Combined Measurement of Diabetes Mellitus Immunological Markers: an Assessment of its Benefits in Adult-Onset Patients

References

• The expert Commitee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997: 20: 1183–1197.
   Google Scholar
• Tuomi T, Groop LC, Zimmet PZ, Rowley MJ, Knowles W, Mackay IR. Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease. Diabetes 1993: 42: 359–362.
   Google Scholar
• Hagopian WA, Karlsen AE, Gottsäter A, Landin-Olsson M, Grubin CE, Sundkvist G, Petersen JS, Boel E, Dyrberg T, Lernmark A. Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes type. J. Clin. Invest. 1993: 91: 368–374.
   Google Scholar
• Juneja R, Palmer JP. Type 1 1/2 diabetes: myth or reality? Autoimmunity 1999: 29: 65–83.
   Google Scholar
• Zimmet P, Turner R, McCarty D, Rowley M, Mackay I. Cru-cial points at diagnosis. Type 2 diabetes or slow type 1 diabe-tes. Diabetes Care 1999: 22 Suppl 2: B59-64.
   Google Scholar
• Groop L, Miettinen A, Groop PH, Merl S, Koskimies S, Bot-tazzo GF. Organ-specific autoimmunity and HLA-DR anti-gens as markers for beta-cell destruction in patients with type II diabetes. Diabetes 1988: 37: 99–103.
   Google Scholar
• Zavala AV, Fabiano de Bruno LE, Cardoso AI, Mota AH, Capucchio M, Poskus E, Fainboim L, Basabe JC. Cellular and humoural autoimmunity markers in type 2 (non-insu-lin-dependent) diabetic patients with secondary drug failure. Diabetologia 1992: 35: 1159–1164.
   Google Scholar
• Hatziagelalci E, Jaeger C, Maeser E, Bretzel RG, Federlin K. GAD 65 antibody but not ICA positivity in adult-onset dia-betic patients is associated with early progression to clinical insulin dependency. Acta Diabetol. 1996: 33: 291–294.
   Google Scholar
• Fukui M, Nakano K, Shigeta H, Yoshimori K, Fujii M, Kite-gawa Y, Mori H, Kajiyama S, Nakamura N, Abe N, Obayashi H, Fukui I, Ohta K, Ohta M, Kondo M. Antibodies to glutamic acid decarboxylase in Japanese diabetic patients with secondary failure of oral hypoglycaemic therapy. Dia-bet. Med. 1997: 14: 148–152.
   Google Scholar
• Banerji MA, Chaiken RL, Huey H, Tuomi T, Norin Al, Mackay IR, Rowley MJ, Zimmet PZ, Lebovitz HE. GAD antibody negative NIDDM in adult black subjects with dia-betic ketoacidosis and increased frequency of human leuko-cyte antigen DR3 and DR4. Flatbush diabetes. Diabetes1994: 43: 741-745.
   Google Scholar
• Maclaren N, Schatz D, Drash A, Grave G. Initial pathogenic events in IDDM. Diabetes 1989: 38: 534–538.
   Google Scholar
• Castello L, Eisenbarth GS. Type-I diabetes: a chronic autoim-mune disease of human, mouse, and rat. Annu. Rev. Immunol. 1990: 8: 647–679.
   Google Scholar
• Brekkeskov S, Aanstoot }1.1, Christgau S, Reetz A, Solimena M, Cascalho M, Folli F, Richter-Olesen H, De Camilli P. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature1990: 347: 151-156.
   Google Scholar
• Lenunark A. Type 1 diabetes. Clin. Chem. 1999: 45: 1331–1338.
   Google Scholar
• Richter W, Endl J, Eiermann TH, Brandt M, Kientsch-Engel R, Thivolet C, Jungfer H, Scherbaum WA. Human mono-clonal islet cell antibodies from a patient with insu-lin-dependent diabetes mellitus reveal glutamate decarboxylase as the target antigen. Proc. Natl. Acad. Sci. U SA 1992: 89: 8467–8471.
   Google Scholar
• Atkinson MA, Kaufman DL, Newman D, Tobin AJ, Maclaren NK. Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes. Acta Diabetol. 1993: 91: 350–356.
   Google Scholar
• Bonifacio E, Lampasona V, Genovese S. Ferrari M, Bosi E. Identification of protein tyrosine phosphatase-like IA2 (islet cell antigen 512) as the insulin-dependent diabetes-related 37/40K autoantigen and a target of islet-cell antibodies. J. Immunol. 1995: 155: 5419–5426.
   Google Scholar
• Myers MA, Rabin DU, Rowley Mi. Pancreatic islet cell cytoplasmic antibody in diabetes is represented by antibodies to islet cell antigen 512 and glutamic acid decarboxylase. Diabetes1995: 44: 1290-1295.
   Google Scholar
• Palmer JP, Asplin CM, Clemons P, Lyen K, Tatpati 0, Raghu PK, Paquette TL. Insulin antibodies in insulin-dependent dia-betics before insulin treatment. Science 1983: 222: 1337–1339.
   Google Scholar
• Verge CF, Gianani R, Kawasaki E, Yu L, Pietropaolo M, Jackson RA, Chase HP, Eisenbarth GS. Prediction of type I diabetes in first-degree relatives using a combination of insu-lin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 1996: 45: 926–933.
   Google Scholar
• Bingley PJ, Christie MR, Bonifacio E, Bonfanti R, Shattock M, Fonte MT, Bottazzo GF, Gale EA. Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes 1994: 43: 1304–1310.
   Google Scholar
• Seissler J, Morgenthaler NG, Achenbach P. Ltunpeter EF, Glawe D, Payton M, Christie M, Scherbaum WA. Combined screening for autoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. The DENIS Study Group. Deutsche Nikotinamid Interventions-Studie. Diabetologia 1996: 39: 1351–1356.
   Google Scholar
• Bingley PJ, Bonifacio E, Williams AJ, Genovese S. Bottazzo GF, Gale EA. Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers. Diabetes1997: 46: 1701-1710.
   Google Scholar
• Borg H, Ferrilund P. Sundkvist G. Protein tyrosine phos-phatase-like protein 1A2-antibodies plus glutamic acid decar-boxylase 65 antibodies’(GADA) indicates autoimmunity as frequently as islet cell antibodies assay in children with recently diagnosed diabetes mellitus. Clin. Chem. 1997: 43: 2358–2363.
   Google Scholar
• Christie MR, Roll U, Payton MA, Hatfield EC, Ziegler AG. Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care 1997: 20: 965–970.
   Google Scholar
• Kultnala P. Savola K, Petersen JS, Vilhäsälo P. Karjalainen J, Löppönen T, Dyrberg T, Akerblom HK, ICnip M. Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. A population-based study. The Childhood Dia-betes in Finland Study Group. J. Clin. Invest. 1998: 101: 327–336.
   Google Scholar
• Wiest-Ladenburger U, Hartmann R, Hartmann U, Berling K, Bohm BO, Richter W. Combined analysis and single-step detection of GAD65 and IA2 autoantibodies in IDDM can replace the histochetnical islet cell antibody test. Diabetes 1997: 46: 565–571.
   Google Scholar
• Dittler J, Seidel D. Schenker M, Ziegler AG. GADIA2-combi determination as first-line screening for improved prediction of type 1 diabetes in relatives. Diabetes 1998: 47: 592–597.
   Google Scholar
• Matthews OR, Cull CA, Stratton IM, Holman R, Turner RC. UKPDS 26: sulphonylurea failure in non-insulin-dependent diabetic patients over six years. UK Prospective Diabetes Study (UKPDS) Group. Diabet. Med, 1998: 15: 297–303.
   Google Scholar
• Stumpo RR, Llera AS, Cardoso Al, Poskus E. Solid versus liquid phase assays in detection of insulin antibodies. Influ-ence of iodination site on labelled insulin binding. J. Immu-nol. Methods. 1994: 169: 241–249.
   Google Scholar
• Grubin CE, Daniels T, Toivola B, Landin-Olsson M, Hago-pian WA, Li L, Karlsen AE, Boel E, Michelsen B, Lenunark A. A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia 1994: 37: 344–350.
   Google Scholar
• Papouchado ML, Valdez SN, Ghiringhelli D, Poskus E, Ennacora MR. Expression of properly folded human gluta-mate decarboxylase 65 as a fusion protein in Escherichia coli. Eur J. Biochem. 1997: 246: 350–359.
   Google Scholar
• Kobayashi T, Nakanishi K, Murase T, Kosaka K. Small doses of subcutaneous insulin as a strategy for preventing slowly progressive beta-cell failure in islet cell antibody-positive patients with clinical features of NIDDM. Diabetes 1996: 45: 622–626.
   Google Scholar
• Winter WE, House DV, Schatz D. Pharmacological approaches to the prevention of autoimmune diabetes. Drugs 1997: 53: 943–956.
   Google Scholar
• Flichtenbusch M, Rabl W, Grassi B, Bachmann W, Standl E, Ziegler AG. Delay of type I diabetes in high risk, first degree relatives by parenteral antigen administration: the Schwabing Insulin Prophylaxis Pilot Trial. Diabetologia 1998: 41: 536–541.
   Google Scholar
• Gale EA. Molecular mechanisms of beta-cell destruction in IDDM: the role of nicotinamide. Horm. Res. 1996: 45 Suppl 1: 39-43.
   Google Scholar
• Pozzilli P, Browne PD, Kolb H. Meta-analysis of nicotina-mide treatment in patients with recent-onset IDDM. The Nicotinamide Trialists. Diabetes Care 1996: 19: 1357–1363.
   Google Scholar
• Bonifacio E, Boitard C, Gleichmann H, Shattock MA, Molenaar JL, Bottazzo GF. Assessment of precision, con-cordance, specificity, and sensitivity of islet cell antibody measurement in 41 assays. Diabetologia 1990: 33: 731–736.
   Google Scholar
• Lemmark Å, Molenaar JL, van Beers WA, Yamaguchi Y, Nagatalci S, Ludvigsson J, Maclaren NK. The Fourth Interna-tional Serum Exchange Workshop to standardize cytoplasmic islet cell antibodies. The Immunology and Diabetes Work-shops and Participating Laboratories. Diabetologia 1991: 34: 534–535.
   Google Scholar
• Maugendre D, Chaillous L, Rohmer V, Lecomte P, Mare-chaud R, Sal P, Marre M, Charbonnel B, Allannic H, Dela-maire M. Multiple antibody status in type 1 diabetic patients and subjects at various risk with islet-cell antibodies. Diabe-tes Metab. 1997: 23: 320–326.
   Google Scholar
• Ongagna JC, Levy-Marchal C. Sensitivity at diagnosis of combined beta-cell autoantibodies in insulin-dependent dia-betic children. French Registry of IDDM in Children Study Group. Diabetes Metab. 1997: 23: 155–160.
   Google Scholar
• Willis J, Scott R, Brown L, Zimmet P. MacKay I, Rowley M. Type 1 diabetes in insulin-treated adult-onset diabetic sub-jects. Diabetes Res. Clin. Pract. 1998: 42: 49–53.
   Google Scholar
• Kasuga A, Maruyama T, Nalcamoto S, Ozawa Y, Suzuki Y, Saruta T. High-titer autoantibodies against glutamic acid decarboxylase plus autoantibodies against insulin and IA-2 predicts insulin requirement in adult diabetic patients. J. Autoimmun 1999: 12: 131–135.
   Google Scholar
• Lohmann T, Sessler J, Verlohren Hi, Schroder S, Rotger J, Dalin K, Morgenthaler N, Scherbaum WA. Distinct genetic and immunological features in patients with onset of IDDM before and after age 40. Diabetes Care 1997: 20: 524–529.
   Google Scholar