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Original Articles

MicroRNA-340-5p inhibits endothelial apoptosis, inflammatory response, and pro-coagulation by targeting KDM4C in anti-neutrophil cytoplasmic antibody (ANCA)-mediated glomerulonephritis through activation of B cells

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Pages 343-352 | Received 21 Dec 2020, Accepted 29 May 2021, Published online: 14 Jun 2021

References

  • Al-Hussain T, Hussein MH, Conca W, et al. Pathophysiology of ANCA-associated Vasculitis. Adv Anat Pathol. 2017;24(4):226–234.
  • Nakazawa D, Masuda S, Tomaru U, et al. Pathogenesis and therapeutic interventions for ANCA-associated vasculitis. Nat Rev Rheumatol. 2019;15(2):91–101.
  • Kallenberg CG. Advances in pathogenesis and treatment of ANCA-associated vasculitis. Discov Med. 2014;18(99):195–201.
  • Bontscho J, Schreiber A, Manz RA, et al. Myeloperoxidase-specific plasma cell depletion by bortezomib protects from anti-neutrophil cytoplasmic autoantibodies-induced glomerulonephritis. J Am Soc Nephrol. 2011;22(2):336–348.
  • Gan PY, Godfrey AS, Ooi JD, et al. Apoptotic cell-induced, antigen-specific immunoregulation to treat experimental antimyeloperoxidase GN. J Am Soc Nephrol. 2019;30(8):1365–1374.
  • Harper JM, Thiru S, Lockwood CM, et al. Myeloperoxidase autoantibodies distinguish vasculitis mediated by anti-neutrophil cytoplasm antibodies from immune complex disease in MRL/Mp-lpr/lpr mice: a spontaneous model for human microscopic angiitis. Eur J Immunol. 1998;28(7):2217–2226.
  • Xiao H, Heeringa P, Hu P, et al. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J Clin Invest. 2002;110(7):955–963.
  • Wang Q, van Timmeren MM, Petersen AH, et al. Age-determined severity of anti-myeloperoxidase autoantibody-mediated glomerulonephritis in mice. Nephrol Dial Transplant. 2017;32:254–264.
  • Choi M, Schreiber A, Eulenberg-Gustavus C, et al. Endothelial NF-κB blockade abrogates ANCA-induced GN. J Am Soc Nephrol. 2017;28(11):3191–3204.
  • Gilkeson GS, Mashmoushi AK, Ruiz P, et al. Endothelial nitric oxide synthase reduces crescentic and necrotic glomerular lesions, reactive oxygen production, and MCP1 production in murine lupus nephritis. PloS One. 2013;8(5):e64650.
  • Lu TX, Rothenberg ME. MicroRNA. J Allergy Clin Immunol. 2018;141(4):1202–1207.
  • Vishnoi A, Rani S. MiRNA biogenesis and regulation of diseases: an overview. Methods Mol Biol. 2017;1509:1–10.
  • Pritchard CC, Cheng HH, Tewari M. MicroRNA profiling: approaches and considerations. Nat Rev Genet. 2012;13(5):358–369.
  • Skoglund C, Carlsen AL, Weiner M, et al. Circulating microRNA expression pattern separates patients with anti-neutrophil cytoplasmic antibody associated vasculitis from healthy controls. Clin Exp Rheumatol. 2015;33:S-64–71.
  • Perez-Hernandez J, Forner MJ, Pinto C, et al. Increased urinary exosomal microRNAs in patients with systemic lupus erythematosus. PloS One. 2015;10(9):e0138618.
  • Churov AV, Oleinik EK, Knip M. MicroRNAs in rheumatoid arthritis: altered expression and diagnostic potential. Autoimmun Rev. 2015;14(11):1029–1037.
  • Zhang J, Chen C, Fu H, et al. MicroRNA-125a-loaded polymeric nanoparticles alleviate systemic lupus erythematosus by restoring effector/regulatory T cells balance. ACS Nano. 2020;14(4):4414–4429.
  • Krebs CF, Kapffer S, Paust HJ, et al. MicroRNA-155 drives TH17 immune response and tissue injury in experimental crescentic GN. J Am Soc Nephrol. 2013;24(12):1955–1965.
  • Rouas R, Merimi M, Najar M, et al. Human CD8+ CD25 + CD127 low regulatory T cells: microRNA signature and impact on TGF-β and IL-10 expression. J Cell Physiol. 2019;234(10):17459–17472.
  • Sudo G, Kagawa T, Kokubu Y, et al. Increase in GFAP-positive astrocytes in histone demethylase GASC1/KDM4C/JMJD2C hypomorphic mutant mice. Genes Cells. 2016;21(3):218–225.
  • Wu L, Wary KK, Revskoy S, et al. Histone demethylases KDM4A and KDM4C regulate differentiation of embryonic stem cells to endothelial cells. Stem Cell Reports. 2015;5(1):10–21.
  • Ortiz-Fernández L, Carmona FD, López-Mejías R, et al. Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis. Ann Rheum Dis. 2018;77(4):589–595.
  • Little MA, Smyth L, Salama AD, et al. Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis. Am J Pathol. 2009;174(4):1212–1220.
  • Sun XJ, Chen M, Zhao MH. Sphingosine-1-phosphate (S1P) enhances glomerular endothelial cells activation mediated by anti-myeloperoxidase antibody-positive IgG. J Cell Mol Med. 2018;22(3):1769–1777.
  • Chiu YK, Lin IY, Su ST, et al. Transcription factor ABF-1 suppresses plasma cell differentiation but facilitates memory B cell formation. J Immunol. 2014;193(5):2207–2217.
  • Schreiber A, Xiao H, Falk RJ, et al. Bone marrow-derived cells are sufficient and necessary targets to mediate glomerulonephritis and vasculitis induced by anti-myeloperoxidase antibodies. J Am Soc Nephrol. 2006;17(12):3355–3364.
  • Witkowski M, Witkowski M, Saffarzadeh M, et al. Vascular miR-181b controls tissue factor-dependent thrombogenicity and inflammation in type 2 diabetes. Cardiovasc Diabetol. 2020;19(1):20.
  • Cornec D, Berti A, Hummel A, et al. Identification and phenotyping of circulating autoreactive proteinase 3-specific B cells in patients with PR3-ANCA associated vasculitis and healthy controls. J Autoimmu. 2017;84:122–131.
  • McClure M, Gopaluni S, Jayne D, et al. B cell therapy in ANCA-associated vasculitis: current and emerging treatment options. Nat Rev Rheumatol. 2018;14(10):580–591.
  • Filiú-Braga LDC, Serejo TRT, Lucena-Araujo AR, et al. Unraveling KDM4 histone demethylase expression and its association with adverse cytogenetic findings in chronic lymphocytic leukemia. Med Oncol. 2019;36(1):3.
  • Hung KH, Woo YH, Lin IY, et al. The KDM4A/KDM4C/NF-κB and WDR5 epigenetic cascade regulates the activation of B cells. Nucleic Acids Res. 2018;46(11):5547–5560.
  • Wu J, Liu S, Liu G, et al. Identification and functional analysis of 9p24 amplified genes in human breast cancer. Oncogene. 2012;31(3):333–341.
  • Yu Y, Schleich K, Yue B, et al. Targeting the senescence-overriding cooperative activity of structurally unrelated H3K9 demethylases in melanoma. Cancer Cell. 2018;33(2):322–336.e328.
  • Cloos PA, Christensen J, Agger K, et al. The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. Nature. 2006;442(7100):307–311.
  • Cheung N, Fung TK, Zeisig BB, et al. Targeting aberrant epigenetic networks mediated by PRMT1 and KDM4C in acute myeloid leukemia. Cancer Cell. 2016;29(1):32–48.
  • Lu C, Ward PS, Kapoor GS, et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature. 2012;483(7390):474–478.
  • Zhao E, Ding J, Xia Y, et al. KDM4C and ATF4 cooperate in transcriptional control of amino acid metabolism. Cell Rep. 2016;14(3):506–519.
  • An Y, Cai H, Zhang Y, et al. circZMYM2 competed endogenously with miR-335-5p to regulate jmjd2c in pancreatic cancer. Biochem Pharmacol. 2018;51:2224–2236.
  • Ratovitski EA. Phospho-ΔNp63α/microRNA network modulates epigenetic regulatory enzymes in squamous cell carcinomas. Cell Cycle. 2014;13(5):749–761.
  • Papadaki S, Tselepis AD. Nonhemostatic activities of factor Xa: are there pleiotropic effects of anti-FXa direct oral anticoagulants? Angiology. 2019;70(10):896–907.
  • McLean K, Schirm S, Johns A, et al. FXa-induced responses in vascular wall cells are PAR-mediated and inhibited by ZK-807834. Thromb Res. 2001;103(4):281–297.

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