193
Views
28
CrossRef citations to date
0
Altmetric
Mini Review

Endogenous type I interferon inducers in autoimmune diseases

MiniReview

, &
Pages 349-352 | Received 30 Sep 2008, Accepted 13 Nov 2008, Published online: 13 Aug 2009

References

  • Rönnblom L, Eloranta ML, Alm GV. The type I IFN system in systemic lupus erythematosus. Arthritis Rheum 2006; 54: 408–420
  • Martin DA, Elkon KB. Autoantibodies make a U-turn: The toll hypothesis for Autoantibody specificity. J Exp Med 2005; 202: 1465–1469
  • Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006; 124: 783–801
  • Finke D, Randers K, Hoerster R, Hennig H, Zawatzky R, Marion T, Brockmann C, Klempt-Giessing K, Jacobsen K, Kirchner H, et al. Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: Implications for induction of SLE. Eur J Immunol 2007; 37: 1702–1709
  • Munoz LE, van Bavel C, Franz S, Berden J, Herrmann M, van der Vlag J. Apoptosis in the pathogenesis of SLE. Lupus 2008; 17: 371–375
  • Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S. Species-specific recognition of single-stranded RNA via TLR 7 and 8. Science 2004; 303: 1526–1529
  • Scofield RH, Farris AD, Horsfall AC, Harley JB. Fine specificity of the autoimmune response to the Ro/SSA and La/SSB RNP. Arthritis Rheum 1999; 42: 199–209
  • Hof D, Raats JM, Pruijn GJ. Apoptotic modifications affect the autoreactivity of the U1 snRNP autoantigen. Autoimmun Rev 2005; 4: 380–388
  • Eloranta ML, Barbasso Helmers S, Ulfgren AK, Rönnblom L, Alm GV, Lundberg IE. A possible mechanism for endogenous activation of the type IE IFN system in myositis patients with anti-Jo-1 or anti-Ro 52/anti-Ro 60 autoantibodies. Arthritis Rheum 2007; 56: 3112–3124
  • Vallin H, Perers A, Alm GV, Rönnblom L. Anti-dsDNA Ab and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-alpha inducer in systemic lupus erythematosus. J Immunol 1999; 163: 6306–6313
  • Kim D, Peck A, Santer D, Patole P, Schwartz SM, Molitor JA, Arnett FC, Elkon KB. Induction of IFN-alpha by scleroderma sera containing autoantibodies to topoisomerase I: Association of higher IFN-alpha activity with lung fibrosis. Arthritis Rheum 2008; 58: 2163–2173
  • Lövgren T, Eloranta ML, Kastner B, Wahren-Herlenius M, Alm GV, Rönnblom L. Induction of IFN-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigens and Sjogren's syndrome autoantigen-associated RNA. Arthritis Rheum 2006; 54: 1917–1927
  • Båve U, Nordmark G, Lövgren T, Rönnelid J, Cajander S, Eloranta ML, Alm GV, Rönnblom L. Activation of the type I IFN system in primary Sjogren's syndrome: A possible etiopathogenic mechanism. Arthritis Rheum 2005; 52: 1185–1195
  • Tian J, Avalos AM, Mao SY, Chen B, Senthil K, Wu H, Parroche P, Drabic S, Golenbock D, Sirois C, et al. TLR-9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol 2007; 8: 487–496
  • Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang YH, Homey B, Cao W, Su B, Nestle FO, Zal T, et al. plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 2007; 449: 564–569
  • Chi H, Flavell RA. Innate recognition of non-self nucleic acid. Genome Biol 2008; 9: 211
  • Gilliet M, Cao W, Liu YJ. plasmacytoid dendritic cells: Sensing nucleic acid in viral infection and autoimmune diseases. Nat Rev Immunol 2008; 8: 594–606
  • Sigurdsson S, Nordmark G, Goring HH, Lindroos K, Wiman AC, Sturfelt G, Jonsen A, Rantapaa-Dahlqvist S, Möller B, Kere J, et al. Polymorphisms in the tyrosine kinase 2 and IRF-5 genes are associated with systemic lupus erythematosus. Am J Hum Genet 2005; 76: 528–537
  • Niewold TB, Kelly JA, Flesch MH, Espinoza LR, Harley JB, Crow MK. Association of the IRF5 risk haplotype with high serum IFN-alpha activity in systemic lupus erythematosus patients. Arthritis Rheum 2008; 58: 2481–2487
  • Sigurdsson S, Nordmark G, Garnier S, Grundberg E, Kwan T, Nilsson O, Eloranta ML, Gunnarsson I, Svenungsson E, Sturfelt G, et al. A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5. Hum Mol Genet 2008; 17: 2868–2876

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.