Google Scholar
• Klingel, K., Stephan, S., Sauter, M., Zell, R., McManus, B.M., Bultmann, B., et al. (1996) "Pathogenesis of murine enterovirus myocarditis: virus dissemination and immune cell targets", J. Virol. 70, 8888–8895.
   PubMed Web of Science ®Google Scholar
• Wessely, R., Henke, A., Zell, R., Kandolf, R. and Knowlton, KU. (1998) "Low-level expression of a mutant coxsackieviral cDNA induces a myocytopathic effect in culture: an approach to the study of enteroviral persistence in cardiac myocytes", Circulation 98, 450–457.
   Google Scholar
• Wessely, R., Klingel, K., Santana, L.F., Dalton, N., Hongo, M., Jonathan, LW., et al. (1998) "Transgenic expression of replication-restricted enteroviral genomes in heart muscle induces defective excitation-contraction coupling and dilated cardio-myopathy", J. Clin. Investig. 102, 1444–1453.
   PubMedGoogle Scholar
• Eremenko, T., Benedetto, A. and Volpe, P. (1972) "Virus infection as a function of the host cell life cycle: replication of poliovirus RNA", J. Gen. Virol. 16, 61–68.
   Google Scholar
• Lake, R.S., Winkler, D.C. and Ludwig, E.H. (1970) "Delay of mengovirus-induced cytopathology in mitotic L cells", J. Virol. 5, 262–263.
   Google Scholar
• Mallucci, L., Wells, V. and Beare, D. (1985) "Cell cycle position and expression of encephalomyocarditis virus in mouse embryo fibroblasts", J. Gen. Virol. 66, 1501–1506.
   Google Scholar
• Suarez, M., Contreras, G. and Fridlender, B. (1975) "Multipli-cation of Coxsackie B1 virus in synchronized HeLa cells", J. Virol. 16, 1337–1339.
   Google Scholar
• Op De Beeck, A. and Caillet-Fauquet, P. (1997) "Viruses and the cell cycle", Prog. Cell Cycle Res. 3, 1–19.
   Google Scholar
• Swanton, C. and Jones, N. (2001) "Strategies in subversion: de-regulation of the mammalian cell cycle by viral gene products", Int. J. Exp. Pathol. 82, 3–13.
   Google Scholar
• Feuer, R., Mena, I., Pagarigan, R.R., Slifka, M.K. and Whitton, J.L. (2002) "Cell cycle status affects coxsackievirus replication, persistence, and reactivation in vitro", J. Virol. 76, 4430–4440.
   PubMed Web of Science ®Google Scholar
• Fujioka, S., Kitaura, Y, Ukimura, A., Deguchi, H., Kawamura, K., Isomura, T., et al. (2000) "Evaluation of viral infection in the myocardium of patients with idiopathic dilated cardiomyopathy", J. Am. Coll. Cardiol. 36, 1920–1926.
   PubMedGoogle Scholar
• Li, Y, Peng, T., Y, Yang, Niu, C., Archard, L.C. and Zhang, H. (2000) "High prevalence of enteroviral genomic sequences in myocardium from cases of endemic cardiomyopathy (Keshan disease) in China", Heart 83, 696–701.
   PubMed Web of Science ®Google Scholar
• Archard, L.C., Khan, M.A., Soteriou, B.A., Zhang, H., Why, H.J., Robinson, N.M., et al. (1998) "Characterization of Coxsackie B virus RNA in myocardium from patients with dilated cardiomyo-pathy by nucleotide sequencing of reverse transcription-nested polymerase chain reaction products", Hum. Pathol. 29, 578–584.
   PubMed Web of Science ®Google Scholar
• Destombes, J., Couderc, T., Thiesson, D., Girard, S., Wilt, S.G. and Blondel, B. (1997) "Persistent poliovirus infection in mouse motoneurons", J. Virol. 71, 1621–1628.
   PubMedGoogle Scholar
• Liu, P., Aitken, K., Kong, Y.Y., Opavsky, M.A., Martino, T., Dawood, F., et al. (2000) "The tyrosine kinase p561ck is essential in coxsackievirus B3-mediated heart disease", Nat. Med. 6, 429–434.
   PubMed Web of Science ®Google Scholar
• Opavsky, MA., Martino, T., Rabinovitch, M., Penninger, J., Richardson, C., Petric, M., et al. (2002) "Enhanced ERK-1/2 activation in mice susceptible to coxsackievirus-induced myo-carditis", J. Clin. Investig. 109, 1561–1569.
   PubMed Web of Science ®Google Scholar
• Brodsky, V.Y., Sarkisov, D.S., Arefyeva, A.M. and Panova, N.W. (1993) "DNA and protein relations in cardiomyocytes. Growth reserve in cardiac muscle", Eur. J. Histochem. 37, 199–206.
   Google Scholar
• Pilipenko, E.V., Pestova, TN., Kolupaeva, V.G., Khitrina, E.V., Poperechnaya, A.N., Agol, V.I., et al. (2000) "A cell cycle-dependent protein serves as a template-specific translation initiation factor", Genes Dev. 14, 2028–2045.
   PubMed Web of Science ®Google Scholar
• Venkatesan, A., Sharma, R. and Dasgupta, A. (2003) "Cell cycle regulation of hepatitis C and encephalomyocarditis virus internal ribosome entry site-mediated translation in human embryonic kidney 293 cells", Virus Res. 94, 85–95.
   PubMedGoogle Scholar
• Pyronnet, S., Pradayrol, L. and Sonenberg, N. (2000) "A cell cycle-dependent internal ribosome entry site", MoL Cell 5, 607–616.
   PubMed Web of Science ®Google Scholar
• Teubner, A., Tillmann, H.L., Schuppan, D., Gericke, G., Maims, M.P. and Stolzel, U. (2002) "Prevalence of circulating autoanti-bodies in healthy individuals", Med. KlM. (Munich) 97, 645–649.
   Google Scholar
• Srinivasappa, J., Saegusa, J., Prabhakar, B.S., Gentry, M.K., Buchmeier, M.J., Wiktor, T.J., et al. (1986) "Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues", J. Virol. 57, 397–401.
   PubMed Web of Science ®Google Scholar
• Kuan, A.P., Chamberlain, W., Malkiel, S., Lieu, H.D., Factor, S.M., Diamond, B., et al. (1999) "Genetic control of autoimmune myocarditis mediated by myosin-specific antibodies", Immuno-genetics 49, 79–85.
   Google Scholar
• Fairfax, A.J. and Groschel-Stewart, U. (1977) "Myosin autoanti-bodies detected by immunofluorescence", Clin. Exp. Immunol. 28, 27–34.
   Google Scholar
• Gauntt, C. and Huber, S.A. (2003) "Coxsackievirus experimental heart diseases", Front Biosci. 8, e23—e35.
   Google Scholar
• Pankuweit, S., Portig, I., Lottspeich, F. and Maisch, B. (1997) "Autoantibodies in sera of patients with myocarditis: characterization of the corresponding proteins by isoelectric focusing and N-terminal sequence analysis", J. MoL Cell. CardioL 29, 77–84.
   PubMedGoogle Scholar
• Wolfgram, L.J., Beisel, K.W. and Rose, N.R. (1985) "Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis", J. Exp. Med. 161, 1112–1121.
   PubMed Web of Science ®Google Scholar
• Neu, N., Craig, S.W., Rose, N.R., Alvarez, F. and Beisel, K.W. (1987) "Coxsackievirus induced myocarditis in mice: cardiac myosin autoantibodies do not cross-react with the virus", Clin. Exp. Immunol. 69, 566–574.
   PubMed Web of Science ®Google Scholar
• Neu, N., Rose, N.R., Beisel, K.W., Herskowitz, A., Gurri-Glass, G. and Craig, S.W. (1987) "Cardiac myosin induces myocarditis in genetically predisposed mice", J. Immunol. 139, 3630–3636.
   PubMed Web of Science ®Google Scholar
• Neu, N., Ploier, B. and Ofner, C. (1990) "Cardiac myosin-induced myocarditis. Heart autoantibodies are not involved in the induction of the disease", J. Immunol. 145, 4094–4100.
   PubMed Web of Science ®Google Scholar
• Neu, N. and Ploier, B. (1991) "Experimentally-induced auto-immune myocarditis: production of heart myosinspecific auto-antibodies within the inflammatory infiltrate", Autoimmunity 8, 317–322.
   PubMed Web of Science ®Google Scholar
• Tam, P.E., Fontana, D.R. and Messner, R.P. (2003) "Coxsackie-virus Bl-induced chronic inflammatory myopathy: differences in induction of autoantibodies to muscle and nuclear antigens by cloned myopathic and amyopathic viruses", J. Lab. Clin. Med. 142, 196–204.
   Google Scholar
• Fairweather, D., Kaya, Z., Shellam, G.R., Lawson, C.M. and Rose, N.R. (2001) "From infection to autoimmunity", J. Autoimmun. 16, 175–186.
   PubMed Web of Science ®Google Scholar
• Huber, S.A. and Lodge, P.A. (1984) "Coxsackievirus B-3 myocarditis in Balb/c mice. Evidence for autoimmunity to myocyte antigens", Am. J. Pathol. 116, 21–29.
   Google Scholar
• Huber, S.A., Lyden, D.C. and Lodge, P.A. (1985) "Immunopatho-genesis of experimental Coxsackievirus induced myocarditis: role of autoimmunity", Herz 10, 1–7.
   PubMedGoogle Scholar
• Estrin, M. and Huber, S.A. (1987) "Autoimmunity is L3T4+ T helper cell and IL-2 independent in BALB/c mice", Am. J. Pathol. 127, 335–341.
   PubMedGoogle Scholar
• Neu, N., Pummerer, C., Rieker, T. and Berger, P. (1993) "T cells in cardiac myosin-induced myocarditis", Clin. Immunol. Immuno-pathol. 68, 107–110.
   Google Scholar
• Neu, N., Klieber, R., Fruhwirth, M. and Berger, P. (1991) "Cardiac myosin-induced myocarditis as a model of postinfectious autoimmunity", Eur. Heart J. 12, 117–120.
   Google Scholar
• Donermeyer, D.L., Beisel, K.W., Allen, P.M. and Smith, S.C. (1995) "Myocarditis-inducing epitope of myosin binds constitu-tively and stably to I-Ak on antigen-presenting cells in the heart", J. Exp. Med. 182, 1291–1300.
   PubMed Web of Science ®Google Scholar
• Pummerer, C.L., Luze, K., Grassl, G., Bachmaier, K., Offner, F., Burrell, S.K., et al. (1996) "Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice", J. Clin. Investig. 97, 2057–2062.
   PubMed Web of Science ®Google Scholar
• Kuhl, A.A., Loddenkemper, C., Westermann, J. and Hoffmann, J.C. (2002) "Role of gamma delta T cells in inflammatory bowel disease", Pathobiology 70, 150–155.
   Google Scholar
• Mukasa, A., Born, W.K. and O'Brien, R.L. (1999) "Inflammation alone evokes the response of a TCR-invariant mouse gamma delta T cell subset", J. Immunol. 162, 4910–4913.
   Google Scholar
• Jameson, J., Ugarte, K., Chen, N., Yachi, P., Fuchs, E., Boismenu, R., et al. (2002) "A role for skin 'N/8 T cells in wound repair", Science 296, 747–749.
   PubMed Web of Science ®Google Scholar
• Jameson, J., Witherden, D. and Havran, W.L. (2003) "T-cell effector mechanisms: y8 and CD id-restricted subsets", Curr. Opin. Immunol. 15, 349–353.
   PubMed Web of Science ®Google Scholar
• Huber, S.A. (2000) "T cells expressing the gamma delta T cell receptor induce apoptosis in cardiac myocytes", Cardiovasc. Res. 45, 579–587.
   Google Scholar
• Huber, S.A., Graveline, D., Newell, M.K., Born, W.K. and O'Brien, RI. (2000) "V-y1 + T cells suppress and Vy4+ T cells promote susceptibility to coxsackievirus B3-induced myocarditis in mice", J. Immunol. 165, 4174–4181.
   Google Scholar
• Huber, S.A., Sartini, D. and Exley, M. (2002) "Vy4+ T cells promote autoimmune CD8+ cytolytic T-lymphocyte activation in coxsackievirus B3-induced myocarditis in mice: role for CD4+ Th 1 cells", J. ViroL 76, 10785–10790.
   PubMedGoogle Scholar
• Gnarpe, H., Gnarpe, J., Gastrin, B. and Hallander, H. (1997) "Chlamydia pneumoniae and myocarditis", Scand. J. Infect. Dis. SuppL 104, 50–52.
   Google Scholar
• Ellis, R.W. (1997) "Infection and coronary heart disease", J. Med. Microbiol. 46, 535–539.
   PubMed Web of Science ®Google Scholar
• Caligiuri, G., Rottenberg, M., Nicoletti, A., Wigzell, H. and Hansson, G.K. (2001) "Chlamydia pneumoniae infection does not induce or modify atherosclerosis in mice", Circulation 103, 2834–2838.
   PubMed Web of Science ®Google Scholar
• Blessing, E., Lin, TM., Campbell, L.A., Rosenfeld, ME., Lloyd, D. and Kuo, C. (2000) "Chlamydia pneumoniae induces inflammatory changes in the heart and aorta of normocholestero-lemic C57BL/6J mice", Infect. Immun. 68, 4765–4768.
   PubMed Web of Science ®Google Scholar
• Smieja, M., Cronin, L., Levine, M., Goldsmith, C.H., Yusuf, S. and Mahony, J.B. (2001) "Previous exposure to Chlamydia pneumo-niae, Helicobacter pylori and other infections in Canadian patients with ischemic heart disease", Can. J. CardioL 17, 270–276.
   Google Scholar
• Wald, N.J., Law, M.R., Morris, J.K., Thou, X., Wong, Y. and Ward, ME. (2000) "Chlamydia pneumoniae infection and mortality from ischaemic heart disease: large prospective study", BMJ 321, 204–207.
   PubMed Web of Science ®Google Scholar
• Bachmaier, K., Neu, N., de la Maza, L.M., Pal, S., Hessel, A. and Penninger, J.M. (1999) "Chlamydia infections and heart disease linked through antigenic mimicry", Science 283, 1335–1339.
   PubMed Web of Science ®Google Scholar
• Bengtsson, E., Birke, G. and Wingstrand, H. (1951) "Acute non-specific myocarditis in scarlet fever and acute haemolytic tonsillitis. A clinical investigation of 3,069 cases of scarlet fever, 798 cases of acute tonsillitis, and 333 cases of haemolytic streptococcus carriers", Cardiologia 18, 360–374.
   PubMedGoogle Scholar
• Friedman, I., Laufer, A., Ron, N. and Davies, A.M. (1971) "Experimental myocarditis: in vitro and in vivo studies of lymphocytes sensitized to heart extracts and group A strepto-cocci", Immunology 20, 225–232.
   Google Scholar
• Cunningham, M.W. (2003) "Autoimmunity and molecular mimicry in the pathogenesis of post-streptococcal heart disease", Front Biosci. 8, S533—S543.
   Google Scholar
• Benoist, C. and Mathis, D. (2001) "Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?", Nat. Immunol. 2, 797–801.
   PubMed Web of Science ®Google Scholar
• Huber, S.A. and Cunningham, M.W. (1996) "Strepto-coccal M.protein peptide with similarity to myosin induces CD4+ T cell-dependent myocarditis in MRL/+ +mice and induces partial tolerance against coxsaldeviral myocarditis", J. Immunol. 156, 3528–3534.
   PubMedGoogle Scholar
• Quinn, A., Kosanke, S., Fischetti, V.A., Factor, S.M. and Cunningham, M.W. (2001) "Induction of autoimmune valvular heart disease by recombinant streptococcal M protein", Infect. Immun. 69, 4072–4078.
   PubMed Web of Science ®Google Scholar
• Galvin, J.E., Hemric, M.E., Kosanke, S.D., Factor, S.M., Quinn, A. and Cunningham, nvv. (2002) "Induction of myocarditis and valvulitis in Lewis rats by different epitopes of cardiac myosin and its implications in rheumatic carditis", Am. J. PathoL 160, 297–306.
   PubMed Web of Science ®Google Scholar
• Ohanian, S.H. and Schwab, J.H. (1967) "Persistence of group a streptococcal cell walls related to chronic inflammation of rabbit dermal connective tissue", J. Exp. Med. 125, 1137–1148.
   PubMed Web of Science ®Google Scholar
• Medina, E., Goldmann, 0., Toppel, A.W. and Chhatwal, G.S. (2003) "Survival of Streptococcus pyogenes within host phagocytic cells: a pathogenic mechanism for persistence and systemic invasion", J. Infect. Dis. 187, 597–603.
   Google Scholar
• Branger, S., Casalta, IP., Habib, G., Collard, F. and Raoult, D. (2003) "Streptococcus pneumoniae endocarditis: persistence of DNA on heart valve material 7 years after infectious episode", J. Clin. Microbiol. 41, 4435–4437.
   PubMed Web of Science ®Google Scholar
• Okada, N., Liszewski, M.K., Atkinson, J.P. and Caparon, M. (1995) "Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus", Proc. Natl Acad. Sci. USA 92, 2489–2493.
   PubMed Web of Science ®Google Scholar
• McQuaid, S. and Cosby, S.L. (2002) "An immunohistochemical study of the distribution of the measles virus receptors, CD46 and SLAM, in normal human tissues and subacute sclerosing panencephalitis", Lab. Investig. 82, 403–409.
   PubMed Web of Science ®Google Scholar
• Ziegler, M., Ziegler, B., Hehmke, B., Dietz, H., Hildmann, W. and Kauert, C. (1984) "Autoimmune response directed to pancreatic beta cells in rats induced by combined treatment with low doses of streptozotocin and complete Freund's adjuvant", Biomed. Biochim. Acta 43, 675–681.
   Google Scholar
• Ziegler, B., Tietz, S., Kohnert, K.D., Kohler, E., Knospe, S., Kloting, I., et al. (1987) "Genetic control of diabetes induction by complete Freund's adjuvant combined with subdiabetogenic doses of streptozotocin in Lewis rats—evidence for transient cytotoxicity against beta cells", Exp. Clin. EndocrinoL 89, 269–275.
   Google Scholar
• Rolandsson, 0., Haney, M.F., Hagg, E., Biber, B. and Lernmark, A. (2002) "Streptozotocin induced diabetes in minipig: a case report of a possible model for type 1 diabetes?", Autoimmunity 35, 261–264.
   Google Scholar
• Hubsch, R.M., Sulzer, A.J. and Kagan, LG. (1976) "Evaluation of an autoimmune type antibody in the sera of patients with Chagas' disease", J. ParasitoL 62, 523–527.
   Google Scholar
• Kierszenbaum, F. (1999) "Chagas' disease and the autoimmunity hypothesis", Clin. Microbiol. Rev. 12, 210–223.
   PubMed Web of Science ®Google Scholar
• Leon, J.S., Wang, K. and Engman, D.M. (2003) "Myosin autoimmunity is not essential for cardiac inflammation in acute Chagas' disease", J. Immunol. 171, 4271–4277.
   PubMed Web of Science ®Google Scholar
• Kierszenbaum, F. (2003) "Views on the autoimmunity hypothesis for Chagas disease pathogenesis", FEMS Immunol. Med. Microbiol. 37, 1–11.
   Google Scholar
• Leon, J.S. and Engman, D.M. (2003) "The significance of autoimmunity in the pathogenesis of chagas heart disease", Front Biosci. 8, E315—E322.
   Google Scholar
• Zhang, L. and Tarleton, R.L. (1999) "Parasite persistence correlates with disease severity and localization in chronic Chagas' disease", J. Infect. Dis. 180, 480–486.
   PubMed Web of Science ®Google Scholar
• Tarleton, R.L. and Zhang, L. (1999) "Chagas disease etiology: autoimmunity or parasite persistence?", ParasitoL Today 15, 94–99.
   PubMedGoogle Scholar