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Original Articles

DL-propargylglycine administration inhibits TET2 and FOXP3 expression and alleviates symptoms of neonatal Cows’ milk allergy in mouse model

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Pages 467-475 | Received 01 Aug 2020, Accepted 10 Oct 2020, Published online: 20 Oct 2020

References

  • D’Auria E, Salvatore S, Pozzi E, et al. Cow’s milk allergy: immunomodulation by dietary intervention. Nutrients. 2019;11(6):1399.
  • Flom JD, Sicherer SH. Epidemiology of cow’s milk allergy. Nutrients. 2019;11(5):1051.
  • Hochwallner H, Schulmeister U, Swoboda I, et al. Cow’s milk allergy: from allergens to new forms of diagnosis, therapy and prevention. Methods. 2014;66(1):22–33.
  • Lifschitz C, Szajewska H. Cow's milk allergy: evidence-based diagnosis and management for the practitioner. Eur J Pediatr. 2015;174(2):141–150.
  • Taniuchi S, Takahashi M, Soejima K, et al. Immunotherapy for cow's milk allergy. Hum Vaccin Immunother. 2017;13(10):2443–2451.
  • Mousan G, Kamat D. Cow’s milk protein allergy. Clin Pediatr (Phila). 2016;55(11):1054–1063.
  • van Esch BC, Schouten B, Blokhuis BR, et al. Depletion of CD4 + CD25+ T cells switches the whey-allergic response from immunoglobulin E- to immunoglobulin free light chain-dependent. Clin Exp Allergy. 2010;40(9):1414–1421.
  • Karlsson MR, Rugtveit J, Brandtzaeg P. Allergen-responsive CD4 + CD25+ regulatory T cells in children who have outgrown cow’s milk allergy. J Exp Med. 2004;199(12):1679–1688.
  • Bedoret D, Singh AK, Shaw V, et al. Changes in antigen-specific T-cell number and function during oral desensitization in cow’s milk allergy enabled with omalizumab. Mucosal Immunol. 2012;5(3):267–276.
  • Lal G, Bromberg JS. Epigenetic mechanisms of regulation of Foxp3 expression. Blood. 2009;114(18):3727–3735.
  • Mabrouk RR, Amer HA, Soliman DA, Mohamed NA, et al. Vitamin D increases percentages of interleukin-10 secreting regulatory T cells in children with cow’s milk allergy. Egypt J Immunol. 2019;26:15–29.
  • Paparo L, Nocerino R, Cosenza L, et al. Epigenetic features of FoxP3 in children with cow’s milk allergy. Clin Epigenetics. 2016;8:86.
  • Sardecka-Milewska I, Łoś-Rycharska E, Gawryjołek J, et al. Role of FOXP3 expression and serum vitamin D and C concentrations when predicting acquisition of tolerance in infants with cow’s milk allergy. J Investig Allergol Clin Immunol. 2020;30(3):182–190.
  • Savilahti EM, Karinen S, Salo HM, et al. Combined T regulatory cell and Th2 expression profile identifies children with cow’s milk allergy. Clin Immunol. 2010;136(1):16–20.
  • Yue X, Lio CJ, Samaniego-Castruita D, et al. Loss of TET2 and TET3 in regulatory T cells unleashes effector function. Nat Commun. 2019;10(1):2011.
  • Liang Y, Yu B, Chen J, et al. Thymic stromal lymphopoietin epigenetically upregulates Fc receptor γ subunit-related receptors on antigen-presenting cells and induces TH2/TH17 polarization through dectin-2. J Allergy Clin Immunol. 2019;144(4):1025–1035.e1027.
  • Someya K, Nakatsukasa H, Ito M, et al. Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation. Int Immunol. 2017;29(8):365–375.
  • Zhong C, Zhu J. Tet2: breaking down barriers to T cell cytokine expression. Immunity. 2015;42(4):593–595.
  • Nair VS, Song MH, Ko M, et al. DNA demethylation of the Foxp3 enhancer is maintained through modulation of ten-eleven-translocation and DNA methyltransferases. Mol Cells. 2016;39(12):888–897.
  • Tan L, Qiu T, Xiang R, et al. Down-regulation of Tet2 is associated with Foxp3 TSDR hypermethylation in regulatory T cell of allergic rhinitis. Life Sci. 2020;241:117101.
  • Wakamatsu E, Omori H, Kawano A, et al. Strong TCR stimulation promotes the stabilization of Foxp3 expression in regulatory T cells induced in vitro through increasing the demethylation of Foxp3 CNS2. Biochem Biophys Res Commun. 2018;503(4):2597–2602.
  • Wu H, Huang X, Qiu H, et al. High salt promotes autoimmunity by TET2-induced DNA demethylation and driving the differentiation of Tfh cells. Sci Rep. 2016;6:28065.
  • Yue X, Trifari S, Äijö T, et al. Control of Foxp3 stability through modulation of TET activity. J Exp Med. 2016;213(3):377–397.
  • Yang R, Qu C, Zhou Y, et al. Hydrogen sulfide promotes Tet1- and Tet2-mediated Foxp3 demethylation to drive regulatory T cell differentiation and maintain immune homeostasis. Immunity. 2015;43(2):251–263.
  • van den Elsen LW, van Esch BC, Hofman GA, et al. Dietary long chain n-3 polyunsaturated fatty acids prevent allergic sensitization to cow’s milk protein in mice. Clin Exp Allergy. 2013;43(7):798–810.
  • Bekpinar S, Unlucerci Y, Uysal M, et al. Propargylglycine aggravates liver damage in LPS-treated rats: possible relation of nitrosative stress with the inhibition of H2S formation. Pharmacol Rep. 2014;66(5):897–901.
  • Oosterhuis NR, Frenay AR, Wesseling S, et al. DL-propargylglycine reduces blood pressure and renal injury but increases kidney weight in angiotensin-II infused rats. Nitric Oxide. 2015;49:56–66.
  • Zhou X, Tang S, Hu K, et al. dl-Propargylglycine protects against myocardial injury induced by chronic intermittent hypoxia through inhibition of endoplasmic reticulum stress. Sleep Breath. 2018;22(3):853–863.
  • Tanaka A, Sakaguchi S. Regulatory T cells in cancer immunotherapy. Cell Res. 2017;27(1):109–118.
  • Vadasz Z, Toubi E. FoxP3 expression in macrophages, cancer, and B cells-is it real? Clin Rev Allergy Immunol. 2017;52(3):364–372.
  • D'Argenio V, Del Monaco V, Paparo L, et al. Altered miR-193a-5p expression in children with cow's milk allergy. Allergy. 2018;73(2):379–386.
  • Meulenbroek LA, van Esch BC, Hofman GA, et al. Oral treatment with β-lactoglobulin peptides prevents clinical symptoms in a mouse model for cow’s milk allergy. Pediatr Allergy Immunol. 2013;24(7):656–664.

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