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Original

FOXP3/Scurfin gene polymorphism is associated with adult onset type 1 diabetes in Japanese, especially in women and slowly progressive-type patients

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Pages 159-167 | Received 19 May 2008, Accepted 18 Sep 2008, Published online: 07 Jul 2009

References

  • Atkinson MA, Maclaren NK. The pathogenesis of insulin dependent diabetes mellitus. N Engl J Med 1994; 331: 1428–1436
  • Sakaguchi S. Regulatory T cells: Key controllers of immunologic self tolerance. Cell 2000; 101: 455–458
  • O'Garra A, Vieira P. Regulatory T cells and mechanisms of immune system control. Nat Med 2004; 10: 801–805
  • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by transcriptional factor foxp3. Science 2003; 299: 1057–1061
  • Khattri R, Cox T, Yasayko SA, Ramsdell F. An essential role for Scurfin in CD4+CD25+T regulatory cells. Nat Immunol 2003; 4: 337–342
  • Wilson RS, Smyk-Peason S, Filipovich AH. Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J Med Genet 2002; 39: 537–545
  • Brunkow ME, Jeffery EW, Hjerrid KA. Disruption of a new forkhead/winged-helix protein, surfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 2001; 27: 68–73
  • Bassuny WM, Ihara K, Sasaki Y, Kuromaru R, Kohno H, Matsuura N, Hara T. A functional polymorphism in the promoter/enhancer region of FOXP3/Scurfin gene associated with type 1 diabetes. Immunogenetics 2003; 55: 149–156
  • Zavatari P, Deidda E, Pitzalis M, Zoa B, Moi L, Lampis R, Contu D, Motzo C, Frongia P, Angius E, Maioli M, Todd JA, Cucca F. No association between variation of FOXP3 gene and common type 1 diabetes in Sardinian population. Diabetes 2004; 53: 1911–1914
  • Nakanishi K. No contribution of a GT microsatellite polymorphism in the promotor region of the FOXP3 gene to susceptibility to type 1 diabetes in the Japanese population. Clin Chim Acta 2007; 384: 171–173
  • Kobayashi T, Tamemoto K, Nakanishi K, Kato N, Okubo M, Kajio H, Sugimoto T, Murase T, Kosaka K. Immunogenetic and clinical characterization of slowly progressive IDDM. Diabetes Care 1993; 16: 780–788
  • Kasuga A, Maruyama T, Nakamoto S, Ozawa Y, Suzuki Y, Saruta T. High-titer autoantibodies against glutamic acid decarboxylase plus autoantibodies against insulin and IA-2 predicts insulin requirement in adult diabetic patients. J Autoimmn 1999; 12: 131–135
  • Suzuki R, Shimada A, Maruyama T, Funae O, Morimoto J, Kodama K, Oikawa Y, Kasuga A, Matsubara K, Saruta T, Narumi S. T-cell function in anti-GAD65+diabetes with residual β cell function. J Autoimmun 2003; 20: 83–90
  • Maruyama T, Shimada A, Kasuga A, Kasatani T, Oikawa Y, Ishii M, Takei I, Suzuki Y, Kobayashi A, Takeda S. Analysis of MHC class II antigens in Japanese IDDM by a novel HLA-typing method, hybridization protection assay. Diabetes Res Clin Pract 1994; 23: 77–84
  • Sanchez E, Rueda B, Orozco G, Oliver J, Vilchez JR, Paco L, Lopez-Nevot MA, Calljas JL, Sabio JM, Gomez-Garcia M, Nieto A, Delgado M, Martin J. Analysis of a GT microsatellite in the promoter of the foxp3/scurfin gene in autoimmune diseases. Human Immunol 2005; 66: 869–873
  • Brusko T, Wasserfall C, McGrail K, Schatz R, Viener HL, Schatz D, Haller M, Rockell J, Gottlieb P, Clare-Salzler M, Atkinson M. No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes. Diabetes 2007; 56: 604–612
  • Ban Y, Tozaki T, Tobe T, Ban Y, Jacobson EM, Concepcion ES, Tomer Y. The regulatory T cell gene FOXP3 and genetic susceptibility to thyroid autoimmunity: An association analysis in Caucasian and Japanese cohorts. J Autoimmun 2007; 28: 201–207
  • Motohashi Y, Yamada S, Yanagawa T, Maruyama T, Suzuki R, Niino M, Fukazawa T, Kasuga A, Hirose H, Matsubara K, Shimada A, Saruta T. Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetes. J Clin Endocrinol Metab 2003; 88: 3137–3140
  • Yamada S, Motohashi Y, Yanagawa T, Maruyama T, Kasuga A, Hirose H, Matsubara K, Shimada A, Saruta T. Neuro D/beta2 gene G → A polymorphism may affect onset pattern of type 1 diabetes. Diabetes Care 2001; 24: 1438–1441

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