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Original Articles

NIK-SIX1 signalling axis regulates high glucose-induced endothelial cell dysfunction and inflammation

, , , , , & show all
Pages 86-94 | Received 06 Sep 2021, Accepted 04 Dec 2021, Published online: 13 Dec 2021

References

  • Bentzon JF, Otsuka F, Virmani R, et al. Mechanisms of plaque formation and rupture. Circ Res. 2014;114(12):1852–1866.
  • Swirski FK, Nahrendorf M. Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure. Science. 2013;339(6116):161–166.
  • Poznyak A, Grechko AV, Poggio P. The diabetes mellitus-atherosclerosis connection: the role of lipid and glucose metabolism and chronic inflammation. 2020;21(5):1835.
  • DeFronzo RA. Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard lecture 2009. Diabetologia. 2010;53(7):1270–1287.
  • Morrish NJ, Wang SL, Stevens LK, et al. Mortality and causes of death in the WHO multinational study of vascular disease in diabetes. Diabetologia. 2001;44(Suppl 2):S14–S21.
  • Leung K. Microbubbles coated with antibody to mucosal addressin cellular adhesion molecule-1. Molecular imaging and contrast agent database (MICAD). Bethesda (MD): National Center for Biotechnology Information (US); 2004.
  • Vanderslice P, Woodside DG. Integrin antagonists as therapeutics for inflammatory diseases. Expert Opin Investig Drugs. 2006;15(10):1235–1255.
  • Ferroni P, Basili S, Paoletti V, et al. Endothelial dysfunction and oxidative stress in arterial hypertension. Nutr Metab Cardiovasc Dis. 2006;16(3):222–233.
  • Gimbrone MA Jr., García-Cardeña G. Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circ Res. 2016;118(4):620–636.
  • Xu S. Therapeutic potential of blood flow mimetic compounds in preventing endothelial dysfunction and atherosclerosis. Pharmacol Res. 2020;155:104737.
  • Mitchell JP, Carmody RJ. NF-κB and the transcriptional control of inflammation. Int Rev Cell Mol Biol. 2018;335:41–84.
  • Chen LJ, Li JM, Zhang WD, et al. LncRNA NEAT1 activates MyD88/NF-κB pathway in bronchopneumonia through targeting miR-155-5p. Autoimmunity. 2021;54(2):104–113.
  • Zhang LZ, Xue H, Qiao CX, et al. MiR-223 promotes pyroptosis of enteritis cells through activating NF-κB signalling pathway by targeting SNIP1 in inflammatory bowel disease. Autoimmunity. 2021;54(6):362–372.
  • Dąbek J, Kułach A, Gąsior Z. Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB): a new potential therapeutic target in atherosclerosis? Pharmacol Rep. 2010;62(5):778–783.
  • Sun SC. The non-canonical NF-κB pathway in immunity and inflammation. Nat Rev Immunol. 2017;17(9):545–558.
  • Zarnegar B, Yamazaki S, He JQ, et al. Control of canonical NF-kappaB activation through the NIK-IKK complex pathway. Proc Natl Acad Sci USA. 2008;105(9):3503–3508.
  • Liu Z, Mar KB, Hanners NW, et al. A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB. Nature. 2019;568(7751):249–253.
  • Kang H, Ma X, Liu J, et al. High glucose-induced endothelial progenitor cell dysfunction. Diab Vasc Dis Res. 2017;14(5):381–394.
  • Tousian H, Razavi BM, Hosseinzadeh H. Alpha-mangostin decreased cellular senescence in human umbilical vein endothelial cells. Daru. 2020;28(1):45–55.
  • Yang S, Yuan HQ, Hao YM, et al. Macrophage polarization in atherosclerosis. Clin Chim Acta. 2020;501:142–146.
  • Zhang C, Zhou T, Chen Z, et al. Coupling of integrin α5 to annexin A2 by flow drives endothelial activation. Circ Res. 2020;127(8):1074–1090.
  • Zhang Y, Lv X, Hu Z, et al. Protection of Mcc950 against high-glucose-induced human retinal endothelial cell dysfunction. Cell Death Dis. 2017;8(7):e2941.
  • Giurdanella G, Lupo G, Gennuso F, et al. Activation of the VEGF-A/ERK/PLA2 axis mediates early retinal endothelial cell damage induced by high glucose: new insight from an in vitro model of diabetic retinopathy. Int J Mol Sci. 2020;21(20):7528.
  • Zhang J, Chen C, Zhang S, et al. LncRNA XIST restrains the activation of Müller cells and inflammation in diabetic retinopathy via stabilizing SIRT1. Autoimmunity. 2021;9:1–10.
  • Kageyama S, Yokoo H, Tomita K, et al. High glucose-induced apoptosis in human coronary artery endothelial cells involves up-regulation of death receptors. Cardiovasc Diabetol. 2011;10:73.
  • Dou L, Jourde-Chiche N. Endothelial toxicity of high glucose and its by-products in diabetic kidney disease. Toxins. 2019;11(10):578.
  • Yu XH, Zheng XL, Tang CK. Nuclear factor-κB activation as a pathological mechanism of lipid metabolism and atherosclerosis. Adv Clin Chem. 2015;70:1–30.
  • Noort AR, van Zoest KP, Weijers EM, et al. NF-κB-inducing kinase is a key regulator of inflammation-induced and tumour-associated angiogenesis. J Pathol. 2014;234(3):375–385.
  • Maracle CX, Agca R, Helder B, et al. Noncanonical NF-κB signaling in microvessels of atherosclerotic lesions is associated with inflammation, atheromatous plaque morphology and myocardial infarction. Atherosclerosis. 2018;270:33–41.
  • Cai Y, Zhang Y, Chen H, et al. MicroRNA-17-3p suppresses NF-κB-mediated endothelial inflammation by targeting NIK and IKKβ binding protein. Acta Pharmacol Sin. 2021;42(12):2046–2057.
  • Kim SR, Jung YR, Kim DH, et al. Caffeic acid regulates LPS-induced NF-κB activation through NIK/IKK and c-Src/ERK signaling pathways in endothelial cells. Arch Pharm Res. 2014;37(4):539–547.
  • Kucharzewska P, Maracle CX, Jeucken KCM, et al. NIK-IKK complex interaction controls NF-κB-dependent inflammatory activation of endothelium in response to LTβR ligation. J Cell Sci. 2019;132(7):jcs225615.
  • Wu W, Ren Z, Li P, et al. Six1: a critical transcription factor in tumorigenesis. Int J Cancer. 2015;136(6):1245–1253.
  • Armat M, Ramezani F, Molavi O, et al. Six family of homeobox genes and related mechanisms in tumorigenesis protocols. Tumori. 2016;2016(3):236–243.
  • Liu Q, Li A, Tian Y, et al. The expression profile and clinic significance of the SIX family in non-small cell lung cancer. J Hematol Oncol. 2016;9(1):119.
  • Yang C, Xu W, Gong J, et al. Six1 overexpression promotes glucose metabolism and invasion through regulation of GLUT3, MMP2 and snail in thyroid cancer cells. Onco Targets Ther. 2020;13:4855–4863.
  • Wang H, Xue W, Ouyang W, et al. miR-23a-3p/SIX1 regulates glucose uptake and proliferation through GLUT3 in head and neck squamous cell carcinomas. J Cancer. 2020;11(9):2529–2539.
  • Pflug KM, Sitcheran R. Targeting NF-κB-Inducing kinase (NIK) in immunity, inflammation, and cancer. Int J Mol Sci. 2020;21(22):8470.

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