Knockdown of circ_0025908 inhibits proliferation, migration, invasion, and inflammation while stimulates apoptosis in fibroblast-like synoviocytes by regulating miR-650-dependent SCUBE2

References

• Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet. 2016;388(10055):2023–2038.
   PubMed Web of Science ®Google Scholar
• Alam J, Jantan I, Bukhari SNA. Rheumatoid arthritis: recent advances on its etiology, role of cytokines and pharmacotherapy. Biomed Pharmacother. 2017;92:615–633.
   PubMed Web of Science ®Google Scholar
• Deane KD, Demoruelle MK, Kelmenson LB, et al. Genetic and environmental risk factors for rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2017;31(1):3–18.
   PubMed Web of Science ®Google Scholar
• Klareskog L, Rönnelid J, Saevarsdottir S, et al. The importance of differences; on environment and its interactions with genes and immunity in the causation of rheumatoid arthritis. J Intern Med. 2020;287(5):514–533.
   PubMedGoogle Scholar
• Melville AR, Kearsley-Fleet L, Buch MH, et al. Understanding refractory rheumatoid arthritis: implications for a therapeutic approach. Drugs. 2020;80(9):849–857.
   PubMedGoogle Scholar
• Kristensen LS, Andersen MS, Stagsted LVW, et al. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. 2019;20(11):675–691.
   PubMed Web of Science ®Google Scholar
• Zhou Z, Sun B, Huang S, et al. Roles of circular RNAs in immune regulation and autoimmune diseases. Cell Death Dis. 2019;10(7):503.
   PubMedGoogle Scholar
• Geng X, Zhao C, Zhang Z, et al. Circ_0088036 facilitates the proliferation and inflammation and inhibits the apoptosis of fibroblast-like synoviocytes through targeting miR-326/FZD4 axis in rheumatoid arthritis. Autoimmunity. 2022;55(3):157–167.
   PubMed Web of Science ®Google Scholar
• Li B, Li N, Zhang L, et al. Hsa_circ_0001859 regulates ATF2 expression by functioning as an MiR-204/211 sponge in human rheumatoid arthritis. J Immunol Res. 2018;2018:9412387.
   PubMed Web of Science ®Google Scholar
• Zhang S, Zhao J, Ma W. Circ-Sirt1 inhibits proliferation, induces apoptosis, and ameliorates inflammation in human rheumatoid arthritis fibroblast-like synoviocytes. Autoimmunity. 2021;54(8):514–525.
   PubMedGoogle Scholar
• Yang X, Li J, Wu Y, et al. Aberrant dysregulated circular RNAs in the peripheral blood mononuclear cells of patients with rheumatoid arthritis revealed by RNA sequencing: novel diagnostic markers for RA. Scand J Clin Lab Invest. 2019;79(8):551–559.
   PubMed Web of Science ®Google Scholar
• Bhaskaran M, Mohan M. MicroRNAs: history, biogenesis, and their evolving role in animal development and disease. Vet Pathol. 2014;51(4):759–774.
   PubMed Web of Science ®Google Scholar
• Hong W, Zhang P, Wang X, et al. The effects of MicroRNAs on key signalling pathways and epigenetic modification in Fibroblast-Like synoviocytes of rheumatoid arthritis. Mediators Inflamm. 2018;2018:9013124.
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhang G, Huang W. MiR-300 promotes the proliferation, migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis by targeting IL-37. Autoimmunity. 2022;1–7.
   Google Scholar
• Zhang S, Meng T, Tang C, et al. MicroRNA-340-5p suppressed rheumatoid arthritis synovial fibroblast proliferation and induces apoptotic cell number by targeting signal transducers and activators of transcription 3. Autoimmunity. 2020;53(6):314–322.
   PubMed Web of Science ®Google Scholar
• Yuan C, Xu L, Du P, et al. miRNA-650 exerts anti-leukemia activity by inhibiting cell proliferation through Gfi1 targeting. Tumori. 2018;104(5):369–374.
   PubMedGoogle Scholar
• Xu L, Yu Q-W, Fang S-Q, et al. MiR-650 inhibits the progression of glioma by targeting FAM83F. Eur Rev Med Pharmacol Sci. 2018;22(23):8391–8398.
   PubMedGoogle Scholar
• Zhou C, Cui F, Li J, et al. MiR-650 represses high-risk non-metastatic colorectal cancer progression via inhibition of AKT2/GSK3beta/E-cadherin pathway. Oncotarget. 2017;8(30):49534–49547.
   PubMedGoogle Scholar
• Wu B-T, Su Y-H, Tsai M-T, et al. A novel secreted, cell-surface glycoprotein containing multiple epidermal growth factor-like repeats and one CUB domain is highly expressed in primary osteoblasts and bones. J Biol Chem. 2004;279(36):37485–37490.
   PubMedGoogle Scholar
• Yang M, Guo M, Hu Y, et al. Scube regulates synovial angiogenesis-related signaling. Med Hypotheses. 2013;81(5):948–953.
   PubMed Web of Science ®Google Scholar
• Taheri M, Eghtedarian R, Dinger ME, et al. Dysregulation of non-coding RNAs in rheumatoid arthritis. Biomed Pharmacother. 2020;130:110617.
   PubMed Web of Science ®Google Scholar
• Bi X, Guo XH, Mo BY, et al. LncRNA PICSAR promotes cell proliferation, migration and invasion of fibroblast-like synoviocytes by sponging miRNA-4701-5p in rheumatoid arthritis. EBioMedicine. 2019;50:408–420.
   PubMed Web of Science ®Google Scholar
• Ingegnoli F, Castelli R, Gualtierotti R. Rheumatoid factors: clinical applications. Dis Markers. 2013;35(6):727–734.
   PubMed Web of Science ®Google Scholar
• Mallya RK, de Beer FC, Berry H, et al. Correlation of clinical parameters of disease activity in rheumatoid arthritis with serum concentration of C-reactive protein and erythrocyte sedimentation rate. J Rheumatol. 1982;9(2):224–228.
   PubMed Web of Science ®Google Scholar
• Bartok B, Firestein GS. Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev. 2010;233(1):233–255.
   PubMed Web of Science ®Google Scholar
• Wen J, Liu J, Wang X, et al. Expression and clinical significance of circular RNAs related to immunity and inflammation in patients with rheumatoid arthritis. Int Immunopharmacol. 2021;92:107366.
   PubMed Web of Science ®Google Scholar
• Zhou X, Xie D, Huang J, et al. Therapeutic effects of (5R)-5-Hydroxytriptolide on Fibroblast-Like synoviocytes in rheumatoid arthritis via lncRNA WAKMAR2/miR-4478/E2F1/p53 axis. Front Immunol. 2021;12:605616.
   PubMed Web of Science ®Google Scholar
• Meng Q, Pan B, Sheng P. Histone deacetylase 1 is increased in rheumatoid arthritis synovium and promotes synovial cell hyperplasia and synovial inflammation in the collagen-induced arthritis mouse model via the microRNA-124-dependent MARCKS-JAK/STAT axis. Clin Exp Rheumatol. 2021;39(5):970–981.
   PubMedGoogle Scholar
• Liu Y, Pan YF, Xue Y-Q, et al. uPAR promotes tumor-like biologic behaviors of fibroblast-like synoviocytes through PI3K/akt signaling pathway in patients with rheumatoid arthritis. Cell Mol Immunol. 2018;15(2):171–181.
   PubMed Web of Science ®Google Scholar
• Bhattaram P, Jones K. Regulation of fibroblast-like synoviocyte transformation by transcription factors in arthritic diseases. Biochem Pharmacol. 2019;165:145–151.
   PubMedGoogle Scholar
• Wang L, et al. Circ_0000396 inhibits rheumatoid arthritis synovial fibroblast growth and inflammatory response via miR-203/HBP1 axis. J Biol Res (Thessalon). 2021;28(1):1.
   PubMed Web of Science ®Google Scholar
• Hao J, Chen Y, Yu Y. Circular RNA circ_0008360 inhibits the proliferation, migration, and inflammation and promotes apoptosis of Fibroblast-Like synoviocytes by regulating miR-135b-5p/HDAC4 axis in rheumatoid arthritis. Inflammation. 2022;45(1):196–211.
   PubMed Web of Science ®Google Scholar
• Xu X, Chen H, Zhang Q, et al. MiR-650 inhibits proliferation, migration and invasion of rheumatoid arthritis synovial fibroblasts by targeting AKT2. Biomed Pharmacother. 2017;88:535–541.
   PubMed Web of Science ®Google Scholar
• Cao Y, Gao W, Tang H, et al. LncRNA TALNEC2 aggravates cerebral ischemia/reperfusion injury via acting as a ceRNA for miR-650 to target apoptotic peptidase activating factor 1. Neuroscience. 2021;458:64–76.
   PubMedGoogle Scholar
• Liu B, Li J, Cairns MJ. Identifying miRNAs, targets and functions. Brief Bioinform. 2014;15(1):1–19.
   PubMed Web of Science ®Google Scholar
• Orlandella FM, Mariniello RM, Iervolino PLC, et al. miR-650 promotes motility of anaplastic thyroid cancer cells by targeting PPP2CA. Endocrine. 2019;65(3):582–594.
   PubMedGoogle Scholar
• Han LL, Yin XR, Zhang SQ. miR-650 promotes the metastasis and Epithelial-Mesenchymal transition of hepatocellular carcinoma by directly inhibiting LATS2 expression. Cell Physiol Biochem. 2018;51(3):1179–1192.
   PubMedGoogle Scholar
• Lin Y-C, Chen C-C, Cheng C-J, et al. Domain and functional analysis of a novel breast tumor suppressor protein, SCUBE2. J Biol Chem. 2011;286(30):27039–27047.
   PubMed Web of Science ®Google Scholar