References
- Llovet JM, Zucman-Rossi J, Pikarsky E, et al. Hepatocellular carcinoma. Nat Rev Dis Primers. 2016;2:16018.
- Yang JD, Hainaut P, Gores GJ, et al. A global view of hepatocellular carcinoma: trends, risk, prevention and management. Nat Rev Gastroenterol Hepatol. 2019;16(10):589–604.
- Qadir MI, Rizvi SZ. miRNA in hepatocellular carcinoma: pathogenesis and therapeutic approaches. Crit Rev Eukaryot Gene Expr. 2017;27(4):355–361.
- Li D, Zhang J, Li J. Role of miRNA sponges in hepatocellular carcinoma. Clin Chim Acta. 2020;500:10–19.
- Li L, Zhao J, Huang S, et al. MiR-93-5p promotes gastric cancer-cell progression via inactivation of the hippo signaling pathway. Gene. 2018;641:240–247.
- Yang W, Bai J, Liu D, et al. MiR-93-5p up-regulation is involved in non-small cell lung cancer cells proliferation and migration and poor prognosis. Gene. 2018;647:13–20.
- Yang Y, Jia B, Zhao X, et al. miR-93-5p may be an important oncogene in prostate cancer by bioinformatics analysis. J Cell Biochem. 2019;120(6):10463–10483.
- Wang X, Liao Z, Bai Z, et al. MiR-93-5p promotes cell proliferation through down-regulating PPARGC1A in hepatocellular carcinoma cells by bioinformatics analysis and experimental verification. Genes (Basel). 2018;9(1):51.
- Shi X, Liu TT, Yu XN, et al. microRNA-93-5p promotes hepatocellular carcinoma progression via a microRNA-93-5p/MAP3K2/c-Jun positive feedback circuit. Oncogene. 2020;39(35):5768–5781.
- Greenberg MVC, Bourc'his D. The diverse roles of DNA methylation in mammalian development and disease. Nat Rev Mol Cell Biol. 2019;20(10):590–607.
- Liu A, Wu Q, Peng D, et al. A novel strategy for the diagnosis, prognosis, treatment, and chemoresistance of hepatocellular carcinoma: DNA methylation. Med Res Rev. 2020;40(5):1973–2018.
- Karimzadeh MR, Pourdavoud P, Ehtesham N, et al. Regulation of DNA methylation machinery by epi-miRNAs in human cancer: emerging new targets in cancer therapy. Cancer Gene Ther. 2021;28(3-4):157–174.
- Ravichandran M, Jurkowska RZ, Jurkowski TP. Target specificity of mammalian DNA methylation and demethylation machinery. Org Biomol Chem. 2018;16(9):1419–1435.
- Wang P, Yan Y, Yu W, et al. Role of ten-eleven translocation proteins and 5-hydroxymethylcytosine in hepatocellular carcinoma. Cell Prolif. 2019;52(4):e12626.
- Cheng YW, Chou CJ, Yang PM. Ten-eleven translocation 1 (TET1) gene is a potential target of miR-21-5p in human colorectal cancer. Surg Oncol. 2018;27(1):76–81.
- Zhaolin Z, Jiaojiao C, Peng W, et al. OxLDL induces vascular endothelial cell pyroptosis through miR-125a-5p/TET2 pathway. J Cell Physiol. 2019;234(5):7475–7491.
- Lv X, Jiang H, Liu Y, et al. MicroRNA-15b promotes neurogenesis and inhibits neural progenitor proliferation by directly repressing TET3 during early neocortical development. EMBO Rep. 2014;15(12):1305–1314.
- Segers VFM, Dugaucquier L, Feyen E, et al. The role of ErbB4 in cancer. Cell Oncol (Dordr)). 2020;43(3):335–352.
- Liu Y, Song L, Ni H, et al. ERBB4 acts as a suppressor in the development of hepatocellular carcinoma. Carcinogenesis. 2017;38(4):465–473.
- Cao LQ, Yang XW, Chen YB, et al. Exosomal miR-21 regulates the TETs/PTENp1/PTEN pathway to promote hepatocellular carcinoma growth. Mol Cancer. 2019;18(1):148.
- Villanueva A. Hepatocellular carcinoma. N Engl J Med. 2019;380(15):1450–1462.
- Dutta R, Mahato RI. Recent advances in hepatocellular carcinoma therapy. Pharmacol Ther. 2017;173:106–117.
- Tricoli L, Niture S, Chimeh U, et al. Role of microRNAs in the development of hepatocellular carcinoma and drug resistance. Front Biosci (Landmark Ed)). 2019;24:382–391.
- Parizadeh SM, Jafarzadeh-Esfehani R, Ghandehari M, et al. MicroRNAs as potential diagnostic and prognostic biomarkers in hepatocellular carcinoma. Curr Drug Targets. 2019;20(11):1129–1140.
- Wei H, Yang Z, Lin B. Overexpression of long non coding RNA CA3-AS1 suppresses proliferation, invasion and promotes apoptosis via miRNA-93/PTEN axis in colorectal cancer. Gene. 2019;687:9–15.
- Hao J, Jin X, Shi Y, et al. miR-93-5p enhance lacrimal gland adenoid cystic carcinoma cell tumorigenesis by targeting BRMS1L. Cancer Cell Int. 2018;18:72.
- Guan H, Li W, Li Y, et al. MicroRNA-93 promotes proliferation and metastasis of gastric cancer via targeting TIMP2. PLoS One. 2017;12(12):e0189490.
- Liu LJ, Yu JJ, Xu XL. MicroRNA-93 inhibits apoptosis and promotes proliferation, invasion and migration of renal cell carcinoma ACHN cells via the TGF-beta/smad signaling pathway by targeting RUNX3. Am J Transl Res. 2017;9:3499–3513.
- Xu D, He XX, Chang Y, et al. Downregulation of MiR-93 expression reduces cell proliferation and clonogenicity of HepG2 cells. Hepatogastroenterology. 2012;59(120):2367–2373.
- Ohta K, Hoshino H, Wang J, et al. MicroRNA-93 activates c-Met/PI3K/akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A. Oncotarget. 2015;6(5):3211–3224.
- Huang H, Wang X, Wang C, et al. The miR-93 promotes proliferation by directly targeting PDCD4 in hepatocellular carcinoma. NEO. 2017;64(05):770–777.
- Chen C, Zheng Q, Kang W, et al. Long non-coding RNA LINC00472 suppresses hepatocellular carcinoma cell proliferation, migration and invasion through miR-93-5p/PDCD4 pathway. Clin Res Hepatol Gastroenterol. 2019;43(4):436–445.
- Naresh A, Long W, Vidal GA, et al. The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells. Cancer Res. 2006;66(12):6412–6420.
- Ni H, Chen L, Song L, et al. ErbB4 acts as a suppressor in colitis and its associated carcinoma by negatively regulating cholesterol metabolism. Carcinogenesis. 2019;40(5):680–686.
- Liu Y, Zhou Q, He XS, et al. Genetic variants in ERBB4 is associated with chronic hepatitis B virus infection. Oncotarget. 2016;7(4):4981–4992.
- Das PM, Thor AD, Edgerton SM, et al. Reactivation of epigenetically silenced HER4/ERBB4 results in apoptosis of breast tumor cells. Oncogene. 2010;29(37):5214–5219.
- Ross SE, Bogdanovic O. TET enzymes, DNA demethylation and pluripotency. Biochem Soc Trans. 2019;47(3):875–885.
- Fuso A, Raia T, Orticello M, et al. The complex interplay between DNA methylation and miRNAs in gene expression regulation. Biochimie. 2020;173:12–16.