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Autoimmunity Volume 41, 2008 - Issue 1
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Original

VH gene usage and CDR3 analysis of B cell receptor in the peripheral blood of patients with PBC

Angela L. Foreman Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis School of Medicine, USA
,
Angela L. Foreman Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis School of Medicine, USA
,
Brigitte Lemercier Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Institut Pasteur, Paris, France
,
Angela L. Foreman Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis School of Medicine, USA
,
Brigitte Lemercier Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Institut Pasteur, Paris, France
,
Annick Lim Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Institut Pasteur, Paris, France
,
Phillipe Kourlisky Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Institut Pasteur, Paris, France
,
Thomas Kenny Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis School of Medicine, USA
,
M. Eric Gershwin Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis School of Medicine, USA
,
Angela L. Foreman Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis School of Medicine, USA
,
Brigitte Lemercier Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Institut Pasteur, Paris, France
,
Annick Lim Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Institut Pasteur, Paris, France
,
Phillipe Kourlisky Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Institut Pasteur, Paris, France
,
Thomas Kenny Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis School of Medicine, USA
,
M. Eric Gershwin Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis School of Medicine, USA
,
Marie-Lise Gougeon Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Institut Pasteur, Paris, France
,
Angela L. Foreman Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis School of Medicine, USA
,
Brigitte Lemercier Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Institut Pasteur, Paris, France
,
Annick Lim Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Institut Pasteur, Paris, France
,
Phillipe Kourlisky Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Institut Pasteur, Paris, France
,
Thomas Kenny Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis School of Medicine, USA
,
M. Eric Gershwin Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis School of Medicine, USA
&
Marie-Lise Gougeon Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Institut Pasteur, Paris, France
 show all
Pages 80-86 | Received 01 Oct 2006, Accepted 04 Nov 2006, Published online: 07 Jul 2009

References

  • Oertelt S, Lian ZX, Cheng CM, Chuang YH, Padgett KA, He XS, Ridgway WM, Ansari AA, Coppel RL, Li MO, Flavell RA, Kronenberg M, Mackay IR, Gershwin ME. Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice. J Immunol 2006; 177: 1655–1660
  • Amano K, Leung PS, Rieger R, Quan C, Wang X, Marik J, Suen YF, Kurth MJ, Nantz MH, Ansari AA, Lam KS, Zeniya M, Matsuura E, Coppel RL, Gershwin ME. Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: Identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid. J Immunol 2005; 174: 5874–5883
  • Benson GD, Kikuchi K, Miyakawa H, Tanaka A, Watnik MR, Gershwin ME. Serial analysis of antimitochondrial antibody in patients with primary biliary cirrhosis. Clin Dev Immunol 2004; 11: 129–133
  • Van de Water J, Ansari AA, Surh CD, Coppel R, Roche T, Bonkovsky H, Kaplan M, Gershwin ME. Evidence for the targeting by 2-oxo-dehydrogenase enzymes in the T cell response of primary biliary cirrhosis. J Immunol 1991; 146: 89–94
  • Kikuchi K, Lian ZX, Kimura Y, Selmi C, Yang GX, Gordon SC, Invernizzi P, Podda M, Coppel RL, Ansari AA, Ikehara S, Miyakawa H, Gershwin ME. Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis. J Autoimmun 2005; 24: 347–352
  • Moritoki Y, Lian ZX, Wulff H, Yang GX, Chuang YH, Lan RY, Ueno Y, Ansari AA, Coppel RL, Mackay IR, Gershwin ME. AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers. Hepatology 2007; 45: 314–322
  • Kikuchi K, Lian ZX, Yang GX, Ansari AA, Ikehara S, Kaplan M, Miyakawa H, Coppel RL, Gershwin ME. Bacterial CpG induces hyper-IgM production in CD27(+) memory B cells in primary biliary cirrhosis. Gastroenterology 2005; 128: 304–312
  • Aoki CA, Borchers AT, Li M, Flavell RA, Bowlus CL, Ansari AA, Gershwin ME. Transforming growth factor beta (TGF-beta) and autoimmunity. Autoimmun Rev 2005; 4: 450–459
  • Voswinkel J, Weisgerber K, Pfreundschuh M, Gause A. B lymphocyte involvement in ankylosing spondylitis: The heavy chain variable segment gene repertoire of B lymphocytes from germinal center-like foci in the synovial membrane indicates antigen selection. Arthritis Res 2001; 3: 189–195
  • Pannetier C, Delassus S, Darche S, Saucier C, Kourilsky P. Quantitative titration of nucleic acids by enzymatic amplification reactions run to saturation. Nucleic Acids Res 1993; 21: 577–583
  • Pannetier C, Even J, Kourilsky P. T-cell repertoire diversity and clonal expansions in normal and clinical samples. Immunol Today 1995; 16: 176–181
  • Bousso P, Kourilsky P. A clonal view of alphabeta T cell responses. Semin Immunol 1999; 11: 423–431
  • Lim A, Baron V, Ferradini L, Bonneville M, Kourilsky P, Pannetier C. Combination of MHC-peptide multimer-based T cell sorting with the immunoscope permits sensitive ex vivo quantitation and follow-up of human CD8+T cell immune responses. J Immunol Methods 2002; 261: 177–194
  • Moteki S, Leung PS, Coppel RL, Dickson ER, Kaplan MM, Munoz S, Gershwin ME. Use of a designer triple expression hybrid clone for three different lipoyl domain for the detection of antimitochondrial autoantibodies. Hepatology 1996; 24: 97–103
  • Grimaldi CM, Hicks R, Diamond B. B cell selection and susceptibility to autoimmunity. J Immunol 2005; 174: 1775–1781
  • Sugimura T, Shiokawa S, Haraoka S, Fujimoto K, Ohshima K, Nakamuta M, Nishimura J. Local antigen-driven oligoclonal expansion of B cells in the liver portal areas of patients with primary biliary cirrhosis. Liver Int 2003; 23: 323–328
  • Kaplan MM, Gershwin ME. Primary biliary cirrhosis. New England. J Med 2005; 353: 1261–1273
  • Aoki CA, Roifman CM, Lian Z-X, Bowlus CL, Norman GL, Shoenfeld Y, Mackay IR, Gershwin ME. IL-receptor alpha deficiency and features of primary biliary cirrhosis. J Autoimmun 2006; 27: 50–53
  • Rieger R, Leung PSC, Jeddeloh MR, Kurth MJ, Nantz MH, Lam KS, Barsky D, Ansari AA, Coppel RL, Mackay IR, Gershwin ME. Identification of 2-nonyoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis. J Autoimmun 2006; 27: 7–16
  • Abbas A, Lohr J, Knoechel B. Balancing autoaggressive and protective T cell responses. J Autoimmun 2007; 28: 59–61, In press
  • Rieger R, Gershwin ME. The X and Y of xenobiotics in primary biliary cirrhosis. J Autoimmun 2007; 28: 76–84

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