Bone marrow mesenchymal stem cells suppress IL-9 in adjuvant-induced arthritis

References

• Gibofsky A. Overview of epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis. Am J Manag Care. 2012;18:S295–S302.
   PubMedGoogle Scholar
• Asquith DL, Miller AM, McInnes IB, et al. Animal models of rheumatoid arthritis. Eur J Immunol. 2009;39:2040–2044.
   PubMed Web of Science ®Google Scholar
• Vasanthi P, Nalini G, Rajasekhar G. Role of tumor necrosis factor‐alpha in rheumatoid arthritis: a review. APLAR J Rheum. 2007;10:270–274.
   Google Scholar
• Bush KA, Walker JS, Lee CS, et al. Cytokine expression and synovial pathology in the initiation and spontaneous resolution phases of adjuvant arthritis: interleukin-17 expression is upregulated in early disease. Clin Exp Immunol. 2001;123:487–495.
   PubMed Web of Science ®Google Scholar
• Sakuma M, Hatsushika K, Koyama K, et al. TGF-beta type I receptor kinase inhibitor down-regulates rheumatoid synoviocytes and prevents the arthritis induced by type II collagen antibody. Int Immunol. 2007;19:117–126.
   PubMed Web of Science ®Google Scholar
• Ciccia F, Guggino G, Rizzo A, et al. Potential involvement of IL-9 and Th9 cells in the pathogenesis of rheumatoid arthritis. Rheumatology (Oxford). 2015;54:2264–2272.
   PubMed Web of Science ®Google Scholar
• Goswami R, Kaplan MH. A brief history of IL-9. J Immunol. 2011;186:3283–3288.
   PubMed Web of Science ®Google Scholar
• Rochman Y, Spolski R, Leonard WJ. New insights into the regulation of T cells by gamma(c) family cytokines. Nat Rev Immunol. 2009;9:480.
   PubMed Web of Science ®Google Scholar
• Nowak EC, Weaver CT, Turner H, et al. IL-9 as a mediator of Th17-driven inflammatory disease. J Exp Med. 2009;206:1653–1660.
   PubMed Web of Science ®Google Scholar
• Dantas AT, Marques CD, da Rocha Junior LF, et al. Increased serum Interleukin-9 levels in rheumatoid arthritis and systemic lupus erythematosus: pathogenic role or just an epiphenomenon? Dis Markers. 2015;2015:519638.
   PubMed Web of Science ®Google Scholar
• Gaies E, Jebabli N, Trabelsi S, et al. Methotrexate side effects: review article. J Drug Metab Toxicol. 2012;3:125.
   PubMedGoogle Scholar
• Robert EN, Dana Y, Michelle AL, et al. Treatment of inflammatory diseases with mesenchymal stem cells. Inflamm Allergy Drug Targets. 2009;8:110–123.
   PubMedGoogle Scholar
• Wang L, Wang L, Cong X, et al. Human umbilical cord mesenchymal stem cell therapy for patients with active rheumatoid arthritis: safety and efficacy. Stem Cells Dev. 2013;22:3192–3202.
   PubMed Web of Science ®Google Scholar
• Djouad F, Bouffi C, Ghannam S, et al. Mesenchymal stem cells: innovative therapeutic tools for rheumatic diseases. Nat Rev Rheumatol. 2009;5:392–399.
   PubMed Web of Science ®Google Scholar
• Li CJ, Chen PK, Sun LY, et al. Enhancement of mitochondrial transfer by antioxidants in human mesenchymal stem cells. Oxid Med Cell Longev. 2017;2017:8510805.
   PubMedGoogle Scholar
• Bauerova K, Paulovicova E, Mihalova D, et al. Study of new ways of supplementary and combinatory therapy of rheumatoid arthritis with immunomodulators. Glucomannan and Imunoglukan in adjuvant arthritis. Toxicol Ind Health. 2009;25:329–335.
   PubMed Web of Science ®Google Scholar
• Kothari S, Thompson A, Agarwal A, et al. Free radicals: their beneficial and detrimental effects on sperm function. Indian J Exp Biol. 2010;48:425–435.
   PubMed Web of Science ®Google Scholar
• Parhiz H, Roohbakhsh A, Soltani F, et al. Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models. Phytother Res. 2015;29:323–331.
   PubMed Web of Science ®Google Scholar
• Mateen S, Moin S, Khan AQ, et al. Increased reactive oxygen species formation and oxidative stress in rheumatoid arthritis. PLoS One. 2016;11:e0152925.
   PubMed Web of Science ®Google Scholar
• Umar S, Kumar A, Sajad M, et al. Hesperidin inhibits collagen-induced arthritis possibly through suppression of free radical load and reduction in neutrophil activation and infiltration. Rheumatol Int. 2013;33:657–663.
   PubMed Web of Science ®Google Scholar
• Snekhalatha U, Anburajan M, Venkatraman B, et al. Evaluation of complete Freund’s adjuvant-induced arthritis in a Wistar rat model. Comparison of thermography and histopathology. Z Rheumatol. 2013;72:375–382.
   PubMed Web of Science ®Google Scholar
• Abdel Aziz MT, Atta HM, Mahfouz S, et al. Therapeutic potential of bone marrow-derived mesenchymal stem cells on experimental liver fibrosis. Clin Biochem. 2007;40:893–899.
   PubMed Web of Science ®Google Scholar
• Abdel Aziz MT, El Asmar MF, Atta HM, et al. Efficacy of mesenchymal stem cells in suppression of hepatocarcinorigenesis in rats: possible role of Wnt signaling. J Exp Clin Cancer Res. 2011;30:49.
   PubMed Web of Science ®Google Scholar
• Takano T, Li YJ, Kukita A, et al. Mesenchymal stem cells markedly suppress inflammatory bone destruction in rats with adjuvant-induced arthritis. Lab Invest. 2014;94:286–296.
   PubMed Web of Science ®Google Scholar
• Haasters F, Prall WC, Anz D, et al. Morphological and immunocytochemical characteristics indicate the yield of early progenitors and represent a quality control for human mesenchymal stem cell culturing. J Anat. 2009;214:759–767.
   PubMed Web of Science ®Google Scholar
• Ahmed YM, Messiha BA, Abo-Saif AA. Protective effects of simvastatin and hesperidin against complete freund’s adjuvant-induced rheumatoid arthritis in rats. Pharmacology. 2015;96:217–225.
   PubMed Web of Science ®Google Scholar
• Li Y, Wang S, Wang Y, et al. Inhibitory effect of the antimalarial agent artesunate on collagen-induced arthritis in rats through nuclear factor kappa B and mitogen-activated protein kinase signaling pathway. Transl Res. 2013;161:89–98.
   PubMed Web of Science ®Google Scholar
• Kehoe O, Cartwright A, Askari A, et al. Intra-articular injection of mesenchymal stem cells leads to reduced inflammation and cartilage damage in murine antigen-induced arthritis. J Transl Med. 2014;12:157.
   PubMed Web of Science ®Google Scholar
• Satoh K. Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clin Chim Acta. 1978;90:37–43.
   PubMed Web of Science ®Google Scholar
• Beutler E, Duron O, Kelly BM. Improved method for the determination of blood glutathione. J Lab Clin Med. 1963;61:882–888.
   PubMed Web of Science ®Google Scholar
• Nishikimi M, Appaji N, Yagi K. The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophys Res Commun. 1972;46:849–854.
   PubMed Web of Science ®Google Scholar
• Atkinson SM, Nansen A, Usher PA, et al. Treatment with anti-C5aR mAb leads to early-onset clinical and mechanistic effects in the murine delayed-type hypersensitivity arthritis model. Autoimmunity. 2015;48:460–470.
   PubMed Web of Science ®Google Scholar
• Kim EY, Chi HH, Rajaiah R, et al. Exogenous tumour necrosis factor α induces suppression of autoimmune arthritis. Arthritis Res Ther. 2008;10:R38.
   PubMedGoogle Scholar
• Chen Y, Wang QW, Zuo J, et al. Anti-arthritic activity of ethanol extract of Claoxylon indicum on Freund’s complete adjuvant-induced arthritis in mice. BMC Complement Altern Med. 2017;17:11.
   PubMed Web of Science ®Google Scholar
• Yang J, Li Q, Yang X, et al. Interleukin-9 is associated with elevated anti–double-stranded DNA antibodies in lupus-prone mice. Mol Med. 2015;21:364–370.
   PubMed Web of Science ®Google Scholar
• Ran C, Jian-hua X. The abnormality and clinical significance of T helper 9 cells and interleukin-9 in patients with rheumatoid arthritis. Chin J Rheumatol. 2012;16:442–445.
   Google Scholar
• Rauber S, Luber M, Weber S, et al. Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells. Nat Med. 2017;23:938–944.
   PubMed Web of Science ®Google Scholar
• Karagiannis F, Wilhelm C. More is less: IL-9 in the resolution of inflammation. Immunity. 2017;47:403–405.
   PubMed Web of Science ®Google Scholar
• Paludan SR. Interleukin-4 and interferon-gamma: the quintessence of a mutual antagonistic relationship. Scand J Immunol. 1998;48:459–468.
   PubMed Web of Science ®Google Scholar
• Mossiat C, Laroche D, Prati C, et al. Association between arthritis score at the onset of the disease and long-term locomotor outcome in adjuvant-induced arthritis in rats. Arthritis Res Ther. 2015;17:184.
   PubMed Web of Science ®Google Scholar
• IH S, TM E. A possible pathogenic role of CD4+ CD25+ T-regulatory cells in psoriasis. Egypt J Immunol. 2007;14:21–31.
   PubMedGoogle Scholar
• Sun L, Wang D, Liang J, et al. Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus. Arthritis Rheum. 2010;62:2467–2475.
   PubMed Web of Science ®Google Scholar
• Glennie S, Soeiro I, Dyson PJ, et al. Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells. Blood. 2005;11:1–2827.
   Web of Science ®Google Scholar
• Jung KH, Song SU, Yi T, et al. Human bone marrow-derived clonal mesenchymal stem cells inhibit inflammation and reduce acute pancreatitis in rats. Gastroenterology. 2011;140:998–1008.
   PubMed Web of Science ®Google Scholar
• Nauta AJ, Kruisselbrink AB, Lurvink E, et al. Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells. J Immunol. 2006;177:2080–2087.
   PubMed Web of Science ®Google Scholar
• Francois M, Romieu-Mourez R, Li M, et al. Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation. Mol Ther. 2012;20:187–195.
   PubMed Web of Science ®Google Scholar
• Gutcher I, Donkor MK, Ma Q, et al. Autocrine transforming growth factor-beta1 promotes in vivo Th17 cell differentiation. Immunity. 2011;34:396–408.
   PubMed Web of Science ®Google Scholar
• He Z, Hua J, Qian D, et al. Intravenous hMSCs ameliorate acute pancreatitis in mice via secretion of tumor necrosis factor-α stimulated gene/protein 6. Sci Rep. 2016;6:38438.
   PubMed Web of Science ®Google Scholar
• Peng Y, Chen X, Liu Q, et al. Mesenchymal stromal cells infusions improve refractory chronic graft versus host disease through an increase of CD5+ regulatory B cells producing interleukin 10. Leukemia. 2015;29:636–646.
   PubMed Web of Science ®Google Scholar
• da Costa Goncalves F, Grings M, Nunes NS, et al. Antioxidant properties of mesenchymal stem cells against oxidative stress in a murine model of colitis. Biotechnol Lett. 2017;39:613–622.
   PubMed Web of Science ®Google Scholar
• Kemp K, Hares K, Mallam E, et al. Mesenchymal stem cell-secreted superoxide dismutase promotes cerebellar neuronal survival. J Neurochem. 2010;114:1569–1580.
   PubMed Web of Science ®Google Scholar
• Ishii T, Mann GE. Redox status in mammalian cells and stem cells during culture in vitro: critical roles of Nrf2 and cystine transporter activity in the maintenance of redox balance. Redox Biol. 2014;2:786–794.
   PubMed Web of Science ®Google Scholar
• Chen MC, Ye YY, Ji G, et al. Hesperidin upregulates heme oxygenase-1 to attenuate hydrogen peroxide-induced cell damage in hepatic L02 cells. J Agric Food Chem. 2010;58:3330–3335.
   PubMed Web of Science ®Google Scholar
• Li R, Cai L, Ren D, et al. Therapeutic effect of 7, 3’-dimethoxy hesperetin on adjuvant arthritis in rats through inhibiting JAK2-STAT3 signal pathway. Int Immunopharmacol. 2012;14:157–163.
   PubMed Web of Science ®Google Scholar
• Li R, Cai L, Xie XF, et al. Hesperidin suppresses adjuvant arthritis in rats by inhibiting synoviocyte activity. Phytother Res. 2010;24:S71–S76.
   PubMed Web of Science ®Google Scholar
• Yeh CC, Kao SJ, Lin CC, et al. The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro. Life Sci. 2007;80:1821–1831.
   PubMed Web of Science ®Google Scholar
• Yamamoto M, Jokura H, Hashizume K, et al. Hesperidin metabolite hesperetin-7-O-glucuronide, but not hesperetin-3′-O-glucuronide, exerts hypotensive, vasodilatory, and anti-inflammatory activities. Food Funct. 2013;4:1346–1351.
   PubMed Web of Science ®Google Scholar
• Nizamutdinova IT, Jeong JJ, Xu GH, et al. Hesperidin, hesperidin methyl chalone and phellopterin from Poncirus trifoliata (Rutaceae) differentially regulate the expression of adhesion molecules in tumor necrosis factor-α-stimulated human umbilical vein endothelial cells. Int Immunopharmacol. 2008;8:670–678.
   PubMed Web of Science ®Google Scholar
• Saiprasad G, Chitra P, Manikandan R, et al. Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis. Eur J Cancer. 2014;50:2489–2507.
   PubMed Web of Science ®Google Scholar