Lower levels of the host protective IL-10 in DCM—a feature of autoimmune pathogenesis?

References

• Levine B, Kalman J, Mayer L, Fillit HM, Packer M. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med 1990; 323(4)236–241
   PubMed Web of Science ®Google Scholar
• Aukrust P, Ueland T, Lien E, Bendtzen K, Muller F, Andreassen AK, Nordoy I, Aass H, Espevik T, Simonsen S, Froland SS, Gullestad L. Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 1999; 83(3)376–382
   PubMed Web of Science ®Google Scholar
• Habib FM, Springall DR, Davies GJ, Oakley CM, Yacoub MH, Polak JM. Tumour necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy. Lancet 1996; 347(9009)1151–1155
   PubMed Web of Science ®Google Scholar
• Torre-Amione G, Kapadia S, Lee J, Durand JB, Bies RD, Young JB, Mann DL. Tumor necrosis factor-alpha and tumor necrosis factor receptors in the failing human heart. Circulation 1996; 93(4)704–711
   PubMed Web of Science ®Google Scholar
• Bradham WS, Bozkurt B, Gunasinghe H, Mann D, Spinale FG. Tumor necrosis factor-alpha and myocardial remodeling in progression of heart failure: A current perspective. Cardiovasc Res 2002; 53(4)822–830
   PubMed Web of Science ®Google Scholar
• Torre-Amione G, Kapadia S, Benedict C, Oral H, Young JB, Mann DL. Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD). J Am Coll Cardiol 1996; 27(5)1201–1206
   PubMed Web of Science ®Google Scholar
• Why HJ, Meany BT, Richardson PJ, Olsen EG, Bowles NE, Cunningham L, Freeke CA, Archard LC. Clinical and prognostic significance of detection of enteroviral RNA in the myocardium of patients with myocarditis or dilated cardiomyopathy. Circulation 1994; 89(6)2582–2589
   PubMed Web of Science ®Google Scholar
• Kuhl U, Pauschinger M, Seeberg B, Lassner D, Noutsias M, Poller W, Schultheiss HP. Viral persistence in the myocardium is associated with progressive cardiac dysfunction. Circulation 2005; 112(13)1965–1970
   PubMed Web of Science ®Google Scholar
• Feldman AM, McNamara D. Myocarditis. N Engl J Med 2000; 343(19)1388–1398
   PubMed Web of Science ®Google Scholar
• Afanasyeva M, Georgakopoulos D, Rose NR. Autoimmune myocarditis: Cellular mediators of cardiac dysfunction. Autoimmun Rev 2004; 3(7–8)476–486
   PubMed Web of Science ®Google Scholar
• Jahns R, Boivin V, Hein L, Triebel S, Angermann CE, Ertl G, Lohse MJ. Direct evidence for a beta 1-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy. J Clin Invest 2004; 113(10)1419–1429
   PubMed Web of Science ®Google Scholar
• Magnusson Y, Marullo S, Hoyer S, Waagstein F, Andersson B, Vahlne A, Guillet JG, Strosberg AD, Hjalmarson A, Hoebeke J. Mapping of a functional autoimmune epitope on the beta 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy. J Clin Invest 1990; 86(5)1658–1663
   PubMed Web of Science ®Google Scholar
• Felix SB, Staudt A, Friedrich GB. Improvement of cardiac function after immunoadsorption in patients with dilated cardiomyopathy. Autoimmunity 2001; 34(3)211–215
   PubMed Web of Science ®Google Scholar
• Magnusson Y, Levin MC, Eggertsen R, Nystrom E, Mobini R, Schaufelberger M, Andersson B. Ser49Gly of beta1-adrenergic receptor is associated with effective beta-blocker dose in dilated cardiomyopathy. Clin Pharmacol Ther 2005; 78(3)221–231
   PubMed Web of Science ®Google Scholar
• Torre-Amione G. Immune activation in chronic heart failure. Am J Cardiol 2005; 95(11A)3C–8C, discussion 38C-40C
   Web of Science ®Google Scholar
• Murray PJ. The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription. Proc Natl Acad Sci USA 2005; 102(24)8686–8691
   PubMed Web of Science ®Google Scholar
• O'Garra A, Vieira P. T(H)1 cells control themselves by producing interleukin-10. Nat Rev Immunol 2007; 7(6)425–428
   PubMed Web of Science ®Google Scholar
• Gazzinelli RT, Wysocka M, Hieny S, Scharton-Kersten T, Cheever A, Kuhn R, Muller W, Trinchieri G, Sher A. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. J Immunol 1996; 157(2)798–805
   PubMed Web of Science ®Google Scholar
• Magnusson Y, Wallukat G, Waagstein F, Hjalmarson A, Hoebeke J. Autoimmunity in idiopathic dilated cardiomyopathy. Characterization of antibodies against the beta 1-adrenoceptor with positive chronotropic effect. Circulation 1994; 89(6)2760–2767
   PubMed Web of Science ®Google Scholar
• Kuhl U, Pauschinger M, Noutsias M, Seeberg B, Bock T, Lassner D, Poller W, Kandolf R, Schultheiss HP. High prevalence of viral genomes and multiple viral infections in the myocardium of adults with “idiopathic” left ventricular dysfunction. Circulation 2005; 111(7)887–893
   PubMed Web of Science ®Google Scholar
• Li Y, Heuser JS, Kosanke SD, Hemric M, Cunningham MW. Protection against experimental autoimmune myocarditis is mediated by interleukin-10-producing T cells that are controlled by dendritic cells. Am J Pathol 2005; 167(1)5–15
   PubMed Web of Science ®Google Scholar
• Gullestad L, Aass H, Fjeld JG, Wikeby L, Andreassen AK, Ihlen H, Simonsen S, Kjekshus J, Nitter-Hauge S, Ueland T, Lien E, Froland SS, Aukrust P. Immunomodulating therapy with intravenous immunoglobulin in patients with chronic heart failure. Circulation 2001; 103(2)220–225
   PubMed Web of Science ®Google Scholar
• Mabuchi N, Tsutamoto T, Wada A, Ohnishi M, Maeda K, Hayashi M, Kinoshita M. Relationship between interleukin-6 production in the lungs and pulmonary vascular resistance in patients with congestive heart failure. Chest 2002; 121(4)1195–1202
   PubMed Web of Science ®Google Scholar
• Torres KC, Antonelli LR, Souza AL, Teixeira MM, Dutra WO, Gollob KJ. Norepinephrine, dopamine and dexamethasone modulate discrete leukocyte subpopulations and cytokine profiles from human PBMC. J Neuroimmunol 2005; 166(1–2)144–157
   PubMed Web of Science ®Google Scholar
• Gullestad L, Ueland T, Brunsvig A, Kjekshus J, Simonsen S, Froland SS, Aukrust P. Effect of metoprolol on cytokine levels in chronic heart failure—a substudy in the metoprolol controlled-release randomised intervention trial in heart failure (MERIT-HF). Am Heart J 2001; 141(3)418–421
   PubMed Web of Science ®Google Scholar