Anti-viral effector T cell responses and trafficking are not dependent upon DRAK2 signaling following viral infection of the central nervous system

References

• Bergmann CC, Lane TE, Stohlman SA. Coronavirus infection of the central nervous system: Host-virus stand-off. Nat Rev Microbiol 2006; 4: 121–132
   PubMed Web of Science ®Google Scholar
• Marten NW, Stohlman SA, Bergmann CC. MHV infection of the CNS: Mechanisms of immune-mediated control. Viral Immunol 2001; 14: 1–18
   PubMed Web of Science ®Google Scholar
• Bergmann CC, Altman JD, Hinton D, Stohlman SA. Inverted immunodominance and impaired cytolytic function of CD8+T cells during viral persistence in the central nervous system. J Immunol 1999; 163: 3379–3387
   Google Scholar
• Ramakrishna C, Stohlman SA, Atkinson RA, Hinton DR, Bergmann CC. Differential regulation of primary and secondary CD8+T cells in the central nervous system. J Immunol 2004; 173: 6265–6273
   Google Scholar
• Bergmann CC, Parra B, Hinton DR, Chandran R, Morrison M, Stohlman SA. Perforin-mediated effector function within the central nervous system requires IFN-gamma-mediated MHC up-regulation. J Immunol 2003; 170: 3204–3213
   Google Scholar
• Stohlman SA, Bergmann CC, Lin MT, Cua DJ, Hinton DR. CTL effector function within the central nervous system requires CD4+T cells. J Immunol 1998; 160: 2896–2904
   PubMed Web of Science ®Google Scholar
• Zhou J, Hinton DR, Stohlman SA, Liu CP, Zhong L, Marten NW. Maintenance of CD8+T cells during acute viral infection of the central nervous system requires CD4+T cells but not interleukin-2. Viral Immunol 2005; 18: 162–169
   Google Scholar
• Lane TE, Asensio VC, Yu N, Paoletti AD, Campbell IL, Buchmeier MJ. Dynamic regulation of alpha- and beta-chemokine expression in the central nervous system during mouse hepatitis virus-induced demyelinating disease. J Immunol 1998; 160: 970–978
   PubMed Web of Science ®Google Scholar
• McIntosh K, . Fields virology. Fields virology3rd ed., BN Fields, et al. Lippincott-Raven Publishers, Philadelphia 1996; 401–430
   Google Scholar
• Adami C, Pooley J, Glomb J, Stecker E, Fazal F, Fleming JO, Baker SC. Evolution of mouse hepatitis virus (MHV) during chronic infection: Quasispecies nature of the persisting MHV RNA. Virology 1995; 209: 337–346
   Google Scholar
• Fleming JO, Trousdale MD, el-Zaatari FA, Stohlman SA, Weiner LP. Pathogenicity of antigenic variants of murine coronavirus JHM selected with monoclonal antibodies. J Virol 1986; 58: 869–875
   PubMed Web of Science ®Google Scholar
• Fleming JO, Houtman JJ, Alaca H, Hinze HC, McKenzie D, Aiken J, Bleasdale T, Baker S. Persistence of viral RNA in the central nervous system of mice inoculated with MHV-4. Adv Exp Med Biol 1993; 342: 327–332
   Google Scholar
• Sanjo H, Kawai T, Akira S. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J Biol Chem 1998; 273: 29066–29071
   PubMed Web of Science ®Google Scholar
• Matsumoto M, Miyake Y, Nagita M, Inoue H, Shitakubo D, Takemoto K, Ohtsuka C, Murakami H, Nakamura N, Kanazawa H. A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger. J Biochem (Tokyo) 2001; 130: 217–225
   PubMed Web of Science ®Google Scholar
• Kuwahara H, Kamei J, Nakamura N, Matsumoto M, Inoue H, Kanazawa H. The apoptosis-inducing protein kinase DRAK2 is inhibited in a calcium-dependent manner by the calcium-binding protein CHP. J Biochem (Tokyo) 2003; 134: 245–250
   PubMedGoogle Scholar
• McGargill MA, Wen BG, Walsh CM, Hedrick SM. A deficiency in Drak2 results in a T cell hypersensitivity and an unexpected resistance to autoimmunity. Immunity 2004; 21: 781–791
   PubMed Web of Science ®Google Scholar
• Friedrich ML, Wen BG, Bain G, Kee BL, Katayama C, Murre C, Hedrick SM, Walsh CM. DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection. Int Immunol 2005; 17: 1379–1390
   PubMed Web of Science ®Google Scholar
• Hirano N, Murakami T, Fujiwara K, Matsumoto M. Utility of mouse cell line DBT for propagation and assay of mouse hepatitis virus. Jpn J Exp Med 1978; 48: 71–75
   PubMedGoogle Scholar
• Pewe L, Xue S, Perlman S. Infection with cytotoxic T-lymphocyte escape mutants results in increased mortality and growth retardation in mice infected with a neurotropic coronavirus. J Virol 1998; 72: 5912–5918
   Google Scholar
• Trifilo MJ, Bergmann CC, Kuziel WA, Lane TE. CC chemokine ligand 3 (CCL3) regulates CD8(+)-T-cell effector function and migration following viral infection. J Virol 2003; 77: 4004–4014
   PubMed Web of Science ®Google Scholar
• Glass WG, Hickey MJ, Hardison JL, Liu MT, Manning JE, Lane TE. Antibody targeting of the CC chemokine ligand 5 results in diminished leukocyte infiltration into the central nervous system and reduced neurologic disease in a viral model of multiple sclerosis. J Immunol 2004; 172: 4018–4025
   PubMed Web of Science ®Google Scholar
• Held KS, Chen BP, Kuziel WA, Rollins BJ, Lane E. Differential roles of CCL2 and CCR2 in host defense to coronavirus infection. Virology 2004; 329: 251–260
   PubMed Web of Science ®Google Scholar
• Liu MT, Keirstead HS, Lane TE. Neutralization of the chemokine CXCL10 reduces inflammatory cell invasion and demyelination and improves neurological function in a viral model of multiple sclerosis. J Immunol 2001; 167: 4091–4097
   PubMedGoogle Scholar
• Lane TE, Liu MT, Chen BP, Asensio VC, Samawi RM, Paoletti AD, Campbell IL, Kunkel SL, Fox HS, Buchmeier MJ. A central role for CD4(+) T cells and RANTES in virus-induced central nervous system inflammation and demyelination. J Virol 2000; 74: 1415–1424
   PubMed Web of Science ®Google Scholar
• Castro RF, Perlman S. CD8+T-cell epitopes within the surface glycoprotein of a neurotropic coronavirus and correlation with pathogenicity. J Virol 1995; 69: 8127–8131
   PubMedGoogle Scholar
• Xue S, Jaszewski A, Perlman S. Identification of a CD4+T cell epitope within the M protein of a neurotropic coronavirus. Virology 1995; 208: 173–179
   PubMed Web of Science ®Google Scholar
• Glabinski AR, Tani M, Tuohy VK, Tuthill RJ, Ransohoff RM. Central nervous system chemokine mRNA accumulation follows initial leukocyte entry at the onset of acute murine experimental autoimmune encephalomyelitis. Brain Behav Immun 1995; 9: 315–330
   PubMed Web of Science ®Google Scholar
• Glabinski AR, Tani M, Strieter RM, Tuohy VK, Ransohoff RM. Synchronous synthesis of alpha- and beta-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis. Am J Pathol 1997; 150: 617–630
   PubMed Web of Science ®Google Scholar
• Olson JK, Girvin AM, Miller SD. Direct activation of innate and antigen-presenting functions of microglia following infection with Theiler's virus. J Virol 2001; 75: 9780–9789
   PubMedGoogle Scholar
• Olson JK, Miller SD. Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J Immunol 2004; 173: 3916–3924
   PubMed Web of Science ®Google Scholar
• Rempel JD, Quina LA, Blakely-Gonzales PK, Buchmeier MJ, Gruol DL. Viral induction of central nervous system innate immune responses. J Virol 2005; 79: 4369–4381
   Google Scholar
• Lane TE, Buchmeier MJ. Murine coronavirus infection: A paradigm for virus-induced demyelinating disease. Trends Microbiol 1997; 5: 9–14
   PubMed Web of Science ®Google Scholar
• Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N, Glimcher LH. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy. Cell 1995; 80: 707–718
   PubMed Web of Science ®Google Scholar
• Chen Y, Inobe J, Kuchroo VK, Baron JL, Janeway CA, Jr, Weiner HL. Oral tolerance in myelin basic protein T-cell receptor transgenic mice: Suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells. Proc Natl Acad Sci USA 1996; 93: 388–391
   PubMed Web of Science ®Google Scholar
• Gimsa U, Wolf SA, Haas D, Bechmann I, Nitsch R. Th2 cells support intrinsic anti-inflammatory properties of the brain. J Neuroimmunol 2001; 119: 73–80
   PubMed Web of Science ®Google Scholar
• Bettelli E, Das MP, Howard ED, Weiner HL, Sobel RA, Kuchroo VK. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J Immunol 1998; 161: 3299–3306
   PubMed Web of Science ®Google Scholar
• Samoilova EB, Horton JL, Chen Y. Acceleration of experimental autoimmune encephalomyelitis in interleukin-10-deficient mice: Roles of interleukin-10 in disease progression and recovery. Cell Immunol 1998; 188: 118–124
   Google Scholar