MiR-20b-5p modulates inflammation, apoptosis and angiogenesis in severe acute pancreatitis through autophagy by targeting AKT3

References

• Zerem E. Treatment of severe acute pancreatitis and its complications. World J Gastroenterol. 2014;20(38):13879–13892.
   PubMed Web of Science ®Google Scholar
• Munir F, Jamshed MB, Shahid N, et al. Advances in immunomodulatory therapy for severe acute pancreatitis. Immunol Lett. 2020;217:72–76.
   PubMed Web of Science ®Google Scholar
• Chen Z, Dong WH, Wu Q, et al. Two-layer regulation of TRAF6 mediated by both TLR4/NF-kB signaling and miR-589-5p increases proinflammatory cytokines in the pathology of severe acute pancreatitis. Am J Transl Res. 2020;12(6):2379–2395.
   PubMed Web of Science ®Google Scholar
• Mao E. Intensive management of severe acute pancreatitis. Ann Transl Med. 2019;7(22):687.
   PubMed Web of Science ®Google Scholar
• Gunjaca I, Zunic J, Gunjaca M, et al. Circulating cytokine levels in acute pancreatitis-model of SIRS/CARS can help in the clinical assessment of disease severity. Inflammation. 2012;35(2):758–763.
   PubMed Web of Science ®Google Scholar
• Tan JH, Cao RC, Zhou L, et al. ATF6 aggravates acinar cell apoptosis and injury by regulating p53/AIFM2 transcription in severe acute pancreatitis. Theranostics. 2020;10(18):8298–8314.
   PubMed Web of Science ®Google Scholar
• Wu XM, Ji KQ, Wang HY, et al. MicroRNA-339-3p alleviates inflammation and edema and suppresses pulmonary microvascular endothelial cell apoptosis in mice with severe acute pancreatitis-associated acute lung injury by regulating Anxa3 via the Akt/mTOR signaling pathway. J Cell Biochem. 2018;119(8):6704–6714.
   PubMed Web of Science ®Google Scholar
• Qian D, Gong J, He Z, et al. Bone marrow-derived mesenchymal stem cells repair necrotic pancreatic tissue and promote angiogenesis by secreting cellular growth factors involved in the SDF-1 α /CXCR4 axis in rats. Stem Cells Int. 2015;2015:306836.
   PubMed Web of Science ®Google Scholar
• Qian D, Song G, Ma Z, et al. MicroRNA-9 modified bone marrow-derived mesenchymal stem cells (BMSCs) repair severe acute pancreatitis (SAP) via inducing angiogenesis in rats. Stem Cell Res Ther. 2018;9(1):282.
   PubMedGoogle Scholar
• Ge N, Xia Q, Yang ZH, et al. Vascular endothelial injury and apoptosis in rats with severe acute pancreatitis. Gastroenterol Res Pract. 2015;2015:235017.
   PubMed Web of Science ®Google Scholar
• Mizushima N. Autophagy: process and function. Genes Dev. 2007;21(22):2861–2873.
   PubMed Web of Science ®Google Scholar
• Wang H, Li C, Jiang Y, et al. Effects of bacterial translocation and autophagy on acute lung injury induced by severe acute pancreatitis. Gastroenterol Res Pract. 2020;2020:1–8.
   Google Scholar
• Yang H, Ma S, Guo Y, et al. Bidirectional effects of pyrrolidine dithiocarbamate on severe acute pancreatitis in a rat model. Dose Response. 2019;17(1):1559325819825905.
   Web of Science ®Google Scholar
• Song G, Liu D, Geng X, et al. Bone marrow-derived mesenchymal stem cells alleviate severe acute pancreatitis-induced multiple-organ injury in rats via suppression of autophagy. Exp Cell Res. 2019;385(2):111674.
   PubMed Web of Science ®Google Scholar
• Wang D, Tang M, Zong P, et al. MiRNA-155 regulates the Th17/treg ratio by targeting SOCS1 in severe acute pancreatitis. Front Physiol. 2018;9:686.
   PubMed Web of Science ®Google Scholar
• Tian R, Wang RL, Xie H, et al. Overexpressed miRNA-155 dysregulates intestinal epithelial apical junctional complex in severe acute pancreatitis. World J Gastroenterol. 2013;19(45):8282–8291.
   PubMed Web of Science ®Google Scholar
• You H, Zhang L, Chen Z, et al. MiR-20b-5p relieves neuropathic pain by targeting Akt3 in a chronic constriction injury rat model. Synapse. 2019;73(12):e22125.
   PubMed Web of Science ®Google Scholar
• Zhao SP, Yu C, Xiang KM, et al. miR-375 inhibits autophagy and further promotes inflammation and apoptosis of acinar cells by targeting ATG7. Pancreas. 2020;49(4):543–551.
   PubMed Web of Science ®Google Scholar
• Li C, Yang L, Wu H, et al. Paeonol inhibits oxidized low-density lipoprotein-induced vascular endothelial cells autophagy by upregulating the expression of miRNA-30a. Front Pharmacol. 2018;9:95.
   PubMed Web of Science ®Google Scholar
• Ma Z, Song G, Zhao D, et al. Bone marrow-derived mesenchymal stromal cells ameliorate severe acute pancreatitis in rats via hemeoxygenase-1-mediated anti-oxidant and anti-inflammatory effects. Cytotherapy. 2019;21(2):162–174.
   PubMed Web of Science ®Google Scholar
• Zheng L, Fu Y, Zhuang L, et al. Simultaneous NF-κB inhibition and E-cadherin upregulation mediate mutually synergistic anticancer activity of celastrol and SAHA in vitro and in vivo. Int J Cancer. 2014;135(7):1721–1732.
   PubMed Web of Science ®Google Scholar
• Wei CM, Liu Q, Song FM, et al. Artesunate inhibits RANKL-induced osteoclastogenesis and bone resorption in vitro and prevents LPS-induced bone loss in vivo. J Cell Physiol. 2018;233(1):476–485.
   PubMed Web of Science ®Google Scholar
• Muramatsu F, Kidoya H, Naito H, et al. microRNA-125b inhibits tube formation of blood vessels through translational suppression of VE-cadherin. Oncogene. 2013;32(4):414–421.
   PubMed Web of Science ®Google Scholar
• Chen C, Cheng P, Xie H, et al. MiR-503 regulates osteoclastogenesis via targeting RANK. J Bone Miner Res. 2014;29(2):338–347.
   PubMed Web of Science ®Google Scholar
• Singh AK, Rooge SB, Varshney A, et al. Global microRNA expression profiling in the liver biopsies of hepatitis B virus-infected patients suggests specific microRNA signatures for viral persistence and hepatocellular injury. Hepatology. 2018;67(5):1695–1709.
   PubMed Web of Science ®Google Scholar
• Yan L, Guo N, Cao Y, et al. miRNA-145 inhibits myocardial infarction-induced apoptosis through autophagy via Akt3/mTOR signaling pathway in vitro and in vivo . Int J Mol Med. 2018;42(3):1537–1547.
   PubMed Web of Science ®Google Scholar
• Xu P, Wang J, Yang ZW, et al. Regulatory roles of the PI3K/Akt signaling pathway in rats with severe acute pancreatitis. PLoS One. 2013;8(11):e81767.
   PubMed Web of Science ®Google Scholar
• Schulte C, Molz S, Appelbaum S, et al. miRNA-197 and miRNA-223 predict cardiovascular death in a cohort of patients with symptomatic coronary artery disease. PLoS One. 2015;10(12):e0145930.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Yan L, Han W. Elevated level of miR-551b-5p is associated with inflammation and disease progression in patients with severe acute pancreatitis. Ther Apher Dial. 2018;22(6):649–655.
   PubMed Web of Science ®Google Scholar
• Fan HN, Chen W, Fan LN, et al. Macrophages-derived p38α promotes the experimental severe acute pancreatitis by regulating inflammation and autophagy. Int Immunopharmacol. 2019;77:105940.
   PubMed Web of Science ®Google Scholar
• Wan JH, Chen J, Wu DY, et al. Regulation of autophagy affects the prognosis of mice with severe acute pancreatitis. Dig Dis Sci. 2018;63(10):2639–2650.
   PubMed Web of Science ®Google Scholar
• Liang P, Jiang B, Li Y, et al. Autophagy promotes angiogenesis via AMPK/Akt/mTOR signaling during the recovery of heat-denatured endothelial cells. Cell Death Dis. 2018;9(12):1152.
   PubMedGoogle Scholar
• Zou J, Fei Q, Xiao H, et al. VEGF-A promotes angiogenesis after acute myocardial infarction through increasing ROS production and enhancing ER stress-mediated autophagy. J Cell Physiol. 2019;234(10):17690–17703.
   PubMed Web of Science ®Google Scholar
• Sung SJ, Kim HK, Hong YK, et al. Autophagy is a potential target for enhancing the anti-angiogenic effect of mebendazole in endothelial cells. Biomol Ther (Seoul)). 2019;27(1):117–125.
   PubMed Web of Science ®Google Scholar
• Torres A, Gubbiotti MA, Iozzo RV. Decorin-inducible Peg3 evokes Beclin 1-mediated autophagy and thrombospondin 1-mediated angiostasis. J Biol Chem. 2017;292(12):5055–5069.
   PubMed Web of Science ®Google Scholar
• Corum DG, Tsichlis PN, Muise-Helmericks RC. AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1. FASEB J. 2014;28(1):395–407.
   PubMed Web of Science ®Google Scholar
• Cai L, Liu X, Guo Q, et al. MiR-15a attenuates peripheral nerve injury-induced neuropathic pain by targeting AKT3 to regulate autophagy. Genes Genomics. 2020;42(1):77–85.
   PubMed Web of Science ®Google Scholar