170
Views
8
CrossRef citations to date
0
Altmetric
Articles

Overexpression of toll-like receptor 9 correlates with podocyte injury in a murine model of autoimmune membranoproliferative glomerulonephritis

, , , , , & show all
Pages 386-398 | Received 17 Jul 2018, Accepted 13 Nov 2018, Published online: 28 Dec 2018

References

  • Tonelli M, Wiebe N, Culleton B, et al. Chronic kidney disease and mortality risk: a systematic review. J Am Soc Nephrol. 2006;17:2034–2047.
  • Coresh J, Astor BC, Greene T, et al. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis. 2003;41:1–12.
  • Nagata M, Ninomiya T, Doi Y, et al. Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population: the Hisayama Study. Nephrol Dial Transplant. 2010;25:2557–2564..
  • Sethi S, Fervenza FC. Membranoproliferative glomerulonephritis - a new look at an old entity. N Engl J Med. 2012;366:1119–1131.
  • Yusuf MG, Das BB, Shaha AC, et al. Histopathological types in adult nephrotic syndrome. Saudi J Kidney Dis Transpl. 2016;27:576–580.
  • Fogo AB, Lusco MA, Najafian B, et al. AJKD atlas of renal pathology: membranoproliferative glomerulonephritis. Am J Kidney Dis. 2015;66:e19–e20.
  • Noris M, Remuzzi G. Glomerular diseases dependent on complement activation, including atypical hemolytic uremic syndrome, membranoproliferative glomerulonephritis, and c3 glomerulopathy: core curriculum. Am J Kidney Dis. 2015;66:359–375.
  • Kumar V, editor. Robbins basic pathology. 8th ed. Philadelphia: Saunders/Elsevier; 2007.
  • Seelen MA, Daha MR. The role of complement in autoimmune renal disease. Autoimmunity. 2006;39:411–415.
  • Santiago-Raber ML, Laporte C, Reininger L, et al. Genetic basis of murine lupus. Autoimmun Rev. 2004;3:33–39.
  • Subramanian S, Tus K, Li QZ, et al. A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc Natl Acad Sci USA. 2006;103:9970–9975.
  • Masum MA, Ichii O, Elewa YHA, et al. Local CD34-positive capillaries decrease in mouse models of kidney disease associating with the severity of glomerular and tubulointerstitial lesions. BMC Nephrol. 2017;18:280.
  • Kimura J O, Ichii K, Miyazono T, et al. Overexpression of toll-like receptor 8 correlates with the progression of podocyte injury in murine autoimmune glomerulonephritis. Sci Rep. 2014;4:7290.
  • Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001;2:675–680.
  • Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010;11:373–384.
  • Baccala R, Gonzalez-Quintial R, Lawson BR, et al. Sensors of the innate immune system: their mode of action. Nat Rev Rheumatol. 2009;5:448–456.
  • Garraud O, Cognasse F. Platelet Toll-like receptor expression: the link between ‘‘danger’’ ligands and inflammation. Iadt. 2010;9:322–333.
  • Andersen-Nissen E, Hawn TR, Smith KD, et al. Cutting edge: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection. J Immunol. 2007;178:4717–4720.
  • Zhang D, Zhang G, Hayden MS, et al. A toll-like receptor that prevents infection by uropathogenic bacteria. Science. 2004;303:1522–1526.
  • Shigeoka AA, Holscher TD, King AJ, et al. TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and-independent pathways. J Immunol. 2007;178:6252–6258.
  • Benigni A, Caroli C, Longaretti L, et al. Involvement of renal tubular Toll-like receptor 9 in the development of tubulointerstitial injury in systemic lupus. Arthritis Rheum. 2007;56:1569–1578.
  • Papadimitraki ED, Tzardi M, Bertsias G, et al. Glomerular expression of toll-like receptor-9 in lupus nephritis but not in normal kidneys: implications for the amplification of the inflammatory response. Lupus. 2009;18:831–835.
  • Machida H, Ito S, Hirose T, et al. Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis. Nephrol Dial Transplant. 2010;25:2530–2537.
  • Anders HJ, Banas B, Linde Y, et al. Bacterial CpG-DNA aggravates glomerulonephritis by TLR9-mediated expression of chemokines and chemokine Receptors. J Am Soc Nephrol. 2003;14:317–326.
  • Anders HJ, Banas B, Schlöndorff D. Signaling danger: toll-like receptors and their potential roles in kidney disease. J Am Soc Nephrol. 2004;15:854–867.
  • Conti F, Spinelli FR, Truglia S, et al. Kidney expression of toll like receptors in lupus nephritis: quantification and clinicopathological correlations. Mediators Inflamm. 2016;2016:1.
  • Takemoto M, Asker N, Gerhardt H, et al. A new method for large scale isolation of kidney glomeruli from mice. Am J Pathol. 2002;161:799–805.
  • Masum MA, Ichii O, Elewa YHA, et al. Modified scanning electron microscopy reveals pathological crosstalk between endothelial cells and podocytes in a murine model of membranoproliferative glomerulonephritis. Sci Rep. 2018;8:10276.
  • Ichii O, Konno A, Sasaki N, et al. Altered balance of inhibitory and active Fc gamma receptors in murine autoimmune glomerulonephritis. Kidney Int. 2008;74:339–347.
  • Shirali AC, Goldstein DR. Tracking the toll of kidney disease. J Am Soc Nephrol. 2008;19:1444–1450.
  • Tsuboi N, Yoshikai Y, Matsuo S, et al. Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells. J Immunol. 2002;169:2026–2033.
  • Patole PS, Pawar RD, Lech M, et al. Expression and regulation of toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice. Nephrol Dial Transplant. 2006;21:3062–3073.
  • Eleftheriadis T, Pissas G, Liakopoulos V, et al. Toll-like receptors and their role in renal pathologies. Inflamm Allergy Drug Targets. 2012;11:464–477.
  • Gurkan S, Cabinian A, Lopez V, et al. Inhibition of type I interferon signaling prevents TLR ligand mediated proteinuria. J Pathol. 2013;231:248–256.
  • Takemura T, Yoshioka K, Murakami N, et al. Cellular localization of inflammatory cytokines in human glomerulonephritis. Virchows Arch. 1994;424:459–464.
  • Gorden KK, Qiu XX, Binsfeld CC, et al. Cutting edge: activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides. J Immunol. 2006;177:6584–6587.
  • Banas MC, Banas B, Hudkins KL, et al. TLR4 links podocytes with the innate immune system to mediate glomerular injury. J Am Soc Nephrol. 2008;19:704–713.
  • Zhu FG, Jiang W, Bhagat L, et al. A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice. Autoimmunity. 2013;46:419–428.
  • Diez-Sampedro A, Lenz O, Fornoni A. Podocytopathy in diabetes: a metabolic and endocrine disorder. Am J Kidney Dis. 2011;58:637–646.
  • Lartigue A, Colliou N, Calbo S, et al. Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus. J Immunol. 2009;183:6207–6216.
  • Timoshanko JR, Kitching AR, Holdsworth SR, et al. Interleukin-12 from intrinsic cells is an effector of renal injury in crescentic glomerulonephritis. J Am Soc Nephrol. 2001;12:464–471.
  • Timoshanko JR, Holdsworth SR, Kitching AR, et al. IFN-gamma production by intrinsic renal cells and bone marrow-derived cells is required for full expression of crescentic glomerulonephritis in mice. J Immunol. 2002;168:4135–4141.
  • Niemir ZI, Stein H, Dworacki G, et al. Podocytes are the major source of IL-1 alpha and IL-1 beta in human glomerulonephritides. Kidney Int. 1997;52:393–403.
  • Takano Y, Yamauchi K, Hayakawa K, et al. Transcriptional suppression of nephrin in podocytes by macrophages: roles of inflammatory cytokines and involvement of the PI3K/Akt pathway. FEBS Lett. 2007;581:421–426.
  • Timoshanko JR, Kitching AR, Iwakura Y, et al. Leukocyte-derived interleukin-1beta interacts with renal interleukin-1 receptor I to promote renal tumour necrosis factor and glomerular injury in murine crescentic glomerulonephritis. Am J Pathol. 2004;164:1967–1977.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.