Increased circulating Tfh17 and PD-1⁺Tfh cells are associated with autoantibodies in Hashimoto’s thyroiditis

References

• Smith MJ, Rihanek M, Coleman BM, et al. Activation of thyroid antigen-reactive B cells in recent onset autoimmune thyroid disease patients. J Autoimmun. 2017;89:82–89.
   PubMed Web of Science ®Google Scholar
• Yu S, Maiti PK, Dyson M, et al. B cell-deficient NOD.H-2h4 mice have CD4 + CD25+ T regulatory cells that inhibit the development of spontaneous autoimmune thyroiditis. J Exp Med. 2006;203:349–358.
   PubMed Web of Science ®Google Scholar
• Hong SH, Braley-Mullen H. Follicular B cells in thyroids of mice with spontaneous autoimmune thyroiditis contribute to disease pathogenesis and are targets of anti-CD20 antibody therapy. J Immunol. 2014;192:897–905.
   PubMed Web of Science ®Google Scholar
• Caturegli P, De Remigis A, Rose NR. Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev. 2014;13:391–397.
   PubMed Web of Science ®Google Scholar
• Morita R, Schmitt N, Bentebibel SE, et al. Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity. 2011;34:108–121.
   PubMed Web of Science ®Google Scholar
• Ma CS, Deenick EK. Human T follicular helper (Tfh) cells and disease. Immunol Cell Biol. 2014;92:64–71.
   PubMed Web of Science ®Google Scholar
• Choi JY, Ho JH, Pasoto SG, et al. Circulating follicular helper-like T cells in systemic lupus erythematosus: association with disease activity. Arthritis Rheumatol. 2015;67:988–999.
   PubMed Web of Science ®Google Scholar
• Ueno H. T follicular helper cells in human autoimmunity. Curr Opin Immunol. 2016;43:24–31.
   PubMed Web of Science ®Google Scholar
• Breitfeld D, Ohl L, Kremmer E, et al. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med. 2000;192:1545–1552.
   PubMed Web of Science ®Google Scholar
• Choi YS, Kageyama R, Eto D, et al. ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity. 2011;34:932–946.
   PubMed Web of Science ®Google Scholar
• Tangye SG, Ma CS, Brink R, et al. The good, the bad and the ugly – TFH cells in human health and disease. Nat Rev Immunol. 2013;13:412–426.
   PubMed Web of Science ®Google Scholar
• He J, Tsai LM, Leong YA, et al. Circulating precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity. 2013;39:770–781.
   PubMed Web of Science ®Google Scholar
• Liu X, Yan X, Zhong B, et al. Bcl6 expression specifies the T follicular helper cell program in vivo. J Exp Med. 2012;209:1841–1852.
   PubMed Web of Science ®Google Scholar
• Chevalier N, Jarrossay D, Ho E, et al. CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses. J Immunol. 2011;186:5556–5568.
   PubMed Web of Science ®Google Scholar
• Fonseca VR, Agua-Doce A, Maceiras AR, et al. Human blood Tfr cells are indicators of ongoing humoral activity not fully licensed with suppressive function. Sci Immunol. 2017;2:eaan1487.
   PubMed Web of Science ®Google Scholar
• Zhu C, Ma J, Liu Y, et al. Increased frequency of follicular helper T cells in patients with autoimmune thyroid disease. J Clin Endocrinol Metab. 2012;97:943–950.
   PubMed Web of Science ®Google Scholar
• Zhang J, Ren M, Zeng H, et al. Elevated follicular helper T cells and expression of IL-21 in thyroid tissues are involved in the pathogenesis of Graves’ disease. Immunol Res. 2015;62:163–174.
   PubMed Web of Science ®Google Scholar
• Theodorsson E. Quality assurance in clinical chemistry: a touch of statistics and a lot of common sense. J Med Biochem. 2016;35:103–112.
   PubMed Web of Science ®Google Scholar
• Xu B, Wang S, Zhou M, et al. The ratio of circulating follicular T helper cell to follicular T regulatory cell is correlated with disease activity in systemic lupus erythematosus. Clin Immunol. 2017;183:46–53.
   PubMed Web of Science ®Google Scholar
• Bentebibel SE, Lopez S, Obermoser G, et al. Induction of ICOS + CXCR3 + CXCR5+ TH cells correlates with antibody responses to influenza vaccination. Sci Transl Med. 2013;5:176ra32.
   PubMed Web of Science ®Google Scholar
• Antonelli A, Ferrari SM, Corrado A, et al. Autoimmune thyroid disorders. Autoimmun Rev. 2015;14:174–180.
   PubMed Web of Science ®Google Scholar
• Wiersinga WM. Thyroid autoimmunity. Endocr Dev. 2014;26:139–157.
   PubMedGoogle Scholar
• Zhu Y, Zou L, Liu YC. T follicular helper cells, T follicular regulatory cells and autoimmunity. Int Immunol. 2016;28:173–179.
   PubMed Web of Science ®Google Scholar
• Fonseca VR, Romao VCAgua-Doce A, et al. Blood T follicular regulatory cells/T follicular helper cells ratio marks ectopic lymphoid structure formation and PD-1(+) ICOS(+) T follicular helper cells Indicate disease activity in primary Sjogren’s syndrome. Arthritis Rheumatol. 2018;70:774–784.
   PubMed Web of Science ®Google Scholar
• Gensous N, Schmitt N, Richez C, et al. T follicular helper cells, interleukin-21 and systemic lupus erythematosus. Rheumatology (Oxford). 2017;56:516–523.
   PubMed Web of Science ®Google Scholar
• Crotty S. T follicular helper cell differentiation, function, and roles in disease. Immunity. 2014;41:529–542.
   PubMed Web of Science ®Google Scholar
• Zhang CJ, Gong Y, Zhu W, et al. Augmentation of circulating follicular helper T cells and their impact on autoreactive B cells in myasthenia gravis. J Immunol. 2016;197:2610–2617.
   PubMed Web of Science ®Google Scholar
• Kamekura R, Takano K, Yamamoto M, et al. Cutting edge: a critical role of lesional T follicular helper cells in the pathogenesis of IgG4-related disease. J Immunol. 2017;199:2624–2629.
   PubMed Web of Science ®Google Scholar
• Viisanen T, Ihantola EL, Nanto-Salonen K, et al. Circulating CXCR5 + PD-1 + ICOS + follicular T helper cells are increased close to the diagnosis of type 1 diabetes in children with multiple autoantibodies. Diabetes. 2017;66:437–447.
   PubMed Web of Science ®Google Scholar
• Sage PT, Sharpe AH. T follicular regulatory cells. Immunol Rev. 2016;271:246–259.
   PubMed Web of Science ®Google Scholar
• Gong Y, Tong J, Wang S. Are follicular regulatory T cells involved in autoimmune diseases? Front Immunol. 2017;8:1790.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Amaro R, Marazuela M. T regulatory (Treg) and T helper 17 (Th17) lymphocytes in thyroid autoimmunity. Endocrine. 2016;52:30–38.
   PubMed Web of Science ®Google Scholar