Modulation of the peripheral immune system after low-dose radon spa therapy: Detailed longitudinal immune monitoring of patients within the RAD-ON01 study

References

• Sokoloff, N. 1898. Röntgenstrahlen gegen Gelenkrheumatismus. Wien. Med. Wochenschr. 48: 570
   Google Scholar
• Franke, A., L. Reiner, H. G. Pratzel, et al. 2000. Long-term efficacy of radon spa therapy in rheumatoid arthritis-a randomized, sham-controlled study and follow-up. Rheumatol. 39: 894–902
   PubMed Web of Science ®Google Scholar
• Falkenbach, A., J. Kovacs, A. Franke, et al. 2005. Radon therapy for the treatment of rheumatic diseases – review and meta-analysis of controlled clinical trials. Rheumatol. Int. 25: 205–210
   PubMed Web of Science ®Google Scholar
• Franke, A., and T. Franke. 2013. Long-term benefits of radon spa therapy in rheumatic diseases: results of the randomised, multi-centre IMuRa trial. Rheumatol. Int. 33: 2839–2850
   PubMed Web of Science ®Google Scholar
• Ott, O. J., C. Jeremias, U. S. Gaipl, et al. 2015. Radiotherapy for benign achillodynia: long-term results of the Erlangen Dose Optimization Trial. Strahlenther.Onkol. 191: 979–984
   PubMed Web of Science ®Google Scholar
• Ott, O. J., C. Jeremias, U. S. Gaipl, et al. 2014. Radiotherapy for benign calcaneodynia: long-term results of the Erlangen Dose Optimization (EDO) trial. Strahlenther. Onkol. 190: 671–675
   PubMed Web of Science ®Google Scholar
• Ott, O. J., S. Hertel, U. S. Gaipl, et al. 2014. The Erlangen Dose Optimization trial for radiotherapy of benign painful shoulder syndrome. Long-term results. Strahlenther. Onkol. 190: 394–398
   PubMed Web of Science ®Google Scholar
• Ott, O. J., S. Hertel, U. S. Gaipl, et al. 2014. The Erlangen Dose Optimization trial for low-dose radiotherapy of benign painful elbow syndrome. Long-term results. Strahlenther. Onkol. 190: 293–297
   PubMed Web of Science ®Google Scholar
• Trott, K. R., and F. Kamprad. 1999. Radiobiological mechanisms of anti-inflammatory radiotherapy. Radiother. Oncol. 51: 197–203
   PubMed Web of Science ®Google Scholar
• Frey, B., S. Hehlgans, F. Rodel, and U. S. Gaipl. 2015. Modulation of inflammation by low and high doses of ionizing radiation: implications for benign and malign diseases. Cancer. Lett. 368: 230–237
   PubMed Web of Science ®Google Scholar
• Manda, K., A. Glasow, D. Paape, and G. Hildebrandt. 2012. Effects of ionizing radiation on the immune system with special emphasis on the interaction of dendritic and T cells. Front. Oncol. 2: 102
   PubMedGoogle Scholar
• Wunderlich, R., A. Ernst, F. Rodel, et al. 2015. Low and moderate doses of ionizing radiation up to 2 Gy modulate transmigration and chemotaxis of activated macrophages, provoke an anti-inflammatory cytokine milieu, but do not impact upon viability and phagocytic function. Clin. Exp. Immunol. 179: 50–61
   PubMed Web of Science ®Google Scholar
• Frischholz, B., R. Wunderlich, P. F. Ruhle, et al. 2013. Reduced secretion of the inflammatory cytokine IL-1β by stimulated peritoneal macrophages of radiosensitive Balb/c mice after exposure to 0.5 or 0.7 Gy of ionizing radiation. Autoimmunity. 46: 323–328
   PubMed Web of Science ®Google Scholar
• Large, M., S. Hehlgans, S. Reichert, et al. 2015. Study of the anti-inflammatory effects of low-dose radiation: the contribution of biphasic regulation of the antioxidative system in endothelial cells. Strahlenther. Onkol. 191: 742–749
   PubMed Web of Science ®Google Scholar
• Rodel, F., L. Keilholz, M. Herrmann, et al. 2007. Radiobiological mechanisms in inflammatory diseases of low-dose radiation therapy. Int. J. Radiat. Biol. 83: 357–366
   PubMed Web of Science ®Google Scholar
• Gaipl, U. S., S. Meister, B. Lodermann, et al. 2009. Activation-induced cell death and total Akt content of granulocytes show a biphasic course after low-dose radiation. Autoimmunity. 42: 340–342
   PubMed Web of Science ®Google Scholar
• Kern, P. M., and L. Keilholz. 2009. Radio-immunological mechanisms of anti-inflammatory treatment: is there a way from the past into the future? Autoimmunity. 42: 337–339
   PubMed Web of Science ®Google Scholar
• Niewald, M., M. H. Seegenschmiedt, O. Micke, et al. 2012. Randomized, multicenter trial on the effect of radiation therapy on plantar fasciitis (painful heel spur) comparing a standard dose with a very low dose: mature results after 12 months’ follow-up. Int. J. Radiat. Oncol. Biol. Phys. 84: e455–e462
   PubMed Web of Science ®Google Scholar
• Kataoka, T. 2013. Study of antioxidative effects and anti-inflammatory effects in mice due to low-dose X-irradiation or radon inhalation. J. Radiat. Res. 54: 587–596
   PubMed Web of Science ®Google Scholar
• Zdrojewicz, Z., and J. J. Strzelczyk. 2006. Radon treatment controversy. Dose-Resp. 4: 106–118
   PubMedGoogle Scholar
• Yamaoka, K., F. Mitsunobu, K. Hanamoto, et al. 2004. Study on biologic effects of radon and thermal therapy on osteoarthritis. J. Pain. 5: 20–25
   PubMed Web of Science ®Google Scholar
• Salomaa, S., K. M. Prise, M. J. Atkinson, et al. 2013. State of the art in research into the risk of low dose radiation exposure – findings of the fourth MELODI workshop. J. Radiol. Prot. 33: 589–603
   PubMed Web of Science ®Google Scholar
• Ruhle, P. F., R. Fietkau, U. S. Gaipl, and B. Frey. 2016. Development of a modular assay for detailed immunophenotyping of peripheral human whole blood samples by multicolor flow cytometry. Int. J. Mol. Sci. 17: 1316
   Web of Science ®Google Scholar
• Pratzel, H. G., and P. Deetjen. 1997. Radon in der Kurortmedizin. I.S.M.H. Verlag, Geretsried
   Google Scholar
• Deetjen, P., A. Falkenbach, D. Harder, et al 2005. Radon als Heilmittel, Therapeutische Wirksamkeit, biologischer Wirkungsmechanismus und vergleichende Risikobewertung. Verlag Dr. Kovac, Hamburg
   Google Scholar
• Santos, I., P. Cantista, and C. Vasconcelos. 2015. Balneotherapy in rheumatoid arthritis – a systematic review. Int. J. Biometeorol. 60: 1287–1301
   PubMed Web of Science ®Google Scholar
• Jacobsen, E. A., R. A. Helmers, J. J. Lee, and N. A. Lee. 2012. The expanding role(s) of eosinophils in health and disease. Blood. 120: 3882–3890
   PubMed Web of Science ®Google Scholar
• Furuta, G. T., F. D. Atkins, N. A. Lee, and J. J. Lee. 2014. Changing roles of eosinophils in health and disease. Ann. Aller. Asth. Immunol. 113: 3–8
   PubMed Web of Science ®Google Scholar
• Zanoni, I., and F. Granucci. 2010. Regulation of antigen uptake, migration, and lifespan of dendritic cell by Toll-like receptors. J. Mol. Med. 88: 873–880
   PubMed Web of Science ®Google Scholar
• Reizis, B., A. Bunin, H. S. Ghosh, et al. 2011. Plasmacytoid dendritic cells: recent progress and open questions. Annu. Rev. Immunol. 29: 163–183
   PubMed Web of Science ®Google Scholar
• Salgado, F. J., J. Lojo, C. M. Fernandez-Alonso, et al. 2002. Interleukin-dependent modulation of HLA-DR expression on CD4and CD8 activated T cells. Immunol. Cell. Biol. 80: 138–147
   PubMed Web of Science ®Google Scholar
• LaSalle, J. M., K. Ota, and D. A. Hafler. 1991. Presentation of autoantigen by human T cells. J. Immunol. 147: 774–780
   PubMed Web of Science ®Google Scholar
• Antoniades, C. G., P. A. Berry, E. T. Davies, et al. 2006. Reduced monocyte HLA-DR expression: a novel biomarker of disease severity and outcome in acetaminophen-induced acute liver failure. Hepatology. 44: 34–43
   PubMed Web of Science ®Google Scholar
• Cheadle, W. G., M. J. Hershman, S. R. Wellhausen, and H. C. Polk,Jr 1991. HLA-DR antigen expression on peripheral blood monocytes correlates with surgical infection. Am. J. Surg. 161: 639–645
   PubMed Web of Science ®Google Scholar
• Buckner, J. H. 2010. Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases. Nat. Rev. Immunol. 10: 849–859
   PubMed Web of Science ®Google Scholar
• Arai, K., S. Yamamura, S. Seki, et al. 1998. Increase of CD57+ T cells in knee joints and adjacent bone marrow of rheumatoid arthritis (RA) patients: implication for an anti-inflammatory role. Clin. Exp. Immunol. 111: 345–352
   PubMed Web of Science ®Google Scholar
• Alzabin, S., and R. O. Williams. 2011. Effector T cells in rheumatoid arthritis: lessons from animal models. FEBS. Lett. 585: 3649–3659
   PubMed Web of Science ®Google Scholar
• Taneja, V., N. Taneja, T. Paisansinsup, et al. 2002. CD4 and CD8 T cells in susceptibility/protection to collagen-induced arthritis in HLA-DQ8-transgenic mice: implications for rheumatoid arthritis. J. Immunol. 168: 5867–5875
   PubMed Web of Science ®Google Scholar
• Lanzavecchia, A., and F. Sallusto. 2005. Understanding the generation and function of memory T cell subsets. Curr. Opin. Immunol. 17: 326–332
   PubMed Web of Science ®Google Scholar
• Mittrucker, H. W., A. Visekruna, and M. Huber. 2014. Heterogeneity in the differentiation and function of CD8′ T cells. Arch. Immunol. Ther. Exp. 62: 449–458
   PubMed Web of Science ®Google Scholar
• Jacobs, R., G. Hintzen, A. Kemper, et al. 2001. CD56bright cells differ in their KIR repertoire and cytotoxic features from CD56dim NK cells. Eur. J. Immunol. 31: 3121–3127
   PubMed Web of Science ®Google Scholar
• Cooper, M. A., T. A. Fehniger, S. C. Turner, et al. 2001. Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset. Blood. 97: 3146–3151
   PubMed Web of Science ®Google Scholar
• Winklmayr, M., C. Kluge, W. Winklmayr, et al. 2015. Radon balneotherapy and physical activity for osteoporosis prevention: a randomized, placebo-controlled intervention study. Radiat. Environ. Biophys. 54: 123–136
   PubMed Web of Science ®Google Scholar
• Jimi, E., and S. Ghosh. 2005. Role of nuclear factor-kappaB in the immune system and bone. Immunol. Rev. 208: 80–87
   PubMed Web of Science ®Google Scholar