Decreased proportions of CD4 + IL17+/CD4 + CD25 + CD127− and CD4 + IL17+/CD4 + CD25 + CD127 − FoxP3+ T cells in children with autoimmune thyroid diseases^*

References

• Weetman, A. P. 2004. Autoimmune thyroid disease. Autoimmunity. 37: 337–340
   PubMed Web of Science ®Google Scholar
• Hasham, A., and Y. Tomer. 2012. Genetic and epigenetic mechanisms in thyroid autoimmunity. Immunol. Res. 54: 204–213
   PubMed Web of Science ®Google Scholar
• Baecher-Allan, C., V. Viglietta, and D. A. Hafler. 2004. Human CD4 + CD25+ regulatory T cells. Semin. Immunol. 16: 89–98
   PubMed Web of Science ®Google Scholar
• Holm, T., J. Nielsen, and V. Claesson. 2004. CD4CD25 regulatory T cells: phenotype and physiology. APMIS. 112: 629–641
   PubMed Web of Science ®Google Scholar
• Liu, W. A., L. Putnam, Z. Xu-Yu, et al. 2006. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med. 10: 1701–1711
   Web of Science ®Google Scholar
• von Boehmer H. 2005. Mechanisms of suppression by suppressor T cells. Nat. Immunol. 6: 338–344
   PubMed Web of Science ®Google Scholar
• Mason, D., and F. Powrie. 1998. Control of immune pathology by regulatory T cells. Curr. Opin. Immunol. 6: 649–655
   Web of Science ®Google Scholar
• Penekos, C., A. Vryonidou, A. D. Gritzapis, et al. 2004. Th1 and Th2 serum cytokine profiles characterize patients with Hashimoto’s thyroiditis (Th1) and Graves’ disease (Th2). Neuroimmunomodulation. 11: 209–213
   PubMed Web of Science ®Google Scholar
• Nistala, K., H. Moncrieffe, K. R. Newton, et al. 2008. Interleukin-17-producingTcells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers. Arthritis Rheum. 58: 875–887
   PubMed Web of Science ®Google Scholar
• Kryczek, I., A. T. Bruce, J. E. Gudjonsson, et al. 2008. Induction of IL-17 T cell trafficking and development by IFN gamma: mechanism and pathological relevance in psoriasis. J. Immunol. 181: 4733–4741
   PubMed Web of Science ®Google Scholar
• Hundorfean, G., M. F. Neurath, and J. Mudter. 2012. Functional relevance of T helper 17 (Th17) cells and the IL-17 cytokine family in inflammatory Bowel disease. Inflamm. Bowel Dis. 18: 180–186
   PubMed Web of Science ®Google Scholar
• Traves, S. L., and L. E. Donnelly. 2008. Th17 cells in airway diseases. Curr. Mol. Med. 8: 416–426
   PubMed Web of Science ®Google Scholar
• Mensah-Brown, E. P., A. Shahin, M. Al-Shamsi, and M. L. Lukic. 2006. New member of the interleukin-12 family of cytokines: IL-23 and IL-27 modulate autoimmune diabetes. Ann. N.Y. Acad. Sci. 1079: 157–160
   PubMed Web of Science ®Google Scholar
• Romagnani, S., E. Maggi, F. Liotta, et al. 2009. Properties and origin of human Th17 cells. Mol. Immunol. 47: 3–7
   PubMed Web of Science ®Google Scholar
• Cosmi, L., R. D. Palma, V. Santarlasci, et al. 2008. Human interleukin 17-producing cells originate from a CD161 + CD4+ T cell precursor. J. Exp. Med. 205: 1903–1916
   PubMed Web of Science ®Google Scholar
• Hirota, K., M. Bruno, and M. Veldhoen. 2010. Development, regulation and functional capacities of Th17 cells. Semin. Immunopathol. 32: 3–16
   PubMed Web of Science ®Google Scholar
• Lytton, S. D., Y. Li, P. D. Olivo, et al. 2010. Novel chimeric thyroid-stimulating hormone-receptor bioassay for thyroid-stimulating immunoglobulins. Clin. Exp. Immunol. 162: 438–446
   PubMed Web of Science ®Google Scholar
• Zhou, J., M. Bi, C. Fan, et al. 2012. Regulatory T cells but not T helper 17 cells are modulated in an animal model of Graves' hyperthyroidism. Clin. Exp. Med. 12: 39–46
   PubMed Web of Science ®Google Scholar
• Dardalhon, V., T. Korn, V. K. Kuchroo, and A. C. Anderson. 2008. Role of Th1 and Th17 cells in organ-specific autoimmunity. J. Autoimmun. 31: 252–256
   PubMed Web of Science ®Google Scholar
• Gonzalez-Amaro, R., and M. Marazuela. 2015. T regulatory (Treg) and T helper (Th17) lymphocytes in thyroid autoimmunity. Endocrine. 52: 30–38
   PubMed Web of Science ®Google Scholar
• Alcaide, P., E. Maganto-Garcia, G. Neton, et al. 2012. Difference in Th1 and Th17 Lymphocyte adhesion to endothelium. J. Immunol. 188: 1421–1430
   PubMed Web of Science ®Google Scholar
• Paust, H. J., J. E. Turner, J. H. Riedel, et al. 2012. Chemokines play a critical role in the cross-regulation of Th1 and Th17 immune responses in murine crescentic glomerulonephritis. Kidney Int. 82: 72–83
   PubMed Web of Science ®Google Scholar
• Damsker, J. M., A. M. Hansen, and R. R. Caspi. 2010. Th1 and Th17 cells: adversaries and collaborators. Ann. N.Y. Acad. Sci. 1183: 211–221
   PubMed Web of Science ®Google Scholar
• Shi, G., C. A. Cox, and B. P. Vistica. 2008. Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cells. J. Immunol. 181: 7205–7213
   PubMed Web of Science ®Google Scholar
• Wang, S. H., and J. R. Baker. 2007. The role of apoptosis in thyroid autoimmunity. Thyroid. 17: 975–979
   PubMed Web of Science ®Google Scholar
• Qin, Q., P. Liu, L. Liu, et al. 2012. The increased but non-predominant expression of Th17- and Th1-specific cytokines in Hashimoto's thyroiditis but not in Graves' disease. Braz. J. Med. Biol. Res. 45: 1202–1208
   PubMed Web of Science ®Google Scholar
• Awasth, A., and V. K. Kuchroo. 2009. IL-17A directly inhibits TH1 cells and thereby suppresses development of intestinal inflammation. Nat. Immunol. 10: 568–570
   PubMed Web of Science ®Google Scholar
• Aerts, N. E., E. J. Dombrecht, D. G. Ebo, et al. 2008. Activated T cells complicate the identification of regulatory T cells in rheumatoid arthritis. Cell. Immunol. 251: 109–115
   PubMed Web of Science ®Google Scholar
• Holmén, N., A. Lundgren, S. Lundin, et al. 2006. Functional CD4 + CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity. Inflamm. Bowel. Dis. 12: 447–456
   PubMed Web of Science ®Google Scholar
• Moniuszko, M., B. Głowińska-Olszewska, M. Rusak, et al. 2013. Decreased CD127 expression on CD4+ T-cells and elevated frequencies of CD4 + CD25 + CD127- T-cells in children with long-lasting type 1 diabetes. Clin. Dev. Immunol. 2013: 459210
   PubMedGoogle Scholar
• Bossowski, A., H. Borysewicz-Sańczyk, N. Wawrusiewicz-Kurylonek, et al. 2014. Analysis of chosen polymorphisms in FoxP3 gene in children and adolescents with autoimmune thyroid diseases. Autoimmunity. 47: 395–400
   PubMed Web of Science ®Google Scholar
• Marazuela, M., M. A. García-López, N. Figueroa-Vega, et al. 2006. Regulatory T cells in human autoimmune thyroid disease. J. Clin. Endocrinol. Metab. 91: 3639–3646
   PubMed Web of Science ®Google Scholar
• Pan, D., Y. H. Shin, G. Gopalakrishnan, et al. 2009. Regulatory T cells in Graves' disease. Clin. Endocrinol. (Oxf). 71: 587–593
   PubMed Web of Science ®Google Scholar
• Nakano, A., M. Watanabe, T. Iida, et al. 2007. Apoptosis-induced decrease of intrathyroidal CD4(+)CD25(+) regulatory T cells in autoimmune thyroid diseases. Thyroid. 17: 25–31
   PubMed Web of Science ®Google Scholar
• Bossowski, A., M. Moniuszko, M. Dąbrowska, et al. 2013. Lower proportions of CD4 + CD25high and CD4+ FoxP3, but not CD4 + CD25 + CD127-FoxP3 + T cell levels in children with autoimmune thyroid diseases. Autoimmunity. 46: 222–230
   PubMed Web of Science ®Google Scholar
• Chaudhry, A., D. Rudra, P. Treuting, et al. 2009. CD4 + regulatory T cells control TH17 responses in a Stat3-dependent manner. Science. 326: 986–991
   PubMed Web of Science ®Google Scholar
• Ichiyama, K., H. Yoshida, Y. Wakabayashi, et al. 2008. Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat. J. Biol. Chem. 283: 17003–17008
   PubMed Web of Science ®Google Scholar
• Zhou, L., J. E. Lopes, M. M. Chong, et al. 2008. TGF-b-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORgammat function. Nature. 453: 236–240
   PubMed Web of Science ®Google Scholar
• Korn, T., M. Mitsdoerffer, A. L. Croxford, et al. 2008. IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc. Natl. Acad. Sci. USA. 105: 18460–18465
   PubMed Web of Science ®Google Scholar
• Voo, K. S., Y. H. Wang, F. R. Santori, et al. 2009. Identification of IL-17 producing FOXP3+ regulatory T cells in humans. Proc. Natl. Acad. Sci. USA. 106: 4793–4798
   PubMed Web of Science ®Google Scholar
• Singh, S. P., H. H. Zhang, J. F. Foley, et al. 2008. Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. J. Immunol. 180: 214–222
   PubMed Web of Science ®Google Scholar