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Original Articles

TGFB1 +869 T > C (rs1800470) variant is independently associated with susceptibility, laboratory activity, and TGF-β1 in patients with systemic lupus erythematosus

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Pages 569-575 | Received 30 Jun 2021, Accepted 30 Aug 2021, Published online: 14 Sep 2021

References

  • Tsokos GC, Lo MS, Reis PC, et al. New insights into the immunopathogenesis of systemic lupus erythematosus. Nat Rev Rheumatol. 2016;12(12):716–730.
  • Kuhn A, Wenzel J, Bijl M. Lupus erythematosus revisited. Semin Immunopathol. 2016;38(1):97–112.
  • Baltus THL, Kallaur AP, Lozovoy MAB, et al. CCR5Δ32 (rs333) polymorphism is associated with the susceptibility to systemic lupus erythematosus in female brazilian patients. Rheumatol Int. 2016;36(1):7–15.
  • Delongui F, Lozovoy MAB, Iriyoda TMV, et al. C-reactive protein +1444CT (rs1130864) genetic polymorphism is associated with the susceptibility to systemic lupus erythematosus and C-reactive protein levels. Clin Rheumatol. 2017;36(8):1779–1788.
  • Guimarães PM, Scavuzzi BM, Stadtlober NP, et al. Cytokines in systemic lupus erythematosus: far beyond Th1/Th2 dualism lupus: cytokine profiles. Immunol Cell Biol. 2017;95(9):824–828.
  • Parks CG, Santos ASE, Barbhaiya M, et al. Understanding the role of environmental factors in the development of systemic lupus erythematosus. Best Pract Res Clin Rheumatol. 2017;31(3):306–320.
  • Pedro EM, Santos LFRF, Scavuzzi BM, et al. Trace elements associated with systemic lupus erythematosus and insulin resistance. Biol Trace Elem Res. 2019;191(1):34–44.
  • Costenbader KH, Feskanich D, Stampfer MJ, et al. Reproductive and menopausal factors and risk of systemic lupus erythematosus in women. Arthritis Rheum. 2007;56(4):1251–1262.
  • Mok CC, Lau CS. Pathogenesis of systemic lupus erythematosus. J Clin Pathol. 2003;56(7):481–490.
  • Tsao BP. Update on human systemic lupus erythematosus genetics. Curr Opin Rheumatol. 2004;16(5):513–521.
  • Yap DYH, Lai KN. The role of cytokines in the pathogenesis of systemic lupus erythematosus - from bench to bedside. Nephrology. 2013;18(4):243–255.
  • Caserta TM, Knisley AA, Tan FK, et al. Genotypic analysis of the TGF beta-509 allele in patients with systemic lupus erythematosus and Sjogren's syndrome. Ann Genet. 2004;47(4):359–363.,.
  • Grainger DJ, Mosedale DE, Metcalfe JC. TGF-b in blood: a complex problem. Cytokine Growth Factor Rev. 2000;11(1-2):133–145.
  • Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor beta in human disease. N Engl J Med. 2000;342(18):1350–1358.
  • Ohtsuka K, Gray JD, Stimmler MM, et al. Decreased production of TGF-beta by lymphocytes from patients with systemic lupus erythematosus. J Immunol. 1998;160(5):2539–2545.
  • Becker-Merok A, Eilertsen GO, Nossent JC. Levels of transforming growth factor-beta are low in systemic lupus erythematosus patients with active disease. J Rheumatol. 2010;37(10):2039–2045.
  • Dang H, Geiser AG, Letterio JJ, et al. SLE-like autoantibodies and sjogren's syndrome-like lymphoproliferation in TGF-beta knockout mice. J Immunol. 1995;155(6):3205–3212.
  • Rezaei A, Ziaee V, Sharabian FT, et al. Lack of association between interleukin-10, transforming growth factor-beta gene polymorphisms and juvenile-onset systemic lupus erythematosus. Clin Rheumatol. 2015;34(6):1059–1064.
  • Paradowska-Gorycka A, Roszak M, Stypinska B, et al. IL-6 and TGF-β polymorphisms, their serum levels, as well as HLA profile, in patients with systemic lupus erythematosus. Clin. Exp Rheumatol. 2019;37:1–13.
  • Lu LY, Cheng HH, Sung PK, et al. Single-nucleotide polymorphisms of transforming growth factor-beta 1 gene in taiwanese patients with systemic lupus erythematosus. J Microbiol Immunol Infect. 2004;37(3):145–152.
  • Wang B, Morinobu A, Kanagawa S, et al. Transforming growth factor beta 1 gene polymorphism in japanese patients with systemic lupus erythematosus. Kobe J Med Sci. 2007;53(1-2):15–23.
  • Sayed SK, Galal SH, Herdam OM, et al. Single nucleotide polymorphism T869C of transforming growth factor-beta 1 gene and systemic lupus erythematosus: association with disease susceptibility and lupus nephritis. Egypt J Immunol. 2014;1(2):9–21.
  • Petri M, Orbai AM, Alarcón GS, et al. Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus. Arthritis Rheumatism. 2012;64(8):2677–2686.
  • Petri M, Genovese M, Engle E, et al. Definition, incidence, and clinical description of flare in systemic lupus erythematosus. A prospective cohort study. Arthritis Rheum. 1991;34(8):937–944.
  • Gladman DD, Ibanez D, Urowitz MB. Systemic lupus erythematosus disease activity index 2000. J Rheumathol. 2002;29(2):288–291.
  • Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet. 2001;68(4):978–989.
  • Stephens M, Scheet P. Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation. Am J Hum Genet. 2005;76(3):449–462.
  • Solé X, Guinó E, Valls J, et al. SNPStats: a web tool for the analysis of association studies. Bioinformatics. 2006;22(15):1928–1929.
  • Fujii D, Brissenden JE, Derynck R, et al. Transforming growth factor beta gene maps to human chromosome 19 long arm and to mouse chromosome 7. Somat Cell Mol Genet. 1986; 12(3):281–288.
  • Verner K, Schatz G. Protein translocation across membranes. Science. 1988;241(4871):1307–1313.
  • Yamada Y, Okuizumi H, Miyauchi A, et al. Association of transforming growth factor beta1 genotype with spinal osteophytosis in japanese women. Arthritis Rheumatism. 2000;43(2):452–460.
  • Schotte H, Willeke P, Rust S, et al. The transforming growth factor-beta1 gene polymorphism (G915C) is not associated with systemic lupus erythematosus . Lupus. 2003;12(2):86–92.
  • Ghodke-Puranik Y, Niewold TB. Immunogenetics of systemic lupus erythematosus: a comprehensive review. J Autoimmun. 2015;64:125–136.
  • Ahmadpoor P, Dalili N, Rostami M. An update on pathogenesis of systemic lupus erythematosus. Iran J Kidney Dis. 2014;8(3):171–184.
  • Atkinson JP. Complement activation and complement receptors in systemic lupus erythematosus. Springer Semin Immunopathol. 1986;9(2-3):179–194.
  • Bombardier C, Gladman DD, Urowitz MB, et al. Derivation of the sledai. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLEArthritis Rheum. 1992;35(6):630–640.
  • Cazac BB, Roes J. TGF-b receptor controls B cell responsiveness and induction of IgA in vivo. Immunity. 2000;13(4):443–451.
  • Shah R, Rahaman B, Hurley CK, et al. Allelic diversity in the TGFB1 regulatory region: characterization of novel functional single nucleotide polymorphisms. Hum Genet. 2006;119(1-2):61–74.
  • Cao H, Zhou Q, Lan R, et al. A functional polymorphism C-509T in TGFβ-1 promoter contributes to susceptibility and prognosis of lone atrial fibrillation in chinese population. PLoS One. 2014;9(11):e112912.
  • Guo Q, Wang Y, Xu D, et al. Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies. Bone Res. 2018;6:15.
  • Terry CF, Loukaci V, Green FR. Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem. 2000;275(24):18138–18144.

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