Increased expression of STAT3 in SLE T cells contributes to enhanced chemokine-mediated cell migration

References

• Tsokos GC, Boumpas DT. Systemic lupus erythematosus. Molecular pathology of autoimmunity, C Bona. Harwood Academic Publishers, Gordon and Breach 2001; 255
   Google Scholar
• Miyara M, Amoura Z, Parizot C, Badoual C, Dorgham K, Trad S, et al. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol 2005; 175(12)8392–8400
   PubMed Web of Science ®Google Scholar
• Desai-Mehta A, Lu L, Ramsey-Goldman R, Datta SK. Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production. J Clin Invest 1996; 97(9)2063–2073
   PubMed Web of Science ®Google Scholar
• Linker-Israeli M, Deans RJ, Wallace DJ, Prehn J, Ozeri-Chen T, Klinenberg JR. Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis. J Immunol 1991; 147(1)117–123
   PubMed Web of Science ®Google Scholar
• Capper ER, Maskill JK, Gordon C, Blakemore AI. Interleukin (IL)-10, IL-1ra and IL-12 profiles in active and quiescent systemic lupus erythematosus: Could longitudinal studies reveal patient subgroups of differing pathology?. Clin Exp Immunol 2004; 138(2)348–356
   Google Scholar
• Crow MK. Interferon pathway activation in systemic lupus erythematosus. Curr Rheumatol Rep 2005; 7(6)463–468
   Google Scholar
• Akira S, Nishio Y, Inoue M, Wang XJ, Wei S, Matsusaka T, et al. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 1994; 77(1)63–71
   PubMed Web of Science ®Google Scholar
• Finbloom DS, Winestock KD. IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes. J Immunol 1995; 155(3)1079–1090
   PubMed Web of Science ®Google Scholar
• Heinrich PC, Behrmann I, Muller-Newen G, Schaper F, Graeve L. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J 1998; 334(Pt 2)297–314
   PubMed Web of Science ®Google Scholar
• Akira S. Roles of STAT3 defined by tissue-specific gene targeting. Oncogene 2000; 19(21)2607–2611
   PubMed Web of Science ®Google Scholar
• Hirano T, Ishihara K, Hibi M. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 2000; 19(21)2548–2556
   PubMed Web of Science ®Google Scholar
• Bhattacharya S, Ray RM, Johnson LR. STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells. Biochem J 2005; 392(Pt 2)335–344
   PubMed Web of Science ®Google Scholar
• Isomoto H, Kobayashi S, Werneburg NW, Bronk SF, Guicciardi ME, Frank DA, et al. Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells. Hepatology 2005; 42(6)1329–1338, Baltimore, Md.
   PubMed Web of Science ®Google Scholar
• Gao SP, Bromberg JF. Touched and moved by STAT3. Sci STKE 2006; 2006(343)pe30
   PubMedGoogle Scholar
• Zhou W, Grandis JR, Wells A. STAT3 is required but not sufficient for EGF receptor-mediated migration and invasion of human prostate carcinoma cell lines. Br J Cancer 2006; 95(2)164–171
   Google Scholar
• McLoughlin RM, Jenkins BJ, Grail D, Williams AS, Fielding CA, Parker CR, et al. IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation. Proc Natl Acad Sci USA 2005; 102(27)9589–9594
   PubMed Web of Science ®Google Scholar
• Kinashi T. Intracellular signalling controlling integrin activation in lymphocytes. Nat Rev Immunol 2005; 5(7)546–559
   PubMed Web of Science ®Google Scholar
• Eskdale J, Gallagher G, Verweij CL, et al. Interleukin 10 secretion in relation to human IL-10 locus haplotypes. Proc Natl Acad Sci USA 1998; 95: 9465–9470
   PubMed Web of Science ®Google Scholar
• Mehrian R, Quismorio FP, et al. Synergistic effect between IL-10 and bcl-2 genotypes in determining susceptibility to systemic lupus erythematosus. Arthritis Rheum 1998; 41: 596–602
   PubMed Web of Science ®Google Scholar
• Means TK, Latz E, Hayashi F, Murali MR, Golenbock DT, Luster AD. Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9. J Clin Invest 2005; 115(2)407–417
   PubMedGoogle Scholar
• Lovgren T, Eloranta ML, Bave U, Alm GV, Ronnblom L. Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG. Arthritis Rheum 2004; 50(6)1861–1872
   PubMedGoogle Scholar
• Krishnan S, Nambiar MP, Warke VG, Fisher CU, Mitchell J, Delaney N, et al. Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosus. J Immunol 2004; 172(12)7821–7831
   PubMed Web of Science ®Google Scholar
• Matsumoto A, Seki Y, Watanabe R, Hayashi K, Johnston JA, Harada Y, et al. A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production. J Exp Med 2003; 197(4)425–436
   Google Scholar
• Wang T, Niu G, Kortylewski M, Burdelya L, Shain K, Zhang S, et al. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat Med 2004; 10(1)48–54, January
   PubMed Web of Science ®Google Scholar
• Silver DL, Naora H, Liu J, Cheng W, Montell DJ. Activated signal transducer and activator of transcription (STAT) 3: Localization in focal adhesions and function in ovarian cancer cell motility. Cancer Res 2004; 64(10)3550–3558
   Google Scholar
• Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, et al. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene 2003; 22(3)319–329
   PubMed Web of Science ®Google Scholar
• Itoh M, Murata T, Suzuki T, Shindoh M, Nakajima K, Imai K, et al. Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells. Oncogene 2006; 25(8)1195–1204
   PubMed Web of Science ®Google Scholar