Apoptotic mechanism in pemphigus autoimmunoglobulins-induced acantholysis—possible involvement of the EGF receptor

References

• Anhalt GJ, Diaz LA. Pemphigus vulgaris–a model for cutaneous autoimmunity. J Am Acad Dermatol 2004; 51: S20–S21
   Google Scholar
• Martel P, Joly P. Pemphigus: Autoimmune diseases of keratinocyte's adhesion molecules. Clin Dermatol 2001; 19: 662–674
   PubMed Web of Science ®Google Scholar
• Stanley JR. Pemphigus and pemphigoid as paradigms of organ-specific, autoantibody-mediated diseases. J Clin Invest 1989; 83: 1443–1448
   PubMed Web of Science ®Google Scholar
• Amagai M. Pemphigus: Autoimmunity to epidermal cell adhesion molecules. Adv Dermatol 1996; 11: 319–352
   PubMedGoogle Scholar
• Grando SA. Autoimmunity to keratinocyte acetylcholine receptors in pemphigus. Dermatology 2000; 201: 290–295
   PubMed Web of Science ®Google Scholar
• Kottke MD, Delva E, Kowalczyk AP. The desmosome: Cell science lessons from human diseases. J Cell Sci 2006; 119: 797–806
   PubMed Web of Science ®Google Scholar
• Bystryn JC, Grando SA. A novel explanation for acantholysis in pemphigus vulgaris: The basal cell shrinkage hypothesis. J Am Acad Dermatol 2006; 54: 513–516
   PubMed Web of Science ®Google Scholar
• Wang X, Brégégère F, Frušić-Zlotkin M, Feinmesser M, Michel B, Milner Y. Possible apoptotic mechanism in epidermal cell acantholysis induced by pemphigus vulgaris autoimmunoglobulins. Apoptosis 2004; 9: 131–143
   PubMed Web of Science ®Google Scholar
• Wang X, Brégégère F, Soroka Y, Frušić-Zlotkin M, Milner Y. Replicative senescence enhances apoptosis induced by pemphigus autoimmune antibodies in human keratinocytes. FEBS Lett 2004; 567: 281–286
   PubMed Web of Science ®Google Scholar
• Frušić-Zlotkin M, Pergamentz R, Michel B, David M, Mimouni D, Brégégère F, Milner Y. The interaction of pemphigus autoimmunoglobulins with epidermal cells: Activation of the Fas apoptotic pathway and the use of caspase activity for pathogenicity tests of pemphigus patients. Ann N Y Acad Sci 2005; 1050: 371–379
   PubMed Web of Science ®Google Scholar
• Puviani M, Marconi A, Cozzani E, Pincelli C. Fas ligand in pemphigus sera induces keratinocyte apoptosis through the activation of caspase-8. J Invest Dermatol 2003; 120: 164–167
   PubMed Web of Science ®Google Scholar
• Pelacho B, Natal C, Espana A, Sanchez-Carpintero I, Iraburu MJ, Lopez-Zabalza MJ. Pemphigus vulgaris autoantibodies induce apoptosis in HaCaT keratinocytes. FEBS Lett 2004; 566: 6–10
   PubMed Web of Science ®Google Scholar
• Li N, Zhao M, Liu Z, Diaz LA. Pathogenic role of apotosis in experimental pemhigus. 67th Annual Meeting of Society of Investigative Dermatology. 2006; 29, J Invest Dermatol
   Google Scholar
• Earnshaw WC, Martins LM, Kaufmann SH. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 1999; 68: 383–424
   PubMed Web of Science ®Google Scholar
• Thornberry NA. Caspases: Key mediators of apoptosis. Chem Biol 1998; 5: 97–103
   PubMed Web of Science ®Google Scholar
• Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature 2001; 411: 355–365
   PubMed Web of Science ®Google Scholar
• Ullrich A, Schlessinger J. Signal transduction by receptors with tyrosine kinase activity. Cell 1990; 61: 203–212
   PubMed Web of Science ®Google Scholar
• Lui VW, Grandis JR. EGFR-mediated cell cycle regulation. Anticancer Res 2002; 22: 1–11
   PubMedGoogle Scholar
• Gaudry CA, Palka HL, Dusek RL, Huen AC, Khandekar MJ, Hudson LG, Green KJ. Tyrosine-phosphorylated plakoglobin is associated with desmogleins but not desmoplakin after epidermal growth factor receptor activation. J Biol Chem 2001; 276: 24871–24880
   PubMed Web of Science ®Google Scholar
• Lorch JH, Klessner J, Park JK, Getsios S, Wu YL, Stack MS, Green KJ. Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells. J Biol Chem 2004; 279: 37191–37200
   PubMed Web of Science ®Google Scholar
• Yin T, Getsios S, Caldelari R, Godsel LM, Kowalczyk AP, Muller EJ, Green KJ. Mechanisms of plakoglobin-dependent adhesion: Desmosome-specific functions in assembly and regulation by EGFR. J Biol Chem 2005; 280: 40355–40363
   PubMed Web of Science ®Google Scholar
• Krupp MN, Connolly DT, Lane MD. Synthesis, turnover, and down-regulation of epidermal growth factor receptors in human A431 epidermoid carcinoma cells and skin fibroblasts. J Biol Chem 1982; 257: 11489–11496
   PubMedGoogle Scholar
• Lee CW. An extract of cultured A431 cells contains major tissue antigens of autoimmune bullous diseases. Br J Dermatol 2000; 143: 821–823
   PubMedGoogle Scholar
• Kyriakis JM, Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 2001; 81: 807–869
   PubMed Web of Science ®Google Scholar
• Takeuchi K, Kato M, Suzuki H, Akhand AA, Wu J, Hossain K, Miyata T, Matsumoto Y, Nimura Y, Nakashima I. Acrolein induces activation of the epidermal growth factor receptor of human keratinocytes for cell death. J Cell Biochem 2001; 81: 679–688
   PubMed Web of Science ®Google Scholar
• Schwarz CS, Seyfried J, Evert BO, Klockgether T, Wullner U. Bcl-2 up-regulates ha-ras mRNA expression and induces c-Jun phosphorylation at Ser73 via an ERK-dependent pathway in PC 12 cells. Neuroreport 2002; 13: 2439–2442
   PubMedGoogle Scholar
• Assefa Z, Garmyn M, Bouillon R, Merlevede W, Vandenheede JR, Agostinis P. Differential stimulation of ERK and JNK activities by ultraviolet B irradiation and epidermal growth factor in human keratinocytes. J Invest Dermatol 1997; 108: 886–891
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhang X, Lebwohl M, DeLeo V, Wei H. Inhibition of ultraviolet B (UVB)-induced c-fos and c-jun expression in vivo by a tyrosine kinase inhibitor genistein. Carcinogenesis 1998; 19: 649–654
   PubMedGoogle Scholar
• Aoyama Y, Owada MK, Kitajima Y. A pathogenic autoantibody, pemphigus vulgaris-IgG, induces phosphorylation of desmoglein 3, and its dissociation from plakoglobin in cultured keratinocytes. Eur J Immunol 1999; 29: 2233–2240
   PubMed Web of Science ®Google Scholar
• Calkins CC, Setzer SV, Jennings JM, Summers S, Tsunoda K, Amagai M, Kowalczyk AP. Desmoglein endocytosis and desmosome disassembly are coordinated responses to pemphigus autoantibodies. J Biol Chem 2006; 281: 7623–7634
   PubMed Web of Science ®Google Scholar
• Reinehr R, Schliess F, Haussinger D. Hyperosmolarity and CD95L trigger CD95/EGF receptor association and tyrosine phosphorylation of CD95 as prerequisites for CD95 membrane trafficking and DISC formation. Faseb J 2003; 17: 731–733
   PubMedGoogle Scholar
• Sanchez-Carpintero I, Espana A, Pelacho B, Lopez Moratalla N, Rubenstein DS, Diaz LA, Lopez-Zabalza MJ. In vivo blockade of pemphigus vulgaris acantholysis by inhibition of intracellular signal transduction cascades. Br J Dermatol 2004; 151: 565–570
   PubMed Web of Science ®Google Scholar
• Rosette C, Karin M. Ultraviolet light and osmotic stress: Activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 1996; 274: 1194–1197
   PubMed Web of Science ®Google Scholar
• He YY, Huang JL, Gentry JB, Chignell CF. Epidermal growth factor receptor down-regulation induced by UVA in human keratinocytes does not require the receptor kinase activity. J Biol Chem 2003; 278: 42457–42465
   PubMed Web of Science ®Google Scholar
• Gulli LF, Palmer KC, Chen YQ, Reddy KB. Epidermal growth factor-induced apoptosis in A431 cells can be reversed by reducing the tyrosine kinase activity. Cell Growth Differ 1996; 7: 173–178
   PubMedGoogle Scholar
• Kottke TJ, Blajeski AL, Martins LM, Mesner PW, Jr, Davidson NE, Earnshaw WC, Armstrong DK, Kaufmann SH. Comparison of paclitaxel-, 5-fluoro-2'-deoxyuridine-, and epidermal growth factor (EGF)-induced apoptosis. Evidence for EGF-induced anoikis. J Biol Chem 1999; 274: 15927–15936
   PubMedGoogle Scholar
• Kaufmann AM, Lichtner RB, Schirrmacher V, Khazaie K. Induction of apoptosis by EGF receptor in rat mammary adenocarcinoma cells coincides with enhanced spontaneous tumour metastasis. Oncogene 1996; 13: 2349–2358
   PubMedGoogle Scholar
• Tikhomirov O, Carpenter G. Bax activation and translocation to mitochondria mediate EGF-induced programmed cell death. J Cell Sci 2005; 118: 5681–5690
   PubMed Web of Science ®Google Scholar
• Lewis DA, Zweig B, Hurwitz SA, Spandau DF. Inhibition of erbB receptor family members protects HaCaT keratinocytes from ultraviolet-B-induced apoptosis. J Invest Dermatol 2003; 120: 483–488
   PubMedGoogle Scholar
• Wang Q, Villeneuve G, Wang Z. Control of epidermal growth factor receptor endocytosis by receptor dimerization, rather than receptor kinase activation. EMBO Rep 2005; 6: 942–948
   PubMed Web of Science ®Google Scholar
• Lamaze C, Schmid S. Recruitment of epidermal growth factor receptors into coated pits requires their activated tyrosine kinase. J Cell Biol 1995; 129: 47–54
   PubMedGoogle Scholar
• Schmidt MHH, Furnari FB, Cavenee WK, Bogler O. Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization. PNAS 2003; 100: 6505–6510
   PubMed Web of Science ®Google Scholar
• Brabyn CJ, Kleine LP. EGF causes hyperproliferation and apoptosis in T51B cells: Involvement of high and low affinity EGFR binding sites. Cell Signal 1995; 7: 139–150
   PubMedGoogle Scholar
• Modjtahedi H, Affleck K, Stubberfield C, Dean C. EGFR blockade by tyrosine kinase inhibitor or monoclonal antibody inhibits growth, directs terminal differentiation and induces apoptosis in the human squamous cell carcinoma HN5. Int J Oncol 1998; 13: 335–342
   PubMed Web of Science ®Google Scholar
• Qiao L, Studer E, Leach K, McKinstry R, Gupta S, Decker R, Kukreja R, Valerie K, Nagarkatti P, El Deiry W, Molkentin J, Schmidt-Ullrich R, Fisher PB, Grant S, Hylemon PB, Dent P. Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: Inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis. Mol Biol Cell 2001; 12: 2629–2645
   PubMed Web of Science ®Google Scholar
• Daub H, Weiss FU, Wallasch C, Ullrich A. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 1996; 379: 557–560
   PubMed Web of Science ®Google Scholar
• Gschwind A, Zwick E, Prenzel N, Leserer M, Ullrich A. Cell communication networks: Epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission. Oncogene 2001; 20: 1594–1600
   PubMed Web of Science ®Google Scholar
• Tsukada S, Simon MI, Witte ON, Katz A. Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase. Proc Natl Acad Sci USA 1994; 91: 11256–11260
   PubMed Web of Science ®Google Scholar
• Luttrell LM, Della Rocca GJ, van Biesen T, Luttrell DK, Lefkowitz RJ. Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation. J Biol Chem 1997; 272: 4637–4644
   PubMedGoogle Scholar
• Zachary I, Rozengurt E. Focal adhesion kinase (p125FAK): A point of convergence in the action of neuropeptides, integrins, and oncogenes. Cell 1992; 71: 891–894
   PubMed Web of Science ®Google Scholar
• Simonson MS, Wang Y, Herman WH. Nuclear signaling by endothelin-1 requires Src protein-tyrosine kinases. J Biol Chem 1996; 271: 77–82
   PubMedGoogle Scholar
• Lev S, Moreno H, Martinez R, Canoll P, Peles E, Musacchio JM, Plowman GD, Rudy B, Schlessinger J. Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. Nature 1995; 376: 737–745
   PubMed Web of Science ®Google Scholar
• Esaki C, Seishima M, Yamada T, Osada K, Kitajima Y. Pharmacologic evidence for involvement of phospholipase C in pemphigus IgG-induced inositol 1,4,5-trisphosphate generation, intracellular calcium increase, and plasminogen activator secretion in DJM-1 cells, a squamous cell carcinoma line. J Invest Dermatol 1995; 105: 329–333
   PubMed Web of Science ®Google Scholar
• Kitajima Y, Aoyama Y, Seishima M. Transmembrane signaling for adhesive regulation of desmosomes and hemidesmosomes, and for cell–cell datachment induced by pemphigus IgG in cultured keratinocytes: Involvement of protein kinase C. J Invest Dermatol Symp Proc 1999; 4: 137–144
   PubMedGoogle Scholar
• Kitajima Y. Adhesion molecules in the pathophysiology of bullous diseases. Eur J Dermatol 1996; 6: 399–405
   Google Scholar
• Lyubimov H, Goldshmit D, Michel B, Oron Y, Milner Y. Pemphigus–identifying the autoantigen and its possible induction of epidermal acantholysis via Ca2+ signalling. Isr J Med Sci 1995; 31: 42–48
   PubMedGoogle Scholar
• Osada K, Seishima M, Kitajima Y. Pemphigus IgG activates and translocates protein kinase C from the cytosol to the particulate/cytoskeleton fractions in human keratinocytes. J Invest Dermatol 1997; 108: 482–487
   PubMed Web of Science ®Google Scholar
• Seishima M, Esaki C, Osada K, Mori S, Hashimoto T, Kitajima Y. Pemphigus IgG, but not bullous pemphigoid IgG, causes a transient increase in intracellular calcium and inositol 1,4,5-triphosphate in DJM-1 cells, a squamous cell carcinoma line. J Invest Dermatol 1995; 104: 33–37
   PubMed Web of Science ®Google Scholar
• He YY, Huang JL, Chignell CF. Delayed and sustained activation of extracellular signal-regulated kinase in human keratinocytes by UVA: Implications in carcinogenesis. J Biol Chem 2004; 279: 53867–53874
   PubMedGoogle Scholar
• Iordanov MS, Sundholm AJ, Simpson EL, Hanifin JM, Ryabinina OP, Choi RJ, Korcheva VB, Schneider P, Magun BE. Cell death-induced activation of epidermal growth factor receptor in keratinocytes: Implications for restricting epidermal damage in dermatitis. J Invest Dermatol 2005; 125: 134–142
   PubMed Web of Science ®Google Scholar
• Pasdar M, Li Z, Chlumecky V. Plakoglobin: Kinetics of synthesis, phosphorylation, stability, and interactions with desmoglein and E-cadherin. Cell motility and the cytoskeleton 1995; 32: 258–272
   PubMed Web of Science ®Google Scholar
• Calautti E, Cabodi S, Stein PL, Hatzfeld M, Kedersha N, Paolo Dotto G. Tyrosine phosphorylation and src family kinases control keratinocyte cell–cell adhesion. J Cell Biol 1998; 141: 1449–1465
   PubMed Web of Science ®Google Scholar
• Pece S, Gutkind JS. Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell–cell contact formation. J Biol Chem 2000; 275: 41227–41233
   PubMedGoogle Scholar
• Nguyen VT, Arredondo J, Chernyavsky AI, Kitajima Y, Pittelkow M, Grando SA. Pemphigus vulgaris IgG and methylprednisolone exhibit reciprocal effects on keratinocytes. J Biol Chem 2004; 279: 2135–2146
   PubMed Web of Science ®Google Scholar
• Hu P, Berkowitz P, O'Keefe EJ, Rubenstein DS. Keratinocyte adherens junctions initiate nuclear signaling by translocation of plakoglobin from the membrane to the nucleus. J Invest Dermatol 2003; 121: 242–251
   PubMed Web of Science ®Google Scholar
• Hakimelahi S, Parker HR, Gilchrist AJ, Barry M, Li Z, Bleackley RC, Pasdar M. Plakoglobin regulates the expression of the anti-apoptotic protein BCL-2. J Biol Chem 2000; 275: 10905–10911
   PubMed Web of Science ®Google Scholar
• Peifer M, McCrea PD, Green KJ, Wieschaus E, Gumbiner BM. The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties. J Cell Biol 1992; 118: 681–691
   PubMed Web of Science ®Google Scholar
• Lo Muzio L, Pannone G, Staibano S, Mignogna MD, Rubini C, Farronato G, Ferrari F, Nocini PF, De Rosa G. Strict correlation between uPAR and plakoglobin expression in pemphigus vulgaris. J Cutan Pathol 2002; 29: 540–548
   PubMedGoogle Scholar
• Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995; 270: 1326–1331
   PubMed Web of Science ®Google Scholar
• Tran SE, Holmstrom TH, Ahonen M, Kahari VM, Eriksson JE. MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors. J Biol Chem 2001; 276: 16484–16490
   PubMedGoogle Scholar
• Jost M, Huggett TM, Kari C, Rodeck U. Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway. Mol Biol Cell 2001; 12: 1519–1527
   PubMed Web of Science ®Google Scholar
• Rodeck U, Jost M, Kari C, Shih DT, Lavker RM, Ewert DL, Jensen PJ. EGF-R dependent regulation of keratinocyte survival. J Cell Sci 1997; 110(Pt 2)113–121
   PubMedGoogle Scholar
• Lee ER, Kang YJ, Kim JH, Lee HT, Cho SG. Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem 2005; 280: 31498–31507
   PubMedGoogle Scholar
• Nowak G. Protein kinase C-alpha and ERK1/2 mediate mitochondrial dysfunction, decreases in active Na+ transport, and cisplatin-induced apoptosis in renal cells. J Biol Chem 2002; 277: 43377–43388
   PubMed Web of Science ®Google Scholar
• Berkowitz P, Hu P, Liu Z, Diaz LA, Enghild JJ, Chua MP, Rubenstein DS. Desmosome signaling. Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization. J Biol Chem 2005; 280: 23778–23784
   PubMed Web of Science ®Google Scholar
• Tebar F, Villalonga P, Sorkina T, Agell N, Sorkin A, Enrich C. Calmodulin regulates intracellular trafficking of epidermal growth factor receptor and the MAPK Signaling Pathway. Mol Biol Cell 2002; 13: 2057–2068
   PubMed Web of Science ®Google Scholar