Molecular Mimicry versus Bystander Activation: Herpetic Stromal Keratitis

References

• Liesegand, T.J. (1999) "Classification of herpes simplex virus keratitis and anterior uveitis", Cornea 18, 127–143.
   Google Scholar
• Liesegand, T.J. (1989) "Epidemiology of ocular herpes simplex. Natural history in Rochester, MN 1950 through 1982", Arch. Ophthalmol. 107, 1160–1165.
   Google Scholar
• Heiligenhaus, A. and Steuhl, KR (1999) "Treatment of HSV-1 stromal keratitis with topical cyclosporine A: a pilot study", Graefe's Arch. Clin. Exp. Ophthalmol. 237, 435–438.
   PubMed Web of Science ®Google Scholar
• Wagner, E.K. and Bloom, D.C. (1997) "Experimental investigation of herpes simplex virus latency", Clin. Microbiol. Rev. 10, 419–443.
   PubMed Web of Science ®Google Scholar
• Garner, LA. and LaVail, J.H. (1999) "Differential anterograde transport of HSV type 1 viral strains in the murine pathway", J. Neurovirol. 5, 140–150.
   Web of Science ®Google Scholar
• Tumpey, TM., Chen, S.-H., Oakes, J.E. and Lausch, RN. (1996) "Neutrophil-mediated suppression of virus replication after herpes simplex virus type 1 infection of the murine cornea", J. Virol. 70, 898–904.
   PubMed Web of Science ®Google Scholar
• Staats, H.F. and Lausch, RN. (1993) "Cytokine expression in vivo during murine herpetic stromal keratitis", J. Immunol. 151, 277–283.
   PubMed Web of Science ®Google Scholar
• Daigle, J. and Carr, D.J.J. (1998) "Androstenediol antagonizes herpes simplex virus type 1-induced encephalitis through the augmentation of type I IFN production", J. Immunol. 160, 3060–3066.
   PubMed Web of Science ®Google Scholar
• Lausch, RN., Chen, S.-H., Tumpey, TM., Su, Y.-H. and Oakes, J.E. (1996) "Early cytokine synthesis in the excised mouse cornea", J. Interferon Cytokine Res. 16, 35–40.
   PubMed Web of Science ®Google Scholar
• Fenton, R.R., Molesworth-Kenyon, S., Oakes, J.E. and Lausch, R.N. (2002) "Linkage of IL-6 with neutrophil chemoattractant expression in virus-induced ocular inflammation", Investig. Ophthalmol. Vis. Sci. 43, 7373–7743.
   Google Scholar
• Thomas, J., Gangappa, S., Kanangat, S. and Rouse, B.T. (1997) "On the essential involvement of neutrophils in the inununopatho-logic disease. Herpetic stromal keratitis", J. Immunol. 158, 1383–1391.
   Google Scholar
• Metcalf, J.F., Hamilton, D.S. and Reichert, R.W. (1976) "Herpetic keratitis in athymic (nude) mice", Infect. Immun. 26, 1164–1171.
   Google Scholar
• Zisman, B., Hirsch, M.S. and Allison, A.C. (1970) "Selective effects of anti-macrophage serum, silica, and anti-lymphocyte serum in pathogenesis of herpes virus infection of young adult mice", J. Immunol. 104, 1155–1159.
   Google Scholar
• Habu, S., Akanatsu, K.I., Tamaoki, N. and Okumura, K. (1984) "In vivo significance of NK cell on resistance against virus (HSV-1) infection in mice", J. Immunol. 133, 2743–2747.
   PubMedGoogle Scholar
• Bauer, K., Mrzyk, S., Van Rooijen, N., Steuhl, K -P. and Heiligenhaus, A. (2001) "Incidence and severity of herpetic stromal keratitis: impaired by the depletion of lymph node macrophages", Exp. Eye Res. 72, 261–269.
   Google Scholar
• Hendricks, R.L., Tumpey, T.M. and Finnegan, A. (1992) "1FN-y and IL-2 are protective in the skin but pathologic in the corneas of HSV-1-infected mice", J. Immunol. 149, 3023–3028.
   PubMed Web of Science ®Google Scholar
• Tang, Q. and Hendricks, R.L. (1996) "Interferon-'y regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas", J. Exp. Med. 184, 1435–1447.
   PubMed Web of Science ®Google Scholar
• Bouley, D.M., Kanangat, S., Wire, W. and Rouse, B.T. (1995) "Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-'y knockout mice", J. Immunol. 155, 3964–3971.
   PubMed Web of Science ®Google Scholar
• Tang, Q., Chen, W. and Hendricks, R.L. (1997) "Proinflammatory functions of IL-2 in herpes simplex virus corneal infection", J. Immunol. 158, 1275–1283.
   PubMed Web of Science ®Google Scholar
• Tough, D.F., Borrow, P. and Sprent, J. (1996) "Induction of bystander T cell proliferation by viruses and type I interferon in vivo", Science 272, 1947–1950.
   Google Scholar
• LeBon, A., Etchart, N., Rossmann, C., Ashton, M., Hou, S., Gewert, D., Borrow, P. and Tough, D.F. (2003) "Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon", Nat. Immunol. 4, 1009–1015.
   Google Scholar
• Samuel, C.E. (1991) "Antiviral actions of interferon. Interferon-regulated cellular proteins and their surprisingly selective antiviral activities", Virology 183, 1–11.
   PubMed Web of Science ®Google Scholar
• Babu, J.S., Thomas, J., Kanangat, S., Morrison, L.A., Knipe, D.M. and Rouse, B.T. (1996) "Viral replication is required for induction of ocular immunopathology by herpes simplex virus", J. Virol. 70, 101–107.
   PubMed Web of Science ®Google Scholar
• Hendricks, R.L., Janowicz, M. and Tumpey, T.M. (1992) "Critical role of corneal Langerhans cells in the CD4 — but not CD8-mediated immunopathology in herpes simplex virus-1-infected mouse corneas", J. Immunol. 148, 2522–2529.
   PubMed Web of Science ®Google Scholar
• Biswas, P.S., Banerjee, K., Kim, B. and Rouse, B.T. (2004) "Mice transgenic for IL-1 receptor antagonist protein are resistant to herpetic stromal keratitis: possible role for IL-1 in herpetic stromal keratitis pathogenesis", J. Immunol. 172, 3736–3744.
   PubMed Web of Science ®Google Scholar
• Lee, S., Zheng, M., Kim, B. and Rouse, B.T. (2002) "Role of matrix metalloproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virus", J. Clin. Investig. 110, 1105–1111.
   PubMed Web of Science ®Google Scholar
• Zheng, M., Deshpande, S., Lee, S., Ferrara, N. and Rouse, B.T. (2001) "Contribution of vascular endothelial growth factor in the neovascularization process during the pathogenesis of herpetic stromal keratitis", J. Virol. 75, 9828–9835.
   PubMed Web of Science ®Google Scholar
• Zheng, M., Klinman, D.M., Gierynska, M. and Rouse, B.T. (2002) "DNA containing CpG motifs induces angiogenesis", Proc. Natl Acad. Sci. USA. 99, 8944–8949.
   Google Scholar
• Lundberg, P., Welander, P., Han, X. and Cantin, E. (2003) "Herpes simplex virus type 1 DNA is immunostimulatory in vitro and in vivo", J. Virol. 77, 11158–11169.
   PubMedGoogle Scholar
• Mercadal, C.M., Bouley, D.M., DeStephano, D. and Rouse, B.T. (1993) "Herpetic stromal keratitis in the reconstituted scid mouse model", J. Virol. 67, 3404–3408.
   PubMedGoogle Scholar
• Chen, H. and Hendricks, R.L. (1998) "B7 costimulatory requirements of T cells at an inflammatory site", J. Immunol. 160, 5045–5052.
   PubMed Web of Science ®Google Scholar
• Seo, S.K., Gebhardt, B.M., Lim, H.Y., Kang, S.W., Higald, S., Varnell, E.D., Hill, J.M., Kaufman, H.E. and Kwon, B.S. (2001) "Murine keratocytes function as antigen-presenting cells", Eur. J. Immunol. 31, 3318–3328.
   PubMed Web of Science ®Google Scholar
• Seo, S.K., Park, H.Y., Choi, J.H., Kim, W.Y., Kim, Y.H., Jung, H.W., Kwon, B.S., Lee, H.W. and Kwon, B.S. (2003) "Blocking 4-1BB/4-1BB ligand interactions prevents herpetic stromal keratitis", J. Immunol. 171, 576–583.
   PubMed Web of Science ®Google Scholar
• Carr, D.J.J., Chodosh, J., Ash, J. and Lane, T.E. (2003) "Effect of anti-CXCL10 monoclonal antibody on herpes simplex virus type 1 keratitis and retinal infection", J. Virol. 77, 10037–10046.
   Google Scholar
• Halford, W.P., Gebhardt, B.M. and Carr, D.J.J. (1996) "Persistent cytokine expression in trigeminal ganglion latently infected with herpes simplex virus type 1", J. Virol. 157, 3542–3549.
   Google Scholar
• Streilein, J.W., Dana, MR. and Ksander, B.R. (1997) "Immunity causing blindness: five different paths to herpes stromal keratitis", Immunol. Today 18, 443–449.
   PubMedGoogle Scholar
• Deshpande, S.P., Zheng, M., Daheshia, M. and Rouse, B.T. (2000) "Pathogenesis of herpes simplex virus-induced ocular immuno-inflammatory lesions in B-cell-defienct mice", J. Virol. 74, 3517–3524.
   Google Scholar
• Maggs, D.J., Chang, E., Nasisse, M.P. and Mitchell, W.J. (1998) "Persistence of herpes simplex virus type 1 DNA in chronic conjunctival and eyelid lesions of mice", J. Virol. 72, 9166–9172.
   Google Scholar
• Gangappa, S., Babu, J.S., Thomas, J., Daheshia, M. and Rouse, B.T. (1998) "Virus-induced immunoinflanunatory lesions in the absence of viral antigen recognition", J. Immunol. 161, 4289–4300.
   PubMedGoogle Scholar
• Welsh, R.M., McNally, J.M., Brehm, MA. and Selin, L.K. (2000) "Consequences of cross-reactive and bystander CTL responses during viral infections", Virology 270, 4–8.
   PubMedGoogle Scholar
• Foster, D.S., Tsai, Y, Monroe, J.G., Campbell, R.C., Destari, M., Knipe, D. and Greene, M.I. (1986) "Genetic studies on murine susceptibility to herpes simplex keratitis", Clin. Immunol. Immunopathol. 40, 313–325.
   PubMedGoogle Scholar
• Avery, A.C., Zhao, Z.-S., Rodriguez, A., Bikoff, E.K., Soheilian, M., Foster, C.S. and Cantor, H. (1995) "Resistance to herpes stromal keratitis conferred by an IgG2a-derived peptide", Nature 376, 431–434.
   PubMedGoogle Scholar
• Zhao, Z.-S., Granucci, F., Yeh, L., Schaffer, P.A. and Cantor, H. (1998) "Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after viral infection", Science 279, 1344–1347.
   PubMed Web of Science ®Google Scholar
• Panoutsakopoulou, V., Sanchirico, ME., Huster, KM., Jansson, M., Granucci, F., Shim, D.J., Wucherpfennig, K.W. and Cantor, H. (2001) "Analysis of the relationship between viral infection and autoinunune disease", Immunity 15, 137–147.
   PubMed Web of Science ®Google Scholar
• Thomas, J. and Rouse, B.T. (1998) "Immunopathology of herpetic stromal keratitis: discordance in CD4+ T cell function between euthymic host and reconstituted SC1D recipients", J. Immunol. 160, 3965–3970.
   Google Scholar
• Koelle, D.M., Reymond, S.N., Chen, H., Kwok, W.W., McClurkan, C., Gyaltsong, T., Petersdorf, E.W., Rotkis, W., Talley, A.R. and Harrison, D.A. (2000) "Tegument-specific, virus-reactive CD4 T cells localize to the cornea in herpes simplex virus interstial keratitis in humans", J. Virol. 74, 10930–10938.
   PubMedGoogle Scholar
• Verjans, G.M., Remeijer, L., Mooy, C.M. and Osterhaus, A.D. (2000) "Herpes simplex virus-specific T cells infiltrate the cornea of patients with herpetic stromal keratitis: no evidence for autoreactive cells", Investig. Ophthalmol. Vis. Sci. 41, 2607–2612.
   PubMedGoogle Scholar
• Tsuchiya, N., Williams, Jr, R.G. and Hutt-Fletcher, L.M. (1990) "Rheumatoid factors may bear the internal image of the Fcy-binding protein of herpes simplex virus type 1", J. Immunol. 144, 4742–4748.
   Google Scholar
• Huemer, RP., Wang, Y, Garred, P., Koistinen, V. and Oppermann, S. (1993) "Herpes simplex virus glycoprotein C: molecular mimicry of complement regulatory proteins by a viral protein", Immunology 79, 639–647.
   Google Scholar
• Schwimmbeck, P.L., Dyrberg, T., Drachman, D.B. and Oldstone, M.B.A. (1989) "Molecular mimicry and myasthenia gravis. An autoantigenic site of the acetylcholine receptor alpha-subunit has biologic activity and reacts immunochemically with herpes simplex cirus", J. Clin. Investig. 84, 1174–1180.
   PubMed Web of Science ®Google Scholar
• Dyrberg, T., Petersen, J.S. and Oldstone, M.B.A. (1990) "Immunological cross-reactivity between mimicking epitopes on a virus protein and a human autoantigen depends on a single amino acid residue", Clin. Immunol. Immunopathol. 54, 290–297.
   PubMedGoogle Scholar
• Gebhardt, B.M. (2000) "Evidence for antigenic cross-reactivity between herpesvirus and the acetylcholine receptor", J. Neuroimmunol. 105, 145–153.
   Google Scholar
• Feldman, L.T., Ellison, A.R., Voytek, C.C., Yang, L., Krause, P. and Margolis, T.P. (2002) "Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice", Proc. Natl Acad. Sci. USA. 99, 978–983.
   PubMed Web of Science ®Google Scholar
• Suvas, S., Kumaraguni, U., Pack, C.D., Lee, S. and Rouse, B.T. (2003) "CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses", J. Exp. Med. 198, 889–901.
   PubMed Web of Science ®Google Scholar
• Daheshia, M., Kuklin, N., Kanangat, S., Manickan, E. and Rouse, B.T. (1997) "Suppression of ongoing ocular inflammatory disease by topical administration of plasmid DNA encoding rIL-10", J. Immunol. 159, 1945–1952.
   PubMed Web of Science ®Google Scholar
• Wasmuth, S., Bauer, D., Yang, Y, Steuhl, K.-P. and Heiligenhaus, A. (2003) "Topical treatment with antisense oligonucleotides targeting tumor necrosis factor-a in herpetic stromal keratitis", Investig. Ophthalmol. Vis. Sci. 44, 5228–5234.
   Google Scholar