Pemphigus antibody induced phosphorylation of keratinocyte proteins

References

• Takeichi M. The cadherins: Cell–cell adhesion molecules controlling animal morphogenesis. Development 1988; 102: 639–655
   PubMed Web of Science ®Google Scholar
• Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science 1991; 251: 1451–1455
   PubMed Web of Science ®Google Scholar
• Butz S, Kemler R. Distinct cadherin–catenin complexes in Ca(2+)-dependent cell–cell adhesion. FEBS Lett 1994; 355: 195–200
   PubMed Web of Science ®Google Scholar
• Ozawa M, Baribault H, Kemler R. The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J 1989; 8: 1711–1717
   PubMed Web of Science ®Google Scholar
• Nagafuchi A, Takeichi M, Tsukita S. The 102 kd cadherin-associated protein: Similarity to vinculin and posttranscriptional regulation of expression. Cell 1991; 65: 849–857
   PubMed Web of Science ®Google Scholar
• Aberle H, Butz S, Stappert J, Weissig H, Kemler R, Hoschuetzky H. Assembly of the cadherin–catenin complex in vitro with recombinant proteins. J Cell Sci 1994; 107: 3655–3663
   PubMed Web of Science ®Google Scholar
• Hulsken J, Birchmeier W, Behrens J. E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J Cell Biol 1994; 127: 2061–2069
   PubMed Web of Science ®Google Scholar
• Ozawa M, Ringwald M, Kemler R. Uvomorulin–catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule. Proc Natl Acad Sci USA 1990; 87: 4246–4250
   PubMed Web of Science ®Google Scholar
• Rimm DL, Koslov ER, Kebriaei P, Cianci CD, Morrow JS. Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex. Proc Natl Acad Sci USA 1995; 92: 8813–8817
   PubMed Web of Science ®Google Scholar
• Garrod DR, Merritt AJ, Nie Z. Desmosomal cadherins. Curr Opin Cell Biol 2002; 14: 537–545
   PubMed Web of Science ®Google Scholar
• Getsios S, Huen AC, Green KJ. Working out the strength and flexibility of desmosomes. Nat Rev Mol Cell Biol 2004; 5: 271–281
   PubMed Web of Science ®Google Scholar
• Hu P, O'Keefe EJ, Rubenstein DS. Tyrosine phosphorylation of human keratinocyte beta-catenin and plakoglobin reversibly regulates their binding to E-cadherin and alpha-catenin. J Invest Dermatol 2001; 117: 1059–1067
   PubMed Web of Science ®Google Scholar
• Hu P, Berkowitz P, O'Keefe EJ, Rubenstein DS. Keratinocyte adherens junctions initiate nuclear signaling by translocation of plakoglobin from the membrane to the nucleus. J Invest Dermatol 2003; 121: 242–251
   PubMed Web of Science ®Google Scholar
• He W, Cowin P, Stokes DL. Untangling desmosomal knots with electron tomography. Science 2003; 302: 109–113
   PubMed Web of Science ®Google Scholar
• Windoffer R, Borchert-Stuhltrager M, Leube RE. Desmosomes: Interconnected calcium-dependent structures of remarkable stability with significant integral membrane protein turnover. J Cell Sci 2002; 115: 1717–1732
   PubMed Web of Science ®Google Scholar
• Beutner EH, Jordan RE. Demonstration of skin antibodies in sera of pemphigus vulgaris patients by direct immunoflourescent staining. Proc Soc Exp Biol Med 1964; 117: 505–510
   PubMed Web of Science ®Google Scholar
• Beutner EH, Prigenzi LS, Hale W, Leme D, et al. Immunofluorescent studies of autoantibodies to intercellular areas of epithelia in Brazilian pemphigus foliaceus. Proc Soc Exp Biol Med 1968; 127: 81–86
   PubMed Web of Science ®Google Scholar
• Anhalt GJ, Labib RS, Voorhees JJ, Beals TF, Diaz LA. Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease. N Engl J Med 1982; 306: 1189–1196
   PubMed Web of Science ®Google Scholar
• Takahashi Y, Patel HP, Labib RS, Diaz LA, Anhalt GJ. Experimentally induced pemphigus vulgaris in neonatal BALB/c mice: A time-course study of clinical, immunologic, ultrastructural, and cytochemical changes. J Invest Dermatol 1985; 84: 41–46
   PubMed Web of Science ®Google Scholar
• Roscoe JT, Diaz L, Sampaio SA, Castro RM, Labib RS, Takahashi Y, Patel H, Anhalt GJ. Brazilian pemphigus foliaceus autoantibodies are pathogenic to BALB/c mice by passive transfer. J Invest Dermatol 1985; 85: 538–541
   PubMed Web of Science ®Google Scholar
• Rock B, Martins CR, Theofilopoulos AN, Balderas RS, Anhalt GJ, Labib RS, Futamura S, Rivitti EA, Diaz LA. The pathogenic effect of IgG4 autoantibodies in endemic pemphigus foliaceus (fogo selvagem). N Engl J Med 1989; 320: 1463–1469
   PubMed Web of Science ®Google Scholar
• Rock B, Labib RS, Diaz LA. Monovalent Fab′ immunoglobulin fragments from endemic pemphigus foliaceus autoantibodies reproduce the human disease in neonatal Balb/c mice. J Clin Invest 1990; 85: 296–299
   PubMed Web of Science ®Google Scholar
• Amagai M, Klaus-Kovtun V, Stanley JR. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell 1991; 67: 869–877
   PubMed Web of Science ®Google Scholar
• Koch PJ, Mahoney MG, Ishikawa H, Pulkkinen L, Uitto J, Shultz L, Murphy GF, Whitaker-Menezes D, Stanley JR. Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol 1997; 137: 1091–1102
   PubMed Web of Science ®Google Scholar
• Amagai M, Tsunoda K, Suzuki H, Nishifuji K, Koyasu S, Nishikawa T. Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus. J Clin Invest 2000; 105: 625–631
   PubMed Web of Science ®Google Scholar
• Mascaro JM, Jr, Espana A, Liu Z, Ding X, Swartz SJ, Fairley JA, Diaz LA. Mechanisms of acantholysis in pemphigus vulgaris: Role of IgG valence. Clin Immunol Immunopathol 1997; 85: 90–96
   PubMedGoogle Scholar
• Anhalt GJ, Till GO, Diaz LA, Labib RS, Patel HP, Eaglstein NF. Defining the role of complement in experimental pemphigus vulgaris in mice. J Immunol 1986; 137: 2835–2840
   PubMedGoogle Scholar
• Mahoney MG, Wang ZH, Stanley JR. Pemphigus vulgaris and pemphigus foliaceus antibodies are pathogenic in plasminogen activator knockout mice. J Invest Dermatol 1999; 113: 22–25
   PubMed Web of Science ®Google Scholar
• Payne AS, Ishii K, Kacir S, Lin C, Li H, Hanakawa Y, Tsunoda K, Amagai M, Stanley JR, Siegel DL. Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display. J Clin Invest 2005; 115: 888–899
   PubMed Web of Science ®Google Scholar
• Futei Y, Amagai M, Sekiguchi M, Nishifuji K, Fujii Y, Nishikawa T. Use of domain-swapped molecules for conformational epitope mapping of desmoglein 3 in pemphigus vulgaris. J Invest Dermatol 2000; 115: 829–834
   PubMed Web of Science ®Google Scholar
• Li N, Aoki V, Hans-Filho G, Rivitti EA, Diaz LA. The role of intramolecular epitope spreading in the pathogenesis of endemic pemphigus foliaceus (fogo selvagem). J Exp Med 2003; 197: 1501–1510
   PubMed Web of Science ®Google Scholar
• Tsunoda K, Ota T, Aoki M, Yamada T, Nagai T, Nakagawa T, Koyasu S, Nishikawa T, Amagai M. Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3. J Immunol 2003; 170: 2170–2178
   PubMed Web of Science ®Google Scholar
• Nguyen VT, Ndoye A, Shultz LD, Pittelkow MR, Grando SA. Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions. [comment]. J Clin Invest 2000; 106: 1467–1479
   PubMed Web of Science ®Google Scholar
• Mahoney MG, Wang Z, Rothenberger K, Koch PJ, Amagai M, Stanley JR. Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris. J Clin Invest 1999; 103: 461–468
   PubMed Web of Science ®Google Scholar
• Wu H, Wang ZH, Yan A, Lyle S, Fakharzadeh S, Wahl JK, Wheelock MJ, Ishikawa H, Uitto J, Amagai M, et al. Protection against pemphigus foliaceus by desmoglein 3 in neonates.[comment]. N Engl J Med 2000; 343: 31–35
   PubMedGoogle Scholar
• Anhalt GJ, Patel HP, Labib RS, Diaz LA, Proud D. Dexamethasone inhibits plasminogen activator activity in experimental pemphigus in vivo but does not block acantholysis. J Immunol 1986; 136: 113–117
   PubMedGoogle Scholar
• Hashinmoto K, Shafran KM, Webber PS, Lazarus GS, Singer KH. Anti-cell surface pemphigus autoantibody stimulates plasminogen activator activity of human epidermal cells. J Exp Med 1983; 157: 259–272
   PubMedGoogle Scholar
• Woo TY, Hogan VA, Patel H, Anhalt GJ, Labib RS, Voorhees JJ, Diaz LA. Specificity and inhibition of the epidermal cell detachment induced by pemphigus IgG in vitro. J Invest Dermatol 1983; 81: 115s–121s
   PubMedGoogle Scholar
• Shimizu A, Ishiko A, Ota T, Tsunoda K, Amagai M, Nishikawa T. IgG binds to desmoglein 3 in desmosomes and causes a desmosomal split without keratin retraction in a pemphigus mouse model. J Invest Dermatol 2004; 122: 1145–1153
   PubMed Web of Science ®Google Scholar
• Aoyama Y, Owada MK, Kitajima Y. A pathogenic autoantibody, pemphigus vulgaris-IgG, induces phosphorylation of desmoglein 3, and its dissociation from plakoglobin in cultured keratinocytes. Eur J Immunol 1999; 29: 2233–2240
   PubMed Web of Science ®Google Scholar
• Berkowitz P, Hu P, Liu Z, Diaz LA, Enghild JJ, Chua MP, Rubenstein DS. Desmosome signaling: Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization. J Biol Chem 2005; 280: 23778–23784
   PubMed Web of Science ®Google Scholar
• Caldelari R, de Bruin A, Baumann D, Suter MM, Bierkamp C, Balmer V, Muller E. A central role for the armadillo protein plakoglobin in the autoimmune disease pemphigus vulgaris. J Cell Biol 2001; 153: 823–834
   PubMed Web of Science ®Google Scholar
• Esaki C, Seishima M, Yamada T, Osada K, Kitajima Y. Pharmacologic evidence for involvement of phospholipase C in pemphigus IgG-induced inositol 1,4,5-trisphosphate generation, intracellular calcium increase, and plasminogen activator secretion in DJM-1 cells, a squamous cell carcinoma line. J Invest Dermatol 1995; 105: 329–333
   PubMed Web of Science ®Google Scholar
• Nguyen VT, Arredondo J, Chernyavsky AI, Kitajima Y, Pittelkow M, Grando SA. Pemphigus vulgaris IgG and methylprednisolone exhibit reciprocal effects on keratinocytes. J Biol Chem 2004; 279: 2135–2146
   PubMed Web of Science ®Google Scholar
• Osada K, Seishima M, Kitajima Y. Pemphigus IgG activates and translocates protein kinase C from the cytosol to the particulate/cytoskeleton fractions in human keratinocytes. J Invest Dermatol 1997; 108: 482–487
   PubMed Web of Science ®Google Scholar
• Seishima M, Esaki C, Osada K, Mori S, Hashimoto T, Kitajima Y. Pemphigus IgG, but not bullous pemphigoid IgG, causes a transient increase in intracellular calcium and inositol 1,4,5-triphosphate in DJM-1 cells, a squamous cell carcinoma line. J Invest Dermatol 1995; 104: 33–37
   PubMed Web of Science ®Google Scholar
• Berkowitz P, Hu P, Prisayanh PS, Diaz LA, Rubenstein DS. Desmoglein-3 trafficking through keratinocyte desmosomes suggests dynamic instability: A kinetic model for PV IgG acantholysis. J Invest Dermatol 2005; 124: A28
   PubMedGoogle Scholar
• Aoyama Y, Kitajima Y. Pemphigus vulgaris-IgG causes a rapid depletion of desmoglein 3 (Dsg3) from the Triton X-100 soluble pools, leading to the formation of Dsg3-depleted desmosomes in a human squamous carcinoma cell line, DJM-1 cells. J Invest Dermatol 1999; 112: 67–71
   PubMed Web of Science ®Google Scholar
• Calkins CC, Setzer SV, Jennings JM, Summers S, Tsunoda K, Amagai M, Kowalczyk AP. Desmoglein endocytosis and desmosome disassembly are coordinated responses to pemphigus autoantibodies. J Biol Chem 2006; 281: 7623–7634
   PubMed Web of Science ®Google Scholar
• Waschke J, Bruggeman P, Baumgartner W, Zillikens D, Drenckhahn D. Pemphigus foliaceus IgG causes dissociation of desmoglein 1-containing junctions without blocking desmoglein 1 transinteraction. J Clin Invest 2005; 115: 3157–3165
   PubMed Web of Science ®Google Scholar
• Seishima M, Satoh S, Nojiri M, Osada K, Kitajima Y. Pemphigus IgG induces expression of urokinase plasminogen activator receptor on the cell surface of cultured keratinocytes. J Invest Dermatol 1997; 109: 650–655
   PubMed Web of Science ®Google Scholar
• Benndorf R, Hayess K, Ryazantsev S, Wieske M, Behlke J, Lutsch G. Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity. J Biol Chem 1994; 269: 20780–20784
   PubMed Web of Science ®Google Scholar
• Geum D, Son GH, Kim K. Phosphorylation-dependent cellular localization and thermoprotective role of heat shock protein 25 in hippocampal progenitor cells. J Biol Chem 2002; 277: 19913–19921
   PubMed Web of Science ®Google Scholar
• Panasenko OO, Kim MV, Marston SB, Gusev NB. Interaction of the small heat shock protein with molecular mass 25 kDa (hsp25) with actin. Eur J Biochem 2003; 270: 892–901
   PubMedGoogle Scholar
• Perng MD, Cairns L, van den IP, Prescott A, Hutcheson AM, Quinlan RA. Intermediate filament interactions can be altered by HSP27 and alphaB-crystallin. J Cell Sci 1999; 112(Pt 13)2099–2112
   PubMed Web of Science ®Google Scholar
• Evgrafov OV, Mersiyanova I, Irobi J, Van Den Bosch L, Dierick I, Leung CL, Schagina O, Verpoorten N, Van Impe K, Fedotov V, et al. Mutant small heat-shock protein 27 causes axonal Charcot-Marie-tooth disease and distal hereditary motor neuropathy. Nat Genet 2004; 36: 602–606
   PubMed Web of Science ®Google Scholar
• Lavoie JN, Hickey E, Weber LA, Landry J. Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27. J Biol Chem 1993; 268: 24210–24214
   PubMed Web of Science ®Google Scholar
• Lavoie JN, Lambert H, Hickey E, Weber LA, Landry J. Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27. Mol Cell Biol 1995; 15: 505–516
   PubMedGoogle Scholar
• Guay J, Lambert H, Gingras-Breton G, Lavoie JN, Huot J, Landry J. Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27. J Cell Sci 1997; 110: 357–368
   PubMed Web of Science ®Google Scholar
• Berkowitz P, Hu P, Warren S, Liu Z, Diaz LA, Rubenstein DS. p38MAPK inhibition prevents disease in pemphigus vulgaris mice. Proc Natl Acad Sci USA 2006; 103: 12885–12860
   PubMedGoogle Scholar
• Ku NO, Liao J, Chou CF, Omary MB. Implications of intermediate filament protein phosphorylation. Cancer Metastasis Rev 1996; 15: 429–444
   Google Scholar
• Omary MB, Ku NO, Liao J, Price D. Keratin modifications and solubility properties in epithelial cells and in vitro. Subcell Biochem 1998; 31: 105–140
   PubMedGoogle Scholar
• Feng L, Zhou X, Liao J, Omary MB. Pervanadate-mediated tyrosine phosphorylation of keratins 8 and 19 via a p38 mitogen-activated protein kinase-dependent pathway. J Cell Sci 1999; 112(Pt 13)2081–2090
   PubMed Web of Science ®Google Scholar
• Liao J, Omary MB. 14-3-3 proteins associate with phosphorylated simple epithelial keratins during cell cycle progression and act as a solubility cofactor. J Cell Biol 1996; 133: 345–357
   PubMedGoogle Scholar
• Aitken A. 14-3-3 proteins on the MAP. Trends Biochem Sci 1995; 20: 95–97
   PubMed Web of Science ®Google Scholar
• Bonnefoy-Berard N, Liu YC, von Willebrand M, Sung A, Elly C, Mustelin T, Yoshida H, Ishizaka K, Altman A. Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells. Proc Natl Acad Sci USA 1995; 92: 10142–10146
   PubMed Web of Science ®Google Scholar
• Conklin DS, Galaktionov K, Beach D. 14-3-3 proteins associate with cdc25 phosphatases. Proc Natl Acad Sci USA 1995; 92: 7892–7896
   PubMed Web of Science ®Google Scholar
• Reichelt J, Furstenberger G, Magin TM. Loss of keratin 10 leads to mitogen-activated protein kinase (MAPK) activation, increased keratinocyte turnover, and decreased tumor formation in mice. J Invest Dermatol 2004; 123: 973–981
   PubMed Web of Science ®Google Scholar
• Ku NO, Fu H, Omary MB. Raf-1 activation disrupts its binding to keratins during cell stress. J Cell Biol 2004; 166: 479–485
   PubMed Web of Science ®Google Scholar
• Butt E, Immler D, Meyer HE, Kotlyarov A, Laass K, Gaestel M. Heat shock protein 27 is a substrate of cGMP-dependent protein kinase in intact human platelets: Phosphorylation-induced actin polymerization caused by HSP27 mutants. J Biol Chem 2001; 276: 7108–7113
   PubMedGoogle Scholar
• Landry J, Huot J. Modulation of actin dynamics during stress and physiological stimulation by a signaling pathway involving p38 MAP kinase and heat-shock protein 27. Biochem Cell Biol 1995; 73: 703–707
   PubMed Web of Science ®Google Scholar
• Chen H, Hewison M, Hu B, Sharma M, Sun Z, Adams JS. An Hsp27-related, dominant-negative-acting intracellular estradiol-binding protein. J Biol Chem 2004; 279: 29944–29951
   PubMedGoogle Scholar
• Miller H, Poon S, Hibbert B, Rayner K, Chen YX, O'Brien ER. Modulation of estrogen signaling by the novel interaction of heat shock protein 27, a biomarker for atherosclerosis, and estrogen receptor beta: Mechanistic insight into the vascular effects of estrogens. Arterioscler Thromb Vasc Biol 2005; 25: e10–e14
   PubMedGoogle Scholar
• Gaudry CA, Palka HL, Dusek RL, Huen AC, Khandekar MJ, Hudson LG, Green KJ. Tyrosine-phosphorylated plakoglobin is associated with desmogleins but not desmoplakin after epidermal growth factor receptor activation. J Biol Chem 2001; 276: 24871–24880
   PubMed Web of Science ®Google Scholar
• Yin T, Getsios S, Caldelari R, Godsel LM, Kowalczyk AP, Muller EJ, Green KJ. Mechanisms of plakoglobin-dependent adhesion: Desmosome-specific functions in assembly and regulation by epidermal growth factor receptor. J Biol Chem 2005; 280: 40355–40363
   PubMed Web of Science ®Google Scholar
• Lorch JH, Klessner J, Park JK, Getsios S, Wu YL, Stack MS, Green KJ. Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells. J Biol Chem 2004; 279: 37191–37200
   PubMed Web of Science ®Google Scholar
• Vosseller K, Sakabe K, Wells L, Hart GW. Diverse regulation of protein function by O-GlcNAc: A nuclear and cytoplasmic carbohydrate post-translational modification. Curr Opin Chem Biol 2002; 6: 851–857
   PubMed Web of Science ®Google Scholar
• Hatsell S, Medina L, Merola J, Haltiwanger R, Cowin P. Plakoglobin is O-glycosylated close to the N-terminal destruction box. J Biol Chem 2003; 278: 37745–37752
   PubMed Web of Science ®Google Scholar
• Hu P, Berkowitz P, Madden VJ, Rubenstein DS. Stabilization of plakoglobin and enhanced keratinocyte cell–cell adhesion by intracellular O-glycosylation. J Biol Chem 2006; 281: 12786–12791
   PubMedGoogle Scholar
• O'Neill LA. Targeting signal transduction as a strategy to treat inflammatory diseases. Nat Rev Drug Discov 2006; 5: 549–562
   PubMed Web of Science ®Google Scholar