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Autoimmunity Volume 52, 2019 - Issue 1
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Original Article

UBASH3A gene polymorphisms and expression profile in rheumatoid arthritis

Xiao-Ke YangDepartment of Rheumatology and Immunology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; View further author information
,
Juan LiuWuxi Center for Disease Control and Prevention, Wuxi, Jiangsu, China; View further author information
,
Shan-Yu ChenDepartment of Rheumatology and Immunology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; View further author information
,
Mu LiDepartment of Rheumatology and Immunology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; View further author information
,
Ming-Ming ZhangDepartment of Rheumatology and Immunology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; View further author information
,
Rui-Xue LengDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; View further author information
,
Hai-Feng PanDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; View further author information
,
Yuan ShenWuxi Center for Disease Control and Prevention, Wuxi, Jiangsu, China; View further author information
,
Wen-Xue LiuWuxi Emergency Medical Centre, Wuxi, Jiangsu, ChinaView further author information
,
Sheng-Qian XuDepartment of Rheumatology and Immunology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; ORCID Iconhttp://orcid.org/0000-0002-9559-1143View further author information
ORCID Icon,
Dong-Qing YeDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; Correspondence[email protected]
View further author information
&
Zong-Wen ShuaiDepartment of Rheumatology and Immunology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; Correspondence[email protected]
View further author information
 show all
Pages 21-26 | Received 16 Aug 2018, Accepted 08 Feb 2019, Published online: 01 Mar 2019

References

  • Kurkó J, Besenyei T, Laki J, et al. Genetics of rheumatoid arthritis - a comprehensive review. Clin Rev Allergy Immunol. 2013;45:170–179.
  • Tobon GJ, Youinou P, Saraux A. The environment, geoepidemiology, and autoimmune disease: rheumatoid arthritis. J Autoimmun. 2010;35:10–14.
  • Hendriks WJ, Pulido R. Protein tyrosine phosphatase variants in human hereditary dis- orders and disease susceptibilities. Biochim Biophys Acta. 2013;1832:1673–1696.
  • Rigden DJ. The histidine phosphatase superfamily: structure and function. Biochem J. 2008;409:333–348.
  • Newman TN, Liverani E, Ivanova E, et al. Members of the novel UBASH3/STS/TULA family of cellular regulators suppress T-cell-driven inflammatory responses in vivo. Immunol Cell Biol. 2014;92:837–850.
  • Barton A, Worthington J. Genetic susceptibility to rheumatoid arthritis: an emerging picture. Arthritis Rheum. 2009;61:1441–1446.
  • Plenge RM. Recent progress in rheumatoid arthritis genetics: one step towards improved patient care. Curr Opin Rheumatol. 2009;21:262–271.
  • Stahl EA, Raychaudhuri S, Remmers EF, et al. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet. 2010;42:508–514.
  • Eyre S, Bowes J, Diogo D, et al. High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet. 2012;44:1336–1340.
  • Okada Y, Wu D, Trynka G, et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature. 2014;506:376–381.
  • Wattenhofer M, Shibuya K, Kudoh J, et al. Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains. Hum Genet. 2001;108:140–147.
  • Kim K, Bang SY, Lee HS, et al. High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. Ann Rheum Dis. 2015;74:e13.
  • Zhernakova A, Stahl EA, Trynka G, et al. Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. PLoS Genet. 2011;7:e1002004.
  • Liu D, Liu J, Cui G, et al. Evaluation of the association of UBASH3A and SYNGR1 with rheumatoid arthritis and disease activity and severity in Han Chinese. Oncotarget. 2017;8:103385–103392.
  • Arnett FC, Edworthy SM, Bloch DA, et al. The American rheumatism association revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31:315–324.
  • Tsygankov AY. Multidomain STS/TULA proteins are novel cellular regulators. IUBMB Life. 2008;60:224–231.
  • San Luis B, Sondgeroth B, Nassar N, et al. Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 and T cell receptor signaling pathways. J Biol Chem. 2011;286:15943–15954.
  • Zenewicz LA, Abraham C, Flavell RA, et al. Unraveling the genetics of autoimmunity. Cell. 2010;140:791–797.
  • Mc Innes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011;365:2205–2219.
  • Goronzy JJ, Weyand CM. T cells in rheumatoid arthritis. Paradigms and facts. Rheum Dis Clin North Am. 1995;21:655–674.
  • Diaz-Gallo LM, Sanchez E, Ortego-Centeno N, et al. Evidence of new risk genetic factor to systemic lupus erythematosus: the UBASH3A gene. PLoS One. 2013;8:e60646.
  • Liu J, Liu J, Ni J, et al. Association of UBASH3A gene polymorphisms and systemic lupus erythematosus in a Chinese population. Gene. 2015;565:116–121.
  • Plagnol V, Howson JM, Smyth DJ, et al. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genet. 2011;7:e1002216.
  • Frederiksen BN, Steck AK, Kroehl M, et al. Evidence of stage- and age-related heterogeneity of non-HLA SNPs and risk of islet autoimmunity and type 1 diabetes: the diabetes autoimmunity study in the young. Clin Dev Immunol. 2013;2013:417657.
  • Ge Y, Concannon P. Molecular-genetic characterization of common, noncoding UBASH3A variants associated with type 1 diabetes. Eur J Hum Genet. 2018;26:1060–1064.
  • Yin X, Latif R, Bahn R, et al. Influence of the TSH receptor gene on susceptibility to Graves' disease and Graves' ophthalmopathy. Thyroid. 2008;18:1201–1206.
  • Tsygankov AY. TULA-family proteins: a new class of cellular regulators. J Cell Physiol. 2013;228:43–49.

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