Identification of nuclear spliceosomal antigens targeted by NOD mouse antibodies following sodium iodide intake

References

• Casiano CA, Tan EM. Recent developments in the understanding of antinuclear autoantibodies. Int Arch Allergy Immunol 1996; 111: 308–313
   PubMedGoogle Scholar
• Routsias JG, Tzioufas AG, Moutsopoulos HM. The clinical value of intracellular autoantigens B-cell epitopes in systemic rheumatic diseases. Clin Chim Acta 2004; 340: 1–25
   PubMed Web of Science ®Google Scholar
• Mavragani CP, Tzioufas AG, Moutsopoulos HM. Sjogren's syndrome: Autoantibodies to cellular antigens. Clin Mol Aspects Int Arch Allergy Immunol 2000; 123: 46–57
   PubMedGoogle Scholar
• Humphreys-Beher MG, Yamachika S, Yamamoto H, Maeda N, Nakagawa Y, Peck AB, Robinson CP. Salivary gland changes in the NOD mouse model for Sjogren's syndrome: Is there a non-immune genetic trigger?. Eur J Morphol 1998; 36 (Suppl): 247–251
   PubMedGoogle Scholar
• Skarstein K, Wahren M, Zaura E, Hattori M, Jonsson R. Characterization of T cell receptor repertoire and anti-Ro/SSA autoantibodies in relation to sialadenitis of NOD mice. Autoimmunity 1995; 22: 9–16
   PubMed Web of Science ®Google Scholar
• Baxter AG, Horsfall AC, Healey D, Ozegbe P, Day S, Williams DG, Cooke A. Mycobacteria precipitate an SLE-like syndrome in diabetes-prone NOD mice. Immunology 1994; 83: 227–231
   PubMed Web of Science ®Google Scholar
• Dohan O, De la Vieja A, Paroder V, Riede LC, Artani M, Reed M, Ginter CS, Carrasco N. The sodium/iodide symporter (NIS): Characterization, regulation, and medical significance. Endocr Rev 2003; 24: 48–77
   PubMed Web of Science ®Google Scholar
• De La Vieja A, Dohan O, Levy O, Carrasco N. Molecular analysis of the sodium/iodide symporter: Impact on thyroid and extrathyroid pathophysiology. Physiol Rev 2000; 80: 1083–1105
   PubMed Web of Science ®Google Scholar
• Spitzweg C, Joba W, Schriever K, Goellner JR, Morris JC, Heufelder AE. Analysis of human sodium iodide symporter immunoreactivity in human exocrine glands. J Clin Endocrinol Metab 1999; 84: 4178–4184
   PubMed Web of Science ®Google Scholar
• Hutchings PR, Verma S, Phillips JM, Harach SZ, Howlett S, Cooke A. Both CD4(+) T cells and CD8(+) T cells are required for iodine accelerated thyroiditis in NOD mice. Cell Immunol 1999; 192: 113–121
   PubMed Web of Science ®Google Scholar
• Rose NR, Rasooly L, Saboori AM, Burek CL. Linking iodine with autoimmune thyroiditis. Environ Health Perspect 1999; 107(Suppl 5)749–752
   PubMedGoogle Scholar
• Rasooly L, Burek CL, Rose NR. Iodine-induced autoimmune thyroiditis in NOD-H-2h4 mice. Clin Immunol Immunopathol 1996; 81: 287–292
   PubMedGoogle Scholar
• Kambach C, Walke S, Nagai K. Structure and assembly of the spliceosomal small nuclear ribonucleoprotein particles. Curr Opin Struct Biol 1999; 9: 222–230
   PubMed Web of Science ®Google Scholar
• Rosen A, Casciola-Rosen L. Autoantigens as substrates for apoptotic proteases: Implications for the pathogenesis of systemic autoimmune disease. Cell Death Differ 1999; 6: 6–12
   PubMed Web of Science ®Google Scholar
• Scherly D, Boelens W, Dathan NA, Kambach C, van Venrooij WJ, Mattaj IW. Binding specificity determinants of U1A and U2B″ proteins. Mol Biol Rep 1990; 14: 181–182
   PubMedGoogle Scholar
• Jaekel HP, Klopsch T, Benkenstein B, Grobe N, Baldauf A, Schoessler W, Werle E. Reactivities to the Sm autoantigenic complex and the synthetic SmD1-aa83-119 peptide in systemic lupus erythematosus and other autoimmune diseases. J Autoimmun 2001; 17: 347–354
   PubMedGoogle Scholar
• McClain MT, Ramsland PA, Kaufman KM, James JA. Anti-sm autoantibodies in systemic lupus target highly basic surface structures of complexed spliceosomal autoantigens. J Immunol 2002; 168: 2054–2062
   PubMedGoogle Scholar
• Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Luhrmann R, Li J, Nagai K. Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs. Cell 1999; 96: 375–387
   PubMed Web of Science ®Google Scholar
• Field M, Williams DG, Charles P, Maini RN. Specificity of anti-Sm antibodies by ELISA for systemic lupus erythematosus: Increased sensitivity of detection using purified peptide antigens. Ann Rheum Dis 1988; 47: 820–825
   PubMed Web of Science ®Google Scholar
• Weatherall D, Sarvetnick N, Shizuru JA. Genetic control of diabetes mellitus. Diabetologia 1992; 35(Suppl 2)S1–S7
   PubMed Web of Science ®Google Scholar
• Lerner EA, Lerner MR, Janeway CA, Jr, Steitz JA. Monoclonal antibodies to nucleic acid-containing cellular constituents: Probes for molecular biology and autoimmune disease. Proc Natl Acad Sci USA 1981; 78: 2737–2741
   PubMed Web of Science ®Google Scholar
• Sleeman JE, Lamond AI. Nuclear organization of pre-mRNA splicing factors. Curr Opin Cell Biol 1999; 11: 372–377
   PubMedGoogle Scholar
• Sleeman JE, Lamond AI. Newly assembled snRNPs associate with coiled bodies before speckles, suggesting a nuclear snRNP maturation pathway. Curr Biol 1999; 9: 1065–1074
   PubMed Web of Science ®Google Scholar
• Martin RM, Silva A, Lew AM. The Igh-1 sequence of the non-obese diabetic (NOD) mouse assigns it to the IgG2c isotype. Immunogenetics 1997; 46: 167–168
   PubMedGoogle Scholar
• Martin RM, Brady JL, Lew AM. The need for IgG2c specific antiserum when isotyping antibodies from C57BL/6 and NOD mice. J Immunol Methods 1998; 212: 187–192
   PubMedGoogle Scholar
• Makino S, Kunimoto K, Muraoka Y, Mizushima Y, Katagiri K, Tochino Y. Breeding of a non-obese, diabetic strain of mice. Jikken Dobutsu 1980; 29: 1–13
   PubMedGoogle Scholar
• Perez B, Kraus A, Lopez G, Cifuentes M, Alarcon-Segovia D. Autoimmune thyroid disease in primary Sjogren's syndrome. Am J Med 1995; 99: 480–484
   PubMed Web of Science ®Google Scholar
• Binder A, Maddison PJ, Skinner P, Kurtz A, Isenberg DA. Sjogren's syndrome: Association with type-1 diabetes mellitus. Br J Rheumatol 1989; 28: 518–520
   PubMedGoogle Scholar
• Ban Y, Tomer Y. Susceptibility genes in thyroid autoimmunity. Clin Dev Immunol 2005; 12: 47–58
   PubMedGoogle Scholar
• Rose NR, Bonita R, Burek CL. Iodine: An environmental trigger of thyroiditis. Autoimmun Rev 2002; 1: 97–103
   PubMedGoogle Scholar
• Casiano CA, Tan EM. Antinuclear autoantibodies: Probes for defining proteolytic events associated with apoptosis. Mol Biol Rep 1996; 23: 211–216
   PubMedGoogle Scholar
• Casiano CA, Ochs RL, Tan EM. Distinct cleavage products of nuclear proteins in apoptosis and necrosis revealed by autoantibody probes. Cell Death Differ 1998; 5: 183–190
   PubMed Web of Science ®Google Scholar
• Gordon TP, Kinoshita G, Cavill D, Keech C, Farris A, Kaufman K, McCluskey J, Purcell A. Restricted specificity of intermolecular spreading to endogenous La (SS-B) and 60 kDa Ro (SS-A) in experimental autoimmunity. Scand J Immunol 2002; 56: 168–173
   PubMed Web of Science ®Google Scholar
• Itoh Y, Itoh K, Frank MB, Reichlin M. Autoantibodies to the Ro/SSA autoantigen are conformation dependent. II: Antibodies to the denatured form of 52 kD Ro/SSA are a cross reacting subset of antibodies to the native 60 kD Ro/SSA molecule. Autoimmunity 1992; 14: 89–95
   PubMed Web of Science ®Google Scholar
• Itoh Y, Reichlin M. Autoantibodies to the Ro/SSA antigen are conformation dependent. I: Anti-60 kD antibodies are mainly directed to the native protein; anti-52 kD antibodies are mainly directed to the denatured protein. Autoimmunity 1992; 14: 57–65
   PubMed Web of Science ®Google Scholar
• Malmegrim KC, Pruijn GJ, van Venrooij WJ. The fate of the U1 snRNP autoantigen during apoptosis: implications for systemic autoimmunity. Isr Med Assoc J 2002; 4: 706–712
   PubMedGoogle Scholar
• Monneaux F, Dumortier H, Steiner G, Briand JP, Muller S. Murine models of systemic lupus erythematosus: B and T cell responses to spliceosomal ribonucleoproteins in MRL/Fas(lpr) and (NZB × NZW)F(1) lupus mice. Int Immunol 2001; 13: 1155–1163
   PubMed Web of Science ®Google Scholar
• Degen WG, Aarssen Y, Pruijn GJ, Utz PJ, van Venrooij WJ. The fate of U1 snRNP during anti-Fas induced apoptosis: Specific cleavage of the U1 snRNA molecule. Cell Death Differ 2000; 7: 70–79
   PubMed Web of Science ®Google Scholar
• Monneaux F, Lozano JM, Patarroyo ME, Briand JP, Muller S. T cell recognition and therapeutic effect of a phosphorylated synthetic peptide of the 70K snRNP protein administered in MR/lpr mice. Eur J Immunol 2003; 33: 287–296
   PubMed Web of Science ®Google Scholar
• Monneaux F, Muller S. Epitope spreading in systemic lupus erythematosus: Identification of triggering peptide sequences. Arthritis Rheum 2002; 46: 1430–1438
   PubMed Web of Science ®Google Scholar
• Leijon K, Hammarstrom B, Holmberg D. Non-obese diabetic (NOD) mice display enhanced immune responses and prolonged survival of lymphoid cells. Int Immunol 1994; 6: 339–345
   PubMed Web of Science ®Google Scholar
• O'Brien BA, Huang Y, Geng X, Dutz JP, Finegood DT. Phagocytosis of apoptotic cells by macrophages from NOD mice is reduced. Diabetes 2002; 51: 2481–2488
   PubMed Web of Science ®Google Scholar
• Leadbetter EA, Rifkin IR, Hohlbaum AM, Beaudette BC, Shlomchik MJ, Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and toll-like receptors. Nature 2002; 416: 603–607
   PubMed Web of Science ®Google Scholar
• Viglianti GA, Lau CM, Hanley TM, Miko BA, Shlomchik MJ, Marshak-Rothstein A. Activation of autoreactive B cells by CpG dsDNA. Immunity 2003; 19: 837–847
   PubMed Web of Science ®Google Scholar
• Muto Y, Pomeranz Krummel D, Oubridge C, Hernandez H, Robinson CV, Neuhaus D, Nagai K. The structure and biochemical properties of the human spliceosomal protein U1C. J Mol Biol 2004; 341: 185–198
   PubMedGoogle Scholar
• Jurica MS, Moore MJ. Pre-mRNA splicing: Awash in a sea of proteins. Mol Cell 2003; 12: 5–14
   PubMed Web of Science ®Google Scholar
• Price SR, Evans PR, Nagai K. Crystal structure of the spliceosomal U2B″ U2A′ protein complex bound to a fragment of U2 small nuclear RNA. Nature 1998; 394: 645–650
   PubMed Web of Science ®Google Scholar