147
Views
33
CrossRef citations to date
0
Altmetric
Original

T cell abnormalities in systemic lupus erythematosus

, , , , , & show all
Pages 339-346 | Published online: 07 Jul 2009

References

  • Cohen PL. T- and B-cell abnormalities in systemic lupus. J Investig Dermatol 1993; 100: 69s–72s
  • Mills JA. Systemic lupus erythematosus. N Engl J Med 1994; 330: 1871–1879
  • Kevil CG, Bullard DC. Roles of leukocyte/endothelial cell adhesion molecules in the pathognenesis of vasculitis. Am J Med 1999; 106: 677–687
  • Kotzin BL. Systemic lupus erythematosus. Cell 1996; 85: 303–306
  • Dayal AK, Kammer GM. The T cell enigma in lupus. Arthritis Rheum 1996; 39: 23–33
  • Sierakowski S, Kucharz EJ, Lightfoot RW, Goodwin JS. Impaired T-cell activation in patients with systemic lupus erythematosus. J Clin Immunol 1989; 9: 469–476
  • Takeuchi T, Amano K, Sekine H, Koide J, Abe T. Upregulated expression and function of integrin adhesive receptors in systemic lupus erythematosus patients with vasculitis. J Clin Investig 1993; 92: 3008–3016
  • Richardson BC PD, Hooper F, Yung RL, O'Rourke K. Lymphocyte function-associated antigen 1 overexpression and T cell autoreactivity. Arthritis Rheum 1994; 37: 1363–1372
  • Pang M, Abe T, Fujihara T, Mori S, Tsuzaka K, Amano K, Koide J, Takeuchi T. aEb7, a novel integrin adhesion molecule is upregulated on T cells from SLE patients with specific epithelial involvement. Arthritis Rheum 1998; 41: 1456–1463
  • Belmont HM, Buyon J, Giorno R, Abramson S. Up-regulation of endothelial cell adhesion molecules characterizes disease activity in systemic lupus erythematosus. The Shwartzman phenomenon revisited. Arthritis Rheum 1994; 37: 376–383
  • Chen WP, Lin CY. Augmented expression of interleukin-6 and interleukin-1 genes in the mesangium of IgM mesangial nephropathy. Nephron 1994; 68: 10–19
  • Malide D, Russo P, Bendayan M. Presence of tumor necrosis factor alpha and interleukin-6 in renal mesangial cells of lupus nephritis patients. Hum Pathol 1995; 26: 558–564
  • Higgins JM, Mandlebrot DA, Shaw SK, Russell GJ, Murphy EA, Chen YT, Nelson WJ, Parker CM, Brenner MB. Direct and regulated interaction of integrin alphaEbeta7 with E-cadherin. J Cell Biol 1998; 140: 197–210
  • Lohmeyer J, Friedrich J, Grimminger F, Maus U, Tenter R, Morr H, Velcovsky HG, Seeger W, Rosseau S. Expression of mucosa-related integrin alphaEbeta7 on alveolar T cells in interstitial lung diseases. Clin Exp Immunol 1999; 116: 340–346
  • Fujihara T, Fujita H, Tsubota K, Saito K, Tsuzaka K, Abe T, Takeuchi T. Preferntial localization of CD8+aEb7+ T cells around acinar epithelial cells with apoptosis in patients with Sjogren's syndrome. J Immunol 1999; 163: 2226–2235
  • Robinson PW, Green SJ, Carter C, Coadwell J, Kilshaw PJ. Studies on transcriptional regulation of the mucosal T-cell integrin alphaEbeta7 (CD103). Immunology 2001; 103: 146–154
  • Gabor MJ, Sedgwick JD, Lemckert FA, Godfrey DI, Korner H. Lymphotoxin controls alphaEbeta7-integrin expression by peripheral CD8+ T cells. Immunol Cell Biol 2001; 79: 323–331
  • Shaw SK, Brenner MB. The beta 7 integrins in mucosal homing and retention. Semin Immunol 1995; 7: 335–342, Issn: 1044–5323
  • Estess P, DeGrendele HC, Pascual V, Siegelman MH. Functional activation of lymphocyte CD44 in peripheral blood is a marker of autoimmune disease activity. J Clin Investig 1998; 102: 1173–1182
  • Griffiths EK, Penninger JM. Communication between the TCR and integrins: Role of the molecular adapter ADAP/Fyb/Slap. Curr Opin Immunol 2002; 14: 317–322
  • Rossetti G, Collinge M, Bender JR, Molteni R, Pardi R. Integrin-dependent regulation of gene expression in leukocytes. Immunol Rev 2002; 186: 189–207
  • Richardson A, Parsons T. A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK. Nature 1996; 380: 538–540, [erratum appears in Nature 1996 Jun 27;381(6585):810]
  • Parsons JT. Focal adhesion kinase: The first ten years. J Cell Sci 2003; 116: 1409–1416
  • Owens LV, Xu L, Marston WA, Yang X, Farber MA, Iacocca MV, Cance WG, Keagy BA. Overexpression of the focal adhesion kinase (p125FAK) in the vascular smooth muscle cells of intimal hyperplasia. J Vasc Surg 2001; 34: 344–349
  • Kammer GM, Perl A, Richardson BC, Tsokos GC. Abnormal T cell signal transduction in systemic lupus erythematosus. Arthritis Rheum 2002; 46: 1139–1154
  • Takeuchi T, Tsuzaka K, Pang M, Amano K, Koide J, Abe T. TCR zeta chain lacking exon 7 in two patients with systemic lupus erythematosus. Int Immunol 1998; 10: 911–921
  • Liossis SN, Ding XZ, Dennis GJ, Tsokos GC. Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain. J Clin Investig 1998; 101: 1448–1457
  • Takeuchi T, Tsuzaka K, Abe T. Altered expression of the T cell receptor-CD3 complex in systemic lupus erythematosus. Int Rev Immunol 2004; 23: 273–291
  • Pang M, Setoyama Y, Tsuzaka K, Yoshimoto K, Amano K, Abe T, Takeuchi T. Defective expression and tyrosine phosphorylation of T cell receptor zeta chain in peripheral blood T cells from systemic lupus erythematosus patients. Clin Exp Immunol 2002; 129: 160–168
  • Wang L, Bronstein N, Hsu V, Baniyash M. Transcriptional regulation of the murine TCR zeta gene. Int Immunol 1995; 7: 1627–1635
  • Nambiar MP, Enyedy EJ, Warke VG, Krishnan S, Dennis G, Wong HK. T cell signalling abnormalities in systemic lupus erythematosus are associated with increased mutations/polymorphisms and splice variants of T cell receptor zeta chain messenger RNA. Arthritis Rheum 2001; 44: 1336–1350
  • Tsuzaka K, Takeuchi T, Onoda N, Pang M, Abe T. Mutations in T cell receptor zeta chain mRNA of peripheral T cells from systemic lupus erythematosus patients. J Autoimmun 1998; 11: 381–385
  • Nambiar MP, Enyedy EJ, Warke VG, Krishnan S, Dennis G, Kammer GM, Tsokos GC. Polymorphisms/mutations of TCR-zeta-chain promoter and 3′ untranslated region and selective expression of TCR zeta-chain with an alternatively spliced 3′ untranslated region in patients with systemic lupus erythematosus. J Autoimmun 2001; 16: 133–142
  • Baniyash M, Hsu VW, Seldin MF, Klausner RD. The isolation and characterization of the murine T cell antigen receptor zeta chain gene. J Biol Chem 1989; 264: 13252–13257
  • Jin YJ, Clayton LK, Howard FD, Koyasu S, Sieh M, Steinbrich R, Tarr GE, Reinherz EL. Molecular cloning of the CD3 eta subunit identifies a CD3 zeta-related product in thymus-derived cells. Proc Natl Acad Sci USA 1990; 87: 3319–3323
  • Clayton LK, D'Adamio L, Howard FD, Sieh M, Hussey RE, Koyasu S, Reinherz EL. CD3 eta and CD3 zeta are alternatively spliced products of a common genetic locus and are transcriptionally and/or post-transcriptionally regulated during T-cell development. Proc Natl Acad Sci USA 1991; 88: 5202–5206
  • Jensen JP, Hou D, Ramsburg M, Taylor A, Dean M, Weissman AM. Organization of the human T cell receptor zeta/eta gene and its genetic linkage to the Fc gamma RII-Fc gamma RIII gene cluster. J Immunol 1992; 148: 2563–2571
  • Nocentini G, Ronchetti S, Bartoli A, Testa G, D'Adamio F, Riccardi C, Migliorati G. T cell receptor iota an alternatively spliced product of the T cell receptor zeta gene. Eur J Immunol 1995; 25: 1405–1409
  • Malter JS. Posttranscriptional regulation of mRNAs important in T cell function. Adv Immunol 1998; 68: 1–49
  • Santis A, Lopez-Cabrera M, Sanchez-Madrid F, Proudfoot N. Expression of the early lymphocyte activation antigen CD69, a C-type lectin, is regulated by mRNA degradation associated with AU-rich motifs. Eur J Immunol 1995; 25: 2142–2146
  • Ono S, Ohno H, Saito T. Rapid turnover of the CD3 zeta chain independent of the TCR-CD3 complex in normal T cells. Immunity 1995; 2: 639–644
  • Tsuzaka K, Fukuhara I, Setoyama Y, Yoshimoto K, Suzuki K, Abe T, Takeuchi T. TCR zeta mRNA with an alternatively spliced 3′-untranslated region detected in systemic lupus erythematosus patients leads to the down-regulation of TCR zeta and TCR/CD3 complex. J Immunol 2003; 171: 2496–2503
  • Enyedy EJ, Nambiar MP, Liossis SN, Dennis G, Kammer GM, Tsokos GC. Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus. Arthritis Rheum 2001; 44: 1114–1121
  • Tsokos GC. Systemic lupus erythematosus. A disease with a complex pathogenesis. Lancet 2001; 358: S65
  • Tsokos GC, Mitchell JP, Juang YT. T cell abnormalities in human and mouse lupus: Intrinsic and extrinsic. Curr Opin Rheumatol 2003; 15: 542–547
  • Takeuchi T, Pang M, Amano K, Koide J, Abe T. Reduced protein tyrosine phosphatase (PTPase) activity of CD45 on peripheral blood lymphocytes in patients with systemic lupus erythematosus. Clin Exp Immunol 1997; 109: 20–26
  • Nambiar MP, Mitchell JP, Ceruti RP, Malloy MA, Tsokos GC. Prevalence of T cell receptor zeta chain deficiency in systemic lupus erythematosus. Lupus 2003; 12: 46–51
  • Maurice MM, Nakamura H, van der Voort EA, van Vliet AI, Staal FJ, Tak PP, Breedveld FC, Verweij CL. Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis. J Immunol 1997; 158: 1458–1465
  • Gringhuis SI, Papendrecht-van der Voort EA, Leow A, Nivine Levarht EW, Breedveld FC, Verweij CL. Effect of redox balance alterations on cellular localization of LAT and downstream T-cell receptor signalling pathways. Mol Cell Biol 2002; 22: 400–411
  • Nambiar MP, Fisher CU, Enyedy EJ, Warke VG, Krishnan S, Tsokos GC. Heat stress downregulates TCR zeta chain expression in human T lymphocytes. J Cell Biochem 2000; 79: 416–426
  • Isomaki P, Panesar M, Annenkov A, Clark JM, Foxwell BM, Chernajovsky Y, Cope AP. Prolonged exposure of T cells to TNF down-regulates TCR zeta and expression of the TCR/CD3 complex at the cell surface. J Immunol 2001; 166: 5495–5507
  • Aoe T, Okamoto Y, Saito T. Activated macrophages induce structural abnormalities of the T cell receptor-CD3 complex. J Exp Med 1995; 181: 1881–1886
  • Abe T, Takeuchi T. Rheumatoid arthritis and tumor necrosis factor alpha. Autoimmunity 2001; 34: 291–303
  • Feldmann M, Elliott MJ, Woody JN, Maini RN. Anti-tumor necrosis factor-alpha therapy of rheumatoid arthritis. Adv Immunol 1997; 64: 283–350
  • Takeuchi T, Amano K, Kameda H. Anti-TNF biological agents in rheumatoid arthritis and other inflammatory diseases. Int Allergology. 2005
  • Rodriguez PC, Zea AH, Culotta KS, Zabaleta J, Ochoa JB, Ochoa AC. Regulation of T cell receptor CD3 z chain expression by l-arginine. J Biol Chem 2002; 277: 21123–21129
  • Brundula V, Rivas LJ, Blasini AM, Paris M, Salazar S, Stekman IL. Diminished levels of T cell receptor zeta chains in peripheral blood T lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum 1999; 42: 1908–1916
  • Nambiar MP, Fisher CU, Warke VG, Krishnan S, Mitchell JP, Delaney N, Tsokos GC. Reconstitution of deficient T cell receptor zeta chain restores T cell signalling and augments T cell receptor/CD3-induced interleukin-2 production in patients with systemic lupus erythematosus. Arthritis Rheum 2003; 48: 1948–1955
  • Clark JM, Annenkov AE, Panesar M, Isomaki P, Chernajovsky Y, Cope AP. T cell receptor ζ reconstitution fails to restore responses of T cells rendered hyporesponsive by tumor necrosis factor α. Proc Natl Acad Sci USA 2004; 101: 1696–1701
  • Sakaguchi N, Takahashi T, Hata H, Nomura T, Tagami T, Yamazaki S, Sakihama T, Matsutani T, Negishi I, Nakatsuru S, et al. Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature 2003; 426: 454–460

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.