62
Views
5
CrossRef citations to date
0
Altmetric
Mini Review

DNA-hydrolyzing Ab: Is catalytic activity a clue for physiological significance?

Minireview

&
Pages 359-361 | Received 18 Nov 2008, Accepted 07 Jan 2009, Published online: 13 Aug 2009

References

  • Gabibov AG, Ponomarenko NA, Tretyak EB, Paltsev MA, Suchkov SV. Catalytic AAb in clinical autoimmunity and modern medicine. Autoimmun Rev 2006; 5: 324–330
  • Hanson CV, Nishiyama Y, Paul S. Catalytic Ab and their applications. Curr Opin Biotechnol 2005; 16(6)631–636, [Epub 2005 Oct 21]
  • Paul S, Volle DJ, Beach CM, Johnson DR, Powell MJ, Massey RJ. Catalytic hydrolysis of vasoactive intestinal peptide by human AAb. Science 1989; 244: 1158–1162
  • Shuster AM, Gololobov GV, Kvashuk OA, Bogomolova AE, Smirnov IV, Gabibov AG. DNA-hydrolyzing AAb. Science 1992; 256: 665–667
  • Kozyr AV, Kolesnikov AV, Aleksandrova ES, Sashchenko LP, Gnuchev NV, Favorov PV, Kotelnikov MA, Iakhnina EI, Astsaturov IA, Prokaeva TB, Alekberova ZS, Suchkov SV, Gabibov AG. Novel functional activities of anti-DNA AAb from sera of patients with lymphoproliferative and autoimmune diseases. Appl Biochem Biotechnol 1998; 75: 45–61
  • Gololobov GV, Mikhalap SV, Starov AV, Kolesnikov AV, Gabibov AG. DNA-protein complexes. Natural targets for DNA-hydrolyzing Ab. Appl Biochem Biotechnol 1994; 47: 305–314, discussion 314–315
  • Belogurov AA, Jr., Kurkova IN, Friboulet A, Thomas D, Misikov VK, Zakharova MY, Suchkov SV, Kotov SV, Alehin AI, Avalle B, Souslova EA, Morse HC, 3rd, Gabibov AG, Ponomarenko NA. Recognition and degradation of MBP peptides by serum AAb: Novel biomarker for multiple sclerosis. J Immunol 2008; 180: 1258–1267
  • Kim Y-R, Kim L-S, Lee S-H, Lee W-R, Sohn J-N, Chung Y-C, Shim H-K, Lee S-C, Kwon M-H, Kim Y-S. Heavy and light chain variable single domains of an anti-DNA binding Ab hydrolyze both ds and ssDNA without sequence specificity. J Biol Chem 2006; 281: 15287–15295
  • Gololobov GV, Rumbley CA, Rumbley JN, Schourov DV, Makarevich OI, Gabibov AG, Voss EW, Jr., Rodkey LS. DNA hydrolysis by monoclonal anti-ssDNA AAb BV 04-01: Origins of catalytic activity. Mol Immunol 1997; 34: 1083–1093
  • Parkhomenko TA, Odintsova ES, Buneva VN, Kunder EV, Zhyltsov IV, Senkovich SA, Generalov II, Nevinsky GA. DNA-hydrolyzing activity of IgG Ab from the sera of patients with diseases caused by different bacterial infections. J Cell Mol Med 2008, [Epub ahead of print]
  • Ponomarenko NA, Aleksandrova ES, Vorobiev II, Durova OM, Kozyr AV, Kolesnikov AV, Telegin GB, Kalinina AR, Suchkov SV, Gabibov AG. Natural Ab catalytic activities in mice with autoimmune disorders. Dokl Biochem 2000; 375: 224–227
  • Alarcon-Segovia D, Ruiz-Arguelles A, Fishbein E. Ab penetration into living cells. I. Intracellular Ig in PBMC in mixed connective tissue disease and SLE. Clin Exp Immunol 1979; 35: 364–375
  • Zhang W, Winkler T, Kalden JR, Reichlin M. Isolation of human anti-idiotypes broadly cross reactive with anti-dsDNA from patients with SLE. Scand J Immunol 2001; 53: 192–197
  • Alarcón-Segovia D, Llorente L. Ab penetration into living cells. IV. Different effects of anti-native DNA and anti-ribonucleoprotein IgG on the cell cycle of activated T gamma cells. Clin Exp Immunol 1983; 52: 365–371
  • Van Helden PD, Van Lill L, Bester AJ, Hoal-Van Helden E. AAb from patients with SLE can affect DNA and RNA synthesis in cultured cells. Biochim Biophys Acta 1989; 1009: 137–142
  • Koren E, Koscec M, Wolfson-Reichlin M, Ebling FM, Tsao B, Hahn BH, Reichlin M. Murine and human Ab to native DNA that cross-react with the A and D SnRNP polypeptides cause direct injury of cultured kidney cells. J Immunol 1995; 154: 4857–4864
  • Kozyr AV, Sashchenko LP, Kolesnikov AV, Zelenova NA, Khaidukov SV, Ignatova AN, Bobik TV, Gabibov AG, Alekberova ZS, Suchkov SV, Gnuchev NV. Anti-DNA AAb reveal toxicity to tumor cell lines. Immunol Lett 2002; 80: 41–47
  • Sashchenko LP, Khaidukov SV, Kozyr AV, Luk'yanova TI, Gabibov AG, Suchkov SV, Bobik TV, Alekberova ZS, Gnuchev NV. Caspase-dependent cytotoxicity of anti-DNA AAb. Dokl Biochem Biophys 2001; 380: 313–315
  • Rivadeneyra-Espinoza L, Ruiz-Arguelles A. Cell-penetrating anti-native DNA Ab trigger apo through both the neglect and programmed pathways. J Autoimmun 2006; 26: 52–56
  • Lee E-J, Jang E-J, Lee E, Yu J, Chung H-Y, Jang Y-J. Cell-penetrating AAb induces caspase-mediated apo through catalytic hydrolysis of DNA. Bioorg Med Chem 2007; 15: 2016–2023
  • Bohm I. IgG deposits can be detected in cell nuclei of patients with both SLE and malignancy. Clin Rheumatol 2007; 26: 1877–1882
  • Bohm I. Nuclear-targeting AAb induced nuclear PARP cleavage accompanied by more pronounced decrease of peripheral white blood cells that Ro/SSA and Ro/SSB Ag-targeting AAb. J Clin Immunol 2005; 25: 99–105

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.