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Mini Review

The translocation of HMGB1 during cell activation and cell death

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Pages 299-301 | Received 17 Oct 2008, Accepted 07 Jan 2009, Published online: 13 Aug 2009

References

  • Bianchi ME. DAMPs, PAMPs and alarmins: All we need to know about danger. J Leukoc Biol 2007; 81: 1–5
  • Goodwin GH, Johns EW. The isolation and purification of the high mobility group (HMG) nonhistone chromosomal proteins. Methods Cell Biol 1977; 16: 257–267
  • Sessa L, Bianchi ME. The evolution of high mobility group box (HMGB) chromatin proteins in multicellular animals. Gene 2007; 387: 133–140
  • Ferrari S, Ronfani L, Calogero S, Bianchi ME. The mouse gene coding for high mobility group 1 protein (HMG1). J Biol Chem 1994; 269: 28803–28808
  • Calogero S, Grassi F, Aguzzi A, Voigtländer T, Ferrier P, Ferrari S, Bianchi ME. The lack of chromosomal protein HMG1 does not disrupt cell growth, but causes lethal hypoglycaemia in newborn mice. Nat Genet 1999; 22: 276–280
  • Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, Frazier A, Yang H, Ivanova S, Borovikova L, Manogue KR, Faist E, Abraham E, Andersson J, Andersson U, Molina PE, Abumrad NN, Sama A, Tracey KJ. HMG-1 as a late mediator of endotoxin lethality in mice. Science 1999; 285: 248–251
  • Andersson U, Wang H, Palmblad K, Aveberger AC, Bloom O, Erlandsson-Harris H, Janson A, Kokkola R, Zhang M, Yang H, Tracey KJ. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med 2000; 192: 565–570
  • Kokkola R, Andersson A, Mullins G, Ostberg T, Treutiger CJ, Arnold B, Nawroth P, Andersson U, Harris RA, Harris HE. RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages. Scand J Immunol 2005; 61: 1–9
  • Park JS, Svetkauskaite D, He Q, Kim JY, Strassheim D, Ishizaka A, Abraham E. Involvement of toll-like receptors 2 and 4 in cellular activation by HMGB1 protein. J Biol Chem 2004; 279: 7370–7377
  • Bonaldi T, Talamo F, Scaffidi P, Ferrera D, Porto A, Bachi A, Rubartelli A, Agresti A, Bianchi ME. Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. EMBO J 2003; 22: 5551–5560
  • Ito I, Fukazawa J, Yoshida M. Post-translational methylation of HMGB1 causes its cytoplasmic localization in neutrophils. J Biol Chem 2007; 282: 16336–16344
  • Gardella S, Andrei C, Ferrera D, Lotti LV, Torrisi MR, Bianchi ME, Rubartelli A. The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway. EMBO Rep 2002; 3: 995–1001
  • Jiang W, Li J, Gallowitsch-Puerta M, Tracey KJ, Pisetsky DS. The effects of CpG DNA on HMGB1 release by murine macrophage cell lines. J Leukoc Biol 2005; 78: 930–936
  • Jiang W, Bell CW, Pisetsky DS. The relationship between apo and high-mobility group protein 1 release from murine macrophages stimulated with lipopolysaccharide or polyinosinic–polycytidylic acid. J Immunol 2007; 178: 6495–6503
  • Pisetsky DS, Jiang W. Role of toll-like receptors in HMGB1 release from macrophages. Ann NY Acad Sci 2007; 1109: 58–65
  • Jiang W, Pisetsky DS. The role of IFNα and nitric oxide in the release of HMGB1 by RAW 264.7 cells stimulated with polyinosinic–polycytidylic acid or lipopolysaccharide. J Immunol 2006; 177: 3337–3343
  • Scaffidi P, Mistelli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002; 418: 191–195
  • Bell CW, Jiang W, Reich CFIII, Pisetsky DS. The extracellular release of HMGB1 during apoptotic cell death. Am J Physiol Cell Physiol 2006; 291: C1318–C1325
  • Kazama H, Ricci JE, Herndon JM, Hoppe G, Green DR, Ferguson TA. Induction of immunological tolerance by apo cells requires caspase-dependent oxidation of high-mobility group box-1 protein. Immunity 2008; 29: 21–32
  • Pisetsky DS, Erlandsson-Harris H, Andersson U. High-mobility group box protein 1 (HMGB1): An alarmin mediating the pathogenesis of rheumatic disease. Arthritis Res Ther 2008; 10: 209–220

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