Individual characterization of stably expanded T cell clones in ankylosing spondylitis patients

References

• Kalams SA, Johnson RP, Trocha AK, Dynan MJ, Ngo HS, D'aquila RT, Kurnick JT, Walker BD. Longitudinal analysis of t cell receptor (tcr) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic t lymphocyte clones reveals a limited tcr repertoire. J Exp Med. 1994; 1791261–1271.
   PubMed Web of Science ®Google Scholar
• Miles JJ, Silins SL, Brooks AG, Davis JE, Misko I, Burrows SR. T-cell grit: Large clonal expansions of virus-specific cd8+ t cells can dominate in the peripheral circulation for at least 18 years. Blood. 2005; 1064412–4413.
   PubMedGoogle Scholar
• Babbe H, Roers A, Waisman A, Lassmann H, Goebels N, Hohlfeld R, Friese M, Schroder R, Deckert M, Schmidt S, . Clonal expansions of cd8(+) t cells dominate the t ell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J Exp Med. 2000; 192393–404.
   PubMed Web of Science ®Google Scholar
• Trevino MA, Teixeiro E, Bragado R. Cd8+ t cells oligoclonally expanded in synovial fluid at onset of spondyloarthropathy selectively proliferate in response to self-antigens: Characterization of cell specificities in nonclonal populations. J Rheumatol. 2004; 311962–1972.
   PubMedGoogle Scholar
• Fitzgerald JE, Ricalton NS, Meyer AC, West SG, Kaplan H, Behrendt C, Kotzin BL. Analysis of clonal cd8+ t cell expansions in normal individuals and patients with rheumatoid arthritis. J Immunol. 1995; 1543538–3547.
   PubMed Web of Science ®Google Scholar
• Skulina C, Schmidt S, Dornmair K, Babbe H, Roers A, Rajewsky K, Wekerle H, Hohlfeld R, Goebels N. Multiple sclerosis: Brain-infiltrating cd8+ t cells persist as clonal expansions in the cerebrospinal fluid and blood. Proc Natl Acad Sci USA. 2004; 1012428–2433.
   PubMed Web of Science ®Google Scholar
• Hofbauer M, Wiesener S, Babbe H, Roers A, Wekerle H, Dornmair K, Hohlfeld R, Goebels N. Clonal tracking of autoaggressive t cells in polymyositis by combining laser microdissection, single-cell pcr, and cdr3-spectratype analysis. Proc Natl Acad Sci USA. 2003; 1004090–4095.
   PubMed Web of Science ®Google Scholar
• Schwab R, Szabo P, Manavalan JS, Weksler ME, Posnett DN, Pannetier C, Kourilsky P, Even J. Expanded cd4+ and cd8+ t cell clones in elderly humans. J Immunol. 1997; 1584493–4499.
   PubMed Web of Science ®Google Scholar
• Ely KH, Ahmed M, Kohlmeier JE, Roberts AD, Wittmer ST, Blackman MA, Woodland DL. Antigen-specific cd8+ t cell clonal expansions develop from memory t cell pools established by acute respiratory virus infections. J Immunol. 2007; 1793535–3542.
   PubMed Web of Science ®Google Scholar
• Ricalton NS, Roberton C, Norris JM, Rewers M, Hamman RF, Kotzin BL. Prevalence of cd8+ t-cell expansions in relation to age in healthy individuals. J Gerontol Biol Sci Med Sci. 1998; 53b196–b203.
   Google Scholar
• Posnett DN, Sinha R, Kabak S, Russo C. Clonal populations of t cells in normal elderly humans: The t cell equivalent to “benign monoclonal gammapathy”. J Exp Med. 1994; 179609–618.
   PubMed Web of Science ®Google Scholar
• Hingorani R, Choi IH, Akolkar P, Gulwani-Akolkar B, Pergolizzi R, Silver J, Gregersen PK. Clonal predominance of t cell receptors within the cd8+ cd45ro+ subset in normal human subjects. J Immunol. 1993; 1515762–5769.
   PubMed Web of Science ®Google Scholar
• Duftner C, Goldberger C, Falkenbach A, Wurzner R, Falkensammer B, Pfeiffer KP, Maerker-Hermann E, Schirmer M. Prevalence, clinical relevance and characterization of circulating cytotoxic cd4+cd28 − t cells in ankylosing spondylitis. Arthritis Res Ther. 2003; 5r292–r300.
   PubMed Web of Science ®Google Scholar
• Duchmann R, Lambert C, May E, Hohler T, Marker-Hermann E. Cd4+ and cd8+ clonal t cell expansions indicate a role of antigens in ankylosing spondylitis; a study in hla-b27+ monozygotic twins. Clin Exp Immunol. 2001; 123315–322.
   PubMedGoogle Scholar
• Schirmer M, Goldberger C, Wurzner R, Duftner C, Pfeiffer KP, Clausen J, Neumayr G, Falkenbach A. Circulating cytotoxic cd8(+) cd28( − ) t cells in ankylosing spondylitis. Arthritis Res. 2002; 471–76.
   PubMedGoogle Scholar
• Suzuki M, Cheng KC, Krug MS, Yoo TJ. Successful prevention of retrocochlear hearing loss in murine experimental allergic encephalomyelitis with t cell receptor vbeta8-specific antibody. Ann Otol Rhinol Laryngol. 1998; 107917–927.
   PubMed Web of Science ®Google Scholar
• Aroeira LS. Tcr vaccination in aluminum adjuvant protects against autoimmune encephalomyelitis. Clin Immunol. 2006; 119252–260.
   PubMedGoogle Scholar
• Haqqi TM, Qu XM, Anthony D, Ma J, Sy MS. Immunization with t cell receptor v beta chain peptides deletes pathogenic t cells and prevents the induction of collagen-induced arthritis in mice. J Clin Invest. 1996; 972849–2858.
   PubMed Web of Science ®Google Scholar
• Offner H, Hashim GA, Vandenbark AA. T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis. Science. 1991; 251430–432.
   PubMed Web of Science ®Google Scholar
• Cohen-Kaminsky S, Jambou F. Prospects for a t-cell receptor vaccination against myasthenia gravis. Expert Rev Vaccines. 2005; 4473–492.
   PubMed Web of Science ®Google Scholar
• Buch T, Waisman A. Protection from autoimmunity by dna vaccination against t-cell receptor. Methods Mol Med. 2006; 127269–280.
   PubMedGoogle Scholar
• D'amato M, Fiorillo MT, Carcassi C, Mathieu A, Zuccarelli A, Bitti PP, Tosi R, Sorrentino R. Relevance of residue 116 of hla-b27 in determining susceptibility to ankylosing spondylitis. Eur J Immunol. 1995; 253199–3201.
   PubMed Web of Science ®Google Scholar
• Bowness P. Hla b27 in health and disease: A double-edged sword?. Rheumatology (Oxford). 2002; 41857–868.
   PubMed Web of Science ®Google Scholar
• Reveille JD. The genetic basis of ankylosing spondylitis. Curr Opin Rheumatol. 2006; 18332–341.
   PubMed Web of Science ®Google Scholar
• Gaston H. Mechanisms of disease: The immunopathogenesis of spondyloarthropathies. Nat Clin Pract Rheumatol. 2006; 2383–392.
   PubMedGoogle Scholar
• Dulphy N, Peyrat MA, Tieng V, Douay C, Rabian C, Tamouza R, Laoussadi S, Berenbaum F, Chabot A, Bonneville M, . Common intra-articular t cell expansions in patients with reactive arthritis: Identical beta-chain junctional sequences and cytotoxicity toward hla-b27. J Immunol. 1999; 1623830–3839.
   PubMed Web of Science ®Google Scholar
• Sun W, Popat U, Hutton G, Zang YC, Krance R, Carrum G, Land GA, Heslop H, Brenner M, Zhang JZ. Characteristics of t-cell receptor repertoire and myelin-reactive t cells reconstituted from autologous haematopoietic stem-cell grafts in multiple sclerosis. Brain. 2004; 127996–1008.
   PubMed Web of Science ®Google Scholar
• Rice P, Longden I, Bleasby A. Emboss: The european molecular biology open software suite. Trends Genet. 2000; 16276–277.
   PubMed Web of Science ®Google Scholar
• Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ. Gapped blast and psi-blast: A new generation of protein database search programs. Nucleic Acids Res. 1997; 253389–3402.
   PubMed Web of Science ®Google Scholar
• Pfaffl MW. A new mathematical model for relative quantification in real-time rt-pcr. Nucleic Acids Res. 2001; 29e45.
   PubMed Web of Science ®Google Scholar
• Ramakers C, Ruijter JM, Deprez RH, Moorman AF. Assumption-free analysis of quantitative real-time polymerase chain reaction (pcr) data. Neurosci Lett. 2003; 33962–66.
   PubMed Web of Science ®Google Scholar
• Wei S, Charmley P, Robinson MA, Concannon P. The extent of the human germline t-cell receptor v beta gene segment repertoire. Immunogenetics. 1994; 4027–36.
   PubMedGoogle Scholar
• Gorski J, Vassai M, Zhu X, Kissela B, Kissella B, Keever C, Flomenberg N. Circulating t cell repertoire complexity in normal individuals and bone marrow recipients analyzed by cdr3 size spectratyping. Correlation with immune status. J Immunol. 1994; 1525109–5119.
   PubMed Web of Science ®Google Scholar
• Tomiyama H, Takata H, Matsuda T, Takiguchi M. Phenotypic classification of human cd8+ t cells reflecting their function: Inverse correlation between quantitative expression of cd27 and cytotoxic effector function. Eur J Immunol. 2004; 34999–1010.
   PubMedGoogle Scholar
• Tomiyama H, Matsuda T, Takiguchi M. Differentiation of human cd8(+) t cells from a memory to memory/effector phenotype. J Immunol. 2002; 1685538–5550.
   PubMedGoogle Scholar
• Romero P, Zippelius A, Kurth I, Pittet MJ, Touvrey C, Iancu EM, Corthesy P, Devevre E, Speiser DE, Rufer N. Four functionally distinct populations of human effector-memory cd8+ t lymphocytes. J Immunol. 2007; 1784112–4119.
   PubMedGoogle Scholar
• Appay V, Dunbar PR, Callan M, Klenerman P, Gillespie GM, Papagno L, Ogg GS, King A, Lechner F, Spina CA, . Memory cd8+ t cells vary in differentiation phenotype in different persistent virus infections. Nat Med. 2002; 8379–385.
   PubMed Web of Science ®Google Scholar
• Dersimonian N, Sugita M, Glass DN, Maier AL, Weinblatt ME, Reme T, Brenner MB. Clonal v alpha 12.1+ t cell expansions in the peripheral blood of rheumatoid arthritis patients. J Exp Med. 1993; 1771623–1631.
   PubMed Web of Science ®Google Scholar
• Khan N, Shariff N, Cobbold M, Bruton R, Ainsworth JA, Sinclair AJ, Nayak L, Moss PA. Cytomegalovirus seropositivity drives the cd8 t cell repertoire toward greater clonality in healthy elderly individuals. J Immunol. 2002; 1691984–1992.
   PubMed Web of Science ®Google Scholar
• Trautmann L, Rimbert M, Echasserieau K, Saulquin X, Neveu B, Dechanet J, Cerundolo V, Bonneville M. Selection of t cell clones expressing high-affinity public tcrs within human cytomegalovirus-specific cd8 t cell responses. J Immunol. 2005; 1756123–6132.
   PubMed Web of Science ®Google Scholar
• Duchmann R, May E, Ackermann B, Goergen B, Meyer zum Buschenfelde KH, Marker-Hermann E. Hla-b27-restricted cytotoxic t lymphocyte responses to arthritogenic enterobacteria or self-antigens are dominated by closely related tcrbv gene segments. A study in patients with reactive arthritis. Scand J Immunol. 1996; 43101–108.
   PubMedGoogle Scholar
• Ruckert C, Fiorillo MT, Loll B, Moretti R, Biesiadka J, Saenger W, Ziegler A, Sorrentino R, Uchanska-Ziegler B. Conformational dimorphism of self-peptides and molecular mimicry in a disease-associated hla-b27 subtype. J Biol Chem. 2006; 2812306–2316.
   PubMedGoogle Scholar
• Fiorillo MT, Maragno M, Butler R, Dupuis ML, Sorrentino R. Cd8(+)t-cell autoreactivity to an hla-b27-restricted self-epitope correlates with ankylosing spondylitis. J Clin Invest. 2000; 10647–53.
   PubMedGoogle Scholar
• Silins SL, Cross SM, Elliott SL, Pye SJ, Burrows JM, Moss DJ, Misko IS. Selection of a diverse tcr repertoire in response to an Epstein-Barr virus-encoded transactivator protein bzlf1 by cd8+ cytotoxic t lymphocytes during primary and persistent infection. Int Immunol. 1997; 91745–1755.
   PubMedGoogle Scholar
• Bourcier KD, Lim DG, Ding YH, Smith KJ, Wucherpfennig K, Hafler DA. Conserved cdr3 regions in t-cell receptor (tcr) cd8(+) t cells that recognize the tax11-19/hla-a*0201 complex in a subject infected with human t-cell leukemia virus type 1: Relationship of t-cell fine specificity and major histocompatibility complex/peptide/tcr crystal structure. J Virol. 2001; 759836–9843.
   PubMedGoogle Scholar
• Utz U, Banks D, Jacobson S, Biddison WE. Analysis of the t-cell receptor repertoire of human t-cell leukemia virus type 1 (htlv-1) tax-specific cd8+ cytotoxic t lymphocytes from patients with htlv-1-associated disease: Evidence for oligoclonal expansion. J Virol. 1996; 70843–851.
   PubMedGoogle Scholar