Effects of polyinosinic-polycytidylic acid and adoptive transfer of immune cells in the LEW.1AR1-iddm rat and in its coisogenic LEW.1AR1 background strain

References

• Leiter EH, Prochazka M, Coleman DL. The non-obese diabetic (NOD) mouse. Am J Pathol 1987; 128: 380–383
   PubMed Web of Science ®Google Scholar
• Wong FS, Janeway CA, Jr. Insulin-dependent diabetes mellitus and its animal models. Curr Opin Immunol 1999; 11: 643–647
   PubMed Web of Science ®Google Scholar
• Lally FJ, Bone AJ. Animal models of type 1 diabetes. Textbook of Diabetes, JC Pickup, G Williams. Blackwell Scienific Publications, Oxford 2003; Vol. 2: 19.1–19.17
   Google Scholar
• Wicker LS, Miller BJ, Mullen Y. Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice. Diabetes 1986; 35: 855–860
   PubMed Web of Science ®Google Scholar
• Bendelac A, Carnaud C, Boitard C, Bach JF. Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells. J Exp Med 1987; 166: 823–832
   PubMed Web of Science ®Google Scholar
• Greiner DL, Mordes JP, Handler ES, Angelillo M, Nakamura N, Rossini AA. Depletion of RT6.1+ T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats. J Exp Med 1987; 166: 461–475
   PubMed Web of Science ®Google Scholar
• Logothetopoulos J, Valiquette N, MacGregor D, Hsia T. Adoptive transfer of insulitis and diabetes in neonates of diabetes-prone and -resistant rats. Tissue localization of injected blasts. Diabetes 1987; 36: 1116–1123
   PubMed Web of Science ®Google Scholar
• Leiter EH, Serreze DV, Prochazka M. The genetics and epidemiology of diabetes in NOD mice. Immunol Today 1990; 11: 147–149
   PubMedGoogle Scholar
• Whalen BJ, Greiner DL, Mordes JP, Rossini AA. Adoptive transfer of autoimmune diabetes mellitus to athymic rats: Synergy of CD4+ and CD8+ T cells and prevention by RT6+ T cells. J Autoimmun 1994; 7: 819–831
   PubMed Web of Science ®Google Scholar
• Jacob HJ, Pettersson A, Wilson D, Mao Y, Lernmark A, Lander ES. Genetic dissection of autoimmune type I diabetes in the BB rat. Nat Genet 1992; 2: 56–60
   PubMed Web of Science ®Google Scholar
• MacMurray AJ, Moralejo DH, Kwitek AE, Rutledge EA, Van Yserloo B, Gohlke P, et al. Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome Res 2002; 12: 1029–1039
   PubMed Web of Science ®Google Scholar
• Hornum L, Romer J, Markholst H. The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1. Diabetes 2002; 51: 1972–1979
   PubMed Web of Science ®Google Scholar
• Moralejo DH, Park HA, Speros SJ, MacMurray AJ, Kwitek AE, Jacob HJ, et al. Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat. J Autoimmun 2003; 21: 315–324
   PubMed Web of Science ®Google Scholar
• Ramanathan S, Poussier P. BB rat lyp mutation and Type 1 diabetes. Immunol Rev 2001; 184: 161–171
   PubMed Web of Science ®Google Scholar
• Markholst H, Eastman S, Wilson D, Andreasen BE, Lernmark A. Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes. J Exp Med 1991; 174: 297–300
   PubMed Web of Science ®Google Scholar
• Klaff LS, Koike G, Jiang J, Wang Y, Bieg S, Pettersson A, et al. BB rat diabetes susceptibility and body weight regulation genes colocalize on chromosome 2. Mamm Genome 1999; 10: 883–887
   PubMed Web of Science ®Google Scholar
• Serreze DV, Gaskins HR, Leiter EH. Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice. J Immunol 1993; 150: 2534–2543
   PubMed Web of Science ®Google Scholar
• Piganelli JD, Martin T, Haskins K. Splenic macrophages from the NOD mouse are defective in the ability to present antigen. Diabetes 1998; 47: 1212–1218
   PubMed Web of Science ®Google Scholar
• Dahlen E, Hedlund G, Dawe K. Low CD86 expression in the nonobese diabetic mouse results in the impairment of both T cell activation and CTLA-4 up-regulation. J Immunol 2000; 164: 2444–2456
   PubMed Web of Science ®Google Scholar
• Hernandez-Hoyos G, Joseph S, Miller NG, Butcher GW. The lymphopenia mutation of the BB rat causes inappropriate apoptosis of mature thymocytes. Eur J Immunol 1999; 29: 1832–1841
   PubMed Web of Science ®Google Scholar
• Joseph S, Diamond AG, Smith W, Baird JD, Butcher GW. BB-DR/Edinburgh: A lymphopenic, non-diabetic subline of BB rats. Immunology 1993; 78: 318–328
   PubMed Web of Science ®Google Scholar
• Solomon M, Sarvetnick N. The pathogenesis of diabetes in the NOD mouse. Adv Immunol 2004; 84: 239–264
   PubMed Web of Science ®Google Scholar
• Lenzen S, Tiedge M, Elsner M, Lortz S, Weiss H, Jorns A, et al. The LEW.1AR1/Ztm-iddm rat: A new model of spontaneous insulin-dependent diabetes mellitus. Diabetologia 2001; 44: 1189–1196
   PubMed Web of Science ®Google Scholar
• Ellerman KE, Like AA. Susceptibility to diabetes is widely distributed in normal class IIu haplotype rats. Diabetologia 2000; 43: 890–898
   PubMed Web of Science ®Google Scholar
• Schumann G, Schnebli HP, Dukor P. Selective stimulation of mouse lymphocyte populations by lectins. Int Arch Allergy Appl Immunol 1973; 45: 331–340
   PubMedGoogle Scholar
• Kunstyr I. Diagnostic microbiology for laboratory animals. Gustav Fischer Verlag, Stuttgart 1992
   Google Scholar
• Hedrich HJ. Genetic monitoring of inbred strains of rat. Gustav Fischer Verlag, Stuttgart 1990
   Google Scholar
• Jörns A. Immunocytochemical and ultrastructural heterogeneities of normal and glibenclamide stimulated pancreatic beta cells in the rat. Virchows Arch 1994; 425: 305–313
   PubMed Web of Science ®Google Scholar
• Jörns A, Tiedge M, Sickel E, Lenzen S. Loss of GLUT2 glucose transporter expression in pancreatic beta cells from diabetic Chinese hamsters. Virchows Arch 1996; 428: 177–185
   PubMed Web of Science ®Google Scholar
• Hsu SM, Raine L, Fanger H. Use of avidin–biotin–peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 1981; 29: 577–580
   PubMed Web of Science ®Google Scholar
• Jörns A, Kubat B, Tiedge M, Wedekind D, Hedrich HJ, Kloppel G, et al. Pathology of the pancreas and other organs in the diabetic LEW.1AR1/Ztm-iddm rat, a new model of spontaneous insulin-dependent diabetes mellitus. Virchows Arch 2004; 444: 183–189
   PubMed Web of Science ®Google Scholar
• Liu D, Darville M, Eizirik DL. Double-stranded ribonucleic acid (RNA) induces beta-cell Fas messenger RNA expression and increases cytokine-induced beta-cell apoptosis. Endocrinology 2001; 142: 2593–2599
   PubMed Web of Science ®Google Scholar
• Sobel DO, Ewel CH, Zeligs B, Abbassi V, Rossio J, Bellanti JA. Poly I:C induction of alpha-interferon in the diabetes-prone BB and normal Wistar rats. Dose-response relationships. Diabetes 1994; 43: 518–522
   PubMed Web of Science ®Google Scholar
• Tough DF, Borrow P, Sprent J. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 1996; 272: 1947–1950
   PubMed Web of Science ®Google Scholar
• Ewel CH, Sobel DO, Zeligs BJ, Bellanti JA. Poly I:C accelerates development of diabetes mellitus in diabetes-prone BB rat. Diabetes 1992; 41: 1016–1021
   PubMed Web of Science ®Google Scholar
• Serreze DV, Hamaguchi K, Leiter EH. Immunostimulation circumvents diabetes in NOD/Lt mice. J Autoimmun 1989; 2: 759–776
   PubMed Web of Science ®Google Scholar
• Moriyama H, Wen L, Abiru N, Liu E, Yu L, Miao D, et al. Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide. Proc Natl Acad Sci USA 2002; 99: 5539–5544
   PubMed Web of Science ®Google Scholar
• Lee MS, Wicker LS, Peterson LB, Sarvetnick N. Pancreatic IL-10 induces diabetes in NOD.B6 Idd3 Idd10 mice. Autoimmunity 1997; 26: 215–221
   PubMed Web of Science ®Google Scholar
• Balasa B, Davies JD, Lee J, Good A, Yeung BT, Sarvetnick N. IL-10 impacts autoimmune diabetes via a CD8+ T cell pathway circumventing the requirement for CD4+ T and B lymphocytes. J Immunol 1998; 161: 4420–4427
   PubMed Web of Science ®Google Scholar
• Falcone M, Sarvetnick N. Cytokines that regulate autoimmune responses. Curr Opin Immunol 1999; 11: 670–676
   PubMed Web of Science ®Google Scholar
• Hill N, Sarvetnick N. Cytokines: Promoters and dampeners of autoimmunity. Curr Opin Immunol 2002; 14: 791–797
   PubMed Web of Science ®Google Scholar
• Arif S, Tree TI, Astill TP, Tremble JM, Bishop AJ, Dayan CM, et al. Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Investig 2004; 113: 451–463
   PubMed Web of Science ®Google Scholar
• Heurtier AH, Boitard C. T-cell regulation in murine and human autoimmune diabetes: The role of TH1 and TH2 cells. Diabetes Metab 1997; 23: 377–385
   PubMed Web of Science ®Google Scholar
• Levings MK, Bacchetta R, Schulz U, Roncarolo MG. The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells. Int Arch Allergy Immunol 2002; 129: 263–276
   PubMed Web of Science ®Google Scholar
• Homann D, von Herrath M. Regulatory T cells and type 1 diabetes. Clin Immunol 2004; 112: 202–209
   PubMed Web of Science ®Google Scholar
• von Herrath M, Homann D. Introducing baselines for therapeutic use of regulatory T cells and cytokines in autoimmunity. Trends Immunol 2003; 24: 540–545
   PubMed Web of Science ®Google Scholar
• McKeever U, Mordes JP, Greiner DL, Appel MC, Rozing J, Handler ES, et al. Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats. Proc Natl Acad Sci USA 1990; 87: 7618–7622
   PubMed Web of Science ®Google Scholar
• Christianson SW, Shultz LD, Leiter EH. Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors. Diabetes 1993; 42: 44–55
   PubMed Web of Science ®Google Scholar
• Sobel DO, Goyal D, Ahvazi B, Yoon JW, Chung YH, Bagg A, et al. Low dose poly I:C prevents diabetes in the diabetes prone BB rat. J Autoimmun 1998; 11: 343–352
   PubMed Web of Science ®Google Scholar
• Metroz-Dayer MD, Mouland A, Brideau C, Duhamel D, Poussier P. Adoptive transfer of diabetes in BB rats induced by CD4 T lymphocytes. Diabetes. 1990; 39: 928–932
   PubMed Web of Science ®Google Scholar
• Yokoi N, Kanazawa M, Kitada K, Tanaka A, Kanazawa Y, Suda S, et al. A non-MHC locus essential for autoimmune type I diabetes in the Komeda diabetes-prone rat. J Clin Investig 1997; 100: 2015–2021
   PubMed Web of Science ®Google Scholar
• Kawano K, Hirashima T, Mori S, Saitoh Y, Kurosumi M, Natori T. New inbred strain of Long-Evans Tokushima lean rats with IDDM without lymphopenia. Diabetes 1991; 40: 1375–1381
   PubMed Web of Science ®Google Scholar
• Mordes JP, Bortell R, Doukas J, Rigby M, Whalen B, Zipris D, et al. The BB/Wor rat and the balance hypothesis of autoimmunity. Diabetes Metab Rev 1996; 12: 103–109
   PubMed Web of Science ®Google Scholar