Metformin reduces autoimmune antibody levels in patients with Hashimoto’s thyroiditis: A systematic review and meta-analysis

References

• Caturegli P , De Remigis A , Rose NR. Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev. 2014;13(4–5):391–397.
   PubMed Web of Science ®Google Scholar
• Biondi B , Cappola AR , Cooper DS. Subclinical hypothyroidism: a review. JAMA. 2019;322(2):153–160.
   PubMed Web of Science ®Google Scholar
• Baker JR, Jr. , Saunders NB , Wartofsky L , et al. Seronegative Hashimoto thyroiditis with thyroid autoantibody production localized to the thyroid. Ann Intern Med. 1988;108(1):26–30.
   PubMed Web of Science ®Google Scholar
• Hollowell JG , Staehling NW , Flanders WD , et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metabol. 2002;87(2):489–499.
   PubMed Web of Science ®Google Scholar
• Ursini F , Russo E , Pellino G , et al. Metformin and autoimmunity: a “new deal” of an old drug. Front Immunol. 2018;9:1236.
   PubMed Web of Science ®Google Scholar
• Pollak M. The effects of metformin on gut microbiota and the immune system as research frontiers. Diabetologia. 2017;60(9):1662–1667.
   PubMed Web of Science ®Google Scholar
• Schuiveling M , Vazirpanah N , Radstake T , et al. Metformin, a new era for an old drug in the treatment of immune mediated disease? CDT. 2018;19(8):945–959.
   Google Scholar
• Yan H , Zhou HF , Hu Y , et al. Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation. J Rheum Dis Treat. 2015;1(1):5.
   PubMedGoogle Scholar
• Yin Y , Choi SC , Xu Z , et al. Glucose oxidation is critical for CD4+ T cell activation in a mouse model of systemic lupus erythematosus. J Immunol. 2016;196(1):80–90.
   PubMed Web of Science ®Google Scholar
• Sun Y , Tian T , Gao J , et al. Metformin ameliorates the development of experimental autoimmune encephalomyelitis by regulating T helper 17 and regulatory T cells in mice. J Neuroimmunol. 2016;292:58–67.
   PubMed Web of Science ®Google Scholar
• Lee SY , Lee SH , Yang EJ , et al. Metformin ameliorates inflammatory bowel disease by suppression of the STAT3 signaling pathway and regulation of the between Th17/Treg balance. PloS ONE . 2015;10(9):e0135858.
   PubMed Web of Science ®Google Scholar
• Wang H , Li T , Chen S , et al. Neutrophil extracellular trap mitochondrial DNA and its autoantibody in systemic lupus erythematosus and a proof-of-concept trial of metformin. Arthritis Rheumatol. 2015;67(12):3190–3200.
   PubMed Web of Science ®Google Scholar
• Marcocci C , Kahaly GJ , Krassas GE , et al. European Group on Graves Selenium and the course of mild Graves’ orbitopathy. N Engl J Med. 2011;364(20):1920–1931.
   PubMed Web of Science ®Google Scholar
• Mantovani G , Isidori AM , Moretti C , et al. Selenium supplementation in the management of thyroid autoimmunity during pregnancy: results of the “SERENA study”, a randomized, double-blind, placebo-controlled trial. Endocrine. 2019;66(3):542–550.
   PubMed Web of Science ®Google Scholar
• Kohrle J. Selenium and the thyroid. Curr Opin Endocrinol Diabet Obes. 2015;22:392–401.
   PubMed Web of Science ®Google Scholar
• Wichman J , Winther KH , Bonnema SJ , et al. Selenium supplementation significantly reduces thyroid autoantibody levels in patients with chronic autoimmune thyroiditis: a systematic review and meta-analysis. Thyroid. 2016;26(12):1681–1692.
   PubMed Web of Science ®Google Scholar
• Krysiak R , Okrzesik J , Okopien B. Different effects of metformin on the hypothalamic-pituitary-thyroid axis in bromocriptine- and cabergoline-treated patients with hashimoto’s thyroiditis and glucose metabolism abnormalities. Exp Clin Endocrinol Diabetes. 2015;123(09):561–566.
   PubMedGoogle Scholar
• Krysiak R , Szkróbka W , Okopień B. Sex-dependent effect of metformin on hypothalamic-pituitary-thyroid axis activity in patients with subclinical hypothyroidism. Pharmacol Rep. 2016;68(6):1115–1119.
   PubMed Web of Science ®Google Scholar
• Krysiak R , Szkrobka W , Okopien B. The effect of metformin on hypothalamic-pituitary-thyroid axis activity in women with interferon-induced hypothyroidism: a Pilot Study. Exp Clin Endocrinol Diabetes. 2016;124(02):71–76.
   PubMedGoogle Scholar
• Dornelles Severo M , Sturmer Andrade T , Correa Junior V , et al. Metformin effect on TSH in subclinical hypothyroidism: randomized, double-blind, placebo-controlled clinical trial. Endocrine. 2018;59(1):66–71.
   PubMed Web of Science ®Google Scholar
• Taylor PN , Albrecht D , Scholz A , et al. Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol. 2018;14(5):301–316.
   PubMed Web of Science ®Google Scholar
• Peeters RP. Subclinical hypothyroidism. N Engl J Med. 2017;376(26):2556–2565.
   PubMed Web of Science ®Google Scholar
• Hu S , Rayman MP. Multiple nutritional factors and the risk of Hashimoto’s thyroiditis. Thyroid. 2017;27(5):597–610.
   PubMed Web of Science ®Google Scholar
• Pitts MW , Kremer PM , Hashimoto AC , et al. Competition between the brain and testes under selenium-compromised conditions: insight into sex differences in selenium metabolism and risk of neurodevelopmental disease. J Neurosci. 2015;35(46):15326–15338.
   PubMed Web of Science ®Google Scholar
• Lee SY , Moon SJ , Kim EK , et al. Metformin suppresses systemic autoimmunity in Roquinsan/san mice through inhibiting B cell differentiation into plasma cells via regulation of AMPK/mTOR/STAT3. J Immunol. 2017;198(7):2661–2670.
   PubMed Web of Science ®Google Scholar
• Diaz A , Romero M , Vazquez T , et al. Metformin improves in vivo and in vitro B cell function in individuals with obesity and type-2 diabetes. Vaccine. 2017;35(20):2694–2700.
   PubMed Web of Science ®Google Scholar
• Zhang S , Pruitt M , Tran D , et al. B cell-specific deficiencies in mTOR limit humoral immune responses. J Immunol. 2013;191(4):1692–1703.
   PubMed Web of Science ®Google Scholar
• Lupoli R , Di Minno A , Tortora A , et al. Effects of treatment with metformin on TSH levels: a meta-analysis of literature studies. J Clin Endocrinol Metabol. 2014;99(1):E143–E148.
   PubMed Web of Science ®Google Scholar
• Sui M , Yu Y , Zhang H , et al. Efficacy of metformin for benign thyroid nodules in subjects with insulin resistance: a systematic review and meta-analysis. Front Endocrinol. 2018;9:494.
   PubMed Web of Science ®Google Scholar
• Meng X , Xu S , Chen G , et al. Metformin and thyroid disease. J Endocrinol. 2017;233(1):R43–R51.
   PubMed Web of Science ®Google Scholar
• Vigersky RA , Filmore-Nassar A , Glass AR. Thyrotropin suppression by metformin. J Clin Endocrinol Metab. 2006;91(1):225–227.
   PubMed Web of Science ®Google Scholar
• Dessein PH , Joffe BI , Stanwix AE. Subclinical hypothyroidism is associated with insulin resistance in rheumatoid arthritis. Thyroid. 2004;14(6):443–446.
   PubMed Web of Science ®Google Scholar
• Khan SH , Fazal N , Ijaz A , et al. Insulin resistance and glucose levels in subjects with subclinical hypothyroidism. J Coll Physicians Surg Pak. 2017;27(6):329–333.
   PubMed Web of Science ®Google Scholar
• Gierach M , Gierach J , Skowronska A , et al. Hashimoto’s thyroiditis and carbohydrate metabolism disorders in patients hospitalised in the Department of Endocrinology and Diabetology of Ludwik Rydygier Collegium Medicum in Bydgoszcz between 2001 and 2010. Endokrynologia Polska. 2012;63:14–17.
   PubMed Web of Science ®Google Scholar
• Maratou E , Hadjidakis DJ , Kollias A , et al. Studies of insulin resistance in patients with clinical and subclinical hypothyroidism. Eur J Endocrinol. 2009;160(5):785–790.
   PubMed Web of Science ®Google Scholar
• Yang N , Yao Z , Miao L , et al. Novel clinical evidence of an association between homocysteine and insulin resistance in patients with hypothyroidism or subclinical hypothyroidism. PloS ONE. 2015;10(5):e0125922.
   PubMed Web of Science ®Google Scholar
• Ujwal Upadya B , Suma M , Srinath K , et al. Effect of insulin resistance in assessing the clinical outcome of clinical and subclinical hypothyroid patients. J Clin Diagn Res. 2015;9(2):OC01–OC04.
   Web of Science ®Google Scholar
• Tuzcu A , Bahceci M , Gokalp D , et al. Subclinical hypothyroidism may be associated with elevated high-sensitive c-reactive protein (low grade inflammation) and fasting hyperinsulinemia. Endocr J. 2005;52(1):89–94.
   PubMed Web of Science ®Google Scholar
• Al Sayed A , Al Ali N , Bo Abbas Y , et al. Subclinical hypothyroidism is associated with early insulin resistance in Kuwaiti women. Endocr J. 2006;53(5):653–657.
   PubMed Web of Science ®Google Scholar