Signals of cell death and tissue turnover during physiological pregnancy, pre-eclampsia, and autoimmunity

References

• Huang FP, Platt N, Wykes M, Major JR, Powell TJ, Jenkins CD, MacPherson GG. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J Exp Med 2000; 191: 435–444
   PubMed Web of Science ®Google Scholar
• Skoberne M, Beignon AS, Larsson M, Bhardwaj N. Apoptotic cells at the crossroads of tolerance and immunity. Curr Top Microbiol Immunol 2005; 289: 259–292
   PubMed Web of Science ®Google Scholar
• Manfredi AA, Sabbadini MG, Rovere-Querini P. Dendritic cells and the shadow line between autoimmunity and disease. Arthritis Rheum 2005; 52: 11–15
   PubMed Web of Science ®Google Scholar
• Mahoney JA, Rosen A. Apoptosis and autoimmunity. Curr Opin Immunol 2005; 17: 583–588
   PubMed Web of Science ®Google Scholar
• Munoz LE, Gaipl US, Franz S, Sheriff A, Voll RE, Kalden JR, Herrmann M. SLE—a disease of clearance deficiency?. Rheumatology (Oxford) 2005; 44: 1101–1107
   PubMed Web of Science ®Google Scholar
• Herrmann M, Voll RE, Zoller OM, Hagenhofer M, Ponner BB, Kalden JR. Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum 1998; 41: 1241–1250
   PubMed Web of Science ®Google Scholar
• Baumann I, Kolowos W, Voll RE, Manger B, Gaipl U, Neuhuber WL, Kirchner T, Kalden JR, Herrmann M. Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus. Arthritis Rheum 2002; 46: 191–201
   PubMed Web of Science ®Google Scholar
• Rovere-Querini P, Sabbadini MG, Di Comite G, Manfredi AA. Novel hints on the pathogenesis of lupus from in vivo models. Future Rheumatol 2006; 1: 217–224
   Google Scholar
• Manfredi AA, Iannacone M, D'Auria F, Rovere-Querini P. The disposal of dying cells in living tissues. Apoptosis 2002; 7: 153–161
   PubMed Web of Science ®Google Scholar
• Peng Y, Kowalewski R, Kim S, Elkon KB. The role of IgM antibodies in the recognition and clearance of apoptotic cells. Mol Immunol 2005; 42: 781–787
   PubMed Web of Science ®Google Scholar
• Quartier P, Potter PK, Ehrenstein MR, Walport MJ, Botto M. Predominant role of IgM-dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow-derived macrophages in vitro. Eur J Immunol 2005; 35: 252–260
   PubMed Web of Science ®Google Scholar
• Lewis MJ, Botto M. Complement deficiencies in humans and animals: Links to autoimmunity. Autoimmunity 2006; 39: 367–378
   PubMed Web of Science ®Google Scholar
• Cohen PL, Caricchio R, Abraham V, Camenisch TD, Jennette JC, Roubey RA, Earp HS, Matsushima G, Reap EA. Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase. J Exp Med 2002; 196: 135–140
   PubMed Web of Science ®Google Scholar
• Hanayama R, Miyasaka K, Nakaya M, Nagata S. MFG-E8-dependent clearance of apoptotic cells, and autoimmunity caused by its failure. Curr Dir Autoimmun 2006; 9: 162–172
   PubMedGoogle Scholar
• Huppertz B, Kadyrov M, Kingdom JC. Apoptosis and its role in the trophoblast. Am J Obstet Gynecol 2006; 195: 29–39
   PubMed Web of Science ®Google Scholar
• Straszewski-Chavez SL, Abrahams VM, Mor G. The role of apoptosis in the regulation of trophoblast survival and differentiation during pregnancy. Endocr Rev 2005; 26: 877–897
   PubMed Web of Science ®Google Scholar
• Bischoff FZ, Lewis DE, Simpson JL. Cell-free fetal DNA in maternal blood: Kinetics, source and structure. Hum Reprod Update 2005; 11: 59–67
   PubMed Web of Science ®Google Scholar
• Abrahams VM, Kim YM, Straszewski SL, Romero R, Mor G. Macrophages and apoptotic cell clearance during pregnancy. Am J Reprod Immunol 2004; 51: 275–282
   PubMed Web of Science ®Google Scholar
• Trowsdale J, Betz AG. Mother's little helpers: Mechanisms of maternal-fetal tolerance. Nat Immunol 2006; 7: 241–246
   PubMed Web of Science ®Google Scholar
• Redman CW, Sargent IL. Latest advances in understanding preeclampsia. Science 2005; 308: 1592–1594
   PubMed Web of Science ®Google Scholar
• Sibai BM. Diagnosis, prevention, and management of eclampsia. Obstet Gynecol 2005; 105: 402–410
   PubMed Web of Science ®Google Scholar
• Moldenhauer JS, Stanek J, Warshak C, Khoury J, Sibai B. The frequency and severity of placental findings in women with preeclampsia are gestational age dependent. Am J Obstet Gynecol 2003; 189: 1173–1177
   PubMed Web of Science ®Google Scholar
• Feinberg BB. Preeclampsia: The death of Goliath. Am J Reprod Immunol 2006; 55: 84–98
   PubMed Web of Science ®Google Scholar
• Rovere-Querini P, Manfredi AA, Sabbadini MG. Environmental adjuvants, apoptosis and the censorship over autoimmunity. Autoimmun Rev 2005; 4: 555–560
   PubMed Web of Science ®Google Scholar
• Bottazzi B, Garlanda C, Salvatori G, Jeannin P, Manfredi A, Mantovani A. Pentraxins as a key component of innate immunity. Curr Opin Immunol 2006; 18: 10–15
   PubMed Web of Science ®Google Scholar
• Fazzini F, Peri G, Doni A, Dell'Antonio G, Dal Cin E, Bozzolo E, D'Auria F, Praderio L, Ciboddo G, Sabbadini MG, Manfredi AA, Mantovani A, Rovere-Querini P. PTX3 in small-vessel vasculitides: An independent indicator of disease activity produced at sites of inflammation. Arthritis Rheum 2001; 44: 2841–2850
   PubMed Web of Science ®Google Scholar
• Salustri A, Garlanda C, Hirsch E, De Acetis M, Maccagno A, Bottazzi B, Doni A, Bastone A, Mantovani G, Beck Peccoz P, Salvatori G, Mahoney DJ, Day AJ, Siracusa G, Romani L, Mantovani A. PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization. Development 2004; 131: 1577–1586
   PubMed Web of Science ®Google Scholar
• Cetin I, Cozzi V, Pasqualini F, Nebuloni M, Garlanda C, Vago L, Pardi G, Mantovani A. Elevated maternal levels of the long pentraxin 3 (PTX3) in preeclampsia and intrauterine growth restriction. Am J Obstet Gynecol 2006; 194: 1347–1353
   PubMed Web of Science ®Google Scholar
• Rovere-Querini P, Antonacci S, Dell'Antonio G, Angeli A, Almirante G, Cin ED, Valsecchi L, Lanzani C, Sabbadini MG, Doglioni C, Manfredi AA, Castiglioni MT. Plasma and tissue expression of the long pentraxin 3 during normal pregnancy and preeclampsia. Obstet Gynecol 2006; 108: 148–155
   PubMed Web of Science ®Google Scholar
• Assi F, Fruscio R, Bonardi C, Ghidini A, Allavena P, Mantovani A, Locatelli A. Pentraxin 3 in plasma and vaginal fluid in women with preterm delivery. BJOG 2007; 114: 143–147
   PubMed Web of Science ®Google Scholar
• Menon R, Fortunato SJ. The role of matrix degrading enzymes and apoptosis in rupture of membranes. J Soc Gynecol Investig 2004; 11: 427–437
   PubMedGoogle Scholar
• Rovere P, Peri G, Fazzini F, Bottazzi B, Doni A, Bondanza A, Zimmermann VS, Garlanda C, Fascio U, Sabbadini MG, Rugarli C, Mantovani A, Manfredi AA. The long pentraxin PTX3 binds to apoptotic cells and regulates their clearance by antigen-presenting dendritic cells. Blood 2000; 96: 4300–4306
   PubMed Web of Science ®Google Scholar
• Baruah P, Propato A, Dumitriu IE, Rovere-Querini P, Russo V, Fontana R, Accapezzato D, Peri G, Mantovani A, Barnaba V, Manfredi AA. The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells and edits the cross-presentation of self, viral and tumor antigens. Blood 2006; 107: 151–158
   PubMed Web of Science ®Google Scholar
• Baruah P, Dumitriu IE, Peri G, Russo V, Mantovani A, Manfredi AA, Rovere-Querini P. The tissue pentraxin PTX3 limits C1q-mediated complement activation and phagocytosis of apoptotic cells by dendritic cells. J Leukoc Biol 2006; 80: 87–95
   PubMed Web of Science ®Google Scholar
• Oppenheim JJ, Yang D. Alarmins: Chemotactic activators of immune responses. Curr Opin Immunol 2005; 17: 359–365
   PubMed Web of Science ®Google Scholar
• Bianchi ME. DAMPs, PAMPs and alarmins: All we need to know about danger. J Leukoc Biol 2007; 81: 1–5
   PubMed Web of Science ®Google Scholar
• Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002; 418: 191–195
   PubMed Web of Science ®Google Scholar
• Ulloa L, Batliwalla FM, Andersson U, Gregersen PK, Tracey KJ. High mobility group box chromosomal protein 1 as a nuclear protein, cytokine, and potential therapeutic target in arthritis. Arthritis Rheum 2003; 48: 876–881
   PubMed Web of Science ®Google Scholar
• Lotze MT, Tracey KJ. High-mobility group box 1 protein (HMGB1): Nuclear weapon in the immune arsenal. Nat Rev Immunol 2005; 5: 331–342
   PubMed Web of Science ®Google Scholar
• Dumitriu IE, Baruah P, Manfredi AA, Bianchi ME, Rovere-Querini P. HMGB1: Guiding immunity from within. Trends Immunol 2005; 26: 381–387
   PubMed Web of Science ®Google Scholar
• Rovere-Querini P, Capobianco A, Scaffidi P, Valentinis B, Catalanotti F, Giazzon M, Dumitriu IE, Müller S, Iannacone M, Traversari C, Bianchi ME, Manfredi AA. HMGB1 is an endogenous immune adjuvant released by necrotic cells. EMBO Rep 2004; 5: 825–830
   PubMed Web of Science ®Google Scholar
• Messmer D, Yang H, Telusma G, Knoll F, Li J, Messmer B, Tracey KJ, Chiorazzi N. High mobility group box protein 1: An endogenous signal for dendritic cell maturation and Th1 polarization. J Immunol 2004; 173: 307–313
   PubMed Web of Science ®Google Scholar
• Dumitriu IE, Bianchi ME, Bacci M, Manfredi AA, Rovere-Querini P. The secretion of HMGB1 is required for the migration of maturing dendritic cells. J Leukoc Biol 2007; 81: 84–91
   PubMed Web of Science ®Google Scholar
• Yang D, Chen Q, Yang H, Tracey KJ, Bustin M, Oppenheim JJ. High mobility group box-1 protein induces the migration and activation of human dendritic cells and acts as an alarmin. J Leukoc Biol 2007; 81: 59–66
   PubMed Web of Science ®Google Scholar
• Bell CW, Jiang W, Reich CF, 3rd, Pisetsky DS. The extracellular release of HMGB1 during apoptotic cell death. Am J Physiol Cell Physiol 2006; 291: C1318–C1325
   PubMed Web of Science ®Google Scholar