329
Views
77
CrossRef citations to date
0
Altmetric
Original

Quantification and molecular characterization of regulatory T cells in connective tissue diseases

, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , & show all
Pages 41-49 | Received 06 May 2008, Accepted 12 Jun 2008, Published online: 07 Jul 2009

References

  • Stockinger B. T lymphocyte tolerance: From thymic deletion to peripheral control mechanisms. Adv Immunol 1999; 71: 229–265
  • Dieckmann D, Plottner H, Berchtold S, Berger T, Schuler G. Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J Exp Med 2001; 193: 1303–1310
  • Jonuleit H, Schmitt E, Stassen M, Tuettenberg A, Knop J, Enk AH. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med 2001; 193: 1285–1294
  • Ng WF, Duggan PJ, Ponchel F, Matarese G, Lombardi G, Edwards AD, Isaacs JD, Lechler RI. Human CD4(+)CD25(+) cells: A naturally occurring population of regulatory T cells. Blood 2001; 98: 2736–2744
  • Godfrrey WR, Ge YG, Sponden DJ, Levine BL, June HCH, Blazar BR, Porter SB. In vitro-expanded human CD4+CD25high T regulatory cells. Blood 2004; 104: 453–461
  • Sakaguchi S, Masahiro O, Setoguchi R, Yagi H, Hori S, Fehervari Z, Shimizu J, Takahashi T, Nomura T. Foxp3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 2006; 212: 8–27
  • Sansom DM, Walker LS. The role of CD28 and cytotoxic T-lymphocytes antigen-4 (CTLA-4) in regulatory T-cell biology. Immunol Rev 2006; 212: 131–148
  • Ermann J, Fathman GC. Costimulatory signals controlling regulatory T cells. Proc Natl Acad Sci USA 2003; 100: 15292–15293
  • McHugh RS, Whitters MJ, Piccirillo CA, Young DA, Shevach EM, Collins M, Byrne MC. CD4(+)CD25(+) immunoregulatory T cells: Gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 2002; 16: 311–323
  • Shevach EM, Stephens GL. The GITR–GITRL interaction: Co-stimulation or contrasuppression of regulatory activity?. Nat Rev Immunol 2006; 6: 613–618
  • Akbar AN, Taams LS, Salmonz M, Vukmanovic-Stejic M. The peripheral generation of CD4+CD25+ regulatory T cells. Immunology 2003; 109: 319–325
  • Tang Q, Bluestone JA. Regulatory T-cell physiology and application to treat autoimmunity. Immunol Rev 2006; 212: 217–237
  • Dejaco C, Duftner C, Grubeck-Loebenstein B, Schirmer M. Imbalance of regulatory T cells in human autoimmune diseases. Immunology 2005; 117: 289–300
  • Lindley S, Dayan CM, Bishop A, Roep BO, Peakman M, Tree TI. Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 2005; 54: 92–99
  • Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 2004; 199: 971–979
  • Ehrenstein MR, Evans JG, Singh A, Moore S, Warnes G, Isenberg DA, Mauri C. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med 2004; 200: 277–285
  • Kriegel MA, Lohmann T, Gabler C, Blank N, Kalden JR, Lorenz HM. Defective suppressor function of human CD4+CD25+ regulatory T cells in autoimmune polyglandular syndrome type II. J Exp Med 2004; 199: 1285–1291
  • Sugiyama H, Gyulai R, Toichi E, Garaczi E, Shimada S, Stevens SR, McCormick TS, Cooper KD. Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: Mechanism underlying unrestrained pathogenic effector T cell proliferation. J Immunol 2005; 174: 164–173
  • Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Schaller JG, Talal N, Winchester RJ. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25: 1271–1277
  • LeRoy EC, Black C, Fleischmajer R, Jablonska S, Krieg T, Medsger TA, Jr., Rowell N, Wollheim F. Scleroderma (systemic sclerosis): Classification, subsets and pathogenesis. J Rheumatol 1988; 15: 202–205
  • Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, Daniels TE, Fox PC, Fox RI, Kassan SS, Pillemer SR, Talal N, Weisman MH, The European Study Group on Classification Criteria for Sjögren's Syndrome. Classification criteria for Sjögren's syndrome: A revised version of the European criteria proposed by the American–European Consensus Group. Ann Rheum Dis 2002; 61: 554–558
  • Bohan A, Peter JB. Polymyositis and dermatomyositis (first of two parts). N Engl J Med 1975; 292: 344–347
  • Stassen M, Fondel S, Bopp T, Richter C, Müller C, Kubach J, Becker C, Knop J, Enk AH, Schmitt S, Schmitt E, Jonuleit H. Human CD25+ regulatory T cells: Two subsets defined by the integrins alpha 4 beta 7 or alpha 4 beta 1 confer distinct suppressive properties upon CD4+T helper cells. Eur J Immunol 2004; 34: 1303–1311
  • Matache C, Onu A, Stefanescu M, Tanaseanu S, Dragomir C, Dolganiuc A, Szegli G. Dysregulation of p56lck kinase in patients with systemic lupus erythematosus. Autoimmunity 2001; 34: 27–38
  • Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA. CD4+CD25high regulatory cells in human peripheral blood. J Immunol 2001; 167: 1245–1253
  • Takahashi T, Tagami T, Yamazaki S, Uede T, Shimizu J, Sakaguchi N, Mak TW, Sakaguchi S. Immunologic self-tolerance maintained by CD25+CD4+ regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2000; 192: 303–310
  • Wing K, Ekmark A, Karlsson H, Rudin A, Suri-Payer E. Characterization of human CD25+CD4+T cells in thymus, cord and adult blood. Immunology 2002; 106: 190–199
  • Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003; 4: 330–336
  • Khattri R, Cox T, Yasayko S-A, Ramsdell F. An essential role for Scurfin in CD4+CD25+T regulatory cells. Natl Immunol 2003; 4: 337–342
  • Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004; 22: 531–562
  • Lim HW, Hillsamer P, Banham AH, Kim CH. Cutting edge: Direct suppression of B cells by CD4+CD25+ regulatory T cells. J Immunol 2005; 175: 4180–4183
  • Bluestone JA, Tang Q. How do CD4+CD25+ regulatory T cells control autoimmunity?. Curr Opin Immunol 2005; 17: 638–642
  • Ni Choileain N, Redmond HP. Regulatory T-cells and autoimmunity. J Surg Res 2006; 130: 124–135
  • Crispin JC, Martínez A, Alcocer-Varela J. Quantification of regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun 2003; 21: 273–276
  • Liu MF, Wang CR, Fung LL, Wu CR. Decreased CD4+CD25+T cells in perpheral blood of patients with systemic lupus erythematosus. Scand J Immunol 2004; 59: 198–202
  • Lee JH, Wang LC, Lin YT, Yang YH, Lin DT, Chiang BL. Inverse correlation between CD4+ regulatory T-cell population and autoantibody levels in paediatric patients with systemic lupus erythematosus. Immunology 2006; 117: 280–286
  • Wei HG, Cai B, Wang LL, Li J, Feng WH. Analysis of Foxp3(+) CD4(+) CD25(+) regulatory cells in peripheral blood of patients with SLE [abstract]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007; 23: 432–435
  • Lyssuk EY, Torgashina AV, Soloviev SK, Nassonov EL, Bykovskaia SN. Reduced number and function of CD4+CD25highFoxP3+ regulatory T cells in patients with systemic lupus erythematosus. Adv Exp Med Biol 2007; 601: 113–119
  • Bonelli M, von Dalwigk K, Savitskaya A, Smolen JS, Scheinecker C. Foxp3 expression in CD4+T cells of patients with systemic lupus erythematosus (SLE): A comparative phenotypic analysis. Ann Rheum Dis 2008; 67: 664–671
  • Baráth S, Soltész P, Kiss E, Aleksza M, Zeher M, Szegedi G, Sipka S. The severity of systemic lupus erythematosus negatively correlates with the increasing number of CD4(+)CD25(high)FoxP3(+) regulatory T cells during repeated plasmapheresis treatments of patients. Autoimmunity 2007; 40: 521–528
  • Suárez A, López P, Gómez J, Gutiérrez C. Enrichment of CD4+ CD25high T cell population in patients with systemic lupus erythematosus treated with glucocorticoids. Ann Rheum Dis 2006; 65: 1512–1517
  • Alvarado-Sánchez B, Hernández-Castro B, Portales-Pérez D, Baranda L, Layseca-Espinosa E, Abud-Mendoza C, Cubillas-Tejeda AC, González-Amaro R. Regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun 2006; 27: 110–118
  • Miyara M, Amoura Z, Parizot C, Badoual C, Dorgham K, Trad S, Nochy D, Debré P, Piette JC, Gorochov G. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol 2005; 175: 8392–8400
  • Valencia X, Yarboro C, Illei G, Lipsky PE. Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol 2007; 178: 2579–2588
  • Gottenberg JE, Lavie F, Abbed K, Gasnault J, Le Nevot E, Delfraissy JF, Taoufik Y, Mariette X. CD4CD25high regulatory T cells are not impaired in patients with primary Sjögren's syndrome. J Autoimmun 2005; 24: 235–242
  • Minami R, Sakai K, Miyamura T, Yamamoto M, Suematsu E. The role of CD4+CD25+ regulatory T cells in patients with Rheumatoid Arthritis [abstract]. Nihon Rinsho Meneki Gakkai Kaishi 2006; 29: 37–42
  • Nocentini G, Ronchetti S, Cuzzocrea S, Riccardi C. GITR/GITRL: More than an effector T cell co-stimulatory system. Eur J Immunol 2007; 37: 1165–1169
  • Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002; 3: 135–142
  • Eggena MP, Walker LS, Nagabhushanam V, Barron L, Chodos A, Abbas AK. Cooperative roles of CTLA-4 and regulatory T cells in tolerance to an islet cell antigen. J Exp Med 2004; 199: 1725–1730
  • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057–1061
  • Karagiannidis C, Akdis M, Holopainen P, Woolley NJ, Hense G, Rückert B, Mantel P-Y, Menz G, Akdis CA, Blaser K, Schmidt-Weber CB. Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma. J Allergy Clin Immunol 2004; 114: 1425–1433
  • Sailler L, Puissant B, Meliani P, Castex JO, Saivin S, Adoue D, Fournie EB, Arlet P, Montastruc JL, Lapeyre-Mestre M, Pourrat J, Blancher A. Blood concentrations of hydroxychloroquine and its desethyl derivative correlate negatively with the percentage of CD45RO+ cells among CD4+ lymphocytes in hydroxychloroquine-treated lupus patients. Ann N Y Acad Sci 2007; 1108: 41–50
  • Stock P, Akbari O, DeKruyff RH, Umetsu DT. Respiratory tolerance is inhibited by the administration of corticosteroids. J Immunol 2005; 175: 7380–7387
  • Bamberger CM, Else T, Bamberger AM, Beil FU, Schulte HM. Regulation of the human interleukin-2 gene by the alpha and beta isoforms of the glucocorticoid receptor. Mol Cell Endocrinol 1997; 136: 23–28
  • Demirkiran A, Kok A, Kwekkeboom J, Kusters JG, Metselaar HJ, Tilanus HW, van der Laan LJW. Low circulating regulatory T-cell levels after acute rejection in liver transplantation. Liver Transplant 2006; 12: 277–284
  • Nelson BH. IL-2, regulatory T cells, and tolerance. J Immunol 2004; 172: 3983–3988

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.